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See detailToward Millimeter-Wave Joint Radar Communications: A Signal Processing Perspective
Mishra, Kumar Vijay; Shankar, Bhavani UL; Koivunen, Visa et al

in IEEE Signal Processing Magazine (2019), 36(5), 100-114

Synergistic design of communications and radar systems with common spectral and hardware resources is heralding a new era of efficiently utilizing a limited radio-frequency (RF) spectrum. Such a joint ... [more ▼]

Synergistic design of communications and radar systems with common spectral and hardware resources is heralding a new era of efficiently utilizing a limited radio-frequency (RF) spectrum. Such a joint radar communications (JRC) model has advantages of low cost, compact size, less power consumption, spectrum sharing, improved performance, and safety due to enhanced information sharing. Today, millimeter-wave (mmwave) communications have emerged as the preferred technology for short distance wireless links because they provide transmission bandwidth that is several gigahertz wide. This band is also promising for short-range radar applications, which benefit from the high-range resolution arising from large transmit signal bandwidths. Signal processing techniques are critical to the implementation of mm-wave JRC systems. Major challenges are joint waveform design and performance criteria that would optimally trade off between communications and radar functionalities. Novel multiple-input, multiple-output (MIMO) signal processing techniques are required because mm-wave JRC systems employ large antenna arrays. There are opportunities to exploit recent advances in cognition, compressed sensing, and machine learning to reduce required resources and dynamically allocate them with low overheads. This article provides a signal processing perspective of mm-wave JRC systems with an emphasis on waveform design. [less ▲]

Detailed reference viewed: 128 (4 UL)
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See detailToward New Approaches for Developing a High Quality Education System in Brazil
Andersen, Katja Natalie UL

in do Céu Ubaiara Brito, Ângela; Ferreira da Silva, Brigida Ticiane (Eds.) Educação em foco: ensaio de pesquisa (2020)

Detailed reference viewed: 44 (5 UL)
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See detailToward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research
Maes; Nowak, Gabriel; Caso, Javier et al

in Molecular Neurobiology (2016), 53(5), 2927-2935

Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g ... [more ▼]

Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g., interleukin-6. Supporting the translational significance of this, a meta-analysis showed that anti-inflammatory drugs may have antidepressant effects. Here, we argue that inflammation and depression research needs to get onto a new track. Firstly, the choice of inflammatory biomarkers in depression research was often too selective and did not consider the broader pathways. Secondly, although mild inflammatory responses are present in depression, other immune-related pathways cannot be disregarded as new drug targets, e.g., activation of cell-mediated immunity, oxidative and nitrosative stress (O&NS) pathways, autoimmune responses, bacterial translocation, and activation of the toll-like receptor and neuroprogressive pathways. Thirdly, anti-inflammatory treatments are sometimes used without full understanding of their effects on the broader pathways underpinning depression. Since many of the activated immune-inflammatory pathways in depression actually confer protection against an overzealous inflammatory response, targeting these pathways may result in unpredictable and unwanted results. Furthermore, this paper discusses the required improvements in research strategy, i.e., path and drug discovery processes, omics-based techniques, and systems biomedicine methodologies. Firstly, novel methods should be employed to examine the intracellular networks that control and modulate the immune, O&NS and neuroprogressive pathways using omics-based assays, including genomics, transcriptomics, proteomics, metabolomics, epigenomics, immunoproteomics and metagenomics. Secondly, systems biomedicine analyses are essential to unravel the complex interactions between these cellular networks, pathways, and the multifactorial trigger factors and to delineate new drug targets in the cellular networks or pathways. Drug discovery processes should delineate new drugs targeting the intracellular networks and immune-related pathways. [less ▲]

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See detailToward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.
Mandenius, Carl-Fredrik; Andersson, Tommy B.; Alves, Paula M. et al

in Alternatives to laboratory animals : ATLA (2011), 39(2), 147-71

Drug-induced liver injury is a common reason for drug attrition in late clinical phases, and even for post-launch withdrawals. As a consequence, there is a broad consensus in the pharmaceutical industry ... [more ▼]

Drug-induced liver injury is a common reason for drug attrition in late clinical phases, and even for post-launch withdrawals. As a consequence, there is a broad consensus in the pharmaceutical industry, and within regulatory authorities, that a significant improvement of the current in vitro test methodologies for accurate assessment and prediction of such adverse effects is needed. For this purpose, appropriate in vivo-like hepatic in vitro models are necessary, in addition to novel sources of human hepatocytes. In this report, we describe recent and ongoing research toward the use of human embryonic stem cell (hESC)-derived hepatic cells, in conjunction with new and improved test methods, for evaluating drug metabolism and hepatotoxicity. Recent progress on the directed differentiation of human embryonic stem cells to the functional hepatic phenotype is reported, as well as the development and adaptation of bioreactors and toxicity assay technologies for the testing of hepatic cells. The aim of achieving a testing platform for metabolism and hepatotoxicity assessment, based on hESC-derived hepatic cells, has advanced markedly in the last 2-3 years. However, great challenges still remain, before such new test systems could be routinely used by the industry. In particular, we give an overview of results from the Vitrocellomics project (EU Framework 6) and discuss these in relation to the current state-of-the-art and the remaining difficulties, with suggestions on how to proceed before such in vitro systems can be implemented in industrial discovery and development settings and in regulatory acceptance. [less ▲]

