Unified Design for Parallel Execution of Coupled Simulations using the Discrete Particle Method

in Proceedings of the Third International Conference on Parallel, Distributed, Grid and Cloud Computing for Engineering (2013)

This paper presents the enhanced design of the Discrete Particle Method (DPM), a simulation tool which provides high quality and fast simulations to solve a broad range industrial processes involving ... [more ▼]

This paper presents the enhanced design of the Discrete Particle Method (DPM), a simulation tool which provides high quality and fast simulations to solve a broad range industrial processes involving granular materials. It enables to resolve mechanical and thermodynamics problems through different simulation modules (motions, chemical conversion). This new design allows to transparently couple the simulation modules in parallel execution. It relies on a unified interface and timebase of the simulation modules and a flexible decomposition in cells of the simulation space. Experimental results study the behavior of the Orthogonal Recursive Bisection (ORB) partitioning algorithm. A good scalability is achieved as the parallel execution on a distributed platform provides a 17-times speedup using 64 processes. [less ▲]

Unified European Gravity Reference Network 2002 (UEGN2002), a Status Report

in Tziavos, Ilias N. (Ed.) Gravity and Geoid 2002 (2003)

Unified Satellite and Terrestrial ACM Design

in International Communications Satellite Systems Conference (ICSSC), Trieste 16-19 October 2017 (2017, October 17)

First step towards integrating satellite and terrestrial standards at the physical layer is to design a unified packet frame structure, and in particular, a unified adaptive coding and modulation (ACM ... [more ▼]

First step towards integrating satellite and terrestrial standards at the physical layer is to design a unified packet frame structure, and in particular, a unified adaptive coding and modulation (ACM) scheme without substantial loss in either of the systems. In this paper we introduce a methodology to design such a set of modulation and coding (MODCOD) combinations. In the first step, we design a set of base MODCODs for the AWGN channel. Then, for any other given channel model, we build a new set of MODCODs through a suitable transformation of the base MODCODs. We mainly focus on two types of channels: (a) non-linear satellite channels, and (b) AWGN channels with fading. We compare our results with latest digital video broadcasting standards, namely, DVB-T2 and DVB-S2X. [less ▲]

A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data.

in Nature Biotechnology (2014), 32(7), 663-669

High-throughput sequencing of related individuals has become an important tool for studying human disease. However, owing to technical complexity and lack of available tools, most pedigree-based ... [more ▼]

High-throughput sequencing of related individuals has become an important tool for studying human disease. However, owing to technical complexity and lack of available tools, most pedigree-based sequencing studies rely on an ad hoc combination of suboptimal analyses. Here we present pedigree-VAAST (pVAAST), a disease-gene identification tool designed for high-throughput sequence data in pedigrees. pVAAST uses a sequence-based model to perform variant and gene-based linkage analysis. Linkage information is then combined with functional prediction and rare variant case-control association information in a unified statistical framework. pVAAST outperformed linkage and rare-variant association tests in simulations and identified disease-causing genes from whole-genome sequence data in three human pedigrees with dominant, recessive and de novo inheritance patterns. The approach is robust to incomplete penetrance and locus heterogeneity and is applicable to a wide variety of genetic traits. pVAAST maintains high power across studies of monogenic, high-penetrance phenotypes in a single pedigree to highly polygenic, common phenotypes involving hundreds of pedigrees. [less ▲]

Uniform gradient estimates on manifolds with a boundary and applications

in Analysis and Mathematical Physics (2018), 8(4), 571-588

We revisit the problem of obtaining uniform gradient estimates for Dirichlet and Neumann heat semigroups on Riemannian manifolds with boundary. As applications, we obtain isoperimetric inequalities, using ... [more ▼]

We revisit the problem of obtaining uniform gradient estimates for Dirichlet and Neumann heat semigroups on Riemannian manifolds with boundary. As applications, we obtain isoperimetric inequalities, using Ledoux's argument, and uniform quantitative gradient estimates, firstly for bounded C^2 functions with boundary conditions and then for the unit spectral projection operators of Dirichlet and Neumann Laplacians. [less ▲]

Unifying Microscopic and Continuum Treatments of van der Waals and Casimir Interactions

in Physical Review Letters (2017), 118(1), 266802

We present an approach for computing long-range van der Waals (vdW) interactions between complex molecular systems and arbitrarily shaped macroscopic bodies, melding atomistic treatments of electronic ... [more ▼]

