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See detailThree Detailed Fluctuation Theorems
Esposito, Massimiliano UL; Van den Broeck, Christian

in Physical Review Letters (2010), 104(9),

The total entropy production of a trajectory can be split into an adiabatic and a nonadiabatic contribution, deriving, respectively, from the breaking of detailed balance via nonequilibrium boundary ... [more ▼]

The total entropy production of a trajectory can be split into an adiabatic and a nonadiabatic contribution, deriving, respectively, from the breaking of detailed balance via nonequilibrium boundary conditions or by external driving.We show that each of them, the total, the adiabatic, and the nonadiabatic trajectory entropy, separately satisfies a detailed fluctuation theorem. [less ▲]

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See detailThree dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase
Radtke, S.; Jörissen, A.; de Leur, H. S. et al

in Journal of Biological Chemistry (2006), 281(7), 4024-34

The oncostatin M receptor (OSMR) is part of receptor complexes for oncostatin M and interleukin-31. Signaling events are triggered by Jaks (Janus kinases) that constitutively bind to membrane-proximal ... [more ▼]

The oncostatin M receptor (OSMR) is part of receptor complexes for oncostatin M and interleukin-31. Signaling events are triggered by Jaks (Janus kinases) that constitutively bind to membrane-proximal receptor regions. Besides their established role in signaling, Jaks are involved in the regulation of the surface expression of several cytokine receptors. Here, we analyzed the structural requirements within the human OSMR that underlie its limited surface expression in the absence of associated Jaks. We identified three dileucine-like motifs within the Jak-binding region of the OSMR that control receptor surface and overall expression. A receptor mutant in which all three motifs were mutated to alanine displayed markedly increased surface expression. Although the surface half-life of this mutant was increased compared with that of the wild-type receptor, no difference in the internalization rate was detectable, implying that these receptors differ in their post-endocytic fate. The protein stability of the wild-type receptor was markedly lower than that of mutant receptors, but could be strongly increased in the presence of the lysosomal inhibitor chloroquine. Our data are consistent with the dileucine motifs being involved in destabilization of receptors devoid of associated Jaks as part of a quality control ensuring signaling competence of OSMRs. [less ▲]

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See detailThree faces of the second law. I. Master equation formulation
Esposito, Massimiliano UL; Van den Broeck, Christian

in Physical Review E (2010), 82(1),

We propose a formulation of stochastic thermodynamics for systems subjected to nonequilibrium constraints i.e. broken detailed balance at steady state and furthermore driven by external time-dependent ... [more ▼]

We propose a formulation of stochastic thermodynamics for systems subjected to nonequilibrium constraints i.e. broken detailed balance at steady state and furthermore driven by external time-dependent forces. A splitting of the second law occurs in this description leading to three second-law-like relations. The general results are illustrated on specific solvable models. The present paper uses a master equation based approach. [less ▲]

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See detailThree faces of the second law. II. Fokker-Planck formulation
Van den Broeck, Christian; Esposito, Massimiliano UL

in Physical Review E (2010), 82(1),

The total entropy production is the sum of two contributions, the so-called adiabatic and nonadiabatic entropy productions, each of which is non-negative. We derive their explicit expressions for ... [more ▼]

The total entropy production is the sum of two contributions, the so-called adiabatic and nonadiabatic entropy productions, each of which is non-negative. We derive their explicit expressions for continuous Markovian processes, discuss their properties, and illustrate their behavior on two exactly solvable models. [less ▲]

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See detailThree kinds of reliabilism
Hofmann, Frank UL

in Philosophical Explorations (2013), 16(1), 59-80

I distinguish between three kinds of reliabilism for epistemic justification, namely, pure reliabilism, evidential reliabilism, and reasons reliabilism, and I argue for reasons reliabilism. Pure ... [more ▼]

I distinguish between three kinds of reliabilism for epistemic justification, namely, pure reliabilism, evidential reliabilism, and reasons reliabilism, and I argue for reasons reliabilism. Pure reliabilism and evidential reliabilism are plagued, most importantly, by the generality problem, and they cannot deal adequately with defeater phenomena. One can avoid these problems only by jettisoning the idea of process reliability. The truth connection – which is essential for any kind of reliabilism – has to be provided in an altogether different way, namely, by means of facts in the world which serve as objective reasons (or evidence). So, as reasons reliabilism says, a justified belief has to be anchored in an objective reason which speaks in favor of its truth. Only in this way can intuitions about defeaters be preserved and explained. And reasons reliabilism can avoid the generality problem. [less ▲]

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See detailThree lectures on Algebraic Microlocal Analysis
Schapira, Pierre UL

E-print/Working paper (2013)

Detailed reference viewed: 91 (1 UL)
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See detailThree methods, four outcomes! How to test the reliability and validity of a graduate survey competence scale
Landmann, Mareike; Kmiotek-Meier, Emilia Alicja UL; Lachmann, Daniel et al

in Huisman, Jeroen; Tight, Malcolm (Eds.) Theory and Method in Higher Education Research. Volume 1 (2015)

