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See detailCyberharcèlement - Quoi faire?
Steffgen, Georges UL

Presentation (2015, November 28)

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See detailCybersecurity of Robotics and Autonomous Systems: Privacy and Safety
Rodriguez Lera, Francisco Javier UL; Llamas, Camino Fernández; Guerrero, Ángel Manuel et al

in Dekoulis, George (Ed.) Robotics - Legal, Ethical and Socioeconomic Impacts (2017)

Robots and autonomous systems in general are set to suffer similar cybersecurity problems that computers have been facing for decades. This is not only worrying for critical tasks such as those performed ... [more ▼]

Robots and autonomous systems in general are set to suffer similar cybersecurity problems that computers have been facing for decades. This is not only worrying for critical tasks such as those performed by surgical, or military robots but also for household robots such as vacuum cleaners or for teleconference robots compromise privacy and safety of their owners. What will happen if these robots are hacked? This study presents a survey on the cybersecurity attacks associated with service robots, and as a result, a taxonomy that classifies the risks faced by users when using service robots, distinguish ing between security and safety threads, is presented. We also present the robot software development phase as one the most relevant ones for the security of robots. [less ▲]

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See detailA cyclic extension of the earthquake flow I
Bonsante, Francesco; Mondello, Gabriele; Schlenker, Jean-Marc UL

in Geometry & Topology (2013), 17(1), 157--234

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See detailA cyclic extension of the earthquake flow II
Bonsante, Francesco; Mondello, Gabriele; Schlenker, Jean-Marc UL

in Annales Scientifiques de l'Ecole Normale Supérieure (2015), 48(4), 811859

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See detailCyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.
Siegmund, S. V.; Wojtalla, A.; Schlosser, M. et al

in Biochemical and biophysical research communications (2016), 470(3), 678-84

The endogenous cannabinoid 2-arachidonoyl glycerol (2-AG) is an anti-fibrotic lipid mediator that induces apoptosis in hepatic stellate cells (HSCs), but not in hepatocytes. However, the exact molecular ... [more ▼]

The endogenous cannabinoid 2-arachidonoyl glycerol (2-AG) is an anti-fibrotic lipid mediator that induces apoptosis in hepatic stellate cells (HSCs), but not in hepatocytes. However, the exact molecular mechanisms of this selective induction of HSC death are still unresolved. Interestingly, the inducible isoform of cyclooxygenase, COX-2, can metabolize 2-AG to pro-apoptotic prostaglandin glycerol esters (PG-GEs). We analyzed the roles of COX-2 and endocannabinoid-derived PG-GEs in the differential susceptibility of primary activated HSCs and hepatocytes toward 2-AG-induced cell death. HSCs displayed significant COX-2 expression in contrast to hepatocytes. Similar to 2-AG, treatment of HSCs with PGD2-GE dose-dependently induced cell death independently from cannabinoid receptors that was accompanied by PARP- and caspase 3-cleavage. In contrast to 2-AG, PGD2-GE failed to induce significant ROS formation in HSCs, and depletion of membrane cholesterol did not rescue HSCs from PGD2-GE-induced apoptosis. These findings indicate differential engagement of initial intracellular signaling pathways by 2-AG and its COX-2-derived metabolite PGD2-GE, but similar final cell death pathways. Other PG-GEs, such as PGE2-or PGF2alpha-GE did not induce apoptosis in HSCs. Primary rat hepatocytes were mainly resistant against 2-AG- and PGD2-GE-induced apoptosis. HSCs, but not hepatocytes were able to metabolize 2-AG to PGD2-GE. As a proof of principle, HSCs from COX-2(-/-) mice lacked PDG2-GE production after 2-AG treatment. Accordingly, COX-2(-/-) HSCs were resistant against 2-AG-induced apoptosis. In conclusion, the divergent expression of COX-2 in HSCs and hepatocytes contributes to the different susceptibility of these cell types towards 2-AG-induced cell death due to the generation of pro-apoptotic PGD2-GE by COX-2 in HSCs. Modulation of COX-2-driven metabolization of 2-AG may provide a novel physiological concept allowing the specific targeting of HSCs in liver fibrosis. [less ▲]

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See detailCyclophilin a binds to linear peptide motifs containing a consensus that is present in many human proteins
Piotukh, K.; Gu, Wei UL; Kofler, M. et al

in Journal of Biological Chemistry (2005), 280(25), 23668-23674

Cyclophilin A ( CypA) is a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells. It might either act as a catalyst for prolyl bond isomerization, or it can ... [more ▼]

