Transdisziplinäre Altersforschung und Partizipation.

in Transdisziplinäre Alter(n)sstudien. Gegenstände und Methoden (2010)

Transfer Learning and Meta Learning Based Fast Downlink Beamforming Adaptation

in IEEE Transactions on Wireless Communications (2021)

This paper studies fast adaptive beamforming optimization for the signal-to-interference-plus-noise ratio balancing problem in a multiuser multiple-input single-output downlink system. Existing deep ... [more ▼]

This paper studies fast adaptive beamforming optimization for the signal-to-interference-plus-noise ratio balancing problem in a multiuser multiple-input single-output downlink system. Existing deep learning based approaches to predict beamforming rely on the assumption that the training and testing channels follow the same distribution which may not hold in practice. As a result, a trained model may lead to performance deterioration when the testing network environment changes. To deal with this task mismatch issue, we propose two offline adaptive algorithms based on deep transfer learning and meta-learning, which are able to achieve fast adaptation with the limited new labelled data when the testing wireless environment changes. Furthermore, we propose an online algorithm to enhance the adaptation capability of the offline meta algorithm in realistic non-stationary environments. Simulation results demonstrate that the proposed adaptive algorithms achieve much better performance than the direct deep learning algorithm without adaptation in new environments. The meta-learning algorithm outperforms the deep transfer learning algorithm and achieves near optimal performance. In addition, compared to the offline meta-learning algorithm, the proposed online meta-learning algorithm shows superior adaption performance in changing environments. [less ▲]

Transfer Learning for Deontic Rule Classification: the Case Study of the GDPR

in INTERNATIONAL CONFERENCE ON LEGAL KNOWLEDGE AND INFORMATION SYSTEMS, Saarbrücken 14-16 December 2022 (2022)

Transfer Learning with Sentence Embeddings for Argumentative Evidence Classification

in Proceedings of the 20th Workshop on Computational Models of Natural Argument (2020)

Transfer of Cultural Capital: A Comparative Analysis of the Interconnection of Well-Being, Precariousness, and Insecurity

Scientific Conference (2010)

Transfer of strategy use by semantic recoding in arithmetic problem solving

in Learning and Instruction (2010), 20

Transfer of strategies between problems sharing the same formal structure is facilitated by a semantic recoding that makes evident the structural similarities between the problems. Two experiments were ... [more ▼]

Transfer of strategies between problems sharing the same formal structure is facilitated by a semantic recoding that makes evident the structural similarities between the problems. Two experiments were carried out among 4th and 5th grade pupils, with an experimental group trained to compare strategies in order to reinterpret an arithmetic word problem so that the calculations are consistent with the interpretation, and a control group. The experimental group in Experiment 1 improved significantly by choosing the alternative strategy in problems different from those used in training but no significant progress was observed in the control group. Experiment 2 showed that the improvement observed in the experimental group could not be attributed to the fact that children only learned to use a superficial rule. These results support the idea that the activity of problem re-representation may be a crucial step in mathematization. [less ▲]

Transfer pricing rules, OECD guidelines, and market distortions

in Journal of Public Economic Theory (2014)

We study the impact of transfer pricing rules on sales prices, firms' organizational structure, and consumers' utility within a two-country monopolistic competition model featuring source-based profit ... [more ▼]

We study the impact of transfer pricing rules on sales prices, firms' organizational structure, and consumers' utility within a two-country monopolistic competition model featuring source-based profit taxes that differ across countries. Firms can either become multinationals, i.e., they serve the foreign market through a fully controlled a¢ liate; or they can become exporters, i.e., they serve the foreign market by contracting with an independent distributor. Compared to the benchmark cases, where tax authorities are either unable to audit firms or where they are able to audit them perfectly, the use of the OECD's Comparable Uncontrolled Price (CUP) or Cost-Plus (CP) rule distorts firms' output and pricing decisions. The reason is that the comparable arm's length transactions between exporters and distributors, which serve as benchmarks, are not efficient. We show that implementing the CUP or CP rules is detrimental to consumers in the low tax country, yet benefits consumers in the high tax country. [less ▲]

Transferability of European-derived cardiometabolic polygenic risk scores in the South Asians and their interplay with family history 2023.03.20.23287470

