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See detailTrust et Fiducie au Luxembourg
Prüm, André UL

in Trust et Fiducie au Luxembourg (2005)

L’internationalisation des rapports juridiques conduit de plus en plus à une imbrication des systèmes juridiques et à la nécessité de reconnaître des institutions juridiques venus d’ailleurs. L’une de ces ... [more ▼]

L’internationalisation des rapports juridiques conduit de plus en plus à une imbrication des systèmes juridiques et à la nécessité de reconnaître des institutions juridiques venus d’ailleurs. L’une de ces institutions, le trust, né dans le système de la common law, s’exporte de plus en plus dans les pays de tradition civiliste. Pour faciliter son acclimatation, la Convention de la Haye relative à la loi applicable au trust et à sa reconnaissance a été adoptée le 1er juillet 1985. Cette Convention entend à la fois permettre la reconnaissance de cette institution par des ordres juridiques qui ne la connaissent pas et fixer à l'égard des pays signataires la loi applicable au trust. A l’aube de sa ratification par la Suisse, des experts venus de différents pays se sont réunis à l’Institut suisse de droit comparé (Lausanne) le 18 mars 2005 pour partager les expériences nationales. Le présent ouvrage publie les rapports exposés à cette occasion. [less ▲]

Detailed reference viewed: 321 (7 UL)
See detailTrust et fiducie. La Convention de La Haye et la nouvelle législation luxembourgeoise
Prüm, André UL; Witz, Claude; Aynès, Laurent

Book published by Montchrestien (2005)

Le présent ouvrage reproduit les actes du colloque de Luxembourg du 11 décembre 2003 consacré au trust et à la nouvelle fiducie luxembourgeoise. D'éminents spécialistes du trust et de la Convention de La ... [more ▼]

Le présent ouvrage reproduit les actes du colloque de Luxembourg du 11 décembre 2003 consacré au trust et à la nouvelle fiducie luxembourgeoise. D'éminents spécialistes du trust et de la Convention de La Haye du 1er juillet 1985 éclairent utilement cette institution clé des pays de Common Law et les solutions de droit international posées par la Convention. La confrontation du trust avec les pays de droit civil est approfondie à la lumière de l'expérience du Grand-Duché qui a ratifié la Convention de La Haye tout en procédant à une réforme substantielle de la fiducie luxembourgeoise. Les auteurs de l'avant-projet de loi présentent en détail la loi du 27 juillet 2003 relative au trust et aux contrats fiduciaires dont l'étude est complétée par l'examen du traitement fiscal. L'ouvrage s'adresse à tous ceux qui s'intéressent au trust et à la fiducie notamment en France, en Belgique et en Suisse où l'on songe à ratifier la Convention de La Haye et à consacrer législativement la fiducie. [less ▲]

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See detailA trust framework for evaluating GNSS signal integrity
Chen, Xihui UL; Lenzini, Gabriele UL; Martins, Miguel et al

in Proceedings of 26th IEEE Computer Security Foundations Symposium (CSF'13) (2013)

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See detailTrust in Abstract Argumentation
Boella, Guido UL; van der Torre, Leon UL; Villata, Serena

in Proceedings of the 4th Mahasarakham International Workshop on Artificial Intelligence (MIWAI'10) (2010)

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See detailA trust-augmented voting scheme for collaborative privacy management
Sun, Yanjie UL; Zhang, Chenyi UL; Pang, Jun UL et al

in Journal of Computer Security (2012), 20(4), 437-459

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See detailA trust-augmented voting scheme for collaborative privacy management
Sun, Yanjie UL; Zhang, Chenyi UL; Pang, Jun UL et al

in Proc. 6th International Workshop on Security and Trust Management (2011)

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See detailTrustworthiness in IoT - A Standards Gap Analysis on Security, Data Protection and Privacy
Samir Labib, Nader UL; Brust, Matthias R. UL; Danoy, Grégoire UL et al

in Samir Labib, Nader; Brust, Matthias R.; Danoy, Grégoire (Eds.) et al Trustworthiness in IoT - A Standards Gap Analysis on Security, Data Protection and Privacy (2019, October)

With the emergence of new digital trends like Internet of Things (IoT), more industry actors and technical committees pursue research in utilising such technologies as they promise a better and optimised ... [more ▼]

