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See detailLa crise financière défie les autorités européennes et américaines de surveillance
Prüm, André UL

in Revue de Droit Bancaire et Financier (2008), (3), 1-3

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See detailLa crise financière est-elle (aussi) une crise du droit pénal? Esquisse d'une dialectique entre une crise factuelle et une crise normative
Rodopoulos, Ioannis UL

in Revue de Science Criminelle et de Droit Pénal Comparé (2013), (1), 1-22

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See detailUne crise mondiale du musée… et des pistes de réflexion luxembourgeoises à trouver 
Schall, Céline UL

Article for general public (2014)

Dans les années 1960, une crise a secoué les musées européens, notamment lorsque leur caractère élitiste a été mis en évidence. À cette époque, leur fréquentation était presqu’exclusivement le fait des ... [more ▼]

Dans les années 1960, une crise a secoué les musées européens, notamment lorsque leur caractère élitiste a été mis en évidence. À cette époque, leur fréquentation était presqu’exclusivement le fait des classes cultivées et on estimait que la possibilité d’apprécier l’art relevait d’une capacité innée – qui ne pouvait donc pas s’apprendre. Cette crise a débouché, dans les années 1970, à un renouvellement de l’approche du musée et à la naissance de ce que l’on a appelé « la nouvelle muséologie », dans le sillage de la pensée de Georges Henri Rivière et du mouvement général de démocratisation culturelle. Depuis, cette démocratisation, la mondialisation et le boom du tourisme culturel notamment ont contribué à faire du musée un élément économique, culturel, identitaire et social incontournable de nos sociétés. Un tout nouveau champ de recherches foisonnant notamment en France, Belgique, Italie ou au Royaume-Uni a accompagné les musées dans une transformation radicale, les conduisant notamment à se multiplier et à mettre le visiteur et la médiation au centre de leur démarche (plutôt que les seules œuvres)... [less ▲]

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See detailCrisi di liquidità dell’impresa e sospensione dell’esecuzione della sentenza ex art. 373 c.p.c.
Ratti, Luca UL

in Il Lavoro nella Giurisprudenza (2004)

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See detailThe "Crisis of Luxembourg". History and Memory of 1867
Jungblut, Marie-Paule UL; Kmec, Sonja UL

in Grandhomme, Jean-Noël (Ed.) 1866, une querelle d'Allemands? Perceptions croisées et mémoire(s) d'un moment clé de l'histoire européenne (2018)

Detailed reference viewed: 94 (9 UL)
See detailCRISPR/CAS9 AND PIGGYBAC MEDIATED LRRK2-G2019S IN VITRO PARKINSON’S DISEASE MODELING
Qing, Xiaobing UL

Doctoral thesis (2017)

Parkinson’s disease (PD), the second most common neurodegenerative disorder, is characterized by the progressive loss of dopaminergic (DA) neurons in the substantial nigra pars compacta (SNpc) area of the ... [more ▼]

