Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailSpezifität der Körperbildstörung für Anorexia nervosa
Rost, Silke UL; Jaite, Charlotte; Sarrar, Lea et al

Poster (2013, May 10)

Detailed reference viewed: 84 (6 UL)
Peer Reviewed
See detailSpezifität der Körperbildstörung für Anorexia nervosa
Rost, Silke UL; Jaite, Charlotte; Sarrar, Lea et al

Scientific Conference (2013, March 09)

Detailed reference viewed: 60 (1 UL)
Full Text
Peer Reviewed
See detailSpherical CR Dehn surgeries
Acosta, Miguel UL

in Pacific Journal of Mathematics (2016), 284(2), 257-282

Consider a three dimensional cusped spherical CR manifold M and suppose that the holonomy representation of $\pi_1(M)$ can be deformed in such a way that the peripheral holonomy is generated by a non ... [more ▼]

Consider a three dimensional cusped spherical CR manifold M and suppose that the holonomy representation of $\pi_1(M)$ can be deformed in such a way that the peripheral holonomy is generated by a non-parabolic element. We prove that, in this case, there is a spherical CR structure on some Dehn surgeries of M. The result is very similar to R. Schwartz's spherical CR Dehn surgery theorem, but has weaker hypotheses and does not give the uniformizability of the structure. We apply our theorem in the case of the Deraux-Falbel structure on the Figure Eight knot complement and obtain spherical CR structures on all Dehn surgeries of slope $-3 + r$ for $r \in \mathbb{Q}^{+}$ small enough. [less ▲]

Detailed reference viewed: 53 (1 UL)
Full Text
Peer Reviewed
See detailSpherical CR uniformization of Dehn surgeries of the Whitehead link complement
Acosta, Miguel UL

in Geometry and Topology (2019), 23(5), 25932664

We apply a spherical CR Dehn surgery theorem in order to obtain infinitely many Dehn surgeries of the Whitehead link complement that carry spherical CR structures. We consider as a starting point the ... [more ▼]

We apply a spherical CR Dehn surgery theorem in order to obtain infinitely many Dehn surgeries of the Whitehead link complement that carry spherical CR structures. We consider as a starting point the spherical CR uniformization of the Whitehead link complement constructed by Parker and Will, using a Ford domain in the complex hyperbolic plane H2C. We deform the Ford domain of Parker and Will in H2C in a one-parameter family. On one side, we obtain infinitely many spherical CR uniformizations on a particular Dehn surgery on one of the cusps of the Whitehead link complement. On the other side, we obtain spherical CR uniformizations for infinitely many Dehn surgeries on the same cusp of the Whitehead link complement. These manifolds are parametrized by an integer n≥4, and the spherical CR structure obtained for n=4 is the Deraux–Falbel spherical CR uniformization of the figure eight knot complement. [less ▲]

Detailed reference viewed: 134 (3 UL)
Full Text
Peer Reviewed
See detailSphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells
Orsini, Marion; Chateauvieux, Sebastien; Rhim, Jiyun et al

in Cell Death and Differentiation (2019), 26(9), 17961812

Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent ... [more ▼]

Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34+ hematopoietic stem/progenitor cells (CD34/HSPCs) from healthy donors. Exogenous synthetic C2- and C6-ceramide as well as bacterial SMase inhibited erythroid differentiation in erythropoietin-induced (Epo)CD34/HSPCs shown by the analysis of various erythroid markers. The neutral SMase inhibitor GW4869 as well as the genetic inhibition of nSMase with small interfering RNA (siRNA) against sphingomyelin phosphodiesterase 3 (SMPD3) prevented the inhibition by TNFα, but not the acid SMase inhibitor desipramine. Moreover, sphingosine-1-phosphate (S1P), a ceramide metabolite, restored erythroid differentiation, whereas TNFα inhibited sphingosine kinase-1, required for S1P synthesis. Analysis of cell morphology and colony formation demonstrated that erythropoiesis impairment was concomitant with a granulomonocytic differentiation in TNFα- and ceramide-treated EpoCD34/HSPCs. Inhibition of erythropoiesis and induction of granulomonocytic differentiation were correlated to modulation of hematopoietic transcription factors (TFs) GATA-1, GATA-2, and PU.1. Moreover, the expression of microRNAs (miR)-144/451, miR-146a, miR-155, and miR-223 was also modulated by TNFα and ceramide treatments, in line with cellular observations. Autophagy plays an essential role during erythropoiesis and our results demonstrate that the TNFα/neutral SMase/ceramide pathway inhibits autophagy in EpoCD34/HSPCs. TNFα- and ceramide-induced phosphorylation of mTORS2448 and ULK1S758, inhibited Atg13S355 phosphorylation, and blocked autophagosome formation as shown by transmission electron microscopy and GFP-LC3 punctae formation. Moreover, rapamycin prevented the inhibitory effect of TNFα and ceramides on erythropoiesis while inhibiting induction of myelopoiesis. In contrast, bafilomycin A1, but not siRNA against Atg5, induced myeloid differentiation, while both impaired erythropoiesis. We demonstrate here that the TNFα/neutral SMase/ceramide pathway inhibits erythropoiesis to induce myelopoiesis via modulation of a hematopoietic TF/miR network and inhibition of late steps of autophagy. Altogether, our results reveal an essential role of autophagy in erythroid vs. myeloid differentiation. [less ▲]

Detailed reference viewed: 21 (0 UL)
Full Text
Peer Reviewed
See detailSphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9
Schenten, Véronique UL; Melchior, Chantal UL; Steinckwich, Nathalie et al

in Journal of Leukocyte Biology (2011), 89(4), 587-596

Neutrophils play a fundamental role in host defense by neutralizing pathogens through the generation of ROS by NOX2. In nonexcitable cells, Ca(2+) influx is essentially mediated via SOCE, a complex ... [more ▼]

Neutrophils play a fundamental role in host defense by neutralizing pathogens through the generation of ROS by NOX2. In nonexcitable cells, Ca(2+) influx is essentially mediated via SOCE, a complex mechanism in which depletion of intracellular Ca(2+) stores from the ER results in Ca(2+) entry through Ca(2+) SOCs at the plasma membrane. In this regard, it is well established that extracellular Ca(2+) entry participates to NOX2 activation. S1P, produced by SphKs, has been involved in Ca(2+) homeostasis and thus, could intervene in NOX2 regulation. The aim of this study was to characterize the importance of SphKs in NOX2 activation and the signaling cascade involved in this mechanism. Treatment of neutrophil-like dHL-60 cells by DHS, a SphK inhibitor, and SphK siRNA inhibited fMLF-induced NOX2 activity. Sequential activation of cells by thapsigargin and the phorbol ester PMA revealed that SphK-regulated NOX2 activity relies on intracellular Ca(2+) store depletion. Confocal microscopy and immunoblot analysis showed that stimulation by thapsigargin and PMA mediated S100A8/A9 recruitment to the plasma membrane and p38 MAPK activation. S100A8/A9 translocation decreased when SphK activity was blocked. This result was confirmed in purified human neutrophils, which were physiologically stimulated by fMLF. In addition, p38 MAPK was found to be regulated by SphKs. These results define a pathway leading to NOX2 activation, in which p38 MAPK-mediated S100A8/A9 translocation is regulated by Ca(2+) store depletion-dependent SphK activation. [less ▲]

Detailed reference viewed: 90 (3 UL)
See detailSpiel in der Grundschule: Multiple Funktionen - maßgebliche Aufgaben
Andersen, Katja Natalie UL; Schwander, Michael Wolfgang

Book published by Klinkhardt (2005)

Detailed reference viewed: 90 (3 UL)
See detailSpiel und Erkenntnis in der Grundschule: Theorie - Empirie - Konzepte
Andersen, Katja Natalie UL

Book published by Kohlhammer (2016)

Während der Kindergarten eine selbstverständliche Domäne des kindlichen Spiels darstellt, ist die Bedeutung des Spiels in der Grundschule als produktives Element der Didaktik des Unterrichts bis heute ... [more ▼]