With the emergence of new digital trends like Internet of Things (IoT), more industry actors and technical committees pursue research in utilising such technologies as they promise a better and optimised management, improved energy efficiency and a better quality living through a wide array of value-added services. However, as sensing, actuation, communication and control become increasingly more sophisticated, such promising data-driven systems generate, process, and exchange larger amounts of security-critical and privacy-sensitive data, which makes them attractive targets of attacks. In turn this affirms the importance of trustworthiness in IoT and emphasises the need of a solid technical and regulatory foundation. The goal of this paper is to first introduce the concept of trustworthiness in IoT, its main pillars namely, security, privacy and data protection, and then analyse the state-of-the-art in research and standardisation for each of these subareas. Throughout the paper, we develop and refer to Unmanned Aerial Vehicles (UAVs) as a promising value-added service example of mobile IoT devices. The paper then presents a thorough gap analysis and concludes with recommendations for future work. [less ▲]

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See detailTrustworthy agent-based recommender system in a mobile P2P environment
Sahli, N.; Lenzini, Gabriele UL; Eertink, H.

in Lecture Notes in Computer Science (2012), 6573 LNAI

Current major P2P systems focus on PCs and do not provide services for the mobile environment. Compared to traditional P2P, characteristics of Mobile P2P include unreliable connections, limited bandwidth ... [more ▼]

Current major P2P systems focus on PCs and do not provide services for the mobile environment. Compared to traditional P2P, characteristics of Mobile P2P include unreliable connections, limited bandwidth and constraints of mobile devices. In addition, nomadic users demand applications and services that are context-aware, personalised, secure, and trustworthy. Recommender systems are one of these applications. In this paper, we aim at building a mobile P2P recommender system which dramatically reduces wireless traffic between peers, brings trustworthiness (each peer can choose to rely on opinions of peers whom he trusts), and ffers unobtrusiveness (the target system is mainly autonomous and requires a minimum user intervention). Our solution is based on multi-agent systems and is illustrated on a slow-food restaurant recommender system. © 2012 Springer-Verlag. [less ▲]

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See detailTrustworthy exams without trusted parties
Bella, Giampaolo; Giustolisi, Rosario; Lenzini, Gabriele UL et al

in Computer and Security (2017), 67

Historically, exam security has mainly focused on threats ascribed to candidate cheating. Such threats have been normally mitigated by invigilation and anti-plagiarism methods. However, as recent exam ... [more ▼]

Historically, exam security has mainly focused on threats ascribed to candidate cheating. Such threats have been normally mitigated by invigilation and anti-plagiarism methods. However, as recent exam scandals confirm, also invigilators and authorities may pose security threats. The introduction of computers into the different phases of an exam, such as candidate registration, brings new security issues that should be addressed with the care normally devoted to security protocols. This paper proposes a protocol that meets a wide set of security requirements and resists threats that may originate from candidates as well as from exam administrators. By relying on a combination of oblivious transfer and visual cryptography schemes, the protocol does not need to rely on any trusted third party. We analyse the protocol formally in ProVerif and prove that it verifies all the stated security requirements. [less ▲]

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See detailTrying to square a circle: A theoretically embedded test for measuring complex problem solving
Greiff, Samuel UL; Funke, Joachim

Scientific Conference (2009, August)

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See detailTTCA: an R package for the identification of differentially expressed genes in time course microarray data
Albrecht, Marco UL; Stichel, Damian; Müller, Benedikt et al

in BMC Bioinformatics (2017), 18(1), 33

Background: The analysis of microarray time series promises a deeper insight into the dynamics of the cellular response following stimulation. A common observation in this type of data is that some genes ... [more ▼]

Background: The analysis of microarray time series promises a deeper insight into the dynamics of the cellular response following stimulation. A common observation in this type of data is that some genes respond with quick, transient dynamics, while other genes change their expression slowly over time. The existing methods for detecting significant expression dynamics often fail when the expression dynamics show a large heterogeneity. Moreover, these methods often cannot cope with irregular and sparse measurements. Results: The method proposed here is specifically designed for the analysis of perturbation responses. It combines different scores to capture fast and transient dynamics as well as slow expression changes, and performs well in the presence of low replicate numbers and irregular sampling times. The results are given in the form of tables including links to figures showing the expression dynamics of the respective transcript. These allow to quickly recognise the relevance of detection, to identify possible false positives and to discriminate early and late changes in gene expression. An extension of the method allows the analysis of the expression dynamics of functional groups of genes, providing a quick overview of the cellular response. The performance of this package was tested on microarray data derived from lung cancer cells stimulated with epidermal growth factor (EGF). Conclusion: Here we describe a new, efficient method for the analysis of sparse and heterogeneous time course data with high detection sensitivity and transparency. It is implemented as R package TTCA (transcript time course analysis) and can be installed from the Comprehensive R Archive Network, CRAN. The source code is provided with the Additional file 1. [less ▲]

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See detailTU DO@50 -- ein froher Wunsch für die Zukunft
Hesse, Markus UL

in Gruehn, Dietwald; Reicher, Christa; Wiechmann, Thorsten (Eds.) 50 Jahre Dortmunder Raumplanung (2019)