E-print/Working paper (2023)

Background & Aims We aimed to investigate the effect of polygenic risk scores (PRSs) derived from individuals of European (EUR) ancestry on common diseases among individuals of South Asian (SAS) ancestry ... [more ▼]

Background & Aims We aimed to investigate the effect of polygenic risk scores (PRSs) derived from individuals of European (EUR) ancestry on common diseases among individuals of South Asian (SAS) ancestry in the UK Biobank (UKB). Additionally, we studied the interaction between PRS and family history (FH) in the same population.Methods To calculate the PRS, we used a previously published panel of SNPs derived from the EUR population and applied it to the individuals of SAS ancestry from the UKB study. We applied the PRS using summary statistics from genome-wide association studies (GWAS) for cardiometabolic and lifestyle diseases such as coronary artery disease (CAD), obesity, and type 2 diabetes (T2D). Each PRS was adjusted according to an individual\textquoterights predicted genetic ancestry to derive an adjusted PRS (aPRS). We calculated the percentiles based on aPRS and divided them according to the percentiles into three categories: low, intermediate, and high. Considering the intermediate-aPRS percentile as a reference, we compared the low and high aPRS categories and generated the odds ratio (OR) estimates.Results The risk of developing severe obesity for individuals of SAS ancestry was almost threefold higher for individuals with high aPRS than for those with intermediate aPRS, with an OR of 3.67 (95% CI = 2.47-5.48, P < 0.01). While the risk of severe obesity was lower in the low-aPRS group (OR = 0.19, CI = 0.05\textendash0.52, P < 0.01). Comparable results were found in the EUR data, where the low-PRS group had an OR of 0.26 (95% CI= 0.24-0.3, P < 0.01) and the high-PRS group had an OR of 3.2 (95% CI = 3.1-3.3, P < 0.01). We observed similar results for CAD and T2D. Further, we show that SAS individuals with a familial history of CAD and T2D with high-aPRS exhibit further higher risk to these diseases, thereby implying a greater genetic predisposition to these conditions.Conclusion Our findings suggest that using CAD, obesity, and T2D GWAS summary statistics predominantly from the EUR population have sufficient power to identify SAS individuals with higher genetic risk. With future GWAS recruiting more SAS participants and tailoring the PRSs towards SAS ancestry, we believe that the predictive power of PRS would improve. [less ▲]

Transfereffekte bei der Selbstregulation von Übungsbedingungen

Scientific Conference (2003, January)

Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons"

in Cell Communication and Signaling (2016), 14(1), 13

Extracellular vesicles are cell-derived vesicles, which can transport various cargos out of cells. From their cell of origin, the content molecules (proteins, non-coding RNAs including miRNAs, DNA and ... [more ▼]

Extracellular vesicles are cell-derived vesicles, which can transport various cargos out of cells. From their cell of origin, the content molecules (proteins, non-coding RNAs including miRNAs, DNA and others) can be delivered to neighboring or distant cells and as such extracellular vesicles can be regarded as vehicles of intercellular communication or "homing pigeons". Extracellular vesicle shuttling is able to actively modulate the tumor microenvironment and can partake in tumor dissemination. In various diseases, including cancer, levels of extracellular vesicle secretion are altered resulting in different amounts and/or profiles of detectable vesicular cargo molecules and these distinct content profiles are currently being evaluated as biomarkers. Apart from their potential as blood-derived containers of specific biomarkers, the transfer of extracellular vesicles to surrounding cells also appears to be involved in the propagation of phenotypic traits. These interesting properties have put extracellular vesicles into the focus of many recent studies.Here we review findings on the involvement of extracellular vesicles in transferring traits of cancer cells to their surroundings and briefly discuss new data on oncosomes, a larger type of vesicle. A pressing issue in cancer treatment is rapidly evolving resistance to many initially efficient drug therapies. Studies investigating the role of extracellular vesicles in this phenomenon together with a summary of the technical challenges that this field is still facing, are also presented. Finally, emerging areas of research such as the analysis of the lipid composition on extracellular vesicles and cutting-edge techniques to visualise the trafficking of extracellular vesicles are discussed. [less ▲]