Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
See detailTree-Based computation in probalistic models
Ignac, Tomasz UL

Doctoral thesis (2010)

Detailed reference viewed: 54 (3 UL)
Peer Reviewed
See detailTreeDet: a web server to explore sequence space.
Carro, Angel; Tress, Michael; de Juan, David et al

in Nucleic acids research (2006), 34(Web Server issue), 110-5

The TreeDet (Tree Determinant) Server is the first release of a system designed to integrate results from methods that predict functional sites in protein families. These methods take into account the ... [more ▼]

The TreeDet (Tree Determinant) Server is the first release of a system designed to integrate results from methods that predict functional sites in protein families. These methods take into account the relation between sequence conservation and evolutionary importance. TreeDet fully analyses the space of protein sequences in either user-uploaded or automatically generated multiple sequence alignments. The methods implemented in the server represent three main classes of methods for the detection of family-dependent conserved positions, a tree-based method, a correlation based method and a method that employs a principal component analyses coupled to a cluster algorithm. An additional method is provided to highlight the reliability of the position in the alignments. The server is available at http://www.pdg.cnb.uam.es/servers/treedet. [less ▲]

Detailed reference viewed: 104 (0 UL)
Full Text
Peer Reviewed
See detailTrees and asymptotic developments for fractional stochastic differential equations
Neuenkirch, Andreas; Nourdin, Ivan UL; Rössler, Andreas et al

in Annales de l'Institut Henri Poincare (B) Probability & Statistics (2009), 45(1), 157-174

Detailed reference viewed: 39 (4 UL)
Full Text
Peer Reviewed
See detailTrefftz polygonal finite element for linear elasticity: convergence, accuracy, and properties
Hirshikesh; Natarajan, Sundararajan; Ratna Kumar, A. K. et al

in Asia Pacific Journal on Computational Engineering (2017)

In this paper, the accuracy and the convergence properties of Trefftz finite element method over arbitrary polygons are studied. Within this approach, the unknown displacement field within the polygon is ... [more ▼]

In this paper, the accuracy and the convergence properties of Trefftz finite element method over arbitrary polygons are studied. Within this approach, the unknown displacement field within the polygon is represented by the homogeneous solution to the governing differential equations, also called as the T-complete set. While on the boundary of the polygon, a conforming displacement field is independently defined to enforce the continuity of the field variables across the element boundary. An optimal number of T-complete functions are chosen based on the number of nodes of the polygon and the degrees of freedom per node. The stiffness matrix is computed by the hybrid formulation with auxiliary displacement frame. Results from the numerical studies presented for a few benchmark problems in the context of linear elasticity show that the proposed method yields highly accurate results with optimal convergence rates. [less ▲]

Detailed reference viewed: 89 (1 UL)
Full Text
Peer Reviewed
See detailTreg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarshi, Koji; Tanoue, Takeshi; Oshima, Kenshiro et al

in Nature (2013), 500

Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases1, 2. Although numerous probiotic microorganisms have been identified3, there remains a ... [more ▼]

Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases1, 2. Although numerous probiotic microorganisms have been identified3, there remains a compelling need to discover organisms that elicit more robust therapeutic responses, are compatible with the host, and can affect a specific arm of the host immune system in a well-controlled, physiological manner. Here we use a rational approach to isolate CD4+FOXP3+ regulatory T (Treg)-cell-inducing bacterial strains from the human indigenous microbiota. Starting with a healthy human faecal sample, a sequence of selection steps was applied to obtain mice colonized with human microbiota enriched in Treg-cell-inducing species. From these mice, we isolated and selected 17 strains of bacteria on the basis of their high potency in enhancing Treg cell abundance and inducing important anti-inflammatory molecules—including interleukin-10 (IL-) and inducible T-cell co-stimulator (ICOS)—in Treg cells upon inoculation into germ-free mice. Genome sequencing revealed that the 17 strains fall within clusters IV, XIVa and XVIII of Clostridia, which lack prominent toxins and virulence factors. The 17 strains act as a community to provide bacterial antigens and a TGF-β-rich environment to help expansion and differentiation of Treg cells. Oral administration of the combination of 17 strains to adult mice attenuated disease in models of colitis and allergic diarrhoea. Use of the isolated strains may allow for tailored therapeutic manipulation of human immune disorders. [less ▲]

Detailed reference viewed: 266 (10 UL)
See detailA Trellis-Based SAT Problem
Franck, Christian UL

Poster (2018, April)

