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See detailSustainable Spatial Development in Luxembourg: Conflicting trajectories of Housing and Mobility
Becker, Tom UL; Carr, Constance UL

Presentation (2010, September)

At the “heart of Europe” lies an often overlooked and little nation: Luxembourg. As founding member of several European and international institutions (EU, OECD, NATO, UN), host to several institutions of ... [more ▼]

At the “heart of Europe” lies an often overlooked and little nation: Luxembourg. As founding member of several European and international institutions (EU, OECD, NATO, UN), host to several institutions of the European Union (Parliament Secretariat, Court of Justice, the European Investment Bank), and ranked 16th among global financial centers (City of London 2010), it is by no means insignificant. Luxembourg’s smallness is in many ways enigmatic. Yet at the same time, it offers scholars of urban studies a unique laboratory in which to study global processes operating within a small frame. This paper presents the recently started research project entitled Sustainable Development in Luxembourg, which has been funded by the Fonds National de la Recherche. The project aims at assessing the current efforts and national and local policy instruments in with regards to their contribution to sustainability goals in spatial development. Unlike its neighbouring nations, Luxembourg seems only just entering a post-flexible era (if at all). The financial ruptures since 2008 have had relatively little impact, and as such, Luxembourg continues to grapple with spatial structural changes associated with its post-industrial and prospering tertiary economy. Its comparably young sustainable development policy is primarily challenged by recent demographic changes, and its geographical specificity. Of its 503 000 residents, roughly 200 000 are landed immigrants. On each working day, the nation’s population increases circa 50% as workers from Lorraine, Wallonia, Saarland, and Rhineland-Palatinate enter the country and commute to work. Each day, the City of Luxembourg’s population doubles in size – and its nodal position in an ever growing Grand Region at the crossroads that lead to Cologne, Paris, and Brussels, is continually strengthening in importance. Concurrent pressures on the real estate market and low rental vacancy rates pose a real barrier to settlement within or near the capital city. Rising of real estate prices, and rapid land-use changes have led to fast growth of outlying municipalities inside and outside of its national borders. There are thus strong impacts at the local level in terms of urban development, with high pressure on the provision of housing and transportation infrastructure, and result in conflicting trajectories in terms of sustainable land-use objectives and the preservation of green spaces within the country. The fields of housing policy and mobility are thus promising case studies towards a more thorough analysis of the significance, policy relevance, barriers, and shortcomings of sustainable spatial development strategies. This research aims at critically examining the discourse of sustainable development, in the context of Luxembourg’s urban and regional transformations and corresponding governance structures. And while sustainable development and sustainability remain highly contested concepts just as they are more ubiquitous than ever as urban planning tools (e.g. Krueger and Gibbs 2007; Newig et. al 2007), the case of an Luxembourg poses questions concerning management within and across borders and thus possible stories of insiders and outsiders, winners and losers. References Becker, T. and Hesse. 2010. “Internationalisierung und Steuer metropolitaner Wohnungsmärkte – Das Beispiel Luxemburg” Information zur Raumentwicklung.“ 5: 403-415. City of London (2010) “Global Financial Centres 7.“ City of London. Krueger R. & D. Gibbs. 2007. (ed.), “The Sustainable Development Paradox: Urban Political Economy in the United States and Europe.” New York: The Guilford Press. Newig, J., Voß, J.-P. & J. Monstadt. 2007. “Governance for Sustainable Development in the Face of Ambivalence, Uncertainty and Distributed Power: an Introduction.” Journal of Environmental Policy & Planning 9 (3-4), 185-192 [less ▲]

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See detailSustainable Spatial Development: Discourse Yes, Implementation Maybe
Carr, Constance UL

Presentation (2012, June)

This paper presents progress achieved within the context of SUSTAINLUX (a research project funded by the Fonds National de la Recherche Luxembourg) and collaborative studies with the Worcester Polytechnic ... [more ▼]

