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See detailStartle eye blink is modulated by baro-afferent feedback
Schulz, André UL; Richter, S.; Lass-Hennemann, J. et al

in Psychophysiology (2009), 46(Supplement 1), 17-17

Detailed reference viewed: 73 (0 UL)
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See detailStartle responding in the context of visceral pain
Ceunen, Erik UL; Zaman, Jonas; Herssens, Natacha et al

in International Journal of Psychophysiology (2015), 98(1), 128-134

This study aimed to investigate affective modulation of eye blink startle by aversive visceral stimulation. Startle blink EMG responses were measured in 31 healthy participants receiving painful ... [more ▼]

This study aimed to investigate affective modulation of eye blink startle by aversive visceral stimulation. Startle blink EMG responses were measured in 31 healthy participants receiving painful, intermittent balloon distentions in the distal esophagus during 4 blocks (positive, negative, neutral or no pictures), and compared with startles during 3 ‘safe’ blocks without esophageal stimulations (positive, negative or neutral emotional pictures). Women showed enhanced startle during blocks with distentions (as compared with ‘safe’ blocks), both when the balloon was in inflated and deflated states, suggesting that fear and/or expectations may have played a role. Men's startle did not differ between distention and non-distention blocks. In this particular study context affective picture viewing did not further impose any effect on startle eye blink responses. The current results may contribute to a better understanding of emotional reactions to aversive interoceptive stimulation. [less ▲]

Detailed reference viewed: 129 (4 UL)
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See detailStartle-Reaktion und Verarbeitungsleistung bei Heroinabhängigkeit
Dürsteler-MacFarland, K. M.; Degen, B.; Albrich, J. et al

in Nervenarzt (2008), 79(Supplement 4), 300-300

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See detailStartups' innovation behavior: An investigation into the role of entrepreneurial motivations
Gundolf, Katherine; Gast, Johanna; Geraudel, Mickaël UL

in International Journal of Innovation Management (2017), 21

Although it is argued that competitiveness and successful performance in the long-term is facilitated if ventures engage in innovations in diverse domains (e.g. product, process, production ... [more ▼]

Although it is argued that competitiveness and successful performance in the long-term is facilitated if ventures engage in innovations in diverse domains (e.g. product, process, production, administration, etc.), the development of diversified innovation has been rarely analyzed. As the entrepreneurs’ initial motivations to startup are likely to influence their subsequent entrepreneurial behavior, this study aims to explore whether and how entrepreneurial motivations affect diversified innovation behavior in startups. Using data on over 48.000 French startups, we present novel insights into the consequences of entrepreneurial motivation for innovation behavior. In fact, we find that distinct startup motivations can have different effects on the development of diverse innovations. As such, our findings contribute to extant research on innovation development of startups and advance the present understanding of the determinants of startups’ innovative behavior [less ▲]

Detailed reference viewed: 172 (5 UL)
See detailSTAST 2011 Proc. of the 1st Workshop on Socio-Technical Aspects in Security and Trust
Coles-Kemp, Lizzie; Lenzini, Gabriele UL; Ryan, Peter UL et al

Book published by IEEE (2011)

Detailed reference viewed: 227 (11 UL)
See detailSTAST 2012 Proc. of the 2nd Int. Workshop on Socio-Technical Aspects in Security and Trust
Lenzini, Gabriele UL; Bella, Giampaolo

Book published by IEEE (2012)

The last few years have consolidated our understanding that security and trust are a socio-technical matter. Hence a call for researchers from different disciplines, such as sociology, psychology and ... [more ▼]

The last few years have consolidated our understanding that security and trust are a socio-technical matter. Hence a call for researchers from different disciplines, such as sociology, psychology and informatics, to construct a holistic vision of security and trust. STAST, the workshop on Socio-Technical Aspects in Security and Trust, is an international event to support such interdisciplinary research. It reaches its second edition in 2012. The first took place at the University of Milano (Milan, Italy), hosted by the International Conference on Network and System Security (NSS). The second edition was held at Harvard University (Cambridge, MA, USA), hosted by the Computer Security Foundation Symposium (CSF) — this volume gathers its post-proceedings. [less ▲]