Detailed reference viewed: 63 (2 UL)
Full Text
Peer Reviewed
See detailTREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study
Ortega-Cubero, S.; Lorenzo-Betancor, O.; Lorenzo, E. et al

in Parkinsonism & related disorders (2015), 21(3), 306-309

INTRODUCTION: Essential tremor (ET) is the most frequent movement disorder in adults. Its pathophysiology is not clearly understood, however there is growing evidence showing common etiologic factors with ... [more ▼]

INTRODUCTION: Essential tremor (ET) is the most frequent movement disorder in adults. Its pathophysiology is not clearly understood, however there is growing evidence showing common etiologic factors with other neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (AD, PD). Recently, a rare p.R47H substitution (rs75932628) in the TREM2 protein (triggering receptor expressed on myeloid cells 2; OMIM: *605086) has been proposed as a risk factor for AD, PD and amyotrophic lateral sclerosis (ALS). The objective of the study was to determine whether TREM2 p.R47H allele is also a risk factor for developing ET. METHODS: This was a cross-sectional multicenter international study. An initial case-control cohort from Spain (n = 456 ET, n = 2715 controls) was genotyped. In a replication phase, a case-control series (n = 897 ET, n = 1449 controls) from different populations (Italy, Germany, North-America and Taiwan) was studied. Owed to the rarity of the variant, published results on p.R47H allele frequency from 14777 healthy controls from European, North American or Chinese descent were additionally considered. The main outcome measure was p.R47H (rs75932628) allelic frequency. RESULTS: There was a significant association between TREM2 p.R47H variant and ET in the Spanish cohort (odds ratio [OR], 5.97; 95% CI, 1.203-29.626; p = 0.042), but it was not replicated in other populations. CONCLUSIONS: These results argue in favor of population-specific differences in the allelic distribution and suggest that p.R47H (rs75932628) variant may contribute to the susceptibility of ET in Spanish population. However, taking into account the very low frequency of p.R47H, further confirmatory analyses of larger ET series are needed. [less ▲]

Detailed reference viewed: 130 (6 UL)
Full Text
Peer Reviewed
See detailTREM2 triggers microglial density and age‐related neuronal loss
Linnartz-Gerlach, Bettina; Bodea, Liviu-Gabriel; Klaus, Christine et al

in Glia (2018)

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to ... [more ▼]

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with aging. The typical aging process goes along with microglial changes and mild neuronal loss, but the exact contribution of TREM2 is still unclear. Aged TREM2 knock‐out mice showed decreased age‐related neuronal loss in the substantia nigra and the hippocampus. Transcriptomic analysis of the brains of 24 months old TREM2 knock‐out mice revealed 211 differentially expressed genes mostly downregulated and associated with complement activation and oxidative stress response pathways. Consistently, 24 months old TREM2 knock‐out mice showed lower transcription of microglial (Aif1 and Tmem119), oxidative stress markers (Inos, Cyba, and Cybb) and complement components (C1qa, C1qb, C1qc, C3, C4b, Itgam, and Itgb2), decreased microglial numbers and expression of the microglial activation marker Cd68, as well as accumulation of oxidized lipids. Cultured microglia of TREM2 knock‐out mice showed reduced phagocytosis and oxidative burst. Thus, microglial TREM2 contributes to age‐related microglial changes, phagocytic oxidative burst, and loss of neurons with possible detrimental effects during physiological aging. [less ▲]

Detailed reference viewed: 174 (16 UL)
Full Text
See detailtrend Analysis and interpretation of Luxembourg’s consumption Footprint NFA 2010 edition, data years 2000 – 2007
Hild, Paula UL; Takagi, Aya; Schmitt, Bianca

Report (2012)

The Ecological Footprint methodology by Global Footprint Network measures human consumption of products and services from different ecosystems in terms of the amount of bioproductive land and sea area ... [more ▼]

