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See detailSTIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells
Bréchard, Sabrina UL; Plançon, Sébastien UL; Melchior, Chantal UL et al

in Biochemical Pharmacology (2009), 78(5), 504-513

Extracellular Ca2+ entry, primarily mediated through store-operated Ca2+ entry (SOCE), is known to be a critical event for NADPH oxidase (NOX2) regulation in neutrophils. While defective NOX2 activity has ... [more ▼]

Extracellular Ca2+ entry, primarily mediated through store-operated Ca2+ entry (SOCE), is known to be a critical event for NADPH oxidase (NOX2) regulation in neutrophils. While defective NOX2 activity has been linked to various inflammatory diseases, regulatory mechanisms that control Ca2+ influx-induced NOX2 activation are poorly understood in SOCE. The role of STIM1, a Ca2+ sensor that transduces the store depletion signal to the plasma membrane, seems well established and supported by numerous studies in non-phagocytic cells. Here, in neutrophil-like HL-60 cells we used a siRNA approach to delineate the effect of STIM1 knock-down on NOX2 activity regulated by Ca2+ influx. Because the function of the STIM1 homolog, STIM2, is still unclear, we determined the consequence of STIM2 knock-down on Ca2+ and NOX2. STIM1 and STIM2 knock-down was effective and isoform specific when assayed by real-time PCR and Western blotting. Consistent with a unique role of STIM1 in the regulation of SOCE, STIM1, but not STIM2, siRNA significantly decreased Ca2+ influx induced by fMLF or the SERCA pump inhibitor thapsigargin. A redistribution of STIM1, originally localized intracellularly, near the plasma membrane was observed by confocal microscopy upon stimulation by fMLF. Inhibition of STIM1-induced SOCE led to a marked decrease in NOX2 activity while STIM2 siRNA had no effect. Thus, our results provide evidence for a role of STIM1 protein in the control of Ca2+ influx in neutrophils excluding a STIM2 involvement in this process. It also places STIM1 as a key modulator of NOX2 activity with a potential interest for anti-inflammatory pharmacological development. [less ▲]

Detailed reference viewed: 102 (4 UL)
See detailStimme - Präsenz - Medialität : Dekonstruktion und Medientheorie
Kohns, Oliver UL

in Mein, Georg; Sieburg, Heinz (Eds.) Medien des Wissens : Interdisziplinäre Aspekte von Medialität (2011)

Detailed reference viewed: 107 (4 UL)
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See detailThe stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
Schlomann, Uwe; Schwamborn, Jens Christian UL; Muller, Myriam et al

in Journal of Cell Science (2009), 122(Pt 12), 2034-42

The rate and direction of axon and dendrite growth depend on multiple guidance signals and growth factors. Semaphorin 3A (Sema3A) acts as a repellent for axons and attractant for dendrites. Here, we show ... [more ▼]

The rate and direction of axon and dendrite growth depend on multiple guidance signals and growth factors. Semaphorin 3A (Sema3A) acts as a repellent for axons and attractant for dendrites. Here, we show that the requirement for integrin engagement distinguishes the response of axons and dendrites to Sema3A in hippocampal neurons. Sema3A promotes the extension of hippocampal dendrites by a pathway that requires focal adhesion kinase (FAK). The stimulation of dendrite growth and FAK phosphorylation by Sema3A depend on integrin engagement. Unlike their function as a target of Sema3A during the collapse of axonal growth cones, integrins facilitate the stimulation of dendrite extension. Conditional inactivation of the genes encoding beta1 integrin or FAK blocks the growth-promoting effect of Sema3A but not the collapse of axonal growth cones. Our results demonstrate that different pathways mediate the stimulation of dendrite growth and the collapse of axonal growth cones by Sema3A. [less ▲]

Detailed reference viewed: 107 (1 UL)
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See detailStimulus und Kognition : Zur Aktivierung mentaler Raumbilder
Lameli, Alfred; Purschke, Christoph UL; Kehrein, Roland

in Linguistik Online (2008), 35(3/08), 55-86

Detailed reference viewed: 50 (1 UL)
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See detailStimulus-dependent modulation of visual neglect in a touch-screen cancellation task
Keller, Ingo; Volkening, Katharina; Müller, Ruta UL

in Neuropsychology (2015), 29(3), 417-420

Objective: Patients with left-sided neglect frequently show omissions and repetitive behavior on cancellation tests. Using a touch-screen-based cancellation task, we tested how visual feedback and ... [more ▼]