Detailed reference viewed: 86 (8 UL)
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See detailSTAT1 regulates p73-mediated Bax gene expression
Soond, S. M.; Carroll, C.; Townsend, P. A. et al

in FEBS Letters (2007), 581(6), 1217-26

Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of ... [more ▼]

Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood. In this study, we found that STAT1 and TA-p73 can interact directly and that p73-mediated Bax promoter activity was observed to be reduced by STAT1 expression in a p53-independent manner for which STAT1 Tyrosine-701 and Serine-727 are key residues. This study presents the first report physically linking STAT1 and TA-p73 signalling and highlights the modulation of the Bax promoter in the context of IFN-gamma stimulation. [less ▲]

Detailed reference viewed: 105 (0 UL)
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See detailSTAT3 is constitutively activated in Hodgkin cell lines
Kube, D.; Holtick, U.; Vockerodt, M. et al

in Blood (2001), 98(3), 762-70

Hodgkin disease (HD) represents a malignant lymphoma in which the putative malignant Hodgkin and Reed-Sternberg cells are rare and surrounded by abundant reactive nonmalignant cells. It has been suggested ... [more ▼]

Hodgkin disease (HD) represents a malignant lymphoma in which the putative malignant Hodgkin and Reed-Sternberg cells are rare and surrounded by abundant reactive nonmalignant cells. It has been suggested that cytokines such as interleukin-6 (IL-6) are involved in the pathogenesis of the disease. The expression of the IL-6 receptor (IL-6R) complex and its link to the activation of signal transducers and activators of transcription (STAT) molecules in HD cell lines was investigated. Gel retardation and Western blot analyses revealed a high level of constitutively activated STAT3 in 5 of 7 HD cell lines, which could not be detected in Burkitt lymphoma cell lines. Different levels of IL-6R protein were measured in various HD cell lines: L428 and Dev cells were characterized by very low levels of gp80 and gp130, on KMH2 cells only gp130 but no gp80 was detected, whereas L540, L591, HDLM2, and L1236 were positive for both gp80 and gp130, suggesting a possible autocrine stimulation of STAT3. However, a further increase in STAT3 activation on IL-6 or IL-6/soluble IL-6R stimulation was not observed. Neutralizing monoclonal antibodies against IL-6, gp80, gp130, or both receptor subunits did not affect the proliferation or the constitutive activation of STAT molecules in HD cell lines. However, the tyrosine kinase inhibitor AG490 blocked the constitutive activation of STAT3 and inhibited spontaneous growth of HD tumor cells. The evidence suggests abnormal STAT signaling and growth regulation in Hodgkin cell lines. (Blood. 2001;98:762-770) [less ▲]

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See detailSTAT3 is enriched in nuclear bodies.
Herrmann, Andreas; Sommer, Ulrike; Pranada, Albert L. et al

in Journal of Cell Science (2004), 117(Pt 2), 339-49

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is involved in a variety of biological functions. It is essential for the signal transduction of interleukin-6 (IL ... [more ▼]