This paper presents progress achieved within the context of SUSTAINLUX (a research project funded by the Fonds National de la Recherche Luxembourg) and collaborative studies with the Worcester Polytechnic Institute.The research has aimed at critically examining the approach of sustainable development, in the context of Luxembourg’s urban and regional governance structures (Carr, Hesse, and Schulz 2010), that have transformed and rescaled (Brenner 1999) against tertiarization of the economy, and Europeanization of the political arena (Schulz 2009; Becker forthcoming) – processes that have had significant impact on the affordability of housing and infrastructure for mobility. To date, the research methods have included mapping the literature and actors relevant to the sustainable integrated development discourse in Luxembourg, performing interviews with practitioners in the field and exploring the role and limitations of this normative discourse in Luxembourg’s social spatial transformation (Carr 2011). Particular attention was paid to structures of decision-making and its relationship to the prevailing real estate market. In addition, comparative research was performed in collaboration with Prof. Krueger. This presentation will talk about the results and conceptualize them within the framework of policy mobility, as has been discussed in recent literature such as Ward (2006), Temenos and McCann (forthcoming), and González (2010). In this way, clear barriers to implementation to sustainable development goals can be identified. References Becker, Tom. forthcoming. “Europäisierung der Städtepolitik ? Das Beispiel ‚CIPU’ in Luxemburg.” Europa Regional. Brenner, Neil. 1999. “Global as Reterritorialisation: The Re-Scaling of Urban Governance in the European Union.” Urban Studies 36(3):431-451. Carr, Constance. 2011. “Luxembourg Sustainable Spatial Development Policy: General Milestones and Circuits.” Laboratoire de Géographie et Aménagement du Territoire. Carr, Constance, Markus Hesse, and Christian Schulz. 2010. “Sustainable Spatial Development in Luxembourg (SUSTAINLUX).” Laboratoire de Géographie et Aménagement du Territoire. Retrieved (http://wwwen.uni.lu/research/flshase/laboratoire_de_geographie_et_amenagement_du_territoire/research/ongoing_projects). González, Sara. 2010. “Bilbao and Barcelona ‘in Motion’. How Urban Regeneration ‘Models’ Travel and Mutate in the Global Flows of Policy Tourism.” Urban Studies 1-22. Schulz, Christian. 2009. “Luxemburgs Wirtschaft.” Pp. 116-117 in Der Luxemburg Atlas du Luxembourg, edited by Patrick Bousch et al. Calbe: Hermann-Josef Emons Verlag. Temenos, Christina, and Eugene McCann. forthcoming. “The local politics of policy mobility: Learning, persuasion, and the production of a municipal sustainability fix.” Environment and Planning A. Ward, Kevin. 2006. “‘Policies in Motion’, Urban Management and State Restructuring: The Trans-Local Expansion of Business Improvement Districts.” International Journal of Urban and Regional Research 30(1):54-75. [less ▲]

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See detailSustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Isomoto, Hajime; Mott, Justin L.; Kobayashi, Shogo et al

in Gastroenterology (2007), 132(1), 384-96

BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in ... [more ▼]

BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. Because suppressor of cytokine signaling 3 (SOCS) controls the IL-6/STAT-3 signaling pathway by a classic feedback loop, the aims of this study were to examine SOCS-3 regulation in human cholangiocarcinoma. METHODS: SOCS-3 expression was assessed in human cholangiocarcinoma tissue and the Mz-ChA-1 and CCLP1 human cholangiocarcinoma cell lines. RESULTS: An inverse correlation was observed between phospho-STAT-3 and SOCS-3 protein expression in cholangiocarcinoma. In those cancers failing to express SOCS-3, extensive methylation of the SOCS-3 promoter was demonstrated in tumor but not in paired nontumor tissue. Likewise, methylation of the socs-3 promoter was also identified in 2 cholangiocarcinoma cell lines. Treatment with a demethylating agent, 5-aza-2'-deoxycytidine (DAC), restored IL-6 induction of SOCS-3, terminated the phospho-STAT-3 response, and reduced cellular levels of Mcl-1. Enforced expression of SOCS-3 also reduced IL-6 induction of phospho-STAT-3 and Mcl-1. Either DAC treatment or enforced SOCS-3 expression sensitized the cells to TRAIL-mediated apoptosis. CONCLUSIONS: SOCS-3 epigenetic silencing is responsible for sustained IL-6/STAT-3 signaling and enhanced Mcl-1 expression in cholangiocarcinoma. [less ▲]

