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See detailBuilding a virtual ligand screening pipeline using free software: a survey
Glaab, Enrico UL

in Briefings in Bioinformatics (2015)

Virtual screening, the search for bioactive compounds via computational methods, provides a wide range of opportunities to speed up drug development and reduce the associated risks and costs. While ... [more ▼]

Virtual screening, the search for bioactive compounds via computational methods, provides a wide range of opportunities to speed up drug development and reduce the associated risks and costs. While virtual screening is already a standard practice in pharmaceutical companies, its applications in preclinical academic research still remain under-exploited, in spite of an increasing availability of dedicated free databases and software tools. In this survey, an overview of recent developments in this field is presented, focusing on free software and data repositories for screening as alternatives to their commercial counterparts, and outlining how available resources can be interlinked into a comprehensive virtual screening pipeline using typical academic computing facilities. Finally, to facilitate the set-up of corresponding pipelines, a downloadable software system is provided, using platform virtualization to integrate pre-installed screening tools and scripts for reproducible application across different operating systems. [less ▲]

Detailed reference viewed: 179 (28 UL)
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See detailBuilding blocks of self-sustained activity in a simple deterministic model of excitable neural networks.
Garcia, Guadalupe Clara UL; Lesne, Annick; Hütt, Marc T et al

in Frontiers in computational neuroscience (2012), 6

Understanding the interplay of topology and dynamics of excitable neural networks is one of the major challenges in computational neuroscience. Here we employ a simple deterministic excitable model to ... [more ▼]

Understanding the interplay of topology and dynamics of excitable neural networks is one of the major challenges in computational neuroscience. Here we employ a simple deterministic excitable model to explore how network-wide activation patterns are shaped by network architecture. Our observables are co-activation patterns, together with the average activity of the network and the periodicities in the excitation density. Our main results are: (1) the dependence of the correlation between the adjacency matrix and the instantaneous (zero time delay) co-activation matrix on global network features (clustering, modularity, scale-free degree distribution), (2) a correlation between the average activity and the amount of small cycles in the graph, and (3) a microscopic understanding of the contributions by 3-node and 4-node cycles to sustained activity. [less ▲]

Detailed reference viewed: 135 (8 UL)
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See detailBuilding Bridges Across Heritage Silos
Kontiza, Kalliopi; Jones, Catherine UL; Padfield, Joseph et al

Poster (2018, June)

This research considers how best to cross the divides that exist between: (1) disparate practices between research fields (2) disparate interpretations of shared cultural heritage by the public and (3 ... [more ▼]

This research considers how best to cross the divides that exist between: (1) disparate practices between research fields (2) disparate interpretations of shared cultural heritage by the public and (3) disparate cultural heritage objects. [less ▲]

Detailed reference viewed: 55 (2 UL)
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See detailBuilding Bridges or a Bridge Too Far? The "Macedonia" Name Agreement, and the Past, Present and Future of Greek Interstate Relations.
Paravantis, Spero UL

Presentation (2019, April 29)

The “Macedonia” name issue has been a constant point of contention between Greece and the newly re-named Republic of North Macedonia, since the breakup of Yugoslavia. With the origins of the dispute ... [more ▼]

The “Macedonia” name issue has been a constant point of contention between Greece and the newly re-named Republic of North Macedonia, since the breakup of Yugoslavia. With the origins of the dispute stretching back to the Second World War, the “Prespa Agreement,” signed between the two Balkan neighbors in June 2018 (coming into force in February 2019) is hoped to be a new beginning in interstate relations in the Balkans. Through Prime Ministers Tspiras and Zeav have adopted warm facades in front of the cameras, significant opposition to the agreement domestically and abroad highlights the transnational / international legacy and implications of this dispute. In this lecture, Dr, Spero Paravantes will examine the history of the dispute over the name “Macedonia.” He will then explain the Prespa Agreement, some of the controversies surrounding it, and he will discuss the role played in the dispute (and in the agreement) by foreign diplomats. He will concluded with an assessment of the domestic and international implications of the Former Yugoslav Republic of Macedonia (FYROM), becoming the Republic of North Macedonia. (Link: http://events.berkeley.edu/index.php/calendar/sn/ies.html?event_ID=124978&date=2019-04-29&filter=Target/Open%20To%20Audiences&filtersel=) (Summary: https://ies.berkeley.edu/sites/default/files/shared/docs/newsletters/IES%20Spring%202019%20News%20final.pdf) [less ▲]