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is involved in a variety of biological functions. It is essential for the signal transduction of interleukin-6 (IL-6) and related cytokines. In response to IL-6 stimulation STAT3 becomes phosphorylated and translocates into the nucleus where it binds to enhancer sequences of target genes. We found that activated STAT3 is enriched in dot-like structures within the nucleus, which we termed STAT3 nuclear bodies. To examine the dynamics of STAT3 nuclear body formation, a fusion protein of STAT3 and yellow fluorescent protein (YFP) was constructed. Studies in living cells have shown that the appearance of STAT3 nuclear bodies is transient, correlating with the timecourse of tyrosine-phosphorylation of STAT3. Furthermore, we show by fluorescence recovery after photobleaching (FRAP) analysis that STAT3 within nuclear bodies consists of a highly mobile and an immobile fraction. Colocalization studies provided evidence that these bodies are accompanied with CREB binding protein (CBP) and acetylated histone H4, which are markers for transcriptionally active chromatin. Moreover, STAT3 nuclear bodies in HepG2 cells are not colocalized with promyelocytic leukemia oncoprotein (PML)-containing bodies; neither is a sumoylation of activated STAT3 detectable. Taken together, our data suggest that STAT3 nuclear bodies are either directly involved in active gene transcription or they serve as reservoirs of activated STAT3. [less ▲]

Detailed reference viewed: 105 (17 UL)
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See detailSTAT5 contributes to interferon resistance of melanoma cells
Wellbrock, C.; Weisser, C.; Hassel, J. C. et al

in Current Biology (2005), 15(18), 1629-39

BACKGROUND: Malignant melanoma is a highly aggressive neoplastic disease whose incidence is increasing rapidly. In recent years, the use of interferon alpha (IFNalpha) has become the most established ... [more ▼]

BACKGROUND: Malignant melanoma is a highly aggressive neoplastic disease whose incidence is increasing rapidly. In recent years, the use of interferon alpha (IFNalpha) has become the most established adjuvant immunotherapy for melanoma of advanced stage. IFNalpha is a potent inhibitor of melanoma cell proliferation, and the signal transducer and activator of transcription STAT1 is crucial for its antiproliferative action. Although advanced melanomas clinically resistant to IFNalpha are frequently characterized by inefficient STAT1 signaling, the mechanisms underlying advanced-stage interferon resistance are poorly understood. RESULTS: Here, we demonstrate that IFNalpha activates STAT5 in melanoma cells and that in IFNalpha-resistant cells STAT5 is overexpressed. Significantly, the knockdown of STAT5 in interferon-resistant melanoma cells restored the growth-inhibitory response to IFNalpha. When STAT5 was overexpressed in IFNalpha-sensitive cells, it counteracted interferon-induced growth inhibition. The overexpressed STAT5 diminished IFNalpha-triggered STAT1 activation, most evidently through upregulation of the inhibitor of cytokine-signaling CIS. CONCLUSIONS: Our data demonstrate that overexpression and activation of STAT5 enable melanoma cells to overcome cytokine-mediated antiproliferative signaling. Thus, overexpression of STAT5 can counteract IFNalpha signaling in melanoma cells, and this finally can result in cytokine-resistant and progressively growing tumor cells. These findings have significant implications for the clinical failure of IFNalpha therapy of advanced melanoma because they demonstrate that IFNalpha induces the activation of STAT5 in melanoma cells, and in STAT5-overexpressing cells, this contributes to IFNalpha resistance. [less ▲]

Detailed reference viewed: 106 (0 UL)
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See detailState Aggregation for Multiagent Communication over Rate-Limited Channels
Mostaani, Arsham UL; Vu, Thang Xuan UL; Chatzinotas, Symeon UL et al

in State Aggregation for Multiagent Communication over Rate-Limited Channels (2020, December)

A collaborative task is assigned to a multiagent system (MAS) in which agents are allowed to communicate. The MAS runs over an underlying Markov decision process and its task is to maximize the averaged ... [more ▼]

