Studying employers’ risk assessment and the role of institutions: An experimental design

E-print/Working paper (2015)

Work Package 7 aims at understanding how early job insecurity can affect an individual’s future career from an employer’s perspective. By paying special attention to the educational background and gender ... [more ▼]

Work Package 7 aims at understanding how early job insecurity can affect an individual’s future career from an employer’s perspective. By paying special attention to the educational background and gender of the applicants, we plan to investigate how employers interpret young applicants’ job insecurity, for example in the form of unemployment or job-mismatch experiences, during recruitment. The negative effects of such experiences on an individual’s chances of being recruited successfully – so called scarring effects – may further vary depending on economic and institutional contexts such as country-specific economic or political conditions, educational structures or economic sectors. By surveying employers from different sectors, we will examine if and how these scarring effects vary between four different countries: Bulgaria, Greece, Norway and Switzerland. We will apply an innovative methodology in the form of an employer-sided survey with an integrated multidimensional vignette experiment in order to simulate the impact of multiple factor s on success and failure when young people who experienced job insecurities apply for new jobs. In the present working paper we summarise the major theoretical concepts that have been used to explain the scarring effects that can result from employer behaviour. Moreover, we outline how we plan to collect data in WP 7 in order to analyse scarring through decision-making on behalf of employers during the recruitment process [less ▲]

Studying Microbial Dynamics in Anaerobic Monofermentation of Energy Crops – is FISH the right Technique

in Microbes in Wastewater and waste Treatment, Bioremediation, and Energy Production (2011)

Studying protein--protein interaction networks: a systems view on diseases

in Briefings in Functional Genomics (2012), 11(6), 497--504

Studying Signal Transduction Networks with a Probabilistic Boolean Network Approach

Doctoral thesis (2015)

In recent years, various modelling approaches in systems biology have been applied for the study and analysis of signal transduction networks. However, each modelling approach has its inherent advantages ... [more ▼]

In recent years, various modelling approaches in systems biology have been applied for the study and analysis of signal transduction networks. However, each modelling approach has its inherent advantages and disadvantages, so the choice has to be made based on research objectives and types of data. In this PhD dissertation, we propose probabilistic Boolean network (PBN) as one of the suitable modelling approaches for studying signal transduction networks with steady-state data. The steady-state distribution of molecular states in PBN can be correlated to the steady-state proteomic profiles generated from wet-lab experiments. In addition, the relevance of interactions within signalling networks can be assessed through the optimised selection probabilities. These features make PBNs ideal for describing the properties of signal transduction networks at steady-state with some uncertainty on network topologies. To investigate the applicability of PBNs for the study of signal transduction networks, we developed optPBN, an optimisation and analysis toolbox in the PBN framework. We demonstrated that optPBN can be applied to optimise a large-scale apoptotic network with 96 nodes and 105 interactions. Also, it allows for network contextualisation in a physiological context of primary hepatocytes through the analysis on optimised selection probabilities. Similarly, we also applied optPBN to study deregulated signal transduction networks in pathological contexts, i.e. the PDGF signalling in gastrointestinal stromal tumour (GIST) and the L-plastin signalling in breast cancer cell lines. By integrating prior information on network topology from literature with context-specific experimental data, contextualised PBNs can be derived which in turn provide additional insights into biological systems such as the importance of certain crosstalk interactions and the comparative signal flows at steady-state in non-metastatic versus metastatic cancer cell lines. In addition to the applications on fundamental research, we also explored the applications of PBNs in a pharmaceutical setting where detailed mechanistic models are usually used. Here, we applied optPBN as a tool for network ontextualisation. A proof-of-concept example on a small model demonstrated that optPBN helped to pre-select the suitable network structure according to the provided experimental data prior to the building and optimisation of detailed mechanistic models. Such application is foreseen to be applied in a pharmaceutical setting and to explore additional applications such as combinatorial drugs’ effect and toxicity screening. [less ▲]

Studying transnational events through web archives

Scientific Conference (2022, June 13)

This presentation was an update of the work of WG2 related to web archives and transnational events I'm leading within the WARCnet project.

Der stumme Chor des Volkes. Populistische Repräsentation im Classical Hollywood

in Dembeck, Till; Forhmann, Jürgen (Eds.) Die Rhetorik des Populismus und das Populäre. Körperschaftsbildungen in der Gesellschaft (2022)

STV+Reductions: Towards Practical Verification of Strategic Ability Using Model Reductions

in Proceedings of AAMAS (2021)

Style et architectonique dans l’œuvre de Claude-Nicolas Ledoux : une utopie de pierre et de papier

Presentation (2006, February 16)

Styles of reason: Historicism, historicizing, and their historical objects in the history of education

in Popkewitz, Thomas S. (Ed.) Rethinking the history of education. Transnational perspectives on its questions, methods, and knowledge (2013)

Styles of Reason: Two Forms of Curriculum History

Presentation (2013)