This chapter presents and discusses various steps to ensure empirical reliability and theoretical validity in the construction of competence scales in graduate surveys. The development of a scale to ... [more ▼]

This chapter presents and discusses various steps to ensure empirical reliability and theoretical validity in the construction of competence scales in graduate surveys. The development of a scale to assess demands of the teacher profession and related abilities in graduates for a German tracer study project serves as an example. Confirmatory factor analysis (CFA), principal component analysis (PCA) and Cronbach’s coefficient alpha are employed to test the reliability of the scale. Differing results illustrate how the method applied influences decisions in the process of developing a scale. Our findings show that multidimensionality can only be tested appropriately by CFA; PCA renders no feasible or similar results to CFA depending on the predetermination of the number of factors; Cronbach’s alpha produces misleading results as the prerequisite assumption of unidimensionality is violated by the data. [less ▲]

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See detailThree models of flexible talent management
Usanova, Ksenia UL; Geraudel, Mickaël UL; D'Armagnac, Sophie et al

Scientific Conference (2019, September 30)

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See detailThree models of power in David Mamet's Oleanna
Weber, Jean-Jacques UL; Culpeper, Jonathan; Short, Mick et al

in Exploring the Language of Drama (1998)

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See detailThree necessary conditions for establishing effective Sustainable Development Goals in the Anthropocene
Norström, Albert et al.; Kyriakopoulou, Efthymia UL

in Ecology and Society (2014), 19(3),

The purpose of the United Nations-guided process to establish Sustainable Development Goals is to galvanize governments and civil society to rise to the interlinked environmental, societal, and economic ... [more ▼]

The purpose of the United Nations-guided process to establish Sustainable Development Goals is to galvanize governments and civil society to rise to the interlinked environmental, societal, and economic challenges we face in the Anthropocene. We argue that the process of setting Sustainable Development Goals should take three key aspects into consideration. First, it should embrace an integrated social-ecological system perspective and acknowledge the key dynamics that such systems entail, including the role of ecosystems in sustaining human wellbeing, multiple cross-scale interactions, and uncertain thresholds. Second, the process needs to address trade-offs between the ambition of goals and the feasibility in reaching them, recognizing biophysical, social, and political constraints. Third, the goal-setting exercise and the management of goal implementation need to be guided by existing knowledge about the principles, dynamics, and constraints of social change processes at all scales, from the individual to the global. Combining these three aspects will increase the chances of establishing and achieving effective Sustainable Development Goals. [less ▲]

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See detailThree point functions in higher spin AdS3 supergravity
Creutzig, T.; Hikida, Y.; Roenne, Peter Browne UL

in Journal of High Energy Physics (2013), 2013(1),

In a previous work we have proposed that the Prokushkin-Vasiliev higher spin N = 2 supergravity on AdS3 is dual to a large N limit of the N = (2,2) ℂPN Kazama- Suzuki model. There is now strong evidence ... [more ▼]

In a previous work we have proposed that the Prokushkin-Vasiliev higher spin N = 2 supergravity on AdS3 is dual to a large N limit of the N = (2,2) ℂPN Kazama- Suzuki model. There is now strong evidence supporting this proposal based on symmetry and spectrum comparison. In this paper we will give further evidence for the duality by studying correlation functions. We compute boundary three point functions with two fermionic operators and one higher spin bosonic current in terms of the bulk supergravity theory. Then we compare with the results in the dual CFT, where the supersymmetry of the theory turns out to be very helpful. In particular we use it to confirm results conjectured in the bosonic case. Moreover, correlators with a fermionic current can be obtained via supersymmetry. © 2013 SISSA, Trieste, Italy. [less ▲]

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See detailThree songs and you are disconnected from cyberspace??? Not in Germany where the industry may ‘turn piracy into profit’
Schmitz, Sandra UL; Ries, Thorsten UL

in European Journal of Law and Technology (2012), 3(1),

Musical and cinematographic works are shared on a large scale via the Internet, often disrespecting copyrights. State initiatives seek to curtail online copyright infringements in different ways; the ... [more ▼]

Musical and cinematographic works are shared on a large scale via the Internet, often disrespecting copyrights. State initiatives seek to curtail online copyright infringements in different ways; the latest being graduated response schemes, where the alleged infringer is initially warned twice before he is sanctioned. In this context questions arise inter alia as regards the identification of the actual infringer, information rights of the rightsholder, reliability of tracking methods or judicial review of the allegations. In this context, it is of some interest to see how these questions are dealt with under similar regimes. This paper outlines how these questions and online copyright infringements in general are targeted under German civil law and how this has become a profitable tool of the music and film industry, in particular following the introduction of further information rights by the Enforcement Directive. It critically evaluates the recent developments in Germany and argues for a more restrictive interpretation of the relevant provision of the German Copyright Act. [less ▲]

