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Peer Reviewed
See detailSupporting the Knowledge Life Cycle
Blessing, Lucienne UL; Wallace, K. M.

in Kluwer Academic Publishers (Ed.) Knowledge Intensive CAD (1999)

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See detailSupporting the Verification of Compliance to Safety Standards via Model-Driven Engineering: Approach, Tool-Support and Empirical Validation
Panesar-Walawege, Rajwinder; Sabetzadeh, Mehrdad UL; Briand, Lionel UL

in Information & Software Technology (2013), 55(1), 836-864

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See detailSupporting young adults with special educational needs (SEN) in obtaining higher qualifications
Limbach-Reich, Arthur UL; Powell, Justin J W UL

Report (2016)

Supporting young adults with special educational needs in obtaining higher qualifications is an ambitious, desirable and noble project, occasionally labeled “university for all” or “full inclusion in ... [more ▼]

Supporting young adults with special educational needs in obtaining higher qualifications is an ambitious, desirable and noble project, occasionally labeled “university for all” or “full inclusion in higher education”. But there is a risk, that beyond inclusive rhetoric, universities persist in being perceived by national policymakers and also perceive themselves as elite organizatins, that is only accessible to highly educated and highly skilled persons that will be successful in labour market competition and so promise to recapitalize (increasingly high) investments in higher education. Not inclusion efforts and individuals with disabilities, but rather national economic growth and international competitiveness are in the centre of contemporary concerns, despite the worldwide ratification of the UN Convention on the Rights of Persons with Disabilities and global acknowledgment of inclusive education as a human right. While some students with disabilities certainly do manage to adapt to the existing systems of higher education, especially when they receive reasonable accommodations they deserve, but there will be other students with more severe disabilities who may need more support to reach their individual learning goals and who may not promise to 'return' the invest. Yet not only those students with disabilities who are labeled as incompatible with employment remain persistently excluded from higher education. Having in mind this risk, the rhetoric of “university for all” has to be reconsidered. At the same time that many universities are seriously challenged by reductions in public funding, universal design principles diffuse worldwide, and the UN Convention mandates accessibility at all levels of learning, including higher education. [less ▲]

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See detailSupporting Youth in African Countries to Advance Local Economies and Community Health: The SDG Lab on Microfinance for Youth and Clean Water
Leist, Anja UL; Avidar, Ornit; Szelest, Linda et al

Report (2018)

In the sub-Saharan African countries, a large number of young adults enters the labour market each year. Scarcity of regular employment opportunities and the wish to become an entrepreneur lead many young ... [more ▼]

In the sub-Saharan African countries, a large number of young adults enters the labour market each year. Scarcity of regular employment opportunities and the wish to become an entrepreneur lead many young people to start their own business. However, young people are often not able to become regular microloan customers due to both higher risks associated with young age and lack of experience with managing finances. If microfinance products should become accessible to young people, the loans need to be accompanied by non-financial services, i.e., financial advice and mentoring. In order to advance local economies and community health, we see two distinct problems around microfinance products for young adults. First, microfinance products combined with non-financial services are not sustainable, i.e. additional external funds are needed that render these microloan products unprofitable in the long run. Second, if improvements in community water, development, and health are envisaged, then new microfinance products need to be designed to serve the purpose of supporting the SDG goals of clean water and sanitation for all. We used an existing initiative of microfinance for young entrepreneurs and applied the social innovation lab methodology to gather experts in relevant fields. The SDG lab, co-sponsored by Future Earth and Appui au Développement Autonome Microfinance Luxembourg and hosted by the University of Luxembourg, first addressed the problem of sustainability of microfinance products for young entrepreneurs. Second, the SDG lab defined actors, processes, and goals to design microfinance products for young people to support the SDG goals of clean water and sanitation for all. [less ▲]

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Peer Reviewed
See detailSuppression of beta3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis.
Ellison, Tim S.; Atkinson, Samuel J.; Steri, Veronica et al

in Disease models & mechanisms (2015), 8(9), 1105-19

Anti-angiogenic treatments against alphavbeta3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through alphavbeta3 ... [more ▼]

Anti-angiogenic treatments against alphavbeta3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through alphavbeta3-integrin-independent mechanisms. Here, we show that suppression of beta3-integrin in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1's mobilisation away from mature focal adhesions following VEGF-stimulation. The simultaneous genetic targeting of both molecules significantly impairs paxillin-1 activation and focal adhesion remodelling in endothelial cells, and therefore inhibits tumour angiogenesis and the growth of already established tumours. These findings provide a firm foundation for testing drugs against these molecules in combination to treat patients with advanced cancers. [less ▲]

