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See detailThe theory question in research capacity building in education: Towards an agenda for research and practice.
Biesta, Gert UL; Allan, J.; Edwards, R. G.

in British Journal of Educational Studies (2011), 59(3), 225-239

Detailed reference viewed: 95 (1 UL)
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See detailTherapeutic strategies for Parkinson's disease based on data derived from genetic research.
Riess, Olaf; Berg, Daniela; Krüger, Rejko UL et al

in Journal of neurology (2003), 250 Suppl 1

Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile ... [more ▼]

Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models. [less ▲]

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See detailTherapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder, Saravanan S.; Alim, Ishraq; Khim, Soah J. et al

in Science translational medicine (2016), 8(328), 32829

Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and prevent neuronal death ... [more ▼]

Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but the mechanisms for this effect remain unclear. We show that the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) family of iron-dependent, oxygen-sensing enzymes are effectors of iron chelation. Molecular reduction of the three HIF-PHD enzyme isoforms in the mouse striatum improved functional recovery after ICH. A low-molecular-weight hydroxyquinoline inhibitor of the HIF-PHD enzymes, adaptaquin, reduced neuronal death and behavioral deficits after ICH in several rodent models without affecting total iron or zinc distribution in the brain. Unexpectedly, protection from oxidative death in vitro or from ICH in vivo by adaptaquin was associated with suppression of activity of the prodeath factor ATF4 rather than activation of an HIF-dependent prosurvival pathway. Together, these findings demonstrate that brain-specific inactivation of the HIF-PHD metalloenzymes with the blood-brain barrier-permeable inhibitor adaptaquin can improve functional outcomes after ICH in several rodent models. [less ▲]

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See detailTherapeutische Interventionen bei dissozialem und aggressivem Verhalten
Schmidt, Alexander F. UL

in Zeitschrift für Verkehrssicherheit (2012), 58

Aggressive und dissoziale Erlebens‐ und Verhaltensweisen sind weit verbreitete Phänomene, deren Heterogenität sich nicht nur in der Vielzahl unterschiedlicher Tatbestände im Strafgesetzbuch niederschlägt ... [more ▼]

Aggressive und dissoziale Erlebens‐ und Verhaltensweisen sind weit verbreitete Phänomene, deren Heterogenität sich nicht nur in der Vielzahl unterschiedlicher Tatbestände im Strafgesetzbuch niederschlägt, sondern auch in den Symptomen verschiedener psychischer Störungen in den standardisierten Diagnosemanualen ihre Entsprechung findet. Aggressives und dissoziales Verhalten stellt das Resultat zugrundeliegender Beeinträchtigungen a) der Impulskontrolle, b) der Emotionsregulation, sowie ausgeprägter c) narzisstisch‐egozentrischer, d) histrionischer, d) süchtiger und e) krimineller Erlebens‐ und Verhaltensweisen dar. Diese lassen sich zum Ausgangspunkt transdiagnostischer therapeutischer Ansätze machen, die mittels spezifischer Interventionen die jeweiligen Problembereiche in sozial erwünschter Weise zu beeinflussen versuchen. Im Folgenden werden in Ergänzung zur Vielzahl störungsspezifischer Behandlungsmethoden therapeutische Ansätze zur Verbesserung der Emotionsregulation, der Selbstkontrolle, des Ärgermanagements und zur Straftäterbehandlung sowie deren empirische Bewährung vorgestellt. [less ▲]

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See detailTherapist-Guided Tablet-Based Telerehabilitation for Patients With Aphasia: Proof-of-Concept and Usability Study.
Gerber, Stephan Moreno; Schutz, Narayan; Uslu, Arif Sinan UL et al

in JMIR rehabilitation and assistive technologies (2019), 6(1), 13163

BACKGROUND: Aphasia is the loss or impairment of language functions and affects everyday social life. The disorder leads to the inability to understand and be understood in both written and verbal ... [more ▼]

