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See detailTriple-A rating? Juncker's vision for the EU's social policy scorecard
Herzog, Mechthild UL

E-print/Working paper (2015)

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See detailTripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP’s Distribution on Microtubules
Koffa, Maria UL; Giannis, Athanassios; Kesisova, Iliana A. et al

in PLoS ONE (2013), 8(3),

Mitotic regulators exhibiting gain of function in tumor cells are considered useful cancer therapeutic targets for the development of small-molecule inhibitors. The human Aurora kinases are a family of ... [more ▼]

Mitotic regulators exhibiting gain of function in tumor cells are considered useful cancer therapeutic targets for the development of small-molecule inhibitors. The human Aurora kinases are a family of such targets. In this study, from a panel of 105 potential small-molecule inhibitors, two compounds Tripolin A and Tripolin B, inhibited Aurora A kinase activity in vitro. In human cells however, only Tripolin A acted as an Aurora A inhibitor. We combined in vitro, in vivo single cell and in silico studies to demonstrate the biological action of Tripolin A, a non-ATP competitive inhibitor. Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237. Interestingly, Tripolin A affected the gradient distribution towards the chromosomes, but not the MT binding of HURP (Hepatoma Up-Regulated Protein), a MT-associated protein (MAP) and substrate of the Aurora A kinase. Therefore Tripolin A reveals a new way of regulating mitotic MT stabilizers through Aurora A phosphorylation. Tripolin A is predicted to bind Aurora A similarly but not identical to MLN8054, therefore it could be used to dissect pathways orchestrated by Aurora kinases as well as a scaffold for further inhibitor development. © 2013 Kesisova et al. [less ▲]

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See detailTrivial Compiler Equivalence: A Large Scale Empirical Study of a Simple, Fast and Effective Equivalent Mutant Detection Technique
Papadakis, Mike UL; Yue, Jia; Harman, Mark et al

in 37th International Conference on Software Engineering (ICSE 2015) (2015)

Detailed reference viewed: 148 (5 UL)
See detailTrobant Foucault en l’aprenentatge permanent
Biesta, Gert UL

in Fejes, A.; Nicoll, K. (Eds.) Foucault i l’aprenentatge permanent: Governent el subjecte. (2010)

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See detailTrois avis sur le décret Magendie
Menetrey, Séverine UL

in Recueil Dalloz (2013)

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See detailTrois visions de l'avenir d'un droit international privé néolibéral
Kinsch, Patrick UL

in Liber amicorum Angelo Davì, vol. I (2019)

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See detailTroisième espace de cohomologie de l'algèbre de Lie des opérateurs différentiels sur une variété à coefficients dans les fonctions
Poncin, Norbert UL

in Bulletin de la Société Royale des Sciences de Liège (1998), 67(6), 339--393

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See detailTrojaner? Antike Mythen in neuen Medien
Amann, Wilhelm UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2011), 310

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See detailTrompe-l'oeil, simulacre et simulation: la rhétorique et l'hyperphoto
Colas-Blaise, Marion UL

in Migliore, T. (Ed.) Stratégies de l'image entre signification et communication (2011)

Detailed reference viewed: 112 (1 UL)
See detailTrop d'impôts pour les célibataires au Luxembourg? (Bref aperçu historique comparatif sur la fiscalité des célibataires dans le monde).
Danescu, Elena UL

Conference given outside the academic context (2019)

Le Grand-Duché de Luxembourg, né dans sa forme actuelle en 1839, est issu, indirectement, de la révolution belge. Parmi les impôts indirects perçus sous le régime hollandais après 1815 figurent:le droit ... [more ▼]

Le Grand-Duché de Luxembourg, né dans sa forme actuelle en 1839, est issu, indirectement, de la révolution belge. Parmi les impôts indirects perçus sous le régime hollandais après 1815 figurent:le droit de mouture sur les céréales, donc un impôt sur le pain, le droit d’abattage qui frappe les bouchers et éleveurs, l’impôt sur le vin qui touche les petits viticulteurs de la Moselle, les accises sur l’alcool qui pénalisent les distilleries industrielles du nord du pays et les milliers de petites distilleries familiales. En matière d’impôts directs, le jeune Grand-Duché hérite de la nouvelle philosophie de la fiscalité introduite par les Lumières et la Révolution française qui remplace l’impôt-tribut par l’impôt échange et introduit le principe d’égalité devant l’impôt et de proportionnalité, c.-à-d. d’impôt à taux unique (flat tax). L’histoire de la fiscalité est ensuite étroitement liée à l’histoire idéologique et politique de l’Etat-nation et de l’Etat social. La réforme fiscale actuelle mérite d'être analysée à la lumière de histoire. [less ▲]

