![]() ; ; et al in Cancer Cell (2008), 13 Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we unravel a mechanism regulating glioma ... [more ▼] Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we unravel a mechanism regulating glioma infiltration. Tumor interaction with the surrounding brain tissue induces CD95 Ligand expression. Binding of CD95 Ligand to CD95 on glioblastoma cells recruits the Src family member Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases. In a murine syngeneic model of intracranial GBM, neutralization of CD95 activity dramatically reduced the number of invading cells. Our results uncover CD95 as an activator of PI3K and, most importantly, as a crucial trigger of basal invasion of glioblastoma in vivo. [less ▲] Detailed reference viewed: 140 (2 UL)![]() ; Steffgen, Georges ![]() in Psychology and Health (2010), 25(1), 137-376 Based on the assumptions of social cognitive theory and self-regulation theory, the present study aimed at exploring psychosocial factors in self-care of diabetes (Edgar & Skinner, 2003; Iannotti et al ... [more ▼] Based on the assumptions of social cognitive theory and self-regulation theory, the present study aimed at exploring psychosocial factors in self-care of diabetes (Edgar & Skinner, 2003; Iannotti et al., 2006; Nouwen et al., 2009). The study sample comprised N 1⁄4 99 patients with type 1 diabetes aged between 12 and 39 years. Participants completed the diabetes self-efficacy scale, the brief illness perceptions questionnaire, the WHO-five index and the summary of diabetes self-care activities scale. Results showed that illness perceptions (i.e. perceived consequences (r1⁄40.28), personal control (r1⁄40.24), treatment control (r1⁄40.27), compre- hension (r1⁄40.27) and emotional response (r1⁄40.27)), as well as well-being (r1⁄40.42) and perceived diabetes self-efficacy (r 1⁄4 0.55) were significantly correlated with self-care. Furthermore, stepwise regression analyses elucidated self-efficacy (1⁄40.44) to be the most powerful predictor of self-care, as illness perceptions and well-being became non significant when introducing self-efficacy. Moreover, self-efficacy completely mediated the effect of well- being on self-care (Sobel t 1⁄4 3.74, p50.01). As for clinical implications of these results, it can be suggested that a stronger emphasise should be given on fostering patients’ confidence in their ability to effectively manage their diabetes. [less ▲] Detailed reference viewed: 130 (3 UL)![]() ; ; et al in Proceedings of the 55th Hawaii International Conference on System Sciences (2022, January 04) Due to blockchains’ intrinsic transparency and immutability, blockchain-based applications are challenged by privacy regulations, such as the EU General Data Protection Regulation. Hence, scaling ... [more ▼] Due to blockchains’ intrinsic transparency and immutability, blockchain-based applications are challenged by privacy regulations, such as the EU General Data Protection Regulation. Hence, scaling blockchain use cases to production often fails to owe to a lack of compliance with legal constraints. As current research mainly focuses on specific use cases, we aim to offer comprehensive guidance regarding the development of blockchain solutions that comply with privacy regulations. Following the action design research method, we contribute a generic framework and design principles to the research domain. In this context, we also emphasize the need for distinguishing between applications based on blockchains’ data integrity and computational integrity guarantees. [less ▲] Detailed reference viewed: 26 (7 UL)![]() Aleksic, Gabrijela ![]() Book published by Information Age Publications (n.d.) I introduce the book starting by my own personal experience of growing up in a mixed family and being myself in a mixed marriage. I describe the structure of the book by building up my own method: how I ... [more ▼] I introduce the book starting by my own personal experience of growing up in a mixed family and being myself in a mixed marriage. I describe the structure of the book by building up my own method: how I chose this topic, who were the people I interviewed, how (interviews, stories, and objects) and why was the single-but-critical instances analysis important. I focus on the richness of the interaction I had with the interviewees. I underlie the phenomenological stories of struggles, trust and vulnerability. The chapters resolve around power relations, expressing affection, in-depth communication, child rearing, conflict