Abattage au marteau-piqueur pneumatique avec piliers de bois dans les années 1920

Learning material (2022)

L'abbaye Neumunster - et tout un ancien quartier urbain

in Abbaye de Neumunster (2004)

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels

in Clinical Genetics (2002), 61(2), 115-125

The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary ... [more ▼]

The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single nucleotide polymorphisms (SNPs) in the coding region of the ABCA1 gene significantly impact plasma lipid levels and the severity of CAD in the general population. They have now identified several SNPs in non-coding regions of ABCA1 which may be important for the appropriate regulation of ABCA1 expression (i.e. in the promoter, intron 1 and the 5′ untranslated region), and have examined the phenotypic effects of these SNPs in the REGRESS population. Out of 12 SNPs, four were associated with a clinical outcome. A threefold increase in coronary events with an increased family history of CAD was evident for the G-191C variant. Similarly, the C69T SNP was associated with a twofold increase in events. In contrast, the C-17G was associated with a decrease in coronary events and the InsG319 was associated with less atherosclerosis. For all these SNPs, the changes in atherosclerosis and CAD occurred without detectable changes in plasma lipid levels. These data suggest that common variation in non-coding regions of ABCA1 may significantly alter the severity of atherosclerosis, without necessarily influencing plasma lipid levels. [less ▲]

ABCDE Tutorial LuxLogAI 2018 - Default entailment course

Scientific Conference (2018)

Abel-Preis an Mathematiker Lennart Carleson

Article for general public (2006)

Abelian varieties over finitely generated fields and the conjecture of Geyer and Jarden on torsion

in Mathematische Nachrichten (2013), 286(13), 1269-1286

In this paper we prove the Geyer-Jarden conjecture on the torsion part of the Mordell-Weil group for a large class of abelian varieties defined over finitely generated fields of arbitrary characteristic ... [more ▼]

In this paper we prove the Geyer-Jarden conjecture on the torsion part of the Mordell-Weil group for a large class of abelian varieties defined over finitely generated fields of arbitrary characteristic. The class consists of all abelian varieties with big monodromy, i.e., such that the image of Galois representation on l-torsion points, for almost all primes l, contains the full symplectic group. [less ▲]

Abelian varieties with tame and surjective Galois representations

Scientific Conference (2013, August)

Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-kappaB signaling.

in Leukemia (2017), 32(1), 72-82

The pathogenesis of chronic lymphocytic leukemia (CLL) has been linked to constitutive NF-kappaB activation but the underlying mechanisms are poorly understood. Here we show that alternative splicing of ... [more ▼]

The pathogenesis of chronic lymphocytic leukemia (CLL) has been linked to constitutive NF-kappaB activation but the underlying mechanisms are poorly understood. Here we show that alternative splicing of the negative regulator of NF-kappaB and tumor suppressor gene CYLD regulates the pool of CD5(+) B cells through sustained canonical NF-kappaB signaling. Reinforced canonical NF-kappaB activity leads to the development of B1 cell-associated tumor formation in aging mice by promoting survival and proliferation of CD5(+) B cells, highly reminiscent of human B-CLL. We show that a substantial number of CLL patient samples express sCYLD, strongly implicating a role for it in human B-CLL. We propose that our new CLL-like mouse model represents an appropriate tool for studying ubiquitination-driven canonical NF-kappaB activation in CLL. Thus, inhibition of alternative splicing of this negative regulator is essential for preventing NF-kappaB-driven clonal CD5(+) B-cell expansion and ultimately CLL-like disease. [less ▲]

The ability to read numbers: A universal measure?

in AERA (2018)

This study tests the hypothesis that there is a single pathway for the order in which children learn to identify numbers. Although a prime facie case can be made, systematic variation might be expected ... [more ▼]

This study tests the hypothesis that there is a single pathway for the order in which children learn to identify numbers. Although a prime facie case can be made, systematic variation might be expected because of teaching, or language of instruction, or country of origin. This study concludes that such variations are minor and that the pathway that children follow when learning to identify numbers follows the same pattern across different groups. This finding is significant in furthering our knowledge of children’s early mathematics development; it suggests that there is a universal developmental scale from which the diverse aspects of mathematical development can be viewed. This lays the foundation for international comparisons of the mathematical development of young children. [less ▲]

L'abolition de l'esclavage fête ses 130 ans au Brésil...

Article for general public (2018)