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See detailToward Real-world Vehicle Placement Optimization in Round-trip Carsharing
Changaival, Boonyarit UL; Danoy, Grégoire UL; Kliazovich, Dzmitry et al

in Proceedings of the Genetic and Evolutionary Computation Conference (2019)

Detailed reference viewed: 147 (14 UL)
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See detailToward systems metabolic engineering in cyanobacteria: opportunities and bottlenecks.
Nogales, Juan; Gudmundsson, Steinn; Thiele, Ines UL

in Bioengineered (2013), 4(3), 158-163

We recently assessed the metabolism of Synechocystis sp PCC6803 through a constraints-based reconstruction and analysis approach and identified its main metabolic properties. These include reduced ... [more ▼]

We recently assessed the metabolism of Synechocystis sp PCC6803 through a constraints-based reconstruction and analysis approach and identified its main metabolic properties. These include reduced metabolic robustness, in contrast to a high photosynthetic robustness driving the optimal autotrophic metabolism. Here, we address how these metabolic features affect biotechnological capabilities of this bacterium. The search for growth-coupled overproducer strains revealed that the carbon flux re-routing, but not the electron flux, is significantly more challenging under autotrophic conditions than under mixo- or heterotrophic conditions. We also found that the blocking of the light-driven metabolism was required for carbon flux re-routing under mixotrophic conditions. Overall, our analysis, which represents the first systematic evaluation of the biotechnological capabilities of a photosynthetic organism, paradoxically suggests that the light-driven metabolism itself and its unique metabolic features are the main bottlenecks in harnessing the biotechnological potential of Synechocystis. [less ▲]

Detailed reference viewed: 78 (2 UL)
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See detailToward Understanding Complex Spin Textures in Nanoparticles by Magnetic Neutron Scattering
G. Vivas, Laura; Yanes, Rocio; Berkov, Dmitry et al

in Physical Review Letters (2020), 125

Detailed reference viewed: 67 (4 UL)
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See detailToward visual autonomous ship board landing of a VTOL UAV
Sanchez Lopez, Jose Luis UL; Saripalli, Srikanth; Campoy, Pascual et al

in 2013 International Conference on Unmanned Aircraft Systems (ICUAS) (2013, May)

In this paper we tackle the problem of landing a helicopter autonomously on a ship deck, using as the main sensor, an on-board colour camera. To create a test-bed, we first adequately simulate the ... [more ▼]

In this paper we tackle the problem of landing a helicopter autonomously on a ship deck, using as the main sensor, an on-board colour camera. To create a test-bed, we first adequately simulate the movement of a ship landing platform on the Sea, for different Sea States, for different ships, randomly and realistically enough. We use a commercial parallel robot to get this movement. Once we had this, we developed an accurate and robust computer vision system to measure the pose of the helipad with respect to the on-board camera. To deal with the noise and the possible fails of the computer vision, a state estimator was created. With all of this, we are now able to develop and test a controller that closes the loop and finish the autonomous landing task. [less ▲]

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See detailTowards 2-Hop Neighbor Management for Heterogeneous Vehicular Networks
Turcanu, Ion UL; Kim, Minsuk; Klingler, Florian

Poster (2020, December)

Message dissemination protocols for vehicular networks often build upon information maintained in neighbor tables. Due to high mobility and scarce channel capacity available in such networks, algorithms ... [more ▼]

Message dissemination protocols for vehicular networks often build upon information maintained in neighbor tables. Due to high mobility and scarce channel capacity available in such networks, algorithms for maintaining neighbor tables must carefully select which information is transmitted at which time. Recent approaches rely on probabilistic data structures (e.g., Bloom filter) for transmitting such neighbor information in order to reduce channel load, yet they still suffer from scarce channel capacities. In this paper, we propose to use multiple communication technologies (heterogeneous networking) for maintaining neighbor tables by building upon recent 2-hop neighbor management strategies. Promising results show an increase of up to 19 % of covered neighbors in comparison to a Baseline approach that only uses one communication technology. [less ▲]

Detailed reference viewed: 116 (15 UL)
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See detailTowards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.
Langley, Gillian R.; Adcock, Ian M.; Busquet, Francois et al

in Drug discovery today (2017), 22(2), 327-339

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research ... [more ▼]

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this. [less ▲]

Detailed reference viewed: 61 (0 UL)
See detailTowards a Closing of the Gender Pay Gap: Country Report Austria.
Egger de Campo, Marianne; Hoenig, Barbara UL; Kreimer, Margareta et al

Report (2002)

Austria shows one of the highest gender wage differentials among the European countries; in 1999, Austrian women's average earnings reached only 65 % of that of their male compatriots. This wage gap ... [more ▼]