resolution strategies, empathy, female identity, future planning, the role of humor, the biggest cultural and linguistic challenges and opportunities. The focus is on the phenomenon captured in single-but-critical instances in participants' stories. I conclude by describing what significance culture has in intimate intercultural relationships. [less ▲] Detailed reference viewed: 284 (18 UL)![]() Haddadan, Shohreh ![]() Scientific Conference (2019, July) Political debates offer a rare opportunity for citizens to compare the candidates’ positions on the most controversial topics of the campaign. Thus they represent a natural application scenario for ... [more ▼] Political debates offer a rare opportunity for citizens to compare the candidates’ positions on the most controversial topics of the campaign. Thus they represent a natural application scenario for Argument Mining. As existing research lacks solid empirical investigation of the typology of argument components in political debates, we fill this gap by proposing an Argument Mining approach to political debates. We address this task in an empirical manner by annotating 39 political debates from the last 50 years of US presidential campaigns, creating a new corpus of 29k argument components, labeled as premises and claims. We then propose two tasks: (1) identifying the argumentative components in such debates, and (2) classifying them as premises and claims. We show that feature-rich SVM learners and Neural Network architectures outperform standard baselines in Argument Mining over such complex data. We release the new corpus USElecDeb60To16 and the accompanying software under free licenses to the research community. [less ▲] Detailed reference viewed: 143 (9 UL)![]() Ganschow, Inna ![]() Article for general public (2021) After someone dies of the coronavirus and medical staff is no longer needed, work for more COVID fighters begins - the morticians. Detailed reference viewed: 32 (0 UL)![]() Nourdin, Ivan ![]() in Electronic Communications in Probability (2011), 16 Detailed reference viewed: 137 (1 UL)![]() Zaagsma, Gerben ![]() Textual, factual or bibliographical database (2023) This repository contains a dataset of known historical Yiddish newspapers and periodicals published in Germany. The list is based upon cataloguing and holding information from the libraries and book ... [more ▼] This repository contains a dataset of known historical Yiddish newspapers and periodicals published in Germany. The list is based upon cataloguing and holding information from the libraries and book listed below. The list is provided as an Excel sheet and is a work in progress. Currently the list contains 227 items, 21 of which are available in digitised form. URLs for the digitised periodicals are provided; the list also provides holding locations for the other periodicals but no direct links (yet) to their online catalog records. Any comments and additions are most welcome, please get in touch via: gerben.zaagsma@uni.lu. [less ▲] Detailed reference viewed: 40 (3 UL)![]() Marmulla, Henning ![]() Presentation (2014, March 25) Detailed reference viewed: 71 (0 UL)![]() Marmulla, Henning ![]() in Gilcher-Holtey, Ingrid (Ed.) Eingreifende Denkerinnen. Weibliche Intellektuelle im 20. und 21. Jahrhundert (2015) Detailed reference viewed: 143 (0 UL)![]() ![]() Peporte, Pit ![]() in Kmec, Sonja; Péporté, Pit (Eds.) Lieux de mémoire au Luxembourg. Vol. 2: Jeux d'échelles (2012) Detailed reference viewed: 177 (4 UL)![]() Sieburg, Heinz ![]() E-print/Working paper (in press) Detailed reference viewed: 178 (12 UL)![]() Dupont, Elona ![]() ![]() Scientific Conference (2023) Detailed reference viewed: 52 (1 UL)![]() Liu, Kui ![]() ![]() ![]() in The 12th IEEE International Conference on Software Testing, Verification and Validation (ICST-2019) (2019, April 24) Properly benchmarking Automated Program Repair (APR) systems should contribute to the development and adoption of the research outputs by practitioners. To that end, the research community must ensure ... [more ▼] Properly benchmarking Automated Program Repair (APR) systems should contribute to the development and adoption of the research outputs by practitioners. To that end, the research community must ensure that it reaches significant milestones by reliably comparing state-of-the-art tools for a better understanding of their strengths and weaknesses. In this work, we identify and investigate a practical bias caused by the fault localization (FL) step in a repair pipeline. We propose to