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See detailSustained improvement of obsessive-compulsive disorder by deep brain stimulation in a woman with residual schizophrenia.
Plewnia, Christian; Schober, Franziska; Rilk, Albrecht et al

in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) (2008), 11(8), 1181-3

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See detailSUSY-structures, representations, and the Peter-Weyl theorem for S^1|1
Kwok, Stephen UL; Carmeli, C.; Fioresi, R.

in Journal of Geometry & Physics (2015)

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See detail« La svolta virale nella filosofia contemporanea”
Roelens, Nathalie UL

Presentation (2016)

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See detailSwarm-based Evaluation of Nonparametric SysML Mechatronics System Design
Chami, Mohammad; Bou Ammar, Haitham; Voos, Holger UL et al

in IEEE International Conference on Mechatronics ICM 2013, Vicenza, Italy, Feb. 2013 (2013, February)

The design of a mechatronics system is considered one of the hardest challenges in industry. This is mainly due to the multidisciplinary nature of the design process that requires the knowledge ... [more ▼]

The design of a mechatronics system is considered one of the hardest challenges in industry. This is mainly due to the multidisciplinary nature of the design process that requires the knowledge integration of the participating disciplines. Previously, we have proposed SysDICE a framework that is capable of: (1) modeling the multidisciplinary information of mechatronics systems using SysML and (2) adopting a nonparametric technique for evaluating such a SysML model. In SysDICE the optimization that led to the determination of the best alternative combinations for satisfying the requirements was time-costly and discarded prohibited combinations. This paper contributes by: (1) proposing an effective method for restricting the set of possible alternative combinations and (2) employing a swarm intelligence based optimization scheme which significantly reduces the computational cost of SysDICE. [less ▲]

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See detailSweet SIXTEEN: Automation via Embedding into Classical Higher-Order Logic
Steen, Alexander UL; Benzmüller, Christoph UL

in Logic and Logical Philosophy (2016), 25(4), 535-554

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See detailSWEET--where are we heading with international type 1 diabetes registries?
Danne, T.; Aschemeier, B.; Perfetti, R. et al

in Pediatric Diabetes (2012), 13(16), 1-4

The authors discuss a project "Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference" (SWEET) led by the International Society for Pediatric and Adolescent Diabetes ... [more ▼]

The authors discuss a project "Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference" (SWEET) led by the International Society for Pediatric and Adolescent Diabetes (ISPAD). The project includes pediatric centres from countries such as Czech, Germany and Greece. They also discuss the European DIAMAP project which addresses clinical research issues for people with diabetes. They believe these initiatives will enable evaluation of invaluable data sets. [less ▲]

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See detailSWEMSA 2019: Finding Small Molecules in Big Data
Schymanski, Emma UL

Presentation (2019)

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See detailSwimming of bacterium Bacillus subtilis with multiple bundles of flagella
Najafi, Javad; Altegoer, Florian; Bange, Gert et al

in SOFT MATTER (2019), 15(48), 10029-10034

We characterize the bundle properties for three different strains of B. subtilis bacteria with various numbers of flagella. Our study reveals that, surprisingly, the number of bundles is independent of ... [more ▼]

We characterize the bundle properties for three different strains of B. subtilis bacteria with various numbers of flagella. Our study reveals that, surprisingly, the number of bundles is independent of the number of flagella, and the formation of three bundles is always the most frequent case. We assume that this relates to the fact that different mutants have the same body length. There is no significant difference between the bundle width and length for distinct strains, but the projected angle between the bundles increases with the flagellar number. Furthermore, we find that the swimming speed is anti-correlated with the projected angle between the bundles, and the wobbling angle between the swimming direction and cell body increases with the number of flagella. Our findings highlight the impact of geometrical properties of bacteria such as body length and bundle configuration on their motility. [less ▲]