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See detailThree Steps Forward and, If Possible, Not a Single Step Back - Luxembourg Perspectives on Societal Discourses Concerning Sexuality.
Baltes-Löhr, Christel UL

in Cultural and Religious Studies (2020), 8(7), 367-385

This article will retrace the developmental lines of societal discourses concerning sexuality as well as the changing significance, acceptance, de-dramatization, and normalization of non-heteronormative ... [more ▼]

This article will retrace the developmental lines of societal discourses concerning sexuality as well as the changing significance, acceptance, de-dramatization, and normalization of non-heteronormative, non-binary configurations of gender. In a first step, the figure of the continuum will be outlined as a theoretical framework and analytic tool for gender diversity. Subsequently, the article will illustrate certain key data points concerning the situation of women and men in Luxembourg and establish a comparison with the European and international situation. Selected research findings will be discussed, although it must be noted that, in the early 2010s, this research was still concerned exclusively with binary configurations of gender. Following a first synopsis, the paper will divert its attention to trans, intersex, non-binary, queer, and agender persons in Luxembourg and will introduce current national and international research findings concerning Luxembourg, as well as national ministerial measures and positionings. Following an excursion towards sexology in medicine as well as teaching and research environments at universities, the article will cast a glance towards the year 2050 and finally illuminate the relation, the four-way connection between physicality, psyche, social behavior, and desire to thus illustrate perspectives towards possible future developments. [less ▲]

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See detailThree theories of Lex Mercatoria
Cuniberti, Gilles UL

in Columbia Journal of Transnational Law (2014), 52

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See detailThree ways to grow faster and better CIGSe
Dale, Phillip UL; Malaquias, Joao Corujo Branco UL; Meadows, Helen UL et al

Scientific Conference (2013)

Detailed reference viewed: 139 (5 UL)
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See detailThree-dimensional arithmetic billiards
Perucca, Antonella UL

E-print/Working paper (n.d.)

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See detailThree-dimensional crack initiation, propagation, branching and junction in non-linear materials by an extended meshfree method without asymptotic enrichment
Bordas, Stéphane UL; Rabczuk, Timon; Zi, Goangseup

in Engineering Fracture Mechanics (2008), 75(5), 943-960

This paper presents a three-dimensional, extrinsically enriched meshfree method for initiation, branching, growth and coalescence of an arbitrary number of cracks in non-linear solids including large ... [more ▼]

This paper presents a three-dimensional, extrinsically enriched meshfree method for initiation, branching, growth and coalescence of an arbitrary number of cracks in non-linear solids including large deformations, for statics and dynamics. The novelty of the methodology is that only an extrinsic discontinuous enrichment and no near-tip enrichment is required. Instead, a Lagrange multiplier field is added along the crack front to close the crack. This decreases the computational cost and removes difficulties involved with a branch enrichment. The results are compared to experimental data, and other simulations from the literature to show the robustness and accuracy of the method. [less ▲]

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See detailThree-Dimensional Crack Propagation with Global Enrichment XFEM and Vector Level Sets
Agathos, Konstantinos; Ventura, Giulio; Chatzi, Eleni et al

Scientific Conference (2015)

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See detailThree-dimensional DEM investigation of the fracture behaviour of thermally degraded rocks with consideration of material anisotropy
Shang, J.; Jayasinghe, Laddu Bhagya UL; Xiao, F. et al

in Theoretical and Applied Fracture Mechanics (2019), 104

A complete understanding of the fracture behaviour of anisotropic rocks under elevated temperatures is fundamentally important for rock and reservoir engineering applications. This paper shows a three ... [more ▼]

A complete understanding of the fracture behaviour of anisotropic rocks under elevated temperatures is fundamentally important for rock and reservoir engineering applications. This paper shows a three-dimensional numerical investigation of the fracture behaviour of anisotropic sandstone, with consideration of the effects of temperature and material anisotropy. In the study, a 3D semi-circular bend (SCB) model was established by using the Discrete Element Method (DEM). The thermal responses of different minerals and the strength anisotropy of incipient bedding planes were considered in the model. The DEM model was calibrated against a series of laboratory experiments on Midgley Grit sandstone (MGS) that exhibits intrinsic anisotropy. The pure mode I, mode II, and mixed-mode (I+II) fracture characteristics of the MGS were investigated under elevated temperatures (up to 600 �C) using the established DEM model. The thermal degradation (i.e., fracturing) of the rock, the fracture load, the evolution of micro-cracks, and the stress-strain relationship around notch tips were analysed, with emphasis on enlightening the micro-mechanisms underlying the fracture behaviour. The results of the study were discussed and then compared with experimental observations and theoretical predictions. � 2019 Elsevier Ltd [less ▲]

Detailed reference viewed: 50 (4 UL)