Austria shows one of the highest gender wage differentials among the European countries; in 1999, Austrian women's average earnings reached only 65 % of that of their male compatriots. This wage gap decreased during the 1980s but again increased in the 1990s, although female employment rates had been rising ever since. In the 2010s, Austria still is among those countries with the highest gender pay gap of the enlarged EU28. This already points to the very main characteristic of the Austrian gender wage gap: Most of the increase of female labour market participation has been realized in part-time jobs, which not only decreases gross earnings but also chances to get promoted, and thus access to better paid jobs. [less ▲]

Detailed reference viewed: 63 (3 UL)
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See detailTowards a common understanding of the precautionary principle?
König, Ariane UL

Article for general public (2000)

Detailed reference viewed: 114 (6 UL)
See detailTowards a complexity turn in border studies? Rückblicke und Ausblicke
Wille, Christian UL

Presentation (2019, December)

Detailed reference viewed: 142 (1 UL)
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See detailTowards a computer-assisted aesthetics of user response
Armaselu, Florentina UL

in Digital Scholarship in the Humanities (2021)

The article focuses on the analysis of the user as an aesthetic category and proposes a methodology for evaluating user response within a framework that combines theoretical background from different ... [more ▼]

The article focuses on the analysis of the user as an aesthetic category and proposes a methodology for evaluating user response within a framework that combines theoretical background from different areas, the theory of aesthetic response, psycholinguistics, appraisal theory, dialogism, and affective stylistics, with the application of digital tools for corpus linguistics and sentiment analysis. Four user types were derived from the corpus linguistics analysis referred to as immersed, distant, sceptical, and enthusiastic users. Each type may encompass a certain degree of intentionality and convey an attitude, implying features such as commitment and honesty, objectivity and engagement with the audience, critical reflection and circumspection, openness to technological novelty, and enjoyment. This assumes that the users involved in usability testing are not neutral or undifferentiated informational entities placed in an experimental context but individuals that respond to the same stimuli and express themselves differently in light of psycholinguistic factors and rules of social interaction. On the other hand, the results of sentiment analysis showed that an experiential analysis, centred not only on the artefact but also on the response and the experience it generates, may enable understanding the user as involved in a hermeneutic process of interpretation during his/her interaction with the studied artefact. Given the small scale of the analysed data, the study does not intend to provide evidence for general or definitive statements but formulates and illustrates a set of interpretative hypotheses and methodological directions for further enquiry aiming at developing an ‘aesthetics’ of user response. [less ▲]

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See detailTowards a cross-cultural assessment of binge-watching: Psychometric evaluation of the “watching TV series motives” and “binge-watching engagement and symptoms” questionnaires across nine languages
Flayelle, Maèva; Castro-Calvo, Jesús; Vögele, Claus UL et al

in Computers in Human Behavior (2020), 111

In view of the growing interest regarding binge-watching (i.e., watching multiple episodes of television (TV) series in a single sitting) research, two measures were developed and validated to assess ... [more ▼]

In view of the growing interest regarding binge-watching (i.e., watching multiple episodes of television (TV) series in a single sitting) research, two measures were developed and validated to assess binge-watching involvement (“Binge-Watching Engagement and Symptoms Questionnaire”, BWESQ) and related motivations (“Watching TV Series Motives Questionnaire”, WTSMQ). To promote international and cross-cultural binge-watching research, the present article reports on the validation of these questionnaires in nine languages (English, French, Spanish, Italian, German, Hungarian, Persian, Arabic, Chinese). Both questionnaires were disseminated, together with additional self-report measures of happiness, psychopathological symptoms, impulsivity and problematic internet use among TV series viewers from a college/university student population (N = 12,616) in 17 countries. Confirmatory factor, measurement invariance and correlational analyses were conducted to establish structural and construct validity. The two questionnaires had good psychometric properties and fit in each language. Equivalence across languages and gender was supported, while construct validity was evidenced by similar patterns of associations with complementary measures of happiness, psychopathological symptoms, impulsivity and problematic internet use. The results support the psychometric validity and utility of the WTSMQ and BWESQ for conducting cross-cultural research on binge-watching. [less ▲]

Detailed reference viewed: 141 (7 UL)
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See detailTowards a Cultural History of Car Sound(s)
Krebs, Stefan UL

in Norton, Peter; Mom, Gijs; Millward, Liz (Eds.) et al Mobility in History : Reviews and Reflections (2011)

Detailed reference viewed: 82 (0 UL)
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See detailTowards a Decision Model Based on Trust and Security Risk Management
Alcalde, Baptiste UL; Dubois, E.; Mauw, Sjouke UL et al

in Proc. 7th Australasian Information Security Conference - AISC'09 (2009)

Detailed reference viewed: 34 (0 UL)
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See detailTowards a decision model based on trust and security risk management. In Ljiljana Brankovic and Willy Susilo
Alcalde, Baptiste UL; Dubois, Eric; Mauw, Sjouke UL et al

in Seventh Australasian Information Security Conference (AISC 2009) (2009)

Detailed reference viewed: 84 (0 UL)