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See detailUnordentliche Verhältnisse. Familie als Argument in Suppliken und Bittbriefen
Gerstenmayer, Christina; Tatarinov, Juliane UL

in Arbeitskreis Repräsentation des SFB 600 (Ed.) Die 'andere' Familie. Repräsentationskritische Analysen von der Frühen Neuzeit bis zur Gegenwart (2013)

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See detailUnpacking Collaboration in Digital History Projects
Kemman, Max UL

Scientific Conference (2017)

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See detailUnpacking Luxembourg Governance through Sustainable Development Policy
Carr, Constance UL

Presentation (2012, February)

Luxembourg has an almost two century history of cross-border political economic interdependence, whether that was through the Zollverein and expansion of the railroads during the 19th century, the steel ... [more ▼]

Luxembourg has an almost two century history of cross-border political economic interdependence, whether that was through the Zollverein and expansion of the railroads during the 19th century, the steel industry that remains largely intact, or the banking and related services sector that dominates the Luxembourgish economy today. Luxembourg has also cultivated deep cross-border connections through its role in the European Union, and establishment of itself as one of the centres for important EU institutions. These structures overlay its otherwise feudal and agricultural legacy. This has led to a political structure that some complain is non-transparent and undemocratic, but that others notice is horizontal, direct, and entails shorter power distances. It has also led to a demos whose membership is defined by the usual legal parameters of nationhood, but at the same time is inter-reliant on cross-border competencies and cycles of de- and reinvestment, as well as personal relations. These paths of governance are easily traced through the mobility of Luxembourg’s sustainable development policies. In so doing, it can be seen that the uncertain governance structure that operates simultaneously multi-scalar, cross-national, and informal, which poses many obstructions to the implementation of environmental policy and renders the normative of sustainable development, that permeates all levels of planning in Luxembourg, postpolitical. [less ▲]

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See detailUnpolitisches Mega-Event oder neue soziale Bewegung?
Sabra, Martina; Schröder, Christian UL

Diverse speeches and writings (2015)

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See detailUnramifiedness of Galois representations attached to weight one Hilbert modular eigenforms mod p
Dimitrov, Mladen; Wiese, Gabor UL

in Journal of the Institute of Mathematics of Jussieu (2018)

The main result of this article states that the Galois representation attached to a Hilbert modular eigenform defined over F_p^bar of parallel weight 1 and level prime to p is unramified above p. This ... [more ▼]

The main result of this article states that the Galois representation attached to a Hilbert modular eigenform defined over F_p^bar of parallel weight 1 and level prime to p is unramified above p. This includes the important case of eigenforms that do not lift to Hilbert modular forms in characteristic 0 of parallel weight 1. The proof is based on the observation that parallel weight 1 forms in characteristic p embed into the ordinary part of parallel weight p forms in two different ways per prime dividing p, namely via `partial' Frobenius operators. MSC: 11F80 (primary); 11F41, 11F33 Keywords: Hilbert modular forms modulo p, weight one, Galois representations [less ▲]

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See detailUnramifiedness of Galois representations attached to weight one Hilbert modular eigenforms mod p
Wiese, Gabor UL

Scientific Conference (2015, November 13)

The talk will summarise the main ideas underlying the recent joint work with Mladen Dimitrov, proving that the existence of Hecke operators T_P, for P dividing p, implies that the Galois representation ... [more ▼]

The talk will summarise the main ideas underlying the recent joint work with Mladen Dimitrov, proving that the existence of Hecke operators T_P, for P dividing p, implies that the Galois representation attached to a mod p Hilbert modular eigenform of parallel weight one and prime-to-p level is unramified above p. This applies, in particular, to non-liftable mod p eigenforms, and can be seen as a refinement of the weight aspect in generalisations of Serre's Modularity Conjecture to Hilbert modular forms. [less ▲]

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See detailUnraveling genomic variation from next generation sequencing data
Pavlopoulos, Georgios A.; Oulas, Anastasis; Iacucci, Ernesto et al

in BioData Mining (2013), 6(1), 13

Elucidating the content of a DNA sequence is critical to deeper understand and decode the genetic information for any biological system. As next generation sequencing (NGS) techniques have become cheaper ... [more ▼]