Objective: Patients with left-sided neglect frequently show omissions and repetitive behavior on cancellation tests. Using a touch-screen-based cancellation task, we tested how visual feedback and distracters influence the number of omissions and perseverations. Method: Eighteen patients with left-sided visual neglect and 18 healthy controls performed four different cancellation tasks on an iPad touch screen: no feedback (the display did not change during the task), visual feedback (touched targets changed their color from black to green), visual feedback with distracters (20 distracters were evenly embedded in the display; detected targets changed their color from black to green), vanishing targets (touched targets disappeared from the screen). Results: Except for the condition with vanishing targets, neglect patients had significantly more omissions and perseverations than healthy controls in the remaining three subtests. Both conditions providing feedback by changing the target color showed the highest number of omissions. Erasure of targets nearly diminished omissions completely. The highest rate of perseverations was observed in the no-feedback condition. The implementation of distracters led to a moderate number of perseverations. Visual feedback without distracters and vanishing targets abolished perseverations nearly completely. Conclusions: Visual feedback and the presence of distracters aggravated hemispatial neglect. This finding is compatible with impaired disengagement from the ipsilesional side as an important factor of visual neglect. Improvement of cancellation behavior with vanishing targets could have therapeutic implications. [less ▲]

Detailed reference viewed: 52 (0 UL)
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See detailStimuluseffekte und Sprachraumkonzepte
Kehrein, Roland; Lameli, Alfred; Purschke, Christoph UL

in Anders, Christina; Hundt, Markus; Lasch, Alexander (Eds.) Perceptual Dialectology - Neue Wege der Dialektologie (2010)

Detailed reference viewed: 82 (0 UL)
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See detailSTIT based deontic logics for the miners puzzle
Sun, Xin UL; Zohreh, Baniasadi

in 12th European Conference on Multi-Agent Systems (2014)

Detailed reference viewed: 79 (8 UL)
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See detailStochastic Analysis of Dead-time Systems using a Hybrid Spectral Method
Duong, Pham UL

in International Journal of Control, Automation, and Systems (2015), 13(5),

Abstract: Control systems often operate in the presence of dead-time. However, in most works, these dead-time systems are studied in a deterministic manner, which have low precision and reliability. Many ... [more ▼]

Abstract: Control systems often operate in the presence of dead-time. However, in most works, these dead-time systems are studied in a deterministic manner, which have low precision and reliability. Many natural systems often suffer stochastic noise that causes fluctuations in their behavior, making their responses deviate from nominal models. Therefore, it is important to investigate such statistical characteristic of states (mean, variance, etc.) for those stochastic systems. This problem is often called statistical analysis of a system. A hybrid spectral method represents a powerful numerical tool for sta- tistical analysis of stochastic linear system. Thus, a hybrid spectral technique is proposed for statistical analysis of the time delay system under affections of random parameters and inputs. Numerical exam- ples are considered to demonstrate the validity of the proposed method. Comparison with the tradition- al Monte-Carlo and the polynomial chaos methods is made to demonstrate the computationally less- demanding feature of the proposed method. [less ▲]

Detailed reference viewed: 72 (2 UL)
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See detailA Stochastic Analysis of Table Tennis
Dominicy, Yves; Ley, Christophe; Swan, Yvik UL

in Brazilian Journal of Probability and Statistics (2013), to appear

Detailed reference viewed: 65 (0 UL)
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See detailA stochastic approach to a priori estimates and Liouville theorems for harmonic maps
Thalmaier, Anton UL; Wang, Feng-Yu

in Bulletin des Sciences Mathématiques (2011), 135(6-7), 816-843

Nonlinear versions of Bismut type formulas for the differential of a harmonic map between Riemannian manifolds are used to establish a priori estimates for harmonic maps. A variety of Liouville type ... [more ▼]

Nonlinear versions of Bismut type formulas for the differential of a harmonic map between Riemannian manifolds are used to establish a priori estimates for harmonic maps. A variety of Liouville type theorems is shown to follow as corollaries from such estimates by exhausting the domain through an increasing sequence of geodesic balls. This probabilistic method is well suited for proving sharp estimates under various curvature conditions. We discuss Liouville theorems for harmonic maps under the following conditions: small image, sublinear growth, non-positively curved targets, generalized bounded dilatation, Liouville manifolds as domains, certain asymptotic behaviour. [less ▲]

