Psychophysiological responses to idiosyncratic stress in Bulimia Nervosa and Binge Eating Disorder.

in Physiology and Behavior (2011), 104

This study examined psychophysiological stress responses to idiosyncratically relevant stress in bulimia nervosa (BN) and binge eating disorder (BED), in relation to autonomic cardiac control and ... [more ▼]

This study examined psychophysiological stress responses to idiosyncratically relevant stress in bulimia nervosa (BN) and binge eating disorder (BED), in relation to autonomic cardiac control and nutritional status. A total of 81 women with BN, BED and healthy controls (HC) took part in an in sensu exposure to idiosyncratic stress. Psychological and peripheral physiological parameters were measured, and tonic heart rate variability, nutritional status, and types of stress were determined. In response to stress exposure, both eating disordered groups showed a stronger reactivity of sadness, and the BED group showed a stronger reactivity of insecurity than the HC group. Desire to binge was increased in the context of interpersonal stress. Stress exposure led to increased cardiovascular activity and reduced electrodermal activity that did not differ by group. The BN-specific symptomatology moderated the association between autonomic cardiac control and psychophysiological stress responses. The results suggest common and specific psychophysiological processes in symptom maintenance through life stress in BN and BED. [less ▲]

Psychophysiologische und behaviorale Korrelate unkontrollierten Essens bei gezügelten Essern

Scientific Conference (2012)

Psychosocial factors mediating the relationship between childhood emotional trauma and Internet gaming disorder: A pilot study

in European Journal of Psychotraumatology (2019), 10

gaming disorder (IGD) has been related to a wide range of detrimental psychological and health consequences. The purpose of the present pilot study was to test the direct and indirect relationships ... [more ▼]

gaming disorder (IGD) has been related to a wide range of detrimental psychological and health consequences. The purpose of the present pilot study was to test the direct and indirect relationships between IGD and emotional trauma, body image dissatisfaction, social anxiety, loneliness, depression, and self-esteem. A total of 242 online gamers completed a survey comprising a comprehensive battery of psychometric self-report scales concerning aforementioned variables. Results indicated that IGD was significantly correlated with all the variables except for body image dissatisfaction. Path analysis indicated an indirect relationship between childhood emotional trauma and IGD through depressive symptoms, while adjusting for gender, age, and number of hours gaming. The findings of the present study indicate that online gamers with a history of emotional abuse and/or neglect have higher levels of depressive symptoms, and that depressive symptoms are important risk factors of IGD. [less ▲]

Psychosomatic pathways to essential hypertension: the combined effect of anger and family history of cardiovascular disorders on cardiovascular reactivity

in Excerpta Medica International Congress Series1241 (2002)

Previous results from our laboratory suggest a combined effect of anger-suppression and family history of cardiovascular disorders in determining cardiovascular responses to mental stress. The present ... [more ▼]

Previous results from our laboratory suggest a combined effect of anger-suppression and family history of cardiovascular disorders in determining cardiovascular responses to mental stress. The present study was designed to determine the effect sizes in cardiovascular reactivity associated with biological risk, psychological risk and the combination of these risk factors using meta-analytical techniques. Results from three independent studies with almost identical experimental procedures provided the basis for the calculation of d, the difference between the means of two groups, divided by the pooled within-group standard deviation. Effect sizes were calculated for the comparison of high versus low biological hypertension risk, high versus low anger suppression, and high versus low combined risk. The results show the largest effect sizes for the comparison of high versus low combined risk. The effect sizes associated with the combination of risk factors were larger than the sum of the effect sizes associated with either factor alone. We conclude that the combination of biological and psychological risk factors in determining cardiovascular reactivity to mental stress is more than the sum of its parts. These findings are discussed in terms of a better understanding of the over-additive effects of multiple cardiovascular risk factors on cardiovascular morbidity and mortality. [less ▲]

Die Psychotechnik im Dienste der Berufsberatung - eine Erinnerung an die Verdienste von Nicolas Braunshausen

in Psychologische Rundschau: Ueberblick Uber die Fortschritte der Psychologie in Deutschland, Oesterreich, und der Schweiz (2021), 72(3), 220-221

Psychotropes et dépendance: profils de consommateurs et trajectoires de leur consommation

Book published by OFDT - Observatoire Français des Drogues et Toxicomanies (2001)

PTGL: a database for secondary structure-based protein topologies.

in Nucleic Acids Research (2010), 38(Database issue), 326-30

With growing amount of experimental data, the number of known protein structures also increases continuously. Classification of protein structures helps to understand relationships between protein ... [more ▼]

With growing amount of experimental data, the number of known protein structures also increases continuously. Classification of protein structures helps to understand relationships between protein structure and function. The main classification methods based on secondary structures are SCOP, CATH and TOPS, which all classify under different aspects, and therefore can lead to different results. We developed a mathematically unique representation of protein structure topologies at a higher abstraction level providing new aspects of classification and enabling for a fast search through the data. Protein Topology Graph Library (PTGL; http://ptgl.zib.de) aims at providing a database on protein secondary structure topologies, including search facilities, the visualization as intuitive topology diagrams as well as in the 3D structure, and additional information. Secondary structure-based protein topologies are represented uniquely as undirected labeled graphs in four different ways allowing for exploration under different aspects. The linear notations, and the 2D and 3D diagrams of each notation facilitate a deeper understanding of protein topologies. Several search functions for topologies and sub-topologies, BLAST search possibility, and links to SCOP, CATH and PDBsum support individual and large-scale investigation of protein structures. Currently, PTGL comprises topologies of 54,859 protein structures. Main structural patterns for common structural motifs like TIM-barrel or Jelly Roll are pre-implemented, and can easily be searched. [less ▲]

The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes

in BMC Medical Genetics (2011), 12(41),

BACKGROUND: The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be ... [more ▼]

BACKGROUND: The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type 1 diabetes. We investigated the association of the C1858T variant with residual beta-cell function (as assessed by stimulated C-peptide, proinsulin and insulin dose-adjusted HbA1c), glycemic control, daily insulin requirements, diabetic ketoacidosis (DKA) and diabetes-related autoantibodies (IA-2A, GADA, ICA, ZnT8Ab) in children during the first year after diagnosis of type 1 diabetes. METHODS: The C1858T variant was genotyped in an international cohort of children (n = 257 patients) with newly diagnosed type 1 diabetes during 12 months after onset. We investigated the association of this variant with liquid-meal stimulated beta-cell function (proinsulin and C-peptide) and antibody status 1, 6 and 12 months after onset. In addition HbA1c and daily insulin requirements were determined 1, 3, 6, 9 and 12 months after diagnosis. DKA was defined at disease onset. RESULTS: A repeated measurement model of all time points showed the stimulated proinsulin level is significantly higher (22%, p = 0.03) for the T allele carriers the first year after onset. We also found a significant positive association between proinsulin and IA levels (est.: 1.12, p = 0.002), which did not influence the association between PTPN22 and proinsulin (est.: 1.28, p = 0.03). CONCLUSIONS: The T allele of the C1858T variant is positively associated with proinsulin levels during the first 12 months in newly diagnosed type 1 diabetes children. [less ▲]

Pubblico ministero europeo e azione penale: stato dell’arte e prospettive di sviluppo

in Coppetta, M.G. (Ed.) Profili del processo penale nella Costituzione europea (2005)

Public Covid-19 Collections and the Second Wave: History and Challenges 26.11.2020

E-print/Working paper (2021)