The Ecological Footprint methodology by Global Footprint Network measures human consumption of products and services from different ecosystems in terms of the amount of bioproductive land and sea area needed to supply these products and services. In other words, the Ecological Footprint calculates the land area needed to produce food, provide resources, produce energy, and absorb the CO2 emissions generated by the supply chains within one year at country level. For the calculations of Luxembourg’s Ecological Footprint, international statistical databases are used to identify the quantities of produced, imported and exported goods and services. Then, Global Footprint Network applies different factors to the quantities to assess the area needed to supply these products and services. Finally, the Consumption Footprint of a nation is divided by the number of inhabitants and compared to other countries at a per capita level (global hectares per capita). This means that the Ecological Footprint can be used as an indicator for the sustainability of a national consumption by assessing human land uses. In the following paragraph, Luxembourg’s Ecological Footprint is discussed in the framework of the environmental indicators of Luxembourg’s competitiveness scoreboard (see Table 9) [MECE, 2010]. Luxembourg’s ranking is rather low for all of the scoreboard indicators: number of ISO 9001 certifications per billion of inhabitants (21 out of 27); number of ISO 14001 certifications per billion of inhabitants (15 out of 27); total greenhouse gas emissions (15 out of 27); renewable energy ration (23 out of 27); quantity of municipal waste per capita per year (24 out of 27); energetic intensity (8 out of 27); transport by car (17 out of 27); Ecological Footprint in gha per capita per year (27 out of 27). Based on the environmental competiveness scoreboard indicators, it can be concluded that in general, Luxembourg’s environmental performance is low compared to the other countries of the European Union. With respect to Luxembourg’s Ecological Footprint, it can be said that Luxembourg’s consumption is not sustainable. The number of planets that would be needed if the world's population lived like the population of Luxembourg in 2007 is about six. However, per year, the biocapacity (bioproductive land) of the planet can only regenerate once. [less ▲]

Detailed reference viewed: 116 (4 UL)
See detailTrends and Players in tax policy: Greece
Pantazatou, Aikaterini UL

Presentation (2013, July)

Detailed reference viewed: 41 (0 UL)
Peer Reviewed
See detailTrends and Players in Tax Policy: Greece
Pantazatou, Aikaterini UL

in M. Lang et al. (Ed.) Trends and Players in Tax Policy (2016)

Detailed reference viewed: 115 (18 UL)
Full Text
Peer Reviewed
See detailTrends and transitions
Vögele, Claus UL

in European Journal of Health Psychology (2018), 25(1), 1

Detailed reference viewed: 63 (1 UL)
Full Text
See detailTrends from 2006-2018 in Health, Health Behaviour, Health Outcomes and Social Context of Adolescents in Luxembourg
Heinz, Andreas UL; van Duin, Claire UL; Kern, Matthias Robert UL et al

Report (2020)

This report shows how 30 health indicators developed in the four Luxembourg HBSC surveys conducted in 2006, 2010, 2014 and 2018. There were positive trends especially in the health behaviour of the pupils ... [more ▼]

This report shows how 30 health indicators developed in the four Luxembourg HBSC surveys conducted in 2006, 2010, 2014 and 2018. There were positive trends especially in the health behaviour of the pupils: they smoke less and drink less alcohol. They also report more frequently that they brush their teeth regularly, eat more fruit and fewer sweets and consume fewer soft drinks. From 2006-2018, however, there were also deteriorations. For example, more pupils feel stressed from school and rate the climate among classmates worse. In addition, there are more pupils who are overweight and exercise less and more pupils report having psychosomatic health complaints. [less ▲]

Detailed reference viewed: 391 (77 UL)
Peer Reviewed
See detailTrends in cannabis consumption among youth in Luxembourg
Catunda, Carolina UL; van Duin, Claire UL; Heinz, Andreas UL et al

Scientific Conference (2019, September)

Background: Cannabis is the most widely consumed illegal drug worldwide. Among adolescents, cannabis use is a risk factor for cognitive decline, mental illness, social problems, and the use of other ... [more ▼]

Background: Cannabis is the most widely consumed illegal drug worldwide. Among adolescents, cannabis use is a risk factor for cognitive decline, mental illness, social problems, and the use of other psychoactive drugs. The current study presents trends in cannabis consumption among adolescents in Luxembourg. Methods: The Health Behaviour in School Aged Children (HBSC) Study in Luxembourg collected data in 2006, 2010, 2014 and 2018 using a standardized paper-pencil questionnaire. In total, 23,346 secondary schools students aged 11 to 18 years old (M=15.51, SD=1.53) responded to questions on cannabis, tobacco and alcohol consumption (lifetime and the past 30 days). Findings: In general, students who never used cannabis significantly increased over the four HBSC study waves (78%, 81.2%, 81%, 84%), whereas trends are similar for boys (74.5%, 77%, 78.2%, 81.4%), but not for girls (81.5%, 85%, 83.2%, 86.3%). Cannabis use (past 30 days) significantly differ for girls (94.1%, 94.1%, 92.8%, 93.7%), but not in general (91.7%, 92%, 90.9%, 91.7%), neither for boys (89.3%, 90.1%, 88.6%, 89.6%). Discussion: Cannabis lifetime use remains high for both genders. While consumption in the last 30 days remained stable for boys, it increased for girls over the past years. Tailored preventive interventions, based on health psychological models, are essential to educate adolescents about the social-cognitive risks of cannabis use and strengthen their capacities and resilience to resist experimental drug use and social pressure. In a context where legalization policies are discussed in various European countries, e-health approaches, for example, could be widely implemented in a cost-effective manner. [less ▲]