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See detailTumaco: Collaboration of Mobile Devices in Hypermedia-based In-Vehicle Infotainment Systems
Grevisse, Christian UL; Rothkugel, Steffen UL

in Libro de Actas del XXI Congreso Argentino de Ciencias de la Computación (CACIC 2015) (2015)

In-Vehicle Infotainment systems nowadays are largely limited to one-to-one relationships with the drivers' mobile phone. In this paper, we propose Tumaco, a SOA-based IVI system, which enables the ... [more ▼]

In-Vehicle Infotainment systems nowadays are largely limited to one-to-one relationships with the drivers' mobile phone. In this paper, we propose Tumaco, a SOA-based IVI system, which enables the seamless integration of all devices of all passengers. Collaborative services can be executed within a cross-platform ecosystem through the use of semantic hypermedia. In addition, passengers may customize their own user experience in order to reduce mental workload. Our prototypical implementation showed the benefits of opening the user experience to all passengers on a car. Finally, we present a framework that enables developers to provide their own services within our ecosystem. [less ▲]

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See detailTumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1
Reuter, Simone; Schnekenburger, Michael; Cristofanon, Silvia et al

in Biochemical Pharmacology (2009), 77(3), 397-411

Gamma-glutamyltransferase (GGT) cleaves the gamma-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when ... [more ▼]

Gamma-glutamyltransferase (GGT) cleaves the gamma-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when overexpressed. Moreover, GGT converts leukotriene (LT) C4 into LTD4 implicated in various inflammatory pathologies. So far the effect of inflammatory stimuli on regulation of GGT expression and activity remained to be addressed. We found that the proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) induced GGT promoter transactivation, mRNA and protein synthesis, as well as enzymatic activity. Remicade, a clinically used anti-TNFalpha antibody, small interfering RNA (siRNA) against p50 and p65 nuclear factor-kappaB (NF-kappaB) isoforms, curcumin, a well characterized natural NF-kappaB inhibitor, as well as a dominant negative inhibitor of kappaB alpha (IkappaBalpha), prevented GGT activation at various levels, illustrating the involvement of this signaling pathway in TNFalpha-induced stimulation. Over-expression of receptor of TNFalpha-1 (TNFR1), TNFR-associated factor-2 (TRAF2), TNFR-1 associated death domain (TRADD), dominant negative (DN) IkappaBalpha or NF-kappaB p65 further confirmed GGT promoter activation via NF-kappaB. Linker insertion mutagenesis of 536 bp of the proximal GGT promoter revealed NF-kappaB and Sp1 binding sites at -110 and -78 relative to the transcription start site, responsible for basal GGT transcription. Mutation of the NF-kappaB site located at -110 additionally inhibited TNFalpha-induced promoter induction. Chromatin immunoprecipitation (ChIP) assays confirmed mutagenesis results and further demonstrated that TNFalpha treatment induced in vivo binding of both NF-kappaB and Sp1, explaining increased GGT expression, and led to RNA polymerase II recruitment under inflammatory conditions. [less ▲]

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See detailTumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity
Ullmann, Pit UL; Nurmik, Martin UL; Schmitz, Martine UL et al

in Cancer Letters (2019), 450

Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including ... [more ▼]

Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma. Intratumoral hypoxia, i.e. reduced oxygen supply following uncontrolled proliferation of cancer cells, is thought to support TIC activity by inducing specific hypoxia-responsive mechanisms that are not yet entirely understood. Using previously established and fully characterized patient-derived TIC cultures, we could observe increased sphere and colony formation under hypoxic conditions. Mechanistically, microRNA (miRNA)-profiling experiments allowed us to identify miR-215 as one of the main hypoxia-induced miRNAs in primary colon TICs. Through stable overexpression of miR-215, followed by a set of functional in vitro and in vivo investigations, miR-215 was pinpointed as a negative feedback regulator, working against the TIC-promoting effects of hypoxia. Furthermore, we could single out LGR5, a bona fide marker of non-neoplastic intestinal stem cells, as a downstream target of hypoxia/miR-215 signaling. The strong tumor- and TIC-suppressor potential of miR-215 and the regulatory role of the hypoxia/miR-215/LGR5 axis may thus represent interesting points of attack for the development of innovative anti-CSC therapy approaches. [less ▲]

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See detailTumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.
Oceandy, Delvac; Pickard, Adam; Prehar, Sukhpal et al

in Circulation (2009), 120(7), 607-16

BACKGROUND: Ras signaling regulates a number of important processes in the heart, including cell growth and hypertrophy. Although it is known that defective Ras signaling is associated with Noonan ... [more ▼]

