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Peer Reviewed
See detailZahlen und Psychomotorik
Wantz, Marc UL

in Motorik (2008), 2

Detailed reference viewed: 87 (0 UL)
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See detailZahlentheorie und Geometrie vereint in der Serre-Vermutung
Wiese, Gabor UL

in Essener Unikate (2008), 33

Detailed reference viewed: 77 (2 UL)
See detailZAP
Melzer, André UL

Report (2010)

Detailed reference viewed: 62 (0 UL)
See detailZAP
Melzer, André UL; Donoso, Véronica

Report (2011)

Detailed reference viewed: 53 (1 UL)
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See detailZarathustra und wir: Wie man wird, was man liest
Dembeck, Till UL

in Dembeck, Till; Busch, Christopher; Jäger, Maren (Eds.) Ichtexte. Beiträge zur Philologie die Individuellen (2019)

Detailed reference viewed: 86 (1 UL)
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Peer Reviewed
See detailZasada rządów prawa w polityce zewnętrznej Unii Europejskiej (Rule of law in the European Union’s external policy)
Gren, Jakub UL

in Przegląd Prawa Konstytucyjnego (Review of Constitutional Law) (2013), 2013(2), 157-175

Rule of law, whose core is „the access to an independent judiciary and judicial review”, fulfills in EU external policy two functions. Firstly, according to the art. 21 of TEU, all EU external actions ... [more ▼]

Rule of law, whose core is „the access to an independent judiciary and judicial review”, fulfills in EU external policy two functions. Firstly, according to the art. 21 of TEU, all EU external actions have to be subdued to the rule of law. Secondly, promoting and consolidating the rule of law is one the objectives of EU external action. In most constitutional systems, a wide margin of appreciation is left as regards to foreign policy and judicial review is considerably limited. In case of EU, the Court’s jurisdiction over EU external policy is differentiated and reflects the old pillar structure. The question which arises here is whether it can be accommodated with the disposition of the art. 2 of TEU, which states that the European Union which is a single legal entity „is founded on the value of rule of law”, and with the principle of EU external policy coherence. [less ▲]

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See detailZastosowanie ANSYS i ANSYS Workbench w procesie projektowania obudów skrzyń biegów
Kedziora, Slawomir UL; Michalski, Przemysław

Scientific Conference (2013, April)

Streszczenie. Praca zawiera opis, wypracowanej przez firmę Eaton, metodyki obliczeń obudów skrzyń biegów zastosowaną w procesie konstruowania wyrobów. Dla lepszego zrozumienia zagadnienia omówione zostały ... [more ▼]

Streszczenie. Praca zawiera opis, wypracowanej przez firmę Eaton, metodyki obliczeń obudów skrzyń biegów zastosowaną w procesie konstruowania wyrobów. Dla lepszego zrozumienia zagadnienia omówione zostały cechy charakterystyczne korpusów wraz z szeregiem wymagań jakim muszą one sprostać (funkcjonalnym, technologicznym, kosztowym). Opracowany proces analizy został maksymalnie ujednolicony i ma zastosowanie zarówno dla przekładni wysokiej jak i niskiej obciążalności. Przedstawiono opracowane wymagania wytrzymałościowe jakie stawia się nowoczesnym konstrukcjom obudów skrzyń biegów, bazując na przeprowadzonych testach w pojazdach i naszym doświadczeniu. Zaprezentowano, jako docelowe rozwiązanie, spójną metodę analizowania obudów, które wykorzystują nowoczesne oprogramowanie metody elementów skończonych – ANSYS, ANSYS Workbench i zdobytą, w czasie testów i procesach walidacji wielu produktów, wiedzę. Model obliczeniowy został bardzo dobrze zweryfikowany, bazuje na wynikach laboratoryjnych badań zmęczeniowych, przeprowadzonych na rzeczywistych produktach, a także rezultatach prób drogowych w rzeczywistych pojazdach. Stworzona metodyka przyczynia się do znacznego skrócenia procesu konstruowania i weryfikacji konstrukcji, ograniczając do minimum konieczność testowania obudów. [less ▲]

Detailed reference viewed: 147 (9 UL)
See detailZäsur und "Stunde Null"? Personelle Brüche und Kontinuiäten in Aachen 1933 und 1945
Tschacher, Werner UL

in Der Krieg ist aus. Politik, Alltag und Medien in Aachen. (2019)

Detailed reference viewed: 54 (1 UL)
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Peer Reviewed
See detailZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas
Sommerova, Lucia; Ondrouskova, Eva; Martisova, Andrea et al

in Cancers (2020), 12

Epithelial-mesenchymal transition (EMT) is a process involved not only in morphogenesis and embryonic development, but also in cancer progression, whereby tumor cells obtain a more aggressive metastatic ... [more ▼]

Epithelial-mesenchymal transition (EMT) is a process involved not only in morphogenesis and embryonic development, but also in cancer progression, whereby tumor cells obtain a more aggressive metastatic phenotype. Anterior gradient protein 2 (AGR2) maintains the epithelial phenotype and blocks the induction of EMT, thus playing an undeniable role in tumor progression. However, the mechanism through which AGR2 expression is regulated, not only during EMT, but also in the early stages of cancer development, remains to be elucidated. In the present study, we show an inverse correlation of AGR2 with ZEB1 (zinc finger enhancer binding protein, EF1) that was verified by analysis of several independent clinical data sets of lung adenocarcinomas. We also identified the ZEB1 binding site within the AGR2 promoter region and confirmed AGR2 as a novel molecular target of ZEB1. The overexpression of ZEB1 decreased the promoter activity of the AGR2 gene, which resulted in reduced AGR2 protein level and the acquisition of a more invasive phenotype of these lung cancer cells. Conversely, silencing of ZEB1 led not only to increased levels of AGR2 protein, but also attenuated the invasiveness of tumor cells. The AGR2 knockout, vice versa, increased ZEB1 expression, indicating that the ZEB1/AGR2 regulatory axis may function in a double negative feedback loop. In conclusion, we revealed for the first time that ZEB1 regulates AGR2 at the transcriptional level, while AGR2 presence contributes to ZEB1 mRNA degradation. Thus, our data identify a new regulatory mechanism between AGR2 and ZEB1, two rivals in the EMT process, tightly associated with the development of metastasis. [less ▲]