BACKGROUND: Aphasia is the loss or impairment of language functions and affects everyday social life. The disorder leads to the inability to understand and be understood in both written and verbal communication and affects the linguistic modalities of auditory comprehension, verbal expression, reading, and writing. Due to heterogeneity of the impairment, therapy must be adapted individually and dynamically to patient needs. An important factor for successful aphasia therapy is dose and intensity of therapy. Tablet computer-based apps are a promising treatment method that allows patients to train independently at home, is well accepted, and is known to be beneficial for patients. In addition, it has been shown to ease the burden of therapists. OBJECTIVE: The aim of this project was to develop an adaptive multimodal system that enables aphasic patients to train at home using language-related tasks autonomously, allows therapists to remotely assign individualized tasks in an easy and time-efficient manner, and tracks the patient's progress as well as creation of new individual exercises. METHODS: The system consists of two main parts: (1) the patient's interface, which allows the patient to exercise, and (2) the therapist's interface, which allows the therapist to assign new exercises to the patient and supervise the patient's progress. The pool of exercises is based on a hierarchical language structure. Using questionnaires, therapists and patients evaluated the system in terms of usability (ie, System Usability Scale) and motivation (ie, adapted Intrinsic Motivation Inventory). RESULTS: A total of 11 speech and language therapists (age: mean 28, SD 7 years) and 15 patients (age: mean 53, SD 10 years) diagnosed with aphasia participated in this study. Patients rated the Bern Aphasia App in terms of usability (scale 0-100) as excellent (score >70; Z=-1.90; P=.03) and therapists rated the app as good (score >85; Z=-1.75; P=.04). Furthermore, patients enjoyed (scale 0-6) solving the exercises (score>3; mean 3.5, SD 0.40; Z=-1.66; P=.049). CONCLUSIONS: Based on the questionnaire scores, the system is well accepted and simple to use for patients and therapists. Furthermore, the new tablet computer-based app and the hierarchical language exercise structure allow patients with different types of aphasia to train with different doses and intensities independently at home. Thus, the novel system has potential for treatment of patients with aphasia as a supplement to face-to-face therapy. [less ▲]

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See detailThere Is No Best Beta-Normalization Strategy for Higher-Order Reasoners
Steen, Alexander UL; Benzmüller, Christoph UL

in Davis, Martin; Fehnker, Ansgar; McIver, Annabelle (Eds.) et al Logic for Programming, Artificial Intelligence, and Reasoning (LPAR) (2015, November)

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See detailThere is no one human scale - Reflections on urban development practice in Luxembourg
Carr, Constance UL; Lutz, Rebecca; Schutz, Kevin

Report (2018)

Detailed reference viewed: 55 (8 UL)
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See detailThere Is No Such Thing as a Monolingual Text! New Tools for Literary Scholarship
Dembeck, Till UL

in Polyphonie: Mehrsprachigkeit_Kreativität_Schreiben (2017), 1

Der Beitrag nimmt ein Argument auf, das in jüngster Vergangenheit sowohl in der Literaturwissenschaft als auch in der Soziolinguistik hervorgebracht wurde: dass nämlich – entgegen der unausgesprochenen ... [more ▼]

Der Beitrag nimmt ein Argument auf, das in jüngster Vergangenheit sowohl in der Literaturwissenschaft als auch in der Soziolinguistik hervorgebracht wurde: dass nämlich – entgegen der unausgesprochenen Überzeugung der modernen Philologien – Einsprachigkeit für (literarische) Texte keinesfalls die Norm ist, sondern dass (literarische) Texte in der Regel, wenn auch in unterschiedlichem Maße und in unterschiedlicher Form, von sprachlicher Vielfalt geprägt sind. Der Aufsatz schlägt das Konzept einer Mehrsprachigkeitsphilologie als einer Methode vor, das Wechselspiel zwischen diesen unterschiedlichen Formen der Mehrsprachigkeit in literarischen Texten zu rekonstruieren und zu interpretieren. Die Methode der Mehrsprachigkeitsphilologie basiert auf einem analytischen Instrumentarium, das es ermöglicht, manifeste wie latente Formen sprachlicher Vielfalt in (literarischen) Texten sichtbar zu machen. Dieses Instrumentarium erlaubt es außerdem, die kulturpolitischen Strategien zu untersuchen, die der literarischen Verwendung von Sprachdifferenzen zugrunde liegen. Der Beitrag zeigt den Nutzen dieses Instrumentariums in kurzen Analysen von Texten aus unterschiedlichen Epochen und literarischen Traditionen. [less ▲]

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See detail“There Was No Green Tick”: Discovering the Functions of a Widget in a Joint Problem-Solving Activity and the Consequences for the Participants’ Discovering Process
Sunnen, Patrick UL; Arend, Béatrice UL; Maquil, Valérie

in Multimodal Technologies and Interaction (2018), 2(4), 1-23

In recent years, tangible user interfaces (TUI) have gained in popularity in educational contexts, among others to implement problem-solving and discovery learning science activities. In the context of an ... [more ▼]