BACKGROUND: Ras signaling regulates a number of important processes in the heart, including cell growth and hypertrophy. Although it is known that defective Ras signaling is associated with Noonan, Costello, and other syndromes that are characterized by tumor formation and cardiac hypertrophy, little is known about factors that may control it. Here we investigate the role of Ras effector Ras-association domain family 1 isoform A (RASSF1A) in regulating myocardial hypertrophy. METHODS AND RESULTS: A significant downregulation of RASSF1A expression was observed in hypertrophic mouse hearts, as well as in failing human hearts. To further investigate the role of RASSF1A in cardiac (patho)physiology, we used RASSF1A knock-out (RASSF1A(-)(/)(-)) mice and neonatal rat cardiomyocytes with adenoviral overexpression of RASSF1A. Ablation of RASSF1A in mice significantly enhanced the hypertrophic response to transverse aortic constriction (64.2% increase in heart weight/body weight ratio in RASSF1A(-)(/)(-) mice compared with 32.4% in wild type). Consistent with the in vivo data, overexpression of RASSF1A in cardiomyocytes markedly reduced the cellular hypertrophic response to phenylephrine stimulation. Analysis of molecular signaling events in isolated cardiomyocytes indicated that RASSF1A inhibited extracellular regulated kinase 1/2 activation, likely by blocking the binding of Raf1 to active Ras. CONCLUSIONS: Our data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway. [less ▲]

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See detailTumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
Baig, Komal UL; Ullmann, Pit UL; Haan, Serge UL et al

in Molecular Cancer (2017)

Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self ... [more ▼]

Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. [less ▲]

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See detailTumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.
Theuring, F.; Gotz, W.; Balling, Rudi UL et al

in Oncogene (1990), 5(2), 225-32

Transgenic mice which expressed SV40 large T-antigen under the control of the MSV enhancer and the SV40 promoter were generated. In animals containing an intact MSV enhancer, total lens cataracts and ... [more ▼]

Transgenic mice which expressed SV40 large T-antigen under the control of the MSV enhancer and the SV40 promoter were generated. In animals containing an intact MSV enhancer, total lens cataracts and neuroectodermal brain tumors, originating in the pineal organ were observed. In contrast, 5' deletion of the MSV enhancer to a residual 53 bp resulted in a different spectrum of pathologies. Whilst lens cataracts still occurred, no brain tumors could be detected. Instead, fibrosarcomas and adenocarcinomas of the kidneys were induced. In addition, tumors of the endocrine pancreas were observed with both transgene constructs. We conclude that the MSV enhancer element is sufficient to direct the expression of the viral reporter gene to the lens and the pineal organ in transgenic mice. Deletion of the MSV enhancer correlates with the loss of DNA elements responsible for the pineal cell specific expression of SV40 large T-antigen. [less ▲]

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See detailThe tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-alpha signalling in cardiomyocytes.
Mohamed, Tamer M. A.; Zi, Min; Prehar, Sukhpal et al

in Cardiovascular research (2014), 103(1), 47-59

AIMS: Tumour necrosis factor-alpha (TNF-alpha) plays a key role in the regulation of cardiac contractility. Although cardiomyocytes are known to express the TNF-alpha receptors (TNFRs), the mechanism of ... [more ▼]

AIMS: Tumour necrosis factor-alpha (TNF-alpha) plays a key role in the regulation of cardiac contractility. Although cardiomyocytes are known to express the TNF-alpha receptors (TNFRs), the mechanism of TNF-alpha signal transmission is incompletely understood. The aim of this study was to investigate whether the tumour suppressor Ras-association domain family protein 1 isoform A (RASSF1A) modulates TNF-alpha signalling in cardiomyocytes. METHODS AND RESULTS: We used RASSF1A knockout (RASSF1A(-/-)) mice and wild-type (WT) littermates in this study. Acute stimulation with a low dose of TNF-alpha (10 microg/kg iv) increased cardiac contractility and intracellular calcium transients' amplitude in WT mice. In contrast, RASSF1A(-/-) mice showed a blunted contractile response. Mechanistically, RASSF1A was essential in the formation of the TNFR complex (TNFRC), where it functions as an adaptor molecule to facilitate the recruitment of TNFR type 1-associated death domain protein and TNFR-associated factor 2 to form the TNF-alpha receptor complex. In the absence of RASSF1A, signal transmission from the TNF-alpha receptor complex to the downstream effectors, such as cytoplasmic phospholipase A2 and protein kinase A, was attenuated leading to the reduction in the activation of calcium handling molecules, such as L-type Ca(2+) channel and ryanodine receptors. CONCLUSION: Our data indicate an essential role of RASSF1A in regulating TNF-alpha signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFRC and in signal transmission to the downstream targets. [less ▲]

Detailed reference viewed: 74 (1 UL)