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See detailSingular representation and teleosemantics
Hofmann, Frank UL

Presentation (2012, February 17)

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See detailSingular spectrum analysis for modeling seasonal signals from GPS time series
Chen, Qiang; van Dam, Tonie UL; Sneeuw, Nico et al

in Journal of Geodynamics (2013), 72

Seasonal signals in GPS time series are of great importance for understanding the evolution of regional mass fluctuations, i.e., ice, hydrology, and ocean mass. Conventionally these signals quasi-annual ... [more ▼]

Seasonal signals in GPS time series are of great importance for understanding the evolution of regional mass fluctuations, i.e., ice, hydrology, and ocean mass. Conventionally these signals quasi-annual and semi-annual signals are modeled by least-squares fitting harmonic terms with a constant amplitude and phase. In reality, however, such seasonal signals are modulated, i.e., they will have a time-variable amplitude and phase. Recently, Davis et al.(2012) proposed a Kalman filter based approach to capture the stochastic seasonal behavior of geodetic time series. Singular Spectrum Analysis (SSA) is a non-parametric method, which uses time domain data to extract information from short and noisy time series without a priori knowledge of the dynamics affecting the time series. A prominent benefit is that trends obtained in this way are not necessarily linear. Further, true oscillations can be amplitude and phase modulated. In this work, we will assess the value of SSA for extracting time-variable seasonal signals from GPS time series. We compare our SSA-based results to those obtained using 1) least-squares analysis and 2) Kalman filtering. Our results demonstrate that SSA is a viable and complementary tool for extracting modulated oscillations from GPS time series. [less ▲]

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See detailSingularités orbifoldes de la variété des caractères
Guerin, Clément UL

Doctoral thesis (2016)

In this thesis, we want to understand some singularities in the character variety. In a first chapter, we justify that the characters of irreducible representations from a Fuchsian group to a complex semi ... [more ▼]

In this thesis, we want to understand some singularities in the character variety. In a first chapter, we justify that the characters of irreducible representations from a Fuchsian group to a complex semi-simple Lie group is an orbifold. The orbifold locus is, then, the characters of bad representations. In the second chapter, we focus on the case where the Lie group is PSL(p,C) with p a prime number. In particular we give an explicit description of this locus. In the third and fourth chapter, we describe the isotropy groups (i.e. the centralizers of bad subgroups) arising in the cases when the Lie group is a quotient SL(n,C) (third chapter) and when the Lie group is a quotient of Spin(n,C) in the fourth chapter. [less ▲]

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See detailSinngemäße Verschiebung. Franz Kafkas Roman "Der Verschollene" und das ‚Projekt der Interkulturalität‘
Heimböckel, Dieter UL

in Weinberg, Manfred; Höhne, Steffen (Eds.) Franz Kafka im interkulturellen Kontext (2019)

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See detailSinnwelt Freizeit - Jugend zwischen Märkten und Verbänden
Willems, Helmut UL; Eckert, Roland; Drieseberg, Thomas

in 3. Symposium: Werte in der Erziehung in Offenburg: Erziehung zur Freiheit (1992)

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See detailSinnwelt Freizeit Jugendliche zwischen Märkten und Verbänden
Eckert, Roland; Drieseberg, Thomas; Willems, Helmut UL

Book published by Leske + Budrich (1990)

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See detailSinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motility.
Bahlawane, Christelle UL; McIntosh, Matthew; Krol, Elizaveta et al

in Molecular plant-microbe interactions : MPMI (2008), 21(11), 1498-509

In order to enter symbiosis with its legume partner, Sinorhizobium meliloti requires regulatory systems for the appropriate responses to its environment. For example, motility is required for the ... [more ▼]

In order to enter symbiosis with its legume partner, Sinorhizobium meliloti requires regulatory systems for the appropriate responses to its environment. For example, motility is required for the chemotactic movement of bacteria toward the compounds released by its host, and exopolysaccharides (EPS) are required for bacterial attachment to the root or for invasion of the infection thread. Previous research has shown that ExoR/ExoS/ChvI as well as the ExpR/Sin quorum-sensing system inversely regulate both motility and EPS production, although the regulation mechanisms were unknown. We were able to attribute the ExpR-mediated regulation of motility to the ability of ExpR to bind a DNA sequence upstream of visN when activated by N-acyl-homoserine lactone. Furthermore, MucR, previously characterized as a regulator of EPS production, also affected motility. MucR inhibited expression of rem encoding an activator of motility gene expression and, consequently, the expression of Rem-regulated genes such as flaF and flgG. Binding of MucR to the rem promoter region was demonstrated and a sequence motif similar to the previously identified MucR binding consensus was identified within this region. The swarming ability of S. meliloti Rm2011 was shown to depend on a functional ExpR/Sin quorum-sensing system and the production of both flagella and EPS. Finally, we propose a model for the coordination of motility and EPS synthesis in S. meliloti. [less ▲]