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See detailSuppression of Decoherence in Fast-Atom Diffraction at Surfaces
Aigner, F.; Simonovic, N.; Solleder, B. et al

in Physical Review Letters (2008), 101(25),

Scattering of fast neutral atoms with keV kinetic energies at alkali-halide surfaces under grazing angles displays intriguing diffraction patterns. The surprisingly strong persistence of quantum coherence ... [more ▼]

Scattering of fast neutral atoms with keV kinetic energies at alkali-halide surfaces under grazing angles displays intriguing diffraction patterns. The surprisingly strong persistence of quantum coherence despite the impulsive interaction with an environment at solid state density and elevated temperatures raises fundamental questions such as to the suppression of decoherence and of the quantum-to-classical crossover. We present an ab initio simulation of the quantum diffraction of fast helium beams at a LiF (100) surface in the < 110 > direction and compare with recent experimental diffraction data. From the quantitative reconstruction of diffraction images the vertical LiF-surface reconstruction, or buckling, can be determined. [less ▲]

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See detailSuppression of extrapyramidal side effects of doxepin by thalamic deep brain stimulation for Tourette syndrome.
Rzesnitzek, L.; Wachter, T.; Krüger, Rejko UL et al

in Neurology (2011), 77(18), 1708-9

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Peer Reviewed
See detailSuppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M. et al

in Journal of immunology (Baltimore, Md. : 1950) (2002), 169(3), 1219-27

G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating ... [more ▼]

G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating intracellular signaling cascades. The G-CSFR encompasses four tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins. Suppressor of cytokine signaling 3 (SOCS-3), also referred to as cytokine-inducible Src homolgy 2-containing protein 3, is a member of a recently discovered family of feedback inhibitors that have been shown to inhibit the Janus kinase/STAT pathway. In this study, we demonstrate that human SOCS-3 is rapidly induced by G-CSF in polymorphonuclear neutrophils as well as in the myeloid precursor cell line U937 and that SOCS-3 negatively regulates G-CSFR-mediated STAT activation. Most importantly, we show that SOCS-3 is recruited to the G-CSFR in a phosphorylation-dependent manner and we identify phosphotyrosine (pY)729 as the major recruitment site for SOCS-3. Furthermore, we demonstrate that SOCS-3 directly binds to this pY motif. Surface plasmon resonance analysis reveals a dissociation constant (K(D)) for this interaction of around 2.8 microM. These findings strongly suggest that the recruitment of SOCS-3 to pY729 is important for the modulation of G-CSFR-mediated signal transduction by SOCS-3. [less ▲]

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See detailSupraferromagnetic correlations in clusters of magnetic nanoflowers
Bender, Philipp Florian UL; Honecker, Dirk UL; Fernández Barquín, Luis

in Applied Physics Letters (2019), 115

Magnetic nanoflowers are densely packed aggregates of superferromagnetically coupled iron oxide nanocrystallites, which excel during magnetic hyperthermia experiments. Here, we investigate the nature of ... [more ▼]

Magnetic nanoflowers are densely packed aggregates of superferromagnetically coupled iron oxide nanocrystallites, which excel during magnetic hyperthermia experiments. Here, we investigate the nature of the moment coupling within a powder of such nanoflowers using spin-resolved small-angle neutron scattering. Within the powder, the nanoparticles are agglomerated to clusters, and we can show that the moments of neighboring nanoflowers tend to align parallel to each other. Thus, the whole system resembles a hierarchical magnetic nanostructure consisting of three distinct levels, i.e., (i) the ferrimagnetic nanocrystallites as building blocks, (ii) the superferromagnetic nanoflowers, and (iii) the supraferromagnetic clusters of nanoflowers. We surmise that such a supraferromagnetic coupling explains the enhanced magnetic hyperthermia performance in the case of interacting nanoflowers. [less ▲]

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See detailSupranational Banking Supervision in Europe: The Construction of a Credible Watchdog
Howarth, David UL; Quaglia, Lucia UL; Gren, Jakub UL

in Journal of Common Market Studies (2015), 53(s1),

Does the institutional design of the European Single Supervisory Mechanism (SSM) and its first assessment of systemically important bank stability bolster the credibility of supranational banking ... [more ▼]