Parkinson’s disease (PD), the second most common neurodegenerative disorder, is characterized by the progressive loss of dopaminergic (DA) neurons in the substantial nigra pars compacta (SNpc) area of the human midbrain with an unclear cause. Mutations revealed by whole genome sequencing (WGS) from familial PD cases may explain how cell loss occurs. Confirmation of this hypothesis has been hampered by the lack of available cell types from affected patients. Transgenic animal models have been used, but differences between these animals and humans have greatly impacted their usefulness for studying human diseases. Additionally, because PD is regarded to only affect humans, reliable human material-based experimental models are urgently needed. Human-induced pluripotent stem cells (hiPSCs)- derived DA neurons provide an opportunity to establish in vitro mutation-related PD models of disease-relevant cells that represent replacement alternatives to in vivo animal experiments. However, these hiPSCs-based PD models have limitations regarding the genetic background differences between patients and healthy controls. Genomic editing of hiPSCs allows for the generation of isogenic cellular models that differ only in the disease-specific mutations of interest. Currently, the biggest concern regarding nuclease-mediated genomic editing is the potentially undesirable alterations associated with remnant sequences, off-target effects and random integration, which may result in cell lines not being truly isogenic. To avoid potential confounding effects and establish a causal link between genotype and phenotype, robust isogenic cell lines free of unwanted mutagenesis are absolutely required for the study of PD. To better understand the pathogenesis of the most prevalent leucine-rich repeat kinase 2 (LRRK2) mutation, G2019S, which causes both familial and sporadic PD, patient hiPSCs have been corrected using the Cre/LoxP recombination system. However, the LoxP site inevitably remaining after excision of the selection cassette can influence gene expression. In this thesis, a “footprint-free” LRRK2-G2019S isogenic model was created using clustered regularly interspaced short palindromic repeats/Cas9-associated (CRISPR/Cas9) system and a piggyBac transposon that can remove selection cassettes without leaving remnants. In LRRK2-G2019S DA neurons, the percentage of tyrosine hydroxylase (TH)-positive neurons with a total neurite length greater than 2 cm was significantly reduced, and the average branch number was also decreased. These PD-like phenotypes could be rescued by administration of the specific LRRK2 inhibitor LRRK2-IN-1 and by the compound BRF110, which activates the Nurr1:RXRa heterodimer to replenish the DA shortage. Our data suggest that the “footprint- free” LRRK2-G2019S isogenic cell lines allow standardized, genetic background-independent, in vitro PD modeling and are suitable for screening novel drugs that have clinical applications. In addition, we have shown that in vitro TH-positive neurons with a total neurite length greater than 2 cm were positive for serine 129 phosphorylated (S129P) α-synuclein, and we hypothesize that S129P α-synuclein plays a role in the maintenance or formation of long neurites. Thus, we have also provided new insights into the roles of LRRK2-G2019S and S129P α-synuclein in PD pathogenesis. Furthermore, we have optimized CRISPR/Cas9-mediated genomic editing in hiPSCs by establishing a FACS-assisted CRISPR/Cas9 editing (FACE) strategy that uses three fluorescent proteins to isolate biallelic-edited cells with no random integration and by using Exonuclease III (ExoIII)-facilitated long single stranded DNA (ssDNA) donor to reduce random integration. [less ▲]

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See detailCritère d'irréductibilité pour les courbes elliptiques semi-stables sur un corps de nombres
David, Agnès UL

E-print/Working paper (2012)

For a fixed number field and an elliptic curve defined and semistable over this number field, we consider the set of prime numbers p such that the Galois representation attached to the p-torsion points of ... [more ▼]

For a fixed number field and an elliptic curve defined and semistable over this number field, we consider the set of prime numbers p such that the Galois representation attached to the p-torsion points of the elliptic curve is reducible. When the number field satisfies a certain necessary condition, we give an explicit bound, depending only on the number field and not on the semistable elliptic curve, for these primes. This generalizes previous results of Kraus. [less ▲]

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See detailCriteria for Centers of Reference for pediatric diabetes--a European perspective
Danne, T.; Lion, S.; Madaczy, L. et al

in Pediatric Diabetes (2012), 13(16), 62-75

' SWEET' is an acronym standing for 'Better control in pediatric and adolescent diabeteS: Working to crEate CEnTers of Reference ( CORs)' and is based on a partnership of established national and European ... [more ▼]

' SWEET' is an acronym standing for 'Better control in pediatric and adolescent diabeteS: Working to crEate CEnTers of Reference ( CORs)' and is based on a partnership of established national and European diabetes organizations such as International Diabetes Federation, Federation of European Nurses in Diabetes, and Primary Care Diabetes Europe (PCDE, www.sweet-project.eu). A three-level classification of centers has been put forward. In addition to centers for local care, SWEET collaborating centers on their way to being a COR have been defined. Peer-audited CORs with a continuous electronic documentation of at least 150 pediatric patients with diabetes treated by a multidisciplinary team based on the International Society for Pediatric and Adolescent Diabetes ( ISPAD) Clinical Practice recommendations have been created in 12 European countries. In 2011, they cared for between 150 to more than 700 youth with diabetes with an average hemoglobin A1c between 7.6 and 9.2%. Although these clinics should not be regarded as representative for the whole country, the acknowledgment as COR includes a common objective of targets and guidelines as well as recognition of expertise in treatment and education at the center. In a first step, the SWEET Online platform allows 12 countries using 11 languages to connect to one unified diabetes database. Aggregate data are de-identified and exported for longitudinal health and economic data analysis. Through their network, the CORs wish to obtain political influence on a national and international level and to facilitate dissemination of new approaches and techniques. The SWEET project hopes to extend from the initial group of centers within countries, throughout Europe, and beyond with the help of the ISPAD network. [less ▲]