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See detailSiO2 /AlGaN/GaN MOSHFET with 0.7 µm gate-length and fmax / fT of 40/24 GHz
Bernát, J.; Gregusová, D.; Heidelberger, G. et al

in Electronics Letters (2005), 41(11), 667-668

The performance of SiO2/AlGaN/GaN MOSHFETs is described. The C–V measurements showed slight increase in sheet carrier density after applying 12 nm-thick PECVD SiO2. The devices exhibited gate leakage ... [more ▼]

The performance of SiO2/AlGaN/GaN MOSHFETs is described. The C–V measurements showed slight increase in sheet carrier density after applying 12 nm-thick PECVD SiO2. The devices exhibited gate leakage current of 5 .10 ^-10 A/mm. Small-signal RF characterisation of 0.7 mm gate length devices yielded an fT of 24 GHz and an fmax of 40 GHz, which are comparable to those typical for state-of-the-art AlGaN/GaN HFETs. [less ▲]

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See detailLa Sipo-SD en Belgique. Une police faible
Majerus, Benoît UL

in Vingtième Siècle (2013), (119), 43--54

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See detailSirenengänge
Mein, Georg UL

in D’Lëtzebuerger Land (2009), 10

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See detailsiRNA screen identifies QPCT as a druggable target for Huntington's disease.
Jimenez-Sanchez, Maria; Lam, Wun; Hannus, Michael et al

in Nature chemical biology (2015), 11(5), 347354

Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity ... [more ▼]

Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity by performing a large-scale 'druggable genome' siRNA screen in human cultured cells, followed by hit validation in Drosophila. We focused on glutaminyl cyclase (QPCT), which had one of the strongest effects on mutant HTT-induced toxicity and aggregation in the cell-based siRNA screen and also rescued these phenotypes in Drosophila. We found that QPCT inhibition induced the levels of the molecular chaperone alphaB-crystallin and reduced the aggregation of diverse proteins. We generated new QPCT inhibitors using in silico methods followed by in vitro screening, which rescued the HD-related phenotypes in cell, Drosophila and zebrafish HD models. Our data reveal a new HD druggable target affecting mutant HTT aggregation and provide proof of principle for a discovery pipeline from druggable genome screen to drug development. [less ▲]

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See detailsis mortuus mundo, vivens iterum deo - Das Leprosenwesen am Mittelrhein bis zum 18. Jahrhundert
Uhrmacher, Martin UL

Scientific Conference (1998, November 13)

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See detailSissi – Sehnsuchtsbilder einer Kaiserin. Die Figur der guten Landesmutter im Historienfilm
Karczmarzyk, Nicole UL

in Kohns, Oliver (Ed.) Perspektiven der politischen Ästhetik (2016)

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See detailSISTA: Learning Optimal Transport Costs under Sparsity Constraints
Dupuy, Arnaud UL; Carlier, Guillaume; Galichon, Alfred et al

in Communications on Pure and Applied Mathematics (in press)

In this paper, we describe a novel iterative procedure called SISTA to learn the underlying cost in optimal transport problems. SISTA is a hybrid between two classical methods, coordinate descent (“S” ... [more ▼]

In this paper, we describe a novel iterative procedure called SISTA to learn the underlying cost in optimal transport problems. SISTA is a hybrid between two classical methods, coordinate descent (“S”-inkhorn) and proximal gradient descent (“ISTA”). It alternates between a phase of exact minimization over the transport potentials and a phase of proximal gradient descent over the parameters of the transport cost. We prove that this method converges linearly, and we illustrate on simulated examples that it is significantly faster than both coordinate descent and ISTA. We apply it to estimating a model of migration, which predicts the flow of migrants using country-specific characteristics and pairwise measures of dissimilarity between countries. This application demonstrates the effectiveness of machine learning in quantitative social sciences. [less ▲]

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See detailLos sistemas educativos: perspectiva histórica, cultural y sociológica
Barbu, Ragnhild UL; Tröhler, Daniel UL

Book published by Octaedro (2012)

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See detailSistemi Medici e Conformità Legale
Bartolini, Cesare UL; Lenzini, Gabriele UL

in Rivista Italiana di Medicina Legale: Dottrina, Casistica, Ricerca Sperimentale, Giurisprudenza e Legislazione (2019), XLI(1/2019), 225-242

The present document addresses the topic of legal compliance of medical systems, that is, hardware and software devices medically used on people for clinical tests, diagnosis, study, and similar purposes ... [more ▼]