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See detailZebrafish models of Dravet syndrome: discovery of antiseizure drug leads and analysis of behavioural comorbidities
Jacmin, Maxime UL

Doctoral thesis (2018)

Dravet syndrome (DS) is one of the most frequent genetic epilepsies, with an incidence of 1/30,000. Most DS patients are pharmacoresistant, in that they do not respond adequately to currently available ... [more ▼]

Dravet syndrome (DS) is one of the most frequent genetic epilepsies, with an incidence of 1/30,000. Most DS patients are pharmacoresistant, in that they do not respond adequately to currently available anticonvulsant drugs (ASDs). Beside the seizure occurrence in these patients, many DS patients also suffer from cognitive impairment that can be aggravated by some of the seizure medications prescribed. Preclinical models such as mouse models of Dravet syndrome have been developed and described to exhibit cognitive deficits similar to those of DS patients, but are only suitable for the evaluation of small number of compounds, thereby limiting their utility for drug discovery. An animal model with higher screening throughput would therefore be of value for drug discovery efforts focused on seizure reduction and decrease of the comorbidities associated with DS. Recent studies on zebrafish have demonstrated its ability to be a promising in vivo model for DS. Two different zebrafish DS models - one based on a loss-of-function mutation in the zebrafish ortholog of SCN1A, the other based on an antisense knockdown of this gene - exhibit seizure-like behaviour and epileptiform discharges that are exacerbated by hyperthermia. The mutant line was also described to display greater anxiety levels. In this Doctoral thesis project, we are investigating these zebrafish DS models with regard to (1) their seizure occurrence and potential reduction following exposure to several anticonvulsant drug candidates, and (2), their cognitive functions in order to determine possible similarities with cognitive impairment in human DS patients. Our results indicate these zebrafish DS models to exhibit memory impairment and higher anxiety levels. These findings provide an initial insight into the resemblance between human patients and zebrafish in terms of comorbidities. Finally, we also identified several novel anticonvulsant compounds and drug candidates with antiseizure activity in these zebrafish DS models. [less ▲]

Detailed reference viewed: 97 (16 UL)
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See detailZehn Thesen zur mehrsprachigen Universität
Hu, Adelheid UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2012), (324), 49-52

Detailed reference viewed: 213 (18 UL)
See detailZehntropie
Schilling, Tanja UL

Presentation (2014, January)

Detailed reference viewed: 41 (0 UL)
See detailZeichenhafte Überlegenheit. Zur Transgressivität des Stierwunders in der 'Silvesterlegende' Konrads von Würzburg
Bendheim, Amelie UL

in Beiträge zur mediävistischen Erzählforschung (2021), 9

Der Aufsatz befragt das Stierwunder in der ›Silvesterlegende‹ Konrads von Würzburg auf seine Funktion im Glaubensdisput zwischen Christen und Juden. Das Wunder, dessen Kraft sich über sein ... [more ▼]

Der Aufsatz befragt das Stierwunder in der ›Silvesterlegende‹ Konrads von Würzburg auf seine Funktion im Glaubensdisput zwischen Christen und Juden. Das Wunder, dessen Kraft sich über sein zeitrahmenüberschreitendes Potenzial begrün-det, vermag nicht nur christliche Überlegenheit in der erzählten Welt auszustellen, sondern erweist sich auch als offen für eine lebensweltliche, politische Inanspruchnahme. Die Heiligenlegende, die so in nicht unproblematischer Weise zum epochen-geschichtlichen Glaubenskonflikt Stellung zu beziehen vermag, rückt damit in engere Beziehung zu ›klassischen‹ Kreuzzugsepen, als es die Gattung qua Definition vermuten ließe. [less ▲]

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See detailZeigepraktiken: How to do quality with things.
Bollig, Sabine UL

in Honig, Michael-Sebastian; Joos, Magdalena; Schreiber, Norbert (Eds.) Was ist ein guter Kindergarten. Theoretische und empirische Analysen zum Qualitätsbegriff in der Pädagogik. (2004)

Detailed reference viewed: 123 (0 UL)
See detailDie Zeit der Arbeit : Lebenswelten der Berg- und Hüttenarbeiter um die Jahrhundertwende
Scuto, Denis UL

Article for general public (1991)

Detailed reference viewed: 63 (0 UL)
See detailDie Zeit der Pfandherrschaften (1388-1437). Luxemburg unter fremder Herrschaft?
Dönges, Christa Annette UL

Scientific Conference (2018, September 28)

Detailed reference viewed: 96 (2 UL)
See detailZeit erfahrbar machen: Überlegungen zum Denken und Erkennen von Kindern
Andersen, Katja Natalie UL

in KiTa aktuell HRS - Fachzeitschrift für Leitungen, Fachkräfte und Träger der Kindertagesbetreuung (2010), 18(3), 58-59

Detailed reference viewed: 83 (6 UL)
See detailZeit erfahrbar machen: Überlegungen zum Denken und Erkennen von Kindern (Reprint)
Andersen, Katja Natalie UL

in KiTa aktuell NRW - Fachzeitschrift für Leitungen, Fachkräfte und Träger der Kindertagesbetreuung (2010), 19(11), 220-221

Detailed reference viewed: 58 (4 UL)