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See detailBuilding bridges or building people? On the role of engineering in education.
Biesta, Gert UL

in Journal of Curriculum Studies (2009), 41(1), 13-16

Detailed reference viewed: 64 (1 UL)
See detailBuilding bridges or taking the ferry: Pidgins, Creoles and Language Acquisition in a Multilingual Setting
Ehrhart, Sabine UL; Hélot, Christine

Presentation (2004, May 21)

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See detailBuilding Capacity for Comparative and International Social Sciences: Inter-organizational Collaboration and EU Research Funding & Degree Programs
Powell, Justin J W UL

Scientific Conference (2019)

In this essay, I present global mega-trends in higher education and science (expansion, competition, collaboration), discuss regional shifts in scientific publication globally since 1900 and systematic ... [more ▼]

In this essay, I present global mega-trends in higher education and science (expansion, competition, collaboration), discuss regional shifts in scientific publication globally since 1900 and systematic attempts to build capacity for knowledge production, especially in research universities. Pure exponential growth in the publication of research articles is matched by rising international, interorganizational, and transdisciplinary collaboration. The implications of these patterns, especially for international and comparative social sciences, are then briefly delineated on the basis of the case of EU research funding (Framework Programmes) and joint degree programs (Erasmus Mundus) that promote sustainable collaborations across borders in Europe. [less ▲]

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See detailBuilding FinTech Ecosystems: Regulatory Sandboxes, Innovation Hubs and Beyond
Zetzsche, Dirk Andreas UL; Buckley, Ross; Arner, Douglas et al

in Washington University Journal of Law & Policy (2020)

Detailed reference viewed: 52 (3 UL)
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See detailBuilding FinTech Ecosystems: Regulatory Sandboxes, Innovation Hubs and Beyond
Buckley, Ross; Arner, Douglas; Veidt, Robin UL et al

in Washington University Journal of Law and Policy (in press), 61

Around the world, regulators and policymakers are working to support the development of financial technology (FinTech) ecosystems. As one example, over 50 jurisdictions have now established or announced ... [more ▼]

Around the world, regulators and policymakers are working to support the development of financial technology (FinTech) ecosystems. As one example, over 50 jurisdictions have now established or announced “financial regulatory sandboxes”. Others have announced or established “innovation hubs”, sometimes incorporating a regulatory sandbox as one element. This article argues that innovation hubs provide all the benefits that the policy discussion associates with regulatory sandboxes, while avoiding most downsides of regulatory sandboxes, and that many benefits typically attributed to sandboxes are the result of inconsistent terminology, and actually accrue from the work of innovation hubs. The paper presents, as the first contribution of its kind, data on regulatory sandboxes and innovation hubs and argues that the data so far available on sandboxes does not justify the statement that regulatory sandboxes are the most effective approach to building FinTech ecosystems. Given that regulatory sandboxes require significant financial contributions, sometimes new legislation, and intense regulatory risk management, and that sandboxes do not work as well on a stand-alone basis (i.e. without an innovation hub), while innovation hubs alone can provide more significant benefits in supporting the development of a FinTech ecosystem, regulators should focus their resources on developing effective innovation hubs, including in appropriate cases a sandbox as one possible element. [less ▲]

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See detailBuilding Jiminy Cricket: An Architecture for Moral Agreements Among Stakeholders
Liao, Beishui; Slavkovik, Marija; van der Torre, Leon UL

in AAAI/ACM Artificial Intelligence, Ethics and Society (2018)

An autonomous system is constructed by a manufacturer, operates in a society subject to norms and laws, and is interacting with end-users. We address the challenge of how the moral values and views of all ... [more ▼]

An autonomous system is constructed by a manufacturer, operates in a society subject to norms and laws, and is interacting with end-users. We address the challenge of how the moral values and views of all stakeholders can be integrated and reflected in the moral behaviour of the autonomous system. We propose an artificial moral agent architecture that uses techniques from normative systems and formal argumentation to reach moral agreements among stakeholders. We show how our architecture can be used not only for ethical practical reasoning and collaborative decision-making, but also for the explanation of such moral behavior. [less ▲]