Detailed reference viewed: 148 (7 UL)
Full Text
Peer Reviewed
See detailTrends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase
Patterson, C.C.; Gyürüs, E.; Rosenbauer, J. et al

in Diabetologia (2012), 55(8), 2142-2147

Aims/hypothesis The aim of the study was to describe 20- year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989–1998) and second ... [more ▼]

Aims/hypothesis The aim of the study was to describe 20- year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989–1998) and second (1999–2008) halves of the period. Methods All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture–recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied. Results Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half. Conclusions/interpretation The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3–4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted. [less ▲]

Detailed reference viewed: 137 (1 UL)
Full Text
Peer Reviewed
See detailTrends in Model-based GUI Testing
Arlt, Stephan UL; Bertolini, Cristiano; Pahl, Simon et al

in Advances in Computers (2012), 86

Detailed reference viewed: 106 (5 UL)
Full Text
Peer Reviewed
See detailTrends in Rainfall and Economic Growth In Africa: A Neglected Cause of the African Growth Tragedy
Barrios, Salvador; Bertinelli, Luisito UL; Strobl, Eric

in Review of Economics and Statistics (2010), 92(2), 350-366

Detailed reference viewed: 203 (3 UL)
Full Text
See detailTrends in service delivery: Psychological practice in rehabilitation settings
Pit-Ten Cate, Ineke UL; Padrone, Frank; Feinblatt, Arlene et al

in Rehabilitation Outllook (1997)

Detailed reference viewed: 78 (2 UL)
Peer Reviewed
See detailTrends in Service Delivery: Psychological Practice in Rehabilitation Settings
Pit-Ten Cate, Ineke UL; Padrone, F; Feinblatt, A et al

Scientific Conference (1995, August)

Detailed reference viewed: 41 (2 UL)
Peer Reviewed
See detailTrends in the incidence of childhood onset diabetes in Europe. 1989-1998
Green, A.; Patterson, C.C.; De Beaufort, Carine UL

in Diabetologia (2001), 44(3), 3-8

AIMS/HYPOTHESIS: To study the epidemiology of childhood-onset (Type I) insulin-dependent diabetes mellitus in Europe, the EURODIAB collaborative group in 1988 established prospective, geographically ... [more ▼]

AIMS/HYPOTHESIS: To study the epidemiology of childhood-onset (Type I) insulin-dependent diabetes mellitus in Europe, the EURODIAB collaborative group in 1988 established prospective, geographically-defined registers of all children diagnosed with Type I diabetes under 15 years of age. This report is based on 24,423 children, registered by 36 centres, with complete participation during the period 1989-1998 and representing most European countries with a population coverage of approximately 20 million children. METHODS: Multiple sources of ascertainment were used to validate the level of ascertainment. Trends in Type I diabetes incidence during the period were analysed using Poisson regression with the results from the 36 centres pooled into nine regions. RESULTS: The standardised average annual incidence rate of Type I diabetes varied more than tenfold between centres. Overall, the annual increase in incidence was 3.2% (95%-CI: 2.7%, 3.7%), being highest for children in the 0-4-year age-group 4.8% (3.8%, 5.9%) and lowest for children in the 10-14-year age group 2.1 % (1.4%, 2.8%). However, the absolute increases in Type I diabetes were roughly similar in the three age-groups of 0-4, 5-9 and 10-14 years. Central Eastern Europe showed the highest increase whereas Sardinia and Northern Europe (except Finland) showed no evidence of an increase. For all age-groups relatively fewer cases had disease onset during the summer months, especially the 10-14-year age-group. CONCLUSION/INTERPRETATION: The extremely large range of incidence rates within Europe has been confirmed. The incidence rate is generally increasing but is more pronounced in some regions than in others. Seasonality at disease onset is apparent even in the youngest age-group. [less ▲]

Detailed reference viewed: 95 (0 UL)