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See detailSWIPE: Monitoring Human Dynamics using Smart Devices
Faye, Sébastien UL; Frank, Raphaël UL; Engel, Thomas UL

in Proceedings of the 7th International Conference on Mobile Computing, Applications and Services (MobiCASE '15) (2015, November)

SWIPE is a platform for sensing, recording and processing human dynamics using smart devices. The idea behind this type of system, which exists for the most part on smartphones, is to consider new metrics ... [more ▼]

SWIPE is a platform for sensing, recording and processing human dynamics using smart devices. The idea behind this type of system, which exists for the most part on smartphones, is to consider new metrics from wearables - in our case smartwatches. These new devices, used in parallel with traditional smartphones, provide clear indicators of the activities and movements performed by the users who wear them. They can also sense environmental data and interactions. The SWIPE architecture is structured around two main elements, namely (1) an Android application deployed directly on the devices, allowing them to synchronize and collect data; and (2) a server for storing and processing the data. This publication is intended to communicate on the platform with both the scientific and the industry communities. SWIPE is freely distributed under a MIT license. [less ▲]

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See detailThe Swiss Apprenticeship System. Its Institutional Specificities and Strengths in International Perspective
Graf, Lukas UL

in AICGS Transatlantic Perspectives (2014)

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See detailSwiss psychiatrists' beliefs and attitudes about internet addiction.
Thorens, Gabriel; Khazaal, Yasser; Billieux, Joël UL et al

in The Psychiatric quarterly (2009), 80(2), 117-23

AIMS: To investigate the beliefs and attitudes of Swiss general psychiatrists toward Internet addiction. METHODS: Ninety-fourth Swiss psychiatrists filled out a questionnaire at a conference of general ... [more ▼]

AIMS: To investigate the beliefs and attitudes of Swiss general psychiatrists toward Internet addiction. METHODS: Ninety-fourth Swiss psychiatrists filled out a questionnaire at a conference of general psychiatry assessing their views on the concept of Internet addiction, their evaluation methods and treatment procedures they use. RESULTS: A cluster analysis revealed three groups: DISBELIEVERS (N = 20) rejected the concept of Internet addiction and its importance, not considering it a real clinical problem and consequently not considering the existence of a specific treatment. The NOSOLOGY BELIEVERS (N = 66) and NOSOLOGY/TREATMENT BELIEVERS (N = 8) assumed that Internet addiction is a real problem. While NOSOLOGY/TREATMENT BELIEVERS asserted the availability of effective treatment (mainly psychological), NOSOLOGY BELIEVERS were less affirmative regarding treatment. CONCLUSION: Thought the concept of Internet addiction is largely acknowledged as a clinical reality by Swiss psychiatrists, routine screening and treatment remain uncommon, mainly due to the belief that efficient treatment is still lacking. [less ▲]

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See detailSwitch of Sensitivity Dynamics Revealed with DyGloSA Toolbox for Dynamical Global Sensitivity Analysis as an Early Warning for System's Critical Transition.
Baumuratova, Tatiana UL; Dobre, Simona; Bastogne, Thierry et al

in PloS one (2013), 8(12), 82973

Systems with bifurcations may experience abrupt irreversible and often unwanted shifts in their performance, called critical transitions. For many systems like climate, economy, ecosystems it is highly ... [more ▼]

Systems with bifurcations may experience abrupt irreversible and often unwanted shifts in their performance, called critical transitions. For many systems like climate, economy, ecosystems it is highly desirable to identify indicators serving as early warnings of such regime shifts. Several statistical measures were recently proposed as early warnings of critical transitions including increased variance, autocorrelation and skewness of experimental or model-generated data. The lack of automatized tool for model-based prediction of critical transitions led to designing DyGloSA - a MATLAB toolbox for dynamical global parameter sensitivity analysis (GPSA) of ordinary differential equations models. We suggest that the switch in dynamics of parameter sensitivities revealed by our toolbox is an early warning that a system is approaching a critical transition. We illustrate the efficiency of our toolbox by analyzing several models with bifurcations and predicting the time periods when systems can still avoid going to a critical transition by manipulating certain parameter values, which is not detectable with the existing SA techniques. DyGloSA is based on the SBToolbox2 and contains functions, which compute dynamically the global sensitivity indices of the system by applying four main GPSA methods: eFAST, Sobol's ANOVA, PRCC and WALS. It includes parallelized versions of the functions enabling significant reduction of the computational time (up to 12 times). DyGloSA is freely available as a set of MATLAB scripts at http://bio.uni.lu/systems_biology/software/dyglosa. It requires installation of MATLAB (versions R2008b or later) and the Systems Biology Toolbox2 available at www.sbtoolbox2.org. DyGloSA can be run on Windows and Linux systems, -32 and -64 bits. [less ▲]