Detailed reference viewed: 208 (17 UL)
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See detailA stochastic approach to the harmonic map heat flow on manifolds with time-dependent Riemannian metric
Guo, Hongxin UL; Philipowski, Robert UL; Thalmaier, Anton UL

in Stochastic Processes and their Applications (2014), 124(11), 3535-3552

We first prove stochastic representation formulae for space–time harmonic mappings defined on manifolds with evolving Riemannian metric. We then apply these formulae to derive Liouville type theorems ... [more ▼]

We first prove stochastic representation formulae for space–time harmonic mappings defined on manifolds with evolving Riemannian metric. We then apply these formulae to derive Liouville type theorems under appropriate curvature conditions. Space–time harmonic mappings which are defined globally in time correspond to ancient solutions to the harmonic map heat flow. As corollaries, we establish triviality of such ancient solutions in a variety of different situations. [less ▲]

Detailed reference viewed: 251 (29 UL)
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See detailStochastic calculus of variations in mathematical finance
Malliavin, Paul; Thalmaier, Anton UL

Book published by Springer-Verlag (2006)

Detailed reference viewed: 209 (13 UL)
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See detailStochastic completeness and gradient representations for sub-Riemannian manifolds
Grong, Erlend; Thalmaier, Anton UL

in Potential Analysis (2019), 51(2), 219-254

Given a second order partial differential operator L satisfying the strong Hörmander condition with corresponding heat semigroup P_t, we give two different stochastic representations of dP_t f for a ... [more ▼]

Given a second order partial differential operator L satisfying the strong Hörmander condition with corresponding heat semigroup P_t, we give two different stochastic representations of dP_t f for a bounded smooth function f. We show that the first identity can be used to prove infinite lifetime of a diffusion of L/2, while the second one is used to find an explicit pointwise bound for the horizontal gradient on a Carnot group. In both cases, the underlying idea is to consider the interplay between sub-Riemannian geometry and connections compatible with this geometry. [less ▲]

Detailed reference viewed: 258 (53 UL)
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See detailA Stochastic Cyber-Attack Detection Scheme for Stochastic Control Systems Based on Frequency-Domain Transformation Technique
Li, Yumei UL; Voos, Holger UL; Darouach, Mohamed

in Au, Man ho (Ed.) International Conference on Network and System Security, NSS 2014, Xi'An, China, 15-17 October 2014 (2014, October 15)

Based on frequency-domain transformation technique, this paper proposes an attack detection scheme for stochastic control systems under stochastic cyber-attacks and disturbances. The focus is on designing ... [more ▼]

Based on frequency-domain transformation technique, this paper proposes an attack detection scheme for stochastic control systems under stochastic cyber-attacks and disturbances. The focus is on designing an anomaly detector for the stochastic control systems. First, we construct a model of stochastic control system with stochastic cyber-attacks which satisfy the Markovian stochastic process. And we also introduced the stochastic attack models that a control system is possibly exposed to. Next, based on the frequency-domain transformation technique and linear algebra theory, we propose an algebraic detection scheme for a possible stochastic cyber-attack. We transform the detector error dynamic equation into an algebraic equation. By analyzing the rank of the stochastic matrix E(Q (z0)) in the algebraic equation, residual information is obtained and anomalies in the stochastic system are detected. In addition, sufficient and necessary conditions guaranteeing the detectability of the stochastic cyber-attacks are obtained. The presented detection approach in this paper is simple, straightforward and more ease to implement. Finally, the results are applied to some physical systems that are respectively subject to a stochastic data denial-of-service (DoS) attack and a stochastic data deception attack on the actuator. The simulation results underline that the detection approach is efficient and feasible in practical application. [less ▲]

Detailed reference viewed: 136 (9 UL)
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See detailStochastic cyber-attacks estimation for nonlinear control systems based on robust H∞ filtering technique
Yumei, Li UL; Voos, Holger UL; Pan, Lin UL et al

in Control and Decision Conference (CCDC), 2015 27th Chinese (2015, May 23)

Detailed reference viewed: 106 (16 UL)
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See detailStochastic derivatives for fractional diffusions
Darses, Sébastien; Nourdin, Ivan UL

in Annals of Probability (2007), 35(5), 1998-2020

Detailed reference viewed: 69 (7 UL)
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See detailStochastic differential equations with coefficients in Sobolev spaces
Fang, Shizan; Luo, Dejun; Thalmaier, Anton UL

in Journal of Functional Analysis (2010), 259(5), 1129-1168

Detailed reference viewed: 217 (4 UL)