Cyclophilin A ( CypA) is a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells. It might either act as a catalyst for prolyl bond isomerization, or it can form stoichiometric complexes with target proteins. We have investigated the linear sequence recognition code for CypA by phage display and found the consensus motif FGPXLp to be selected after five rounds of panning. The peptide FGP-DLPAGD showed inhibition of the isomerase reaction and NMR chemical shift mapping experiments highlight the CypA interaction epitope. Ligand docking suggests that the peptide was able to bind to CypA in the cis- and trans-conformation. Protein Data Bank searches reveal that many human proteins contain the consensus motif, and several of these protein motifs are shown to interact with CypA in vitro. These sequences represent putative target sites for binding of CypA to intracellular proteins. [less ▲]

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See detailCytokine-mediated growth inhibition of human melanoma cells
Kortylewski, M.; Heinrich, P. C.; Mackiewicz, A. et al

in Advances in Experimental Medicine and Biology (2001), 495

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See detailCytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Kirchmeyer, Melanie; Servais, Florence UL; Hamdorf, Matthias et al

in Journal of leukocyte biology (2018)

Interleukin-6 (IL-6)-type cytokines play important roles in liver (patho-)biology. For instance, they regulate the acute phase response to inflammatory signals and are involved in hepatocarcinogenesis ... [more ▼]

Interleukin-6 (IL-6)-type cytokines play important roles in liver (patho-)biology. For instance, they regulate the acute phase response to inflammatory signals and are involved in hepatocarcinogenesis. Much is known about the regulation of protein-coding genes by cytokines whereas their effects on the miRNome is less well understood. We performed a microarray screen to identify microRNAs (miRNAs) in human hepatocytes which are modulated by IL-6-type cytokines. Using samples of 2 donors, 27 and 68 miRNAs (out of 1,733) were found to be differentially expressed upon stimulation with hyper-IL-6 (HIL-6) for up to 72 h, with an overlap of 15 commonly regulated miRNAs. qPCR validation revealed that miR-146b-5p was also consistently up-regulated in hepatocytes derived from 2 other donors. Interestingly, miR-146b-5p (but not miR-146a-5p) was induced by IL-6-type cytokines (HIL-6 and OSM) in non-transformed liver-derived PH5CH8 and THLE2 cells and in Huh-7 hepatoma cells, but not in HepG2 or Hep3B hepatoma cells. We did not find evidence for a differential regulation of miR-146b-5p expression by promoter methylation, also when analyzing the TCGA data set on liver cancer samples. Inducible overexpression of miR-146b-5p in PH5CH8 cells followed by RNA-Seq analysis revealed effects on multiple mRNAs, including those encoding IRAK1 and TRAF6 crucial for Toll-like receptor signaling. Indeed, LPS-mediated signaling was attenuated upon overexpression of miR-146b-5p, suggesting a regulatory loop to modulate inflammatory signaling in hepatocytes. Further validation experiments suggest DNAJC6, MAGEE1, MPHOSPH6, PPP2R1B, SLC10A3, SNRNP27, and TIMM17B to be novel targets for miR-146b-5p (and miR-146a-5p). [less ▲]

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See detailCytoplasmic STAT proteins associate prior to activation
Haan, Serge UL; Kortylewski, M.; Behrmann, Iris UL et al

in Biochemical Journal (2000), 345 Pt 3

The commonly accepted model of STAT factor activation at the cytoplasmic part of the receptor assumes that signal transducers and activators of transcription (STATs) are recruited from a cytoplasmic pool ... [more ▼]

The commonly accepted model of STAT factor activation at the cytoplasmic part of the receptor assumes that signal transducers and activators of transcription (STATs) are recruited from a cytoplasmic pool of monomeric STAT proteins. Based on a previous observation that non-phosphorylated STAT3-Src homology 2 domains dimerize in vitro, we investigated whether the observed dimerization is of physiological relevance within the cellular context. We show that STAT1 and STAT3 are pre-associated in non-stimulated cells. Apparently, these complexes are not able to translocate into the nucleus. We provide evidence that the event of STAT activation is more complex than previously assumed. [less ▲]

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See detailCytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer.
Lee, JY; Talhi, O; Jang, D et al

in Cancer Letters (2018)

Coumarins are natural compounds with antioxidant, anti-inflammatory and anti-cancer potential known to modulate inflammatory pathways. Here, non-toxic biscoumarin OT52 strongly inhibited proliferation of ... [more ▼]

Coumarins are natural compounds with antioxidant, anti-inflammatory and anti-cancer potential known to modulate inflammatory pathways. Here, non-toxic biscoumarin OT52 strongly inhibited proliferation of non-small cell lung cancer cells with KRAS mutations, inhibited stem-like characteristics by reducing aldehyde dehydrogenase expression and abrogated spheroid formation capacity. This cytostatic effect was characterized by cell cycle arrest and onset of senescence concomitant with endoplasmic reticulum and Golgi stress, leading to metabolic alterations. Mechanistically, this cellular response was associated with the novel capacity of biscoumarin OT52 to inhibit STAT3 transactivation and expression of its target genes linked to proliferation. These results were validated by computational docking of OT52 to the STAT3 DNA-binding domain. Combination treatments of OT52 with subtoxic concentrations of Bcl-xL and Mcl-1-targeting BH3 protein inhibitors triggered synergistic immunogenic cell death validated in colony formation assays as well as in vivo by zebrafish xenografts. [less ▲]