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See detailThe "Trotter" Open-Air School, Milan (1922-1977): A City of Youth or Risky Business?
Thyssen, Geert UL

in Paedagogica Historica (2009), 45(1-2), 157-170

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See detailTroubles du comportement socio-émotionnel et impulsivité: une approche cognitive et neuropsychologique
Van der Linden, Martial; Rochat, Lucien; Billieux, Joël UL

in Azouvy, P.; Mazaux, J.-M.; Pradat-Diehl, P. (Eds.) Comportement et lésions cérébrales - actes des 19e entretiens de la fondation Garches (2006)

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See detailTRPV1 regulates excitatory innervation of OLM neurons in the hippocampus.
I. Hurtado-Zavala, Joaquin; Ramachandran, Binu; Ahmed, Saheeb et al

in Nature Communications (2017)

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See detailDas Truckwerk in der Frühen Neuzeit Zur Historiographie der Bildung Erwachsener mittels Medien
te Heesen, Kerstin UL

in Schäffer, Burkhard; Schemmann, Michael; Dörner, Olaf (Eds.) Erwachsenenbildung im Kontext. Theoretische Rahmungen, empirische Spielräume und praktische Regulative (2012)

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See detailTrue or False Contradictions between Life Time Contracts and Platform Work Contracts?
Ratti, Luca UL

Scientific Conference (2019, March)

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See detailTrue single-molecule DNA sequencing of a pleistocene horse bone.
Orlando, Ludovic; Ginolhac, Aurélien UL; Raghavan, Maanasa et al

in Genome research (2011), 21(10), 1705-19

Second-generation sequencing platforms have revolutionized the field of ancient DNA, opening access to complete genomes of past individuals and extinct species. However, these platforms are dependent on ... [more ▼]

Second-generation sequencing platforms have revolutionized the field of ancient DNA, opening access to complete genomes of past individuals and extinct species. However, these platforms are dependent on library construction and amplification steps that may result in sequences that do not reflect the original DNA template composition. This is particularly true for ancient DNA, where templates have undergone extensive damage post-mortem. Here, we report the results of the first "true single molecule sequencing" of ancient DNA. We generated 115.9 Mb and 76.9 Mb of DNA sequences from a permafrost-preserved Pleistocene horse bone using the Helicos HeliScope and Illumina GAIIx platforms, respectively. We find that the percentage of endogenous DNA sequences derived from the horse is higher among the Helicos data than Illumina data. This result indicates that the molecular biology tools used to generate sequencing libraries of ancient DNA molecules, as required for second-generation sequencing, introduce biases into the data that reduce the efficiency of the sequencing process and limit our ability to fully explore the molecular complexity of ancient DNA extracts. We demonstrate that simple modifications to the standard Helicos DNA template preparation protocol further increase the proportion of horse DNA for this sample by threefold. Comparison of Helicos-specific biases and sequence errors in modern DNA with those in ancient DNA also reveals extensive cytosine deamination damage at the 3' ends of ancient templates, indicating the presence of 3'-sequence overhangs. Our results suggest that paleogenomes could be sequenced in an unprecedented manner by combining current second- and third-generation sequencing approaches. [less ▲]

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See detailTruffle Pigs, Research Questions, and Histories of Education
Tröhler, Daniel UL

in Popkewitz, Thomas (Ed.) Rethinking the History of Education. Transnational perspectives on its questions, methods, and knowledge (2013)

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See detailTrügerisches Gedächtnis
Reuter, Robert UL

Article for general public (2014)

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See detailTrumpland
Scuto, Denis UL

Article for general public (2016)

Detailed reference viewed: 51 (8 UL)