We present an approach for computing long-range van der Waals (vdW) interactions between complex molecular systems and arbitrarily shaped macroscopic bodies, melding atomistic treatments of electronic fluctuations based on density functional theory in the former with continuum descriptions of strongly shape dependent electromagnetic fields in the latter, thus capturing many-body and multiple scattering effects to all orders. Such a theory is especially important when considering vdW interactions at mesoscopic scales, i.e., between molecules and structured surfaces with features on the scale of molecular sizes, in which case the finite sizes, complex shapes, and resulting nonlocal electronic excitations of molecules are strongly influenced by electromagnetic retardation and wave effects that depend crucially on the shapes of surrounding macroscopic bodies. We show that these effects together can modify vdW interaction energies and forces, as well as molecular shapes deformed by vdW interactions, by orders of magnitude compared to previous treatments based on Casimir-Polder, nonretarded, or pairwise approximations, which are valid only at macroscopically large or atomic-scale separations or in dilute insulating media, respectively. [less ▲]

L’UniGR-Center for Border Studies et ses outils d’analyse

Scientific Conference (2019, October)

Unilateral Holmes tremor, clearly responsive to cerebrospinal fluid release, in a patient with an ischemic midbrain lesion and associated chronic hydrocephalic ventricle enlargement. Case report.

in Journal of neurosurgery (2006), 104(3), 448-51

The authors describe a 58-year-old man with sudden onset of a unilateral tremor caused by a midbrain lesion that affected the substantia nigra and the cerebellothalamic pathway. There were also clinical ... [more ▼]

The authors describe a 58-year-old man with sudden onset of a unilateral tremor caused by a midbrain lesion that affected the substantia nigra and the cerebellothalamic pathway. There were also clinical and neuroimaging signs of a communicating chronic hydrocephalus. The patient was severely handicapped by this tremor, which was a typical Holmes tremor with rest, posture, and intention components. Parkinson disease or multiple-system atrophy as causes for the tremor could be ruled out by DaTSCAN and 123I iodobenzamide and single-photon emission computerized tomography (SPECT), respectively. The tremor was completely supressed by temporary and permanent cerebrospinal fluid release after ventriculoperitoneal shunt placement, without any additional medication, for a period of 6 months. Afterward, the tremor returned, and the patient had to be treated by a stereotactic electrode implantation in the contralateral ventralis intermedius nucleus, which led to complete tremor suppression during the 1.5-year follow-up period. In this case report, the authors present the clinical description and the electrophysiological, SPECT, and magnetic resonance imaging data of a rare combination of symptoms and their surgical treatment. [less ▲]

Unilaterally increased expression of mGluR5 in dorsal horn neurons following knee joint inflammation

in Society for Neuroscience Abstracts 23 (1997)

»Uninteressiertes Weltineresse«. Über die Ausbildung einer ästhetischen (Denk-)Haltung im Werk Hannah Arendts

Book published by Fink (2015)

In meiner Dissertation untersuche ich die implizite Ästhetik im Werk Hannah Arendts. Ich gehe von der These aus, dass Ästhetik und Humanität in ihrem Werk eng miteinander verknüpft sind, da die Ausbildung ... [more ▼]

In meiner Dissertation untersuche ich die implizite Ästhetik im Werk Hannah Arendts. Ich gehe von der These aus, dass Ästhetik und Humanität in ihrem Werk eng miteinander verknüpft sind, da die Ausbildung einer ästhetischen (Denk-)Haltung eine Kultivierung des Geistes impliziert, die das Denken erst für den öffentlichen Raum vorbereitet. Wesentlich an der Kultivierung des Geistes ist für Arendt dabei die Ausbildung des Geschmacks. Überraschenderweise liest Arendt die Kritik der Urteilskraft als Referenztheorie und findet dort Kants ›wahre‹ politische Theorie vor: Der Geschmack als Inbegriff der Humanitas avanciert bei ihr zur conditio sine qua non des Politischen. Er ermöglicht es, Menschen qua ästhetischer Haltung als ›Zweck-in-sich-selbst‹ zu betrachten. Es wird daher deutlich, dass für Arendt das Ästhetische als Inbegriff des Politischen zu verstehen ist. [less ▲]