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See detailThe SWITCH study (sensing with insulin pump therapy to control HbA(1c)): design and methods of a randomized controlled crossover trial on sensor-augmented insulin pump efficacy in type 1 diabetes suboptimally controlled with pump therapy
Conget, I.; Battelino, T.; Giménez, M. et al

in Diabetes Technology & Therapeutics (2011), 13(1), 49-54

BACKGROUND: studies investigating the effect of real-time continuous glucose monitoring (CGM) combined with pump therapy on glycemic outcomes in type 1 diabetes are increasing. Pump therapy is well ... [more ▼]

BACKGROUND: studies investigating the effect of real-time continuous glucose monitoring (CGM) combined with pump therapy on glycemic outcomes in type 1 diabetes are increasing. Pump therapy is well established as a "gold standard" for insulin delivery, offering improvements over multiple daily insulin injections. However, there is still a proportion of subjects using continuous subcutaneous insulin infusion in whom goals for metabolic control are far from achieved or benefits of this type of insulin therapy are transient. The SWITCH (Sensing With Insulin pump Therapy to Control HbA(1c) [hemoglobin A1c]) study is a multicenter, randomized, controlled, crossover study to evaluate if adding CGM to experienced pump patients with suboptimal metabolic control will provide additional insight enabling clinical and therapeutic benefit. METHODS: subjects meeting the inclusion criteria were randomized to Sensor On or Sensor Off arms for 6 months, after a 1-month run-in period. Following a 4-month washout period, the subjects crossed over to the other study arm for 6 months. The primary end point was the between arm difference in HbA(1c) levels. Among others, additional end points include time spent in different glycemic ranges, percentage of patients with HbA(1c) <7%, number of hypoglycemic events, glucose variability parameters, safety outcomes, treatment satisfaction, and quality of life. RESULTS: recruitment occurred between January 2008 and February 2009. A total of 153 patients were randomized. Study completion is anticipated in July 2010. CONCLUSIONS: the results will establish if adding CGM to existing, capable, insulin pump users can enable better metabolic control. [less ▲]

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See detailSwitchable dissociation of excitons bound at strained CdTe/CdS interfaces
Enders, Florian; Budweg, Arne; Zeng, Peng et al

in Nanoscale (2018)

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See detailSwitched adaptive quantiser for speech compression based on optimal companding and correlation
Despotovic, Vladimir UL; Peric, Zoran; Velimirovic, Lazar et al

in IET Signal Processing (2011), 5(7), 701-707

This study describes a novel adaptive quantiser based on the optimal companding technique. Adaptation is achieved by adjusting the input of the fixed or non-adaptive quantiser according to the estimated ... [more ▼]

This study describes a novel adaptive quantiser based on the optimal companding technique. Adaptation is achieved by adjusting the input of the fixed or non-adaptive quantiser according to the estimated and quantised gain on each particular frame. In such a way better quantiser adaptation to the varying input statistics is provided. Selection of the appropriate bit rate is performed depending on the value of the correlation coefficient ρ on each frame. The decision thresholds for ρ are determined under the condition that the signal to quantisation noise ratio does not drop under 34.3ρdB, satisfying the G.712 standard quality of speech, while decreasing the bit rate. The information about the gain and about the chosen bit rate is then transferred as a side information to a decoder. Although this slightly increases the side information, the overall savings in the bit rate have shown to be substantial. Theoretical and experimental results are provided, which point out the benefits that can be achieved using the proposed algorithm. [less ▲]

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