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See detailCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
Kischkel, F. C.; Hellbardt, S.; Behrmann, Iris UL et al

in EMBO Journal (1996), 14(22), 5579-88

APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In a search to identify intracellular signaling molecules coupling to ... [more ▼]

APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In a search to identify intracellular signaling molecules coupling to oligomerized APO-1, several cytotoxicity-dependent APO-1-associated proteins (CAP) were immunoprecipitated from the apoptosis-sensitive human leukemic T cell line HUT78 and the lymphoblastoid B cell line SKW6.4. CAP1-3 (27-29 kDa) and CAP4 (55 kDa), instantly detectable after the crosslinking of APO-1, were associated only with aggregated (the signaling form of APO-1) and not with monomeric APO-1. CAP1 and CAP2 were identified as serine phosphorylated MORT1/FADD. The association of CAP1-4 with APO-1 was not observed with C-terminally truncated non-signaling APO-1. In addition, CAP1 and CAP2 did not associate with an APO-1 cytoplasmic tail carrying the lprcg amino acid replacement. Moreover, no APO-1-CAP association was found in the APO-1+, anti-APO-1-resistant pre-B cell line Boe. Our data suggest that in vivo CAP1-4 are the APO-1 apoptosis-transducing molecules. [less ▲]

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See detailD is for democracy: Critical education between inclusion and interruption
Biesta, Gert UL

in Ze’ev, I. Gur (Ed.) The possibility/impossibiloity of a new critical language in education. (2010)

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See detailD wie Damals
Heimböckel, Dieter UL

Article for general public (2012)

Detailed reference viewed: 45 (0 UL)
See detailD'"Erfanne" vun der Nationalliteratur am Essai sur la poésie luxembourgeoise (1854) vum Félix Thyes
Glesener, Jeanne UL

in Millim, Anne-Marie; De Toffoli, Ian (Eds.) Madernismen in Luxemburg. Traditionen-Variationen-Brüche. Modernismes au Luxembourg. Traditions-Variations-Ruptures (2019)

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See detailD’Aarbechtsgediechtnes an d’Léiere bei Kanner
Engel de Abreu, Pascale UL

Article for general public (2011)

Dës Brochure soll derzou bäidroen, fir Iech d’Konzept “Aarbechtsgediechtnes” méi nozebréngen. Dir fannt an dëser Brochure Informatiounen iwwer d’Verbindung tëschent dem Aarbechtsgediechtnes an dem Léiere ... [more ▼]

Dës Brochure soll derzou bäidroen, fir Iech d’Konzept “Aarbechtsgediechtnes” méi nozebréngen. Dir fannt an dëser Brochure Informatiounen iwwer d’Verbindung tëschent dem Aarbechtsgediechtnes an dem Léiere bei Kanner; iwwer méiglech Léierschwieregkeete vu Kanner mat Aarbechtsgediechtnesproblemer; a wéi een dës Problemer an der Klass erkenne kann an deem entgéintwierke kann. Ech beschreiwen och kuerz mäin aktuelle Fuerschungsprojet op der Universitéit Lëtzebuerg, dee sech mat den Auswierkunge vun der Méisproochegkeet op d’Aarbechtsgediechtnes beschäftegt. [less ▲]

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See detail“D’après une histoire vraie”
Barthelmebs-Raguin, Hélène UL

in Ferry, Ariane; Provini, Sandra (Eds.) Figures et personnages de criminelles, des histoires tragiques au roman policier (in press)

Detailed reference viewed: 27 (0 UL)
See detailD'Atlantropa à Desertec: macro-projeter le continent ressource du 20e siècle
Hertweck, Florian UL; Lopez, Fanny

in Rouillard, Dominique (Ed.) Afriques. Architecture, infrastructures et territoires en devenir (2015)

Detailed reference viewed: 91 (1 UL)
See detailD'Chancegläichheet vun Fraën a Männer an der Städtepolitik
Becker, Tom UL

Scientific Conference (2009)

Detailed reference viewed: 32 (0 UL)
See detailD’Chorale Municipale vu Schëffleng. E ganz besonnesche Chouer
Sagrillo, Damien UL

in Sagrillo, Damien; Gliedner, Gilbert (Eds.) Joer Chorale Municipale. 50 Joer Chorale “Minettsro’sen Schëffleng 2014 (2016)

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See detailD’Exekutivfunktiounen an d’Sproochentwécklung bei jonken Immigrantekanner zu Lëtzebuerg
Engel de Abreu, Pascale UL

Conference given outside the academic context (2012)

Detailed reference viewed: 71 (2 UL)