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See detailBuilding Lifecycle Management System for Enhanced Closed Loop Collaboration
Kubler, Sylvain UL; Buda, Andrea; Robert, Jérémy UL et al

in 13th IFIP International Conference on Product Lifecycle Management (PLM16) (2016, June 29)

In the past few years, the architecture, engineering and construction (AEC) industry has carried out efforts to develop BIM (Building Information Modelling) facilitating tools and standards for enhanced ... [more ▼]

In the past few years, the architecture, engineering and construction (AEC) industry has carried out efforts to develop BIM (Building Information Modelling) facilitating tools and standards for enhanced collaborative working and information sharing. Lessons learnt from other industries and tools such as PLM (Product Lifecycle Management) – established tool in manufacturing to manage the engineering change process – revealed interesting potential to manage more efficiently the building design and construction processes. Nonetheless, one of the remaining challenges consists in closing the information loop between multiple building lifecycle phases, e.g. by capturing information from middle-of-life processes (i.e., use and maintenance) to re-use it in end-of-life processes (e.g., to guide disposal decision making). Our research addresses this lack of closed-loop system in the AEC industry by proposing an open and interoperable Web-based building lifecycle management system. This paper gives (i) an overview of the requirement engineering process that has been set up to integrate efforts, standards and directives of both the AEC and PLM industries, and (ii) first proofs-of-concept of our system implemented on two distinct campus. [less ▲]

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See detailBuilding relationships between school, family and community to enhance students' school persistence and avoid Early School Leaving (ESL)
Poncelet, Débora UL; Billa, Jean; Schürnbrand, Carmen et al

Report (2015)

Dropout is a multidimensional phenomenon, resulting from a combination of personal, family and school factors that interact with each other. The combination of risk factors (or protective factors) is an ... [more ▼]

Dropout is a multidimensional phenomenon, resulting from a combination of personal, family and school factors that interact with each other. The combination of risk factors (or protective factors) is an event or a condition that increase (or reduce) the likelihood of an individual experience of emotional or behavioural problems, that may contribute to school dropout. The decision to stop school education is the result of a long evolutionary process that is characterized by an accumulation of frustrations, often induced by academic failures and difficult relationships with peers, teachers, and parents. Through involvement in educational aspects, families especially play an important role in student success and affect conditions that might lead to dropping out: positive impact on school performance, enhancing motivation and school involvement, improving well-being and school behaviours, building a constructive and efficient relationship between school and family could be an efficient way to avoid school dropout. In this session, our exchanges and reflections aim at comparing and analyzing issues, experiences, ideas, and questions from different interventions of European representatives. Through these different contributions, we try to highlight concrete policies for UE countries regarding the connections that we can do between school dropout and relationships between school, family and community. [less ▲]

Detailed reference viewed: 92 (12 UL)
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See detailBuilding Secure Resources to Ensure Safe Computations in Distributed and Potentially Corrupted Environments
Varrette, Sébastien UL; Roch, Jean-Louis; Duc, Guillaume et al

in Euro-Par 2008, Workshop on Secure, Trusted, Manageable and Controllable Grid Services (SGS'08) (2008)

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See detailBuilding social capital through civic education in VET: A comparative study of Finland and Luxembourg (1960-1970)
Gardin, Matias UL

in Nordic Journal of Educational History (2016), 3(1), 75-94

Whereas social scientists and educationalists often make different assumptions about education, common to both groups is to render schooling responsible for the development of citizenship rights. Yet, a ... [more ▼]

Whereas social scientists and educationalists often make different assumptions about education, common to both groups is to render schooling responsible for the development of citizenship rights. Yet, a comparison of Finnish and Luxembourgian curriculum strategies in relation to building social capital – understood in the context of civic education in VET – has not been explored. Then, this study analyses these aspects during 1960–1970, for the period is regarded as the starting point for democratisation of education after WWII. The justification for the countries is based on their differences. However, both countries also experienced similar pressures to democratise education – especially regarding their VET – which need to be investigated, since little attention has been paid to the question of how the reforms of their former structures were legitimated by civic education. The conclusion addresses the importance of general education for the future of vocational careers. [less ▲]

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See detailBuilding specifications as a domain-specific aspect language
Kramer, Max E.; Klein, Jacques UL; Steel, Jim R. H.