highlight the different fault localization configurations used in the literature, and their impact on APR systems when applied to the Defects4J benchmark. Then, we explore the performance variations that can be achieved by "tweaking'' the FL step. Eventually, we expect to create a new momentum for (1) full disclosure of APR experimental procedures with respect to FL, (2) realistic expectations of repairing bugs in Defects4J, as well as (3) reliable performance comparison among the state-of-the-art APR systems, and against the baseline performance results of our thoroughly assessed kPAR repair tool. Our main findings include: (a) only a subset of Defects4J bugs can be currently localized by commonly-used FL techniques; (b) current practice of comparing state-of-the-art APR systems (i.e., counting the number of fixed bugs) is potentially misleading due to the bias of FL configurations; and (c) APR authors do not properly qualify their performance achievement with respect to the different tuning parameters implemented in APR systems. [less ▲] Detailed reference viewed: 251 (18 UL)![]() ; Murphy, Emily ![]() in Higher Education Quarterly (2020) Detailed reference viewed: 83 (2 UL)![]() ![]() Sunnen, Patrick ![]() ![]() ![]() Scientific Conference (2013, November 22) Detailed reference viewed: 102 (3 UL)![]() Pailler, Fred ![]() Presentation (2022, June 09) Detailed reference viewed: 42 (3 UL)![]() Limbach-Reich, Arthur ![]() Presentation (2021, May) Social service providers in the Greater Region report that many children in need of special care and social assistance find themselves in cross-border situations. The legal regulations and practices for ... [more ▼] Social service providers in the Greater Region report that many children in need of special care and social assistance find themselves in cross-border situations. The legal regulations and practices for the care of children and adolescents can vary considerably from country to country. This can cause delays, breaks or deterioration in the quality of support and sometimes irreversibly worsen the child's situation. Depending on the situation, diagnoses and access to social, medical-social or legal services can change considerably. The EURQUA project deals with cross-border child protection and disability rights within a multinational perspective. [less ▲] Detailed reference viewed: 127 (7 UL)![]() Venken, Machteld ![]() in Mink, Georges; Neumayer, Laure (Eds.) History, Memory and Politics in Central, East and South East Europe (2012) Detailed reference viewed: 41 (1 UL)![]() Badder, Anastasia ![]() Scientific Conference (2021, November 17) For decades, Luxembourg funded its recognized religious communities; recently, with a goal of greater secularization, the state made major changes (and cuts) to its funding scheme. This move revived ... [more ▼] For decades, Luxembourg funded its recognized religious communities; recently, with a goal of greater secularization, the state made major changes (and cuts) to its funding scheme. This move revived simmering tensions in the Jewish community, comprised of one Orthodox and one Liberal synagogue and represented to the state by a single Orthodox-led administrative body (la communauté israélite du Luxembourg, or CIL). Emboldened by growing membership and fearing a loss of their already-precarious autonomy and financial support, the Liberal congregation has begun pushing for representation on the CIL, which the Orthodox congregation in turn resists. In the process, Orthodox leadership is forced to reflect on their own practices and values in sometimes uncomfortable ways. As they jostle for control of the CIL, each side makes claims to truth, authenticity, and authority based on drastically different ethics and visions of the future for Luxembourg and its Jewish community. In board meetings, general assemblies, and conversations, old conflicts around the 'right' kind of Jewish life and current and future shape and needs of the Jewish community are rearticulated as the two congregations debate who can and should be the state's interlocutor. Based on 31 months of fieldwork, this paper explores how a reorganization of state administrative control reignited an old struggle within Luxembourg's Jewish community and how two congregations with different histories, ethical projects, and anticipated futures fight to define Jewishness, community, and a good Jewish life and to maintain (or gain) the right to represent Judaism to the Luxembourgish state. [less ▲] Detailed reference viewed: 23 (0 UL) |
||