Elucidating the content of a DNA sequence is critical to deeper understand and decode the genetic information for any biological system. As next generation sequencing (NGS) techniques have become cheaper and more advanced in throughput over time, great innovations and breakthrough conclusions have been generated in various biological areas. Few of these areas, which get shaped by the new technological advances, involve evolution of species, microbial mapping, population genetics, genome-wide association studies (GWAs), comparative genomics, variant analysis, gene expression, gene regulation, epigenetics and personalized medicine. While NGS techniques stand as key players in modern biological research, the analysis and the interpretation of the vast amount of data that gets produced is a not an easy or a trivial task and still remains a great challenge in the field of bioinformatics. Therefore, efficient tools to cope with information overload, tackle the high complexity and provide meaningful visualizations to make the knowledge extraction easier are essential. In this article, we briefly refer to the sequencing methodologies and the available equipment to serve these analyses and we describe the data formats of the files which get produced by them. We conclude with a thorough review of tools developed to efficiently store, analyze and visualize such data with emphasis in structural variation analysis and comparative genomics. We finally comment on their functionality, strengths and weaknesses and we discuss how future applications could further develop in this field. [less ▲]

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See detailUnraveling the combinatorial mechanisms linking the gut microbiome to Parkinson’s disease
Wilmes, Paul UL

Scientific Conference (2018, September)

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See detailUNRAVELING THE COMPLEX GENETICS OF NEUROLOGICAL DISORDERS
Bobbili, Dheeraj Reddy UL

Doctoral thesis (2018)

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See detailUnraveling the nature of room temperature grain growth in nanocrystalline materials
Ames, M.; Markmann, J.; Karos, R. et al

in Acta Materialia (2008), 56

We report on the observation of real-time-resolved room temperature grain growth in nanocrystalline metals. We find that neither the time evolution of size can be modeled by standard growth theories nor ... [more ▼]

We report on the observation of real-time-resolved room temperature grain growth in nanocrystalline metals. We find that neither the time evolution of size can be modeled by standard growth theories nor are there any other systems aware to us that manifest a similar growth behaviour. We detect a transition from an initially self-similar slow growth to abnormal grain growth. Its onset seems to be associated with the simultaneous decrease of microstrain with increasing grain size. Abnormal grain growth is considered as a generic feature of nanocrystallinity but is a transient state since we observed in the late stage of coarsening, using orientational imaging microscopy, a monomodal grain size distribution. We empirically find a nonlinear-response-type of growth law which is in agreement with the observed coarsening kinetics. [less ▲]

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See detailUnraveling the stability of polypeptide helices: Critical role of van der Waals interactions
Tkatchenko, Alexandre UL; Rossi, M.; Blum, V. et al

in Physical Review Letters (2011), 106(11),

Folding and unfolding processes are important for the functional capability of polypeptides and proteins. In contrast with a physiological environment (solvated or condensed phases), an in vacuo study ... [more ▼]

Folding and unfolding processes are important for the functional capability of polypeptides and proteins. In contrast with a physiological environment (solvated or condensed phases), an in vacuo study provides well-defined "clean room" conditions to analyze the intramolecular interactions that largely control the structure, stability, and folding or unfolding dynamics. Here we show that a proper consideration of van der Waals (vdW) dispersion forces in density-functional theory (DFT) is essential, and a recently developed DFT+vdW approach enables long time-scale ab initio molecular dynamics simulations at an accuracy close to "gold standard" quantum-chemical calculations. The results show that the inclusion of vdW interactions qualitatively changes the conformational landscape of alanine polypeptides, and greatly enhances the thermal stability of helical structures, in agreement with gas-phase experiments. © 2011 American Physical Society. [less ▲]

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See detailUnravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness
Galtsidis, Sotirios UL; Logotheti, S.; Pavlopoulou, A. et al

in Cancer Letters (2017), 388

The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated ... [more ▼]

The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated networks which are commonly perturbed in cancer. Herein, we aimed to characterize a p73-regulated network that mediates cell migration and restores anti-oncogenic responses in p53-mutant cancer cells. In this study, we demonstrate that p73 regulates a network underlying cell migration, which consists of MIR34A/MIR3158/vimentin/β-catenin/lef1. The p73 isoforms transactivate the miRNA components (MIR34A/MIR3158) of this network, which in turn, downregulate their EMT-related mRNA co-targets (vimentin/β-catenin/lef1) to decrease cell-migration. Modulation of this network, by increasing the level of the novel p73-dependent target MIR3158, was found to induce anti-oncogenic/anti-invasive responses in p53-mutant cancer cells. Taken together, a p73-regulated, MIR3158-containing, network restores anti-invasive phenotypes in p53-mutant cancer cells; this property could be exploited towards the development of anticancer therapeutics. © 2016 Elsevier Ireland Ltd [less ▲]