In recent years, tangible user interfaces (TUI) have gained in popularity in educational contexts, among others to implement problem-solving and discovery learning science activities. In the context of an interdisciplinary and cross-institutional collaboration, we conducted a multimodal EMCA-based video user study involving a TUI-mediated bicycle mechanics simulation. This article focusses on the discovering work of a group of three students with regard to a particular tangible object (a red button), designed to support participants engagement with the underlying physics aspects and its consequences with regard to their engagement with the targeted mechanics aspects. [less ▲]

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See detailThermal and chemical glass transition of thermosets in the presence of two types of inorganic nanoparticles
Baller, Jörg UL; Thomassey, Matthieu UL; Ziehmer, Markus UL et al

in Thermoplastic and thermosetting polymers and composites (2011)

Detailed reference viewed: 34 (2 UL)
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See detailThermal and electrical aging of laser braze-welded aluminum–copper interconnects
Solchenbach, Tobias UL; Plapper, Peter UL; Greger, Manfred UL et al

in Translational Materials Research (2014), 1(1), 015001

Aluminum–copper (Al–Cu) interconnects are of great interest for a variety of electrical applications, such as lithium-ion batteries. In this paper, the effects of thermal and electrical aging on the ... [more ▼]

Aluminum–copper (Al–Cu) interconnects are of great interest for a variety of electrical applications, such as lithium-ion batteries. In this paper, the effects of thermal and electrical aging on the intermetallic compound growth of laser braze-welded Al–Cu interconnects are reported. Thermal aging was studied in a temperature range from 200 to 500 °C for durations between 1 and 120 h. Electrical aging was studied with 200 A direct current application with different polarities and durations between 1 and 24 h. The formation of intermetallic compounds was found to be dependent on the type of aging and, for electrical aging, on the polarity of the current. The growth of intermetallic compounds under the influence of the electric current was distinctly higher than for thermal annealing conditions. The formation of voids at the transition between intermetallic compounds indicates that electromigration may be the main driving force for the accelerated intermetallic growth. [less ▲]

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See detailThermal and electronic fluctuations of flexible adsorbed molecules: Azobenzene on Ag(111)
Maurer, Reinhard J.; Liu, Wei; Poltavskyi, Igor UL et al

in Physical Review Letters (2016), 116

Detailed reference viewed: 175 (4 UL)
See detailThermal and mechanical properties of styrene butadiene rubber/alumina nanocomposites
Sushko, Rymma UL; Baller, Jörg UL; Sanctuary, Roland UL

Poster (2013, March)

SBR is a rubber material with high technical relevance. In order to enhance the mechanical properties of the rubber one method consists e. g. in dispersing inorganic nanoparticles in the polymer matrix ... [more ▼]

SBR is a rubber material with high technical relevance. In order to enhance the mechanical properties of the rubber one method consists e. g. in dispersing inorganic nanoparticles in the polymer matrix. By doing so, the properties of a given composite can be tuned either by changing the nanoparticle concentration or by modifying the surface properties of the fillers. Both interventions have indeed the potential to take influence on the structure and properties of the interphases emerging between the fillers and the polymer matrix. In this contribution we report on the glass transition behavior of SBR/alumina nanocomposites when the concentration and surface properties of the Al2O3 nanoparticles are changed. We also discuss the influence of the fillers on the shear stiffness of the rubber material. The samples were investigated by temperature modulated differential scanning calorimetry (TMDSC) and dynamic mechanical analysis (DMA). TMDSC investigations shed light on a surprising behavior of the glass transition temperature when the nanoparticle concentration is changed: at low filler contents the quasi-static glass transition temperature Tg passes through a minimum. While further increasing the nanoparticle content Tg increases to finally saturate at high concentrations. One of the main DMA results is that increasing of the Al2O3 concentration induces a quasi-solid-like frequency-independent response of the nanocomposites in the low frequency regime. [less ▲]

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See detailThermal comfort of a new university building in Luxembourg with passive cooling
Thewes, Andreas UL; Maas, Stefan UL; Scholzen, Frank UL et al

in Thermal comfort of a new university building in Luxembourg with passive cooling (2010)

The new Luxembourgish university buildings should comply with a low energy standard, which was defined for typical offices and smaller lecture rooms by a thermal end-energy lower than 14 kWh/m3a and an ... [more ▼]

