Singing a Meaning to War Experiences

Presentation (2009)

The Single Supervisory Mechanism: Institutional Design, Punitive Powers and the Interplay with Criminal Law

in Allegrezza, Silvia (Ed.) The Enforcement Dimension of the Single Supervisory Mechanism (2020)

Single and Multiobjective Evolutionary Algorithms for Clustering Biomedical Information with Unknown Number of Clusters

in Bioinspired Optimization Methods and Their Applications (2018)

This article presents single and multiobjective evolutionary approaches for solving the clustering problem with unknown number of clusters. Simple and ad-hoc operators are proposed, aiming to keep the ... [more ▼]

This article presents single and multiobjective evolutionary approaches for solving the clustering problem with unknown number of clusters. Simple and ad-hoc operators are proposed, aiming to keep the evolutionary search as simple as possible in order to scale up for solving large instances. The experimental evaluation is performed considering a set of real problem instances, including a real-life problem of analyzing biomedical information in the Parkinson's disease map project. The main results demonstrate that the proposed evolutionary approaches are able to compute accurate trade-off solutions and efficiently handle the problem instance involving biomedical information. [less ▲]

A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion

in Stem Cell Reports (2022)

Single crystalline cylindrical nanowires – toward dense 3D arrays of magnetic vortices

in Scientific Reports (2016), 6

Single Point Stochastic Search Algorithms for the Multi Level Lot Sizing Problem

in Computers and Operations Research (2005), 32

Single Resolution Board: another Meroni extension or another Chapter to Europe's Constitutional Transformation?

in SSRN Electronic Journal (2019)

The establishment of the Single Resolution Board (SRB) has pushed the constitutional boundaries of agencification further. After elaborating on the SRB’s powers and safeguards, one can argue that its ... [more ▼]

The establishment of the Single Resolution Board (SRB) has pushed the constitutional boundaries of agencification further. After elaborating on the SRB’s powers and safeguards, one can argue that its governance structure combined with its policymaking powers distinguish the SRB from all other agencies. While trying to assess its legality of establishment and empowerment, this paper seeks to identify the nature of the empowerment, whether Meroni is still fit for purpose, and whether the limits of institutional balance have been bent or indeed broken. After expressing concerns as to the SRB’s compliance with the current EU institutional framework, the paper offers an alternative for exiting this constitutional deadlock by applying Weiler’s theory of constitutional transformation. Such a solution would legitimize the SRB as well as facilitate the functioning of Banking Union. [less ▲]

A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation

in Journal of Biological Chemistry (1997), 272(8), 5269-74

We established a system of receptor chimeras that enabled us to induce heterodimerization of different cytoplasmic tails. Fusion constructs were created that are composed of the extracellular parts of the ... [more ▼]

We established a system of receptor chimeras that enabled us to induce heterodimerization of different cytoplasmic tails. Fusion constructs were created that are composed of the extracellular parts of the interleukin-5 receptor alpha and beta chains, respectively, and the transmembrane and intracellular parts of gp130, the signal transducing chain of the interleukin-6 receptor complex. In COS-7 transfectants we observed a dose-dependent interleukin-5-inducible STAT1 activation for which the presence of both the alpha and the beta chain chimera was needed. No STAT activity was detected if one of the cytoplasmic tails of the receptor complex was deleted, indicating that STAT activity resulted from a receptor dimer rather than from higher receptor aggregates. We further investigated whether dimerization of STAT1 depends on the juxtaposition of two STAT recruitment modules in a receptor complex. We show that a receptor dimer with only a single STAT1 docking site was still able to lead to STAT1 activation. This indicates that the formation of a paired set of STAT binding sites in a receptor complex is not the prerequisite for STAT factor dimerization. Our findings are discussed in view of alternative STAT dimerization models. [less ▲]

Single station monitoring of volcanoes using seismic ambient noise

in Geophysical Research Letters (2016)

Seismic ambient noise cross correlation is increasingly used to monitor volcanic activity. However, this method is usually limited to volcanoes equipped with large and dense networks of broadband stations ... [more ▼]

Seismic ambient noise cross correlation is increasingly used to monitor volcanic activity. However, this method is usually limited to volcanoes equipped with large and dense networks of broadband stations. The single station approach may provide a powerful and reliable alternative to the classical “cross-stations” approach when measuring variation of seismic velocities. We implemented it on the Piton de la Fournaise in Reunion Island, a very active volcano with a remarkable multi-disciplinary continuous monitoring. Over the past decade, this volcano was increasingly studied using the traditional cross-correlation technique and therefore represents a unique laboratory to validate our approach. Our results, tested on stations located up to 3.5 km from the eruptive site, performed as well as the classical approach to detect the volcanic eruption in the 1-2 Hz frequency band. This opens new perspectives to successfully forecast volcanic activity at volcanoes equipped with a single 3-component seismometer. [less ▲]

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects

in Nature (2019)