Does the institutional design of the European Single Supervisory Mechanism (SSM) and its first assessment of systemically important bank stability bolster the credibility of supranational banking supervision in Europe? One crucial measure of credibility with regard to the SSM and NCA supervision of less significant banks — the large majority of euro area headquartered bank not subject to direct ECB supervision — is the assurance of consistent supervision in the euro area. This involves some degree of convergence of NCA supervision in order to prevent national supervisory forebearance of struggling banks. This contribution thus examines whether or not the design of the SSM provides the foundation to build convergence in euro area supervision of less significant banks, despite very different national supervisory practices and institutional frameworks. The Principal-Agent approach is used to assess the credibility of the SSM design in terms of providing the foundation for consistent supervision. This contribution also examines the credibility of the ECB’s direct supervision of significant banks. The management of the ECB’s Comprehensive Assessment of signficant banks can be seen as the first step in demonstrating the capacity of the ECB to make difficult decisions with regard to the stability of the euro area’s banks. [less ▲]

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See detailSuprarégionalisation transfrontalière? Grande Région Saar-Lor-Lux
Evrard, Estelle UL

Doctoral thesis (2013)

European Union integration policy has challenged traditional border functions resulting in regionalisation processes and policy makers facing diverse functional interdependencies across multiple scales ... [more ▼]

European Union integration policy has challenged traditional border functions resulting in regionalisation processes and policy makers facing diverse functional interdependencies across multiple scales and territories. Local and regional authorities participate in a European multi-level governance system. Within regions, cross-border cooperation institutionalises distinct forms of governance. This thesis investigates the regionalisation process launched across borders at a subnational level using the case study of the Greater Region Saar-Lor-Lux. Conceptually, this study defines regionalization as construction of a region. This analysis of cross-border cooperation in the Greater Region explains “cross-border supraregionalisation” through three processes. First, the discursive construction of a cross-border strategy illustrates the complexity of joint positioning. The metropolitan impetus advocated in the Greater Region reveals the ambivalent objectives of the partners and the dominance of the metropolitan discourse at the national and European level. Second, beyond the institutional cooperation space (“Vertragraum”), the space of the mandate (“Mandatsraum”) serves as a medium to territorialise the joint strategy. It results from the ideal projection of the strategy in space and thus, evokes a bordering process. This “soft space” is constantly negotiated between the partners and illustrates patterns of cross-border spatial empowerment. Third, the study analyses the extent to which cross-border partners delegate responsibilities and legitimacy to joint cross-border institutions, especially through the innovative legal instrument European Grouping for Territorial Cooperation. [less ▲]

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See detailSur certains sous-groupes de torsion de Jacobiennes de courbes hyperelliptiques de genre g > 0
Leprévost, Franck UL

in Manuscripta Mathematica (1997), 92(I), 47-63

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See detailSur des classes de fonctions à seuil caractérisables par des contraintes relationnelles
Couceiro, Miguel; Lehtonen, Erkko UL; Schölzel, Karsten UL

in Marichal, Jean-Luc; Essounbouli, Najib; Guelton, Kevin (Eds.) Actes des 22èmes rencontres francophones sur la Logique Floue et ses Applications, 10-11 octobre 2013, Reims, France (2013, October)

Motivated by modal semantics induced by majority games, we consider the class of threshold functions. It was shown by L. Hellerstein that this class is characterizable by relational constraints (or ... [more ▼]

Motivated by modal semantics induced by majority games, we consider the class of threshold functions. It was shown by L. Hellerstein that this class is characterizable by relational constraints (or equivalently, by functional equations), but that there is no characterization by means of finitely many constraints. In this paper, we present a complete classification of classes of threshold functions induced by Boolean clones, into whether they are characterizable by finitely many relational constraints. Moreover we provide sets of constraints characterizing each of such classes. [less ▲]

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See detailSur la complétude de certaines variétés pseudo-riemanniennes localement homogènes.
Tholozan, Nicolas UL

in Annales de l'Institut Fourier (2015), 65(5), 1921-1952

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Peer Reviewed
See detailSur les garanties autonomes; L'escompte, Le cautionnement d'un compte courant et les cartes bancaires
Prüm, André UL

in Le crédit & ses garanties. Edition 2004 (2004)

Le crédit et ses garanties présente au lecteur, dans une approche inédite en la matière, sous la forme de 67 fiches pratiques, l'ensemble des questions auxquelles il peut se trouver confronté, soit au ... [more ▼]