in DSAL'12 - Proceedings of the 7th Workshop on Domain-Specific Aspect Languages (2012)

In the construction industry an increasing number of buildings are designed using semantically rich three-dimensional models. In parallel, additional information is specified in a natural-language ... [more ▼]

In the construction industry an increasing number of buildings are designed using semantically rich three-dimensional models. In parallel, additional information is specified in a natural-language document called a building specification. 1 As not all details are present in the model these specifications have to be interpreted whenever costs are estimated or other analyses are performed. In this paper, we argue that building specifications contain cross-cutting concerns. We also argue that domain experts should be given the ability to formulate building specifications using a domain-specific aspect language so that the corresponding details can automatically be integrated into the model. The language needs to support a multitude of domain-specific abstractions that are absent in the building meta-model. Therefore we propose to allow the domain experts to extend the language iteratively by defining interpretation patterns [1]. Such a model enriching specification will improve tasks requiring detailed information and will allow for earlier or even concurrent development of the building specification along with the model. © 2012 ACM. [less ▲]

Detailed reference viewed: 130 (0 UL)
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See detailBuilding Strategic Cooperation: The Implementation of Cross-Sectoral Youth Policy in Luxembourg - Findings from an Evaluation Study
Residori, Caroline UL; Reichert, Claudine; Biewers, Sandra UL et al

Report (2015)

This report summarises the main findings of the evaluation of the Luxemburgish Youth Pact for an international audience and focuses on the implementation of a cross‐sectoral youth policy and cross ... [more ▼]

This report summarises the main findings of the evaluation of the Luxemburgish Youth Pact for an international audience and focuses on the implementation of a cross‐sectoral youth policy and cross-sectoral collaboration. [less ▲]

Detailed reference viewed: 109 (19 UL)
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See detailBuilding the Social Graph of the History of European Integration
Wieneke, Lars UL; During, Marten UL; Silaume, Ghislain et al

in Nadamoto, Akiyo; Jatowt, Adam; Wierzbicki, Adam (Eds.) et al Social Informatics (2014)

Detailed reference viewed: 170 (9 UL)
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See detailBuilding up Explainability in Multi-layer Perceptrons for Credit Risk Modeling
Sharma, Rudrani; Schommer, Christoph UL; Vivarelli, Nicolas

in Sharma, Rudrani (Ed.) Building up Explainability in Multi-layer Perceptrons for Credit Risk Modeling (2020, October 09)

Granting loans is one of the major concerns of financial institutions due to the risks of default borrowers. Default prediction by the neural networks is a popular technique for credit risk modeling ... [more ▼]

Granting loans is one of the major concerns of financial institutions due to the risks of default borrowers. Default prediction by the neural networks is a popular technique for credit risk modeling. Neural networks generally offer the accurate predictions that help banks to prevent financial losses and grow their business by approving more creditworthy borrowers. Although neural networks are capable of capturing the complex, non-linear relationships between a large number of features and output, these models act as black boxes. This is a graduation project paper that is focused on loan default risk prediction by multi-layer perceptron neural network and building up explainability to some degree in the trained neural networks through sensitivity analysis. The architecture of a multi-layer perceptron neural network with the best result is used to help the credit-risk manager in explaining why an applicant is a defaulter or non-defaulter. The prediction of a trained multi-layer perceptron neural network is explained by mapping input features and target variables directly using a model-agnostic explanation as well as a modelspecific explanation. Lastly, a comparison is performed between two explanation methods. [less ▲]

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See detailBuilding VCL Models and Automatically Generating Z Specifications from Them
Amalio, Nuno UL; Glodt, Christian UL; Kelsen, Pierre UL

in Formal Methods - 17th International Symposium on Formal Methods (2011)

VCL is a visual and formal language for abstract specification of software systems. Its novelty lies in its capacity to describe predicates visually. This paper presents work-in-progress on a tool for VCL ... [more ▼]

VCL is a visual and formal language for abstract specification of software systems. Its novelty lies in its capacity to describe predicates visually. This paper presents work-in-progress on a tool for VCL; the tool version presented here supports the VCL notations of structural and assertion diagrams (a subset of the whole VCL suite), enabling the generation of Z specifications from them. [less ▲]

Detailed reference viewed: 101 (2 UL)