The new Luxembourgish university buildings should comply with a low energy standard, which was defined for typical offices and smaller lecture rooms by a thermal end-energy lower than 14 kWh/m3a and an electricity use for HVAC and lighting of max. 6 kWh/m3a. Consequently it was necessary to find ways to avoid the need for mechanical ventilation and air-conditioning. The heat consumption was minimized by an air-tight and well insulated building envelope. A difficulty was posed by special outside façade elements which were set-up as a grid over the complete outer surface as an architectural element. To prevent the risk of overheating during summer, it is necessary to reduce the solar gains by optimizing the window sizes and the glazing types, as well as through the installation of movable indoor shading elements. Nevertheless enough daylight should enter the rooms to limit the consumption of electricity for artificial lighting. Hence detailed dynamic simulations were performed using TRNSYS and TRNFLOW to ensure thermal comfort without active cooling. The effective electricity consumption of a newly installed state-of-the-art lighting system, including presence detectors and daylight controllers for dimming, was measured in a test installation to determine the internal loads by lighting. Radiation and illuminance measurements were performed on sample elements of the façade grid. The results were used to verify the daylight simulations and to analyze the benefits of daylight controllers. Several iterative steps were taken to gradually improve the building by introducing different modifications, e.g. reduction of the window sizes, installation of a lighting control system, improving the night ventilation and effective use of the thermal inertia of the building. [less ▲]

Detailed reference viewed: 146 (18 UL)
See detailThermal Conversion of Solid Fuels
Peters, Bernhard UL

Book published by WIT Press (2003)

Detailed reference viewed: 383 (16 UL)
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See detailThermal Glass Transition Beyond the Vogel-Fulcher-Tammann Behavior for Glass Forming Diglycidylether of Bisphenol A
Krüger, Jan-Kristian UL; Britz, Th; Baller, Jörg UL et al

in Physical Review Letters (2002), 89

For the low molecular weight fragile liquid diglycidyl ether of bisphenol A we report, based on Brillouin and dielectric spectroscopy, on a thermal glass transition where the relaxation time of the α ... [more ▼]

For the low molecular weight fragile liquid diglycidyl ether of bisphenol A we report, based on Brillouin and dielectric spectroscopy, on a thermal glass transition where the relaxation time of the α process does not go to infinity. Instead, the structural α relaxation disappears spontaneously at the transition point. That discontinuity in relaxation time coincides with a kink in the longitudinal hypersonic velocity and determines unambiguously the transition from the liquid to the glassy state. [less ▲]

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See detailThermal Model of a Solar Hybrid Module as the Heat Source for a CO2 Heat Pump
Rullof, Johannes UL; Lambers, Klaus Jürgen; Blieske, Ulf et al

in Proceedings of 2017 International Energy and Sustainability Conference (IESC 2016) (2017)

In recent years, the possibility of combining photovoltaics (PV) and solar thermal collectors into one solar hybrid module (PVT-module) has been increasingly investigated. PVT-modules produce thermal and ... [more ▼]

In recent years, the possibility of combining photovoltaics (PV) and solar thermal collectors into one solar hybrid module (PVT-module) has been increasingly investigated. PVT-modules produce thermal and electrical energy at the same time. Since the efficiency of a photovoltaic module decreases with increasing temperature, the temperature of the heat transfer media is often limited to about 30 °C and the PVT-module is combined with a heat pump, which increases the temperature on the “warm side”. A common approach is to integrate the PVT-module directly as an evaporator in a heat pump system (PVT-direct). This paper presents a thermal model of a PVT-direct module as the heat source for a R744/CO2 heat pump. Due to the combined effect of flow channel patterns, solar radia-tion, the ambient conditions and possible condensation and frost formation, heat transfer and thermal distribution conditions of the PVT-direct evaporator are inevitably com-plicated to determine. The proposed thermal model of this hybrid solar module that has CO2 direct evaporation in microchannels will be used to simulate the behavior of the module under different climatic operating conditions. Fur-thermore, it will quantify all energy inputs and/or losses as well as their influence on the total energy supplied by the PVT-module. This will be used to investigate the overall CO2-PVT heat pump system performance in prospective simulations. [less ▲]

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See detailThermal sensitivity during rest and exercise: a sex comparison
Gerrett, Nicola; Ouzzahra, Yacine UL; Coleby, Samantha et al

in European Journal of Applied Physiology (2014)

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See detailThermal sensitivity to warmth during rest and exercise: a sex comparison
Gerrett, Nicola; Ouzzahra, Yacine UL; Coleby, S et al

in European Journal of Applied Physiology (2014)

Detailed reference viewed: 85 (0 UL)