A collaborative task is assigned to a multiagent system (MAS) in which agents are allowed to communicate. The MAS runs over an underlying Markov decision process and its task is to maximize the averaged sum of discounted one-stage rewards. Although knowing the global state of the environment is necessary for the optimal action selection of the MAS, agents are limited to individual observations. The inter-agent communication can tackle the issue of local observability, however, the limited rate of the inter-agent communication prevents the agent from acquiring the precise global state information. To overcome this challenge, agents need to communicate their observations in a compact way such that the MAS compromises the minimum possible sum of rewards. We show that this problem is equivalent to a form of rate-distortion problem which we call the task-based information compression. State Aggregation for Information Compression (SAIC) is introduced here to perform the task-based information compression. The SAIC is shown, conditionally, to be capable of achieving the optimal performance in terms of the attained sum of discounted rewards. The proposed algorithm is applied to a rendezvous problem and its performance is compared with two benchmarks; (i) conventional source coding algorithms and the (ii) centralized multiagent control using reinforcement learning. Numerical experiments confirm the superiority and fast convergence of the proposed SAIC. [less ▲]

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See detailState aid and tax law
Micheau, Claire UL

Book published by Wolters Kluwer (2012)

Detailed reference viewed: 81 (6 UL)
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See detailState aid and taxation in EU law
Micheau, Claire UL

in Szyszczak, Erika (Ed.) Research Handbook on European State Aid Law (2011)

Detailed reference viewed: 130 (3 UL)
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See detailState Aid Law of the European Union
Hofmann, Herwig UL; Micheau, Claire

Book published by Oxford University Press (2016)

Detailed reference viewed: 193 (8 UL)
See detailState aid, subsidy and tax incentives under EU and WTO law
Micheau, Claire UL

Book published by Kluwer Law International (2014)

Detailed reference viewed: 214 (15 UL)
See detailState Aid, Subsidy and Tax Incentives under EU and WTO Law
Micheau, Claire UL

Doctoral thesis (2010)

Detailed reference viewed: 194 (10 UL)
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See detailState and output feedback control for Takagi-Sugeno systems with saturated actuators
Bezzaoucha, Souad UL; Marx, Benoît; Maquin, Didier et al

in International Journal of Adaptive Control and Signal Processing (2015)

In the present paper, a Takagi-Sugeno (T-S) model is used to simultaneously represent the behaviour of a nonlinear system and its saturated actuators. With the T-S formalism and the Lyapunov approach ... [more ▼]

In the present paper, a Takagi-Sugeno (T-S) model is used to simultaneously represent the behaviour of a nonlinear system and its saturated actuators. With the T-S formalism and the Lyapunov approach, stabilization conditions are expressed as Linear Matrix Inequalities (LMIs) for different controller designs. Static Parallel Distributed Compensation (PDC) state feedback, static and dynamic PDC output feedback controllers for nonlinear saturated systems are proposed. The descriptor approach is used to obtain relaxed conditions to compute the controller gains. The nonlinear cart-pendulum system is used to illustrate the proposed control laws. [less ▲]

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See detailState and Path Effectivity Models for Logics of Multi-Player Games
Goranko, Valentin; Jamroga, Wojciech UL

in Proceedings of AAMAS 2012 (2012)

Detailed reference viewed: 42 (1 UL)
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See detailState constrained tracking control for nonlinear systems
Bezzaoucha, Souad UL; Marx, Benoît; Maquin, Didier et al

in Journal of the Franklin Institute (2015), 352(7), 2866-2886

This work addresses the model reference tracking control problem. It aims to highlight the encountered difficulties and the proposed solutions to achieve the tracking objective. Based on a literature ... [more ▼]

This work addresses the model reference tracking control problem. It aims to highlight the encountered difficulties and the proposed solutions to achieve the tracking objective. Based on a literature overview of linear and nonlinear reference tracking, the achievements and the limitations of the existing strategies are highlighted. This motivates the present work to propose clear control algorithms for perfect and approximate tracking controls of nonlinear systems described by Takagi-Sugeno models. First, perfect nonlinear tracking control is addressed and necessary structural conditions are stated. If these conditions do not hold, approximate tracking control is proposed and the choice of the reference model to be tracked as well as the choice of the criterion to be minimized are discussed with respect to the desired objectives. The case of constrained control input is also considered in order to anticipate and counteract the effect of the control saturation. [less ▲]

Detailed reference viewed: 136 (2 UL)