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See detailCriteria for p-ordinarity of Families of Elliptic curves over infinitely many number fields
Freitas, Nuno; Tsaknias, Panagiotis UL

in International Journal of Number Theory (2015), 11(1), 81-87

Detailed reference viewed: 76 (4 UL)
See detailCritic of Amy Gutmann - The Constructive Potential of Communitarian Values for Liberalism
Graf, Lukas UL

E-print/Working paper (2005)

The view of Amy Gutmann is that communitarians have been unsuccessful in undermining liberalism. However, she thinks that their work presents a welcome challenge to it. In her opinion, the communitarian ... [more ▼]

The view of Amy Gutmann is that communitarians have been unsuccessful in undermining liberalism. However, she thinks that their work presents a welcome challenge to it. In her opinion, the communitarian criticism, rather than giving good reason to abandon liberalism, is of use in an attempt to discover a liberalism that successfully combines communitarian with liberal values. This paper examines the extent to which Gutmann successfully shows that communitarian values, like kinship, affection, or a sense of common purpose, have the latent but unrealized capacity to serve to improve liberalism. [less ▲]

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See detailCritical Analysis of Fiction Essays in Discourse Stylistics
Weber, Jean-Jacques UL

Book published by Rodopi (1992)

Detailed reference viewed: 140 (0 UL)
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See detailA Critical Analysis of Legal Requirements Engineering from the Perspective of Legal Practice
Boella, Guido; Humphreys, Llio UL; Muthuri, Robert UL et al

in Seventh IEEE Workshop on Requirements Engineering and Law (2014)

This paper reviews existing approaches to representing legal knowledge for legal requirements engineering. Legal requirement methodologies are rarely developed together with legal practitioners, with the ... [more ▼]

This paper reviews existing approaches to representing legal knowledge for legal requirements engineering. Legal requirement methodologies are rarely developed together with legal practitioners, with the result that often approaches are based on a simplified view of law which prevents their acceptance by legal practitioners. In this paper, we analyse how legal practitioners build legal knowledge and possibilities for existing approaches in RELaw to mirror legal practice. [less ▲]

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See detailCritical behaviour of nanocrystalline gadolinium: evidence for random uniaxial dipolar universality class
Ferdinand, A.; Probst, A.-C.; Michels, Andreas UL et al

in Journal of Physics : Condensed Matter (2014), 26

Detailed reference viewed: 135 (7 UL)
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See detailA Critical Co/Autoethnographic Exploration of Self: Becoming Science Education Researchers in Diverse Cultural and Linguistic Landscapes
Park, Jennifer; Wilmes, Sara UL

in Bazzul, Jesse; Siry, Christina (Eds.) Critical voices in science education research: Narratives of academic journeys (2019)

This chapter illustrates the process of collaborative autoethnography (co-autoethnography) we used to construct space, in order to critically explore ourselves, and the contexts we study. Through a co ... [more ▼]

This chapter illustrates the process of collaborative autoethnography (co-autoethnography) we used to construct space, in order to critically explore ourselves, and the contexts we study. Through a co-autoethnographic process, we aimed to better understand our positioning in our lived experiences and to generate an understanding of how reflective critical research approaches could transform us, as well as the communities in which we were immersed. In this chapter, we share the process of our collective analysis of autoethnographic narratives (Coia L, Taylor M, Co/autoethnography: Exploring our teaching selves collaboratively. In L. Fitzgerald, M. Heston, D. Tidwell (Eds.), Research methods for the self-study of practice (pp. 3–16). Netherlands: Springer, 2009), which stemmed from our experiences living and conducting education research in multilingual and multicultural contexts. Our ethnographic method of data collection, analysis, and interpretation was generated from our journeys as researchers – moving to, living, and conducting research in culturally and linguistically diverse (CLD) environments. We share this process, and some lessons we learned, with the hope that other researchers may find co-autoethnography a cathartic methodology to explore and challenge their own perspectives relative to cultural and linguistic diversity in their lives and in their research. [less ▲]

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See detailCritical discussion of the special issue current innovations in computer-based assessment.
Greiff, Samuel UL; Scherer, Ronny; Kirschner, Paul A.

in Computers in Human Behavior (2017), 76

Detailed reference viewed: 41 (3 UL)
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See detailA critical discussion on the use of the notion of conviviality for digital cities
Caire, Patrice UL

in Proceedings of Web Communities 2007, Salamanca, Spain, February 2007, pp. 193–200 (2007, February 10)

Detailed reference viewed: 39 (0 UL)