Le crédit et ses garanties présente au lecteur, dans une approche inédite en la matière, sous la forme de 67 fiches pratiques, l'ensemble des questions auxquelles il peut se trouver confronté, soit au moment où il contracte un crédit et qu'il doit fournir les inévitables garanties qu'exige le prêteur, soit au moment de l'échéance, notamment lorsque son créancier entend mettre en œuvre la ou les garanties constituées. S'y ajoutent celles que pourra se poser celui qui, le cas échéant, se porte ou s'est porté garant du crédit. Sont ainsi présentées les diverses techniques du crédit, immobilier et mobilier, en droit commun et en droit de la consommation : prêt à intérêts classique, prêt à la consommation, crédit-bail mobilier et LOA, ouverture de crédit en compte courant, cartes de crédit... Une place majeure, justifiée par leur grande diversité et leur importance en cas de difficultés, est réservée aux techniques de garantie en usage dans la pratique, tant réelles (hypothèque, gages et nantissements, droit de rétention, dépôt de garantie, clause de réserve de propriété) que personnelles (assurance du crédit, cautionnement, garantie autonome). Parmi ces dernières, le cautionnement bénéficie d'un traitement privilégié, parce qu'il reste la garantie la plus largement pratiquée et qu'il donne lieu au contentieux le plus abondant. Organisé par études thématiques, l'ouvrage aborde les sujets traités sous forme de questions-réponses. Partant du fait pour aller vers le droit, chaque étude présente - l'exposé des principales questions pratiques, - les réponses approfondies et argumentées (assorties de conseils pratiques), - les précisions jurisprudentielles, - les outils : formules et modèles, adresses utiles... - le guide de recherche : textes applicables, références au Juris-Classeur, bibliographie. Ces différentes rubriques permettent d'accéder directement à l'information recherchée. [less ▲]

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See detailSur les représentations galoisiennes des formes modulaires de Hilbert de poids un en caractéristique p
Wiese, Gabor UL

Presentation (2017, April 11)

Dans cet exposé, je vais donner les idées principales de mon travail avec Mladen Dimitrov dans lequel nous démontrons que la représentation galoisienne associée à toute forme modulaire de Hilbert de poids ... [more ▼]

Dans cet exposé, je vais donner les idées principales de mon travail avec Mladen Dimitrov dans lequel nous démontrons que la représentation galoisienne associée à toute forme modulaire de Hilbert de poids un en caractéristique p et de niveau premier à p est non-ramifiée en p. Ce résultat s'applique notamment à des formes qui ne se relèvent pas en caractéristique zéro, et peut être vu comme la précision d'un aspect du poids dans la généralisation de la conjecture de modularité de Serre aux formes de Hilbert. [less ▲]

Detailed reference viewed: 71 (5 UL)
See detailSur les représentations galoisiennes des formes modulaires de Hilbert de poids un en caractéristique p
Wiese, Gabor UL

Presentation (2017, January 19)

Dans cet exposé, je vais donner les idées principales de mon travail avec Mladen Dimitrov dans lequel nous démontrons que la représentation galoisienne associée à toute forme modulaire de Hilbert de poids ... [more ▼]

Dans cet exposé, je vais donner les idées principales de mon travail avec Mladen Dimitrov dans lequel nous démontrons que la représentation galoisienne associée à toute forme modulaire de Hilbert de poids un en caractéristique p et de niveau premier à p est non-ramifiée en p. Ce résultat s'applique notamment à des formes qui ne se relèvent pas en caractéristique zéro, et peut être vu comme la précision d'un aspect du poids dans la généralisation de la conjecture de modularité de Serre aux formes de Hilbert. [less ▲]

Detailed reference viewed: 38 (2 UL)
See detailSur les représentations galoisiennes en théorie de Galois inverse
Wiese, Gabor UL

Presentation (2014, February 10)

On présentera un travail en commun avec Sara Arias-de-Reyna, Luis Dieulefait et Sug Woo Shin où nous réalisons, pour tout n pair et tout d, le groupe PGSp_n(F_{p^d}) ou PSp_n(F_{p^d}) comme groupe de ... [more ▼]

On présentera un travail en commun avec Sara Arias-de-Reyna, Luis Dieulefait et Sug Woo Shin où nous réalisons, pour tout n pair et tout d, le groupe PGSp_n(F_{p^d}) ou PSp_n(F_{p^d}) comme groupe de Galois sur les nombres rationnels, pour p dans un ensemble de densité positive. La démonstration est basée sur des systèmes compatibles de représentations galoisiennes ayant des propriétés locales spéciales. Au début de l'exposé on esquissera la stratégie; elle est basée sur un travail en commun avec Dieulefait dans le cas de la dimension 2. On expliquera ensuite l'existence d'un corps global et minimal tel que presque toute représentation résiduelle d'un système compatible peut être définie projectivement sur le corps résiduel. En plus, on énoncera une classification simple des représentations symplectiques contenant une transvection dans leur image. Finalement, on expliquera l'existence du système compatible désiré et comment utiliser des techniques de minoration du niveau pour obtenir notre application au problème de Galois inverse. [less ▲]

Detailed reference viewed: 50 (2 UL)