Während der Kindergarten eine selbstverständliche Domäne des kindlichen Spiels darstellt, ist die Bedeutung des Spiels in der Grundschule als produktives Element der Didaktik des Unterrichts bis heute kaum ins Blickfeld getreten. Das Buch fragt nach der Bedeutung des Spiels in der Schule und nach Spielformen, die sich produktiv im Unterricht einsetzen lassen. Es führt dafür das theoretische Wissen über die Struktur des Spiels mit dem Wissen um die kindliche Erkenntnistätigkeit im Rahmen einer qualitativ-empirischen Studie zusammen und entwickelt Grundsätze der Unterrichtsgestaltung in der Grundschule, um Elemente des Spielens und Erkennens im Unterricht zu verknüpfen. [less ▲]

Detailed reference viewed: 144 (9 UL)
See detailSpiel und Zufall in G.E. Lessings ‘Lustspiel’ Minna von Barnhelm
Küpper, Achim UL

Presentation (2010)

Detailed reference viewed: 11 (0 UL)
See detailSpiel und Zufall in Gotthold Ephraim Lessings ‘Lustspiel’ Minna von Barnhelm.
Küpper, Achim UL

in Gerrekens, Louis; Küpper, Achim (Eds.) Hasard. Der Spieler in der deutschsprachigen Literaturgeschichte. (2012)

Detailed reference viewed: 20 (0 UL)
Full Text
See detailSpiel-Werke. Perspektiven auf literarische Spiele und Games
Sieburg, Heinz UL; Amann, Wilhelm UL

Book published by transcript (2020)

Detailed reference viewed: 54 (4 UL)
Full Text
See detailSpielen mit Gewalt - Gewalt in digitalen Spielen
Melzer, André UL

in Gudehus, C.; Christ, M. (Eds.) Gewalt. Ein interdisziplinäres Handbuch (2013)

Detailed reference viewed: 47 (2 UL)
See detailSpielen Vorurteile im Fremdsprachenunterricht eine positive Rolle?
Hu, Adelheid UL

in Bredella, L. (Ed.) Verstehen und Verständigung durch Sprachenlernen? Dokumentation des 15. Kongresses für Fremdsprachendidaktik, veranstaltet von der DGFF vom 4.-6. Oktober 1993 in Giessen (1995)

Detailed reference viewed: 254 (1 UL)
See detailSpielerischer Umgang mit Schrift und Sprache: Zugänge zum kreativen Schreiben
Andersen, Katja Natalie UL

in Praxis Grundschule (2010), 33(1), 43-45

Detailed reference viewed: 96 (3 UL)
See detailSpielzeugwelten
Andersen, Katja Natalie UL

in Duncker, Ludwig; Lieber, Gabriele (Eds.) Bildung in der Kindheit: Handbuch zum ästhetischen Lernen für Kindergarten und Grundschule (2009)

Detailed reference viewed: 38 (2 UL)
Full Text
Peer Reviewed
See detailSpillovers to small business credit risk
Wolff, Christian UL

in Small Business Economics (2020)

Do large credit risk shocks spill over to small businesses and affect their real economic activity? Using information on small business credit risk, we find that small businesses show increased default ... [more ▼]

Do large credit risk shocks spill over to small businesses and affect their real economic activity? Using information on small business credit risk, we find that small businesses show increased default and bankruptcy rates following a shock to a customer industry. On an industry level, the shock to a customer industry is followed by a decrease in industry markups, disproportionate closure of firms, and cutbacks in inventories. Our analysis quantifies the elevated credit risk among small businesses and suggests a non-negligible 0.83% increase in expected losses on a diversified loan portfolio following a credit risk shock. This study provides banks and supervisors with greater clarity on timing and on the extent of elevated small business credit risk. It also allows them to assess the exposure of a bank portfolio to fluctuations in small business default rate. Such improved default prediction reduces credit rationing to the small business economy. [less ▲]

Detailed reference viewed: 53 (2 UL)
Full Text
See detailSpillovers to small business credit risk
Wolff, Christian UL

Report (2019)

Detailed reference viewed: 42 (6 UL)