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See detailAbsence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.
Guo, Chun; Willem, Michael; Werner, Alexander et al

in Human molecular genetics (2006), 15(6), 989-98

Both the dystrophin-glycoprotein complex and alpha7beta1 integrin have critical roles in the maintenance of muscle integrity via the provision of mechanical links between muscle fibres and the basement ... [more ▼]

Both the dystrophin-glycoprotein complex and alpha7beta1 integrin have critical roles in the maintenance of muscle integrity via the provision of mechanical links between muscle fibres and the basement membrane. Absence of either dystrophin or alpha7 integrin results in a muscular dystrophy. To clarify the role of alpha7 integrin and dystrophin in muscle development and function, we generated integrin alpha7/dystrophin double-mutant knockout (DKO) mice. Surprisingly, DKO mice survived post-natally and were indistinguishable from wild-type, integrin alpha7-deficient and mdx mice at birth, but died within 24-28 days. Histological analysis revealed a severe muscular dystrophy in DKO mice with endomysial fibrosis and ectopic calcification. Weight loss was correlated with the loss of muscle fibres, indicating that progressive muscle wasting in the double mutant was most likely due to inadequate muscle regeneration. The data further support that premature death of DKO mice is due to cardiac and/or respiratory failure. The integrin alpha7/dystrophin-deficient mouse model, therefore, resembles the pathological changes seen in Duchenne muscular dystrophy and suggests that the different clinical severity of dystrophin deficiency in human and mouse may be due to a fine-tuned difference in expression of dystrophin and integrin alpha7 in both species. Together, these findings indicate an essential role for integrin alpha7 in the maintenance of dystrophin-deficient muscles. [less ▲]

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See detailAbsence of Low-Level Visual Difference Between Canonical and Noncanonical Finger-Numeral Configurations
Di Luca, Samuel UL; Pesenti, Mauro

in Experimental Psychology (2010), 507(3), 202-07

Canonical finger numeral configurations are named faster than less familiar finger configurations and activate a semantic place-coding representation as symbolic stimuli. However, this does not exclude ... [more ▼]

Canonical finger numeral configurations are named faster than less familiar finger configurations and activate a semantic place-coding representation as symbolic stimuli. However, this does not exclude categorically the possibility that mere visuo-perceptual differences between canonical and noncanonical finger configurations may induce differences in processing speed. This study capitalizes on the fact that, in typical visual-detection tasks, participants focus on low-level visuo-perceptual features to detect a target among distractors sharing the same high-level semantic features, producing the so-called pop-out effect. Participants had to decide whether a canonical finger configuration was present among a set of distractors expressing the same numerosity in a noncanonical way. The results showed that the time needed to detect the presence of the target grew linearly with the number of distractors. This indicates that the canonical target enjoyed no perceptual saliency among the noncanonical configurations (i.e., no pop-out effect) excluding visuo-perceptual differences as the source of the better identification of and semantic access of canonical configurations. [less ▲]

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See detailAbsence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Ashrafi, Amer UL; Garcia, Pierre UL; Kollmus, Heike et al

in Neurobiology of Aging (2017), 58

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy ... [more ▼]

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy and Parkinson’s disease (PD). In the case of PD, the main current option for alleviating motor symptoms are dopamine replacement therapies, which have limitations because of side effects, and reduced effectiveness over the long term. Research on new non-dopaminergic PD drug targets has indicated that inhibition of RGS4 could be an effective adjuvant treatment option. The effectiveness of RGS4 inhibition for an array of PD-linked functional and structural neuroprotection endpoints has not yet been demonstrated. Here, we use the 6-Hydroxydopamine (6-OHDA) lesioning model of the nigrostriatal pathway in mice to address this question. We observe, using a battery of behavioral and pathological measures, that mice deficient for RGS4 are not protected from 6-OHDA induced injury, and show enhanced susceptibility in some measures of motor function. Our results suggest that inhibition of RGS4 as a non-dopaminergic target for PD should be approached with caution. [less ▲]

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See detailAbsence of strong skew scattering in crystals with multi-sheeted Fermi surfaces
Hönemann, Albert; Herschbach, Christian; Fedorov, Dmitry UL et al

in Journal of Physics: Condensed Matter (2019), 31

We consider an extrinsic contribution to the anomalous and spin Hall effect in dilute alloys based on Fe, Co, Ni, and Pt hosts with different substitutional impurities. It is shown that a strong skew ... [more ▼]

We consider an extrinsic contribution to the anomalous and spin Hall effect in dilute alloys based on Fe, Co, Ni, and Pt hosts with different substitutional impurities. It is shown that a strong skew-scattering mechanism is absent in such crystals with multi-sheeted Fermi surfaces. Based on this finding, we conclude on the mutual exclusion of strong intrinsic and skew-scattering contributions to the considered transport phenomena. It also allows us to draw general conclusions in which materials with a giant anomalous Hall effect caused by the skew scattering can be achieved. [less ▲]

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See detailThe Absent Character of Gene in Hanif Kureishi's The Buddha of Suburbia
Weber, Jean-Jacques UL

in Notes on Contemporary Literature (2001), 31

Detailed reference viewed: 143 (4 UL)
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See detailAbsolute continuity and convergence of densities for random vectors on Wiener chaos
Nourdin, Ivan UL; Nualart, David; Poly, Guillaume Joseph UL et al

in Electronic Journal of Probability (2013), 18(22), 1--19

Detailed reference viewed: 70 (2 UL)
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See detailAbsolute flow field estimation for the Nordic seas from combined gravimetric, altimetric, and in situ data
Hunegnaw, Addisu UL; Siegismund, Frank; Hipkin, Roger et al

in Journal of Geophysical Research. Oceans (2009), 114(C2),

Detailed reference viewed: 34 (4 UL)
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See detailAbsolute Free Energies for Biomolecules in Implicit or Explicit Solvent
Berryman, Josh UL; Schilling, Tanja UL

in Physics Procedia (2014), 57

Detailed reference viewed: 165 (16 UL)
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See detailAbsolute Gravity Measurements at LNE
Merlet, Sébastien; Francis, Olivier UL; Palinkas, Vjotech et al

in Peshekhonov, Vladimir (Ed.) Proceedings of the International Symposium on Terrestrial Gravimetry: static and mobile measurements (2008)

Detailed reference viewed: 71 (1 UL)
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See detailAbsolute gravity measurements at the Conrad Observatory by the University of Luxembourg
Francis, Olivier UL

Article for general public (2014)

Detailed reference viewed: 133 (11 UL)
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See detailAbsolute gravity measurements in Belgium: a tool for geodynamic interpretation
Van Camp, Michel; Francis, Olivier UL; Camelbeeck, Thierry

in Degryse, Patrick; Sintubin, Manuel (Eds.) Contributions to the Geology of Belgium and Northwest Europe (2002)

Detailed reference viewed: 45 (2 UL)