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See detailUnravelling the border-facade of France : a multi-level modelling of cross-border commuting
Pigeron-Piroth, Isabelle UL; Caruso, Geoffrey UL; Le Texier, Marion

in Caruso, Geoffrey; Gerber, Philippe; Jones, Catherine (Eds.) et al 21st European Colloquium on Theoretical and Quantitative Geography (ECTQG), Book of Abstracts, Mondorf-las-Bains, 5-9 septembre 2019 (2019, September 09)

Given its central position in Western Europe, France is the European country where cross-border commuting is most intense. Over 350000 residents cross the national border everyday to go to work. Cross ... [more ▼]

Given its central position in Western Europe, France is the European country where cross-border commuting is most intense. Over 350000 residents cross the national border everyday to go to work. Cross-border commuting raises a lot of concerns for planners on both side of each border, especially for provisioning transport infrastructure and local public services but also because it impacts land and housing markets, especially when salary differentials are high. While there is a lot of research about the daily functioning of specific borders (e.g. France-Switzerland or France-Luxembourg), generalization is lacking and spatial heterogeneities impede our understanding of the very determinants of cross-border commuting, such as the role of benefits differentials, transport costs and distance, or the relative availability of jobs at residential places and across the border. Further, these effects are most likely mediated differently by the socio-demographic characteristics of workers, their employment sector, and the quality of their residential environment at large. This suggests that an individual approach and a spatially detailed approach is needed, which contrasts sharply with the fact that most European-wide studies of cross-border commuting are conducted at very aggregated spatial scales (NUTS 2 or 3). [less ▲]

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See detailThe unreliable readers of Sam Selvon's Moses Ascending
Weber, Jean-Jacques UL

in Sprache und Literatur in Wissenschaft und Unterricht (2001), 34

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See detailUnsere Zeit ist reicher an Ausdrucksmitteln als an Persönlichkeiten. Walther Rathenaus Verhältnis zu Literatur und Kunst
Heimböckel, Dieter UL

in Hense, Karl-Heinz; Sabrow, Martin (Eds.) Leitbild oder Erinnerungsort? Neue Beiträge zu Walther Rathenau (2003)

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See detailDer unsichtbare Zweite. Gegenschüsse im One-Actor-Movie
Pause, Johannes UL

in Doll, Martin (Ed.) Cutting Edge! Aktuelle Positionen der Filmmontage (2019)

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See detailUnsupervised intrinsic calibration from a single frame using a "plumb-line" approach
Melo, Rui; Goncalves Almeida Antunes, Michel UL; Barreto, João Pedro et al

in International Conference on Computer Vision (ICCV) (2013, December)

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See detailUnsupervised Learning in Reservoir Computing: Modeling Hippocampal Place Cells for Small Mobile Robots
Antonelo, Eric Aislan UL; Schrauwen, Benjamin; Stroobandt, Dirk

in Alippi, Cesare; Polycarpou, Marios; Panayiotou, Christos (Eds.) et al Artificial Neural Networks -- ICANN 2009 (2009)

Biological systems (e.g., rats) have efficient and robust localization abilities provided by the so called, place cells, which are found in the hippocampus of rodents and primates (these cells encode ... [more ▼]

Biological systems (e.g., rats) have efficient and robust localization abilities provided by the so called, place cells, which are found in the hippocampus of rodents and primates (these cells encode locations of the animal's environment). This work seeks to model these place cells by employing three (biologically plausible) techniques: Reservoir Computing (RC), Slow Feature Analysis (SFA), and Independent Component Analysis (ICA). The proposed architecture is composed of three layers, where the bottom layer is a dynamic reservoir of recurrent nodes with fixed weights. The upper layers (SFA and ICA) provides a self-organized formation of place cells, learned in an unsupervised way. Experiments show that a simulated mobile robot with 17 noisy short-range distance sensors is able to self-localize in its environment with the proposed architecture, forming a spatial representation which is dependent on the robot direction. [less ▲]

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