The present document addresses the topic of legal compliance of medical systems, that is, hardware and software devices medically used on people for clinical tests, diagnosis, study, and similar purposes, mainly with respect to EU law. The work briefly overviews the applicable laws and regulations and discusses the relevance on medical systems of concepts that General Data Protection Regulation (GDPR) covers in a wider scope, such as data protection and transparency. The document looks into the practical meaning of legal compliance in a medical system and in the software that defines its behavior. Granted that any lawfulness decision is a prerogative of the judicial authority, the document concludes by suggesting currently-available means, such as official conformity checks, standards, but also conformity guidelines during development, to build a reasonably compliant medical system, or to check for its conformity. [less ▲]

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See detailSite-selective functionalization of plasmonic nanopores for enhanced fluorescence emission rate and Förster Resonance Energy Transfer
Zambrana-Puyalto, Xavier; Maccaferri, Nicolò UL; Ponzellini, Paolo et al

in Nanoscale Advances (2019), 1(6), 2454-2461

In this work, we use a site-selective functionalization strategy to decorate plasmonic nanopores with fluorescent dyes. Using an easy and robust fabrication method, we manage to build plasmonic rings on ... [more ▼]

In this work, we use a site-selective functionalization strategy to decorate plasmonic nanopores with fluorescent dyes. Using an easy and robust fabrication method, we manage to build plasmonic rings on top of dielectric nanotubes with different inner diameters. The modulation of the dimension of the nanopores allows us to tailor their field confinement and their Purcell Factor in the visible spectral range. In order to investigate how the changes in geometry influence the fluorescence emission rate efficiency, thiol-conjugated dyes are anchored on the plasmonic ring, thus forming a functional nanopore. We study the lifetime of ATTO 520 and ATTO 590 attached in two different configurations: single dye, and FRET pair. For the single dye configuration, we observe that the lifetime of both single dyes decreases as the size of the nanopore is reduced. The smallest nanopores yield an experimental Purcell Factor of 6. For the FRET pair configuration, we measure two regimes. For large nanopore sizes, the FRET efficiency remains constant. Whereas for smaller sizes, the FRET efficiency increases from 30 up to 45% with a decrease of the nanopore size. These findings, which have been supported by numerical simulations, may open new perspectives towards energy transfer engineering in plasmonic nanopores with potential applications in photonics and biosensing, in particular in single-molecule detection and sequencing.In this work, we use a site-selective functionalization strategy to decorate plasmonic nanopores with fluorescent dyes. Using an easy and robust fabrication method, we manage to build plasmonic rings on top of dielectric nanotubes with different inner diameters. The modulation of the dimension of the nanopores allows us to tailor their field confinement and their Purcell Factor in the visible spectral range. In order to investigate how the changes in geometry influence the fluorescence emission rate efficiency, thiol-conjugated dyes are anchored on the plasmonic ring, thus forming a functional nanopore. We study the lifetime of ATTO 520 and ATTO 590 attached in two different configurations: single dye, and FRET pair. For the single dye configuration, we observe that the lifetime of both single dyes decreases as the size of the nanopore is reduced. The smallest nanopores yield an experimental Purcell Factor of 6. For the FRET pair configuration, we measure two regimes. For large nanopore sizes, the FRET efficiency remains constant. Whereas for smaller sizes, the FRET efficiency increases from 30 up to 45% with a decrease of the nanopore size. These findings, which have been supported by numerical simulations, may open new perspectives towards energy transfer engineering in plasmonic nanopores with potential applications in photonics and biosensing, in particular in single-molecule detection and sequencing. [less ▲]

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See detailSite-Selective Integration of MoS2 Flakes on Nanopores by Means of Electrophoretic Deposition
Mosconi, Dario; Giovannini, Giorgia; Jacassi, Andrea et al

in ACS Omega (2019), 4(5), 9294-9300

Here, we propose an easy method for site-selective deposition of two-dimensional (2D) material flakes onto nanoholes by means of electrophoretic deposition. This method can be applied to both simple flat ... [more ▼]

Here, we propose an easy method for site-selective deposition of two-dimensional (2D) material flakes onto nanoholes by means of electrophoretic deposition. This method can be applied to both simple flat nanostructures and complex three-dimensional structures incorporating nano- holes. The deposition method is here used for the decoration of large ordered arrays of plasmonic structures with either a single or few layers of MoS2 . In principle, the plasmonic field generated by the nanohole can significantly interact with the 2D layer leading to enhanced light−material interaction. This makes our platform an ideal system for hybrid 2D material/ plasmonic investigations. The engineered deposition of 2D materials on plasmonic nanostructures is useful for several important applications such as enhanced light emission, strong coupling, hot-electron generation, and 2D material sensors. Site-selective integration of MoS2 flakes on nanopores by means of electrophoretic deposition. [less ▲]

Detailed reference viewed: 142 (2 UL)