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See detailA Novel Model-Predictive Cruise Controller for Electric Vehicles and Energy-Efficient Driving
Schwickart, Tim Klemens UL; Voos, Holger UL; Minaglou, Jean-Régis UL et al

in A Novel Model-Predictive Cruise Controller for Electric Vehicles and Energy-Efficient Driving (2014, July)

This paper presents a novel energy-efficient model-predictive cruise control formulation for electric vehicles. A predictive eco-cruise controller involves the minimisation of a compromise between terms ... [more ▼]

This paper presents a novel energy-efficient model-predictive cruise control formulation for electric vehicles. A predictive eco-cruise controller involves the minimisation of a compromise between terms related to driving speed and energy consumption which are in general both described by nonlinear differential equations. In this work, a coordinate transformation is used which leads to a linear differential motion equation without loss of information. The energy consumption is modeled by the maximum of a set of linear functions which is determined implicitly by the optimisation problem and thus leads to a piecewise linear model. The reformulations finally result in a model-predictive control approach with quadratic cost function, linear prediction model and linear constraints that corresponds to a piecewise linear system behaviour and allows a fast real-time implementation with guaranteed convergence. The controller and the underlying dynamic model are designed to meet the properties of a series-production electric vehicle whose characteristics are identified by measurements. Simulation results of the MPC controller and the simulation model in closed-loop operation finally provide a proof of concept. [less ▲]

Detailed reference viewed: 196 (17 UL)
See detailNovel MSM-2DEG PD/HEMT Photoreceiver for 10 Gbit/s Operation
Horstmann, M.; Muttersbach, J.; v.d.Hart, A. et al

in Proceedings of the 26th European Solid State Devices Research Conference, Bologna, Italy (1996)

Detailed reference viewed: 21 (0 UL)
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See detailA Novel Multi-objectivisation Approach for Optimising the Protein Inverse Folding Problem
Nielsen, Sune Steinbjorn UL; Danoy, Grégoire UL; Jurkowski, Wiktor et al

in Applications of Evolutionary Computation: 18th European Conference, EvoApplications 2015, Copenhagen, Denmark, April 8-10, 2015, Proceedings (2015)

In biology, the subject of protein structure prediction is of continued interest, not only to chart the molecular map of the living cell, but also to design proteins of new functions. The Inverse Folding ... [more ▼]

In biology, the subject of protein structure prediction is of continued interest, not only to chart the molecular map of the living cell, but also to design proteins of new functions. The Inverse Folding Problem (IFP) is in itself an important research problem, but also at the heart of most rational protein design approaches. In brief, the IFP consists in finding sequences that will fold into a given structure, rather than determining the structure for a given sequence - as in conventional structure prediction. In this work we present a Multi Objective Genetic Algorithm (MOGA) using the diversity-as-objective (DAO) variant of multi-objectivisation, to optimise secondary structure similarity and sequence diversity at the same time, hence pushing the search farther into wide-spread areas of the sequence solution-space. To control the high diversity generated by the DAO approach, we add a novel Quantile Constraint (QC) mechanism to discard an adjustable worst quantile of the population. This DAO-QC approach can efficiently emphasise exploitation rather than exploration to a selectable degree achieving a trade-off producing both better and more diverse sequences than the standard Genetic Algorithm (GA). To validate the final results, a subset of the best sequences was selected for tertiary structure prediction. The super-positioning with the original protein structure demonstrated that meaningful sequences are generated underlining the potential of this work. [less ▲]

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See detailA Novel Network Integrating a miRNA-203/SNAI1 Feedback Loop which Regulates Epithelial to Mesenchymal Transition.
Moes, Michèle UL; Le Béchec, Antony UL; Crespo, Isaac UL et al

in PLoS ONE (2012), 7(4), 35440

Background: The majority of human cancer deaths are caused by metastasis. The metastatic dissemination is initiated by the breakdown of epithelial cell homeostasis. During this phenomenon, referred to as ... [more ▼]

Background: The majority of human cancer deaths are caused by metastasis. The metastatic dissemination is initiated by the breakdown of epithelial cell homeostasis. During this phenomenon, referred to as epithelial to mesenchymal transition (EMT), cells change their genetic and trancriptomic program leading to phenotypic and functional alterations. The challenge of understanding this dynamic process resides in unraveling regulatory networks involving master transcription factors (e.g. SNAI1/2, ZEB1/2 and TWIST1) and microRNAs. Here we investigated microRNAs regulated by SNAI1 and their potential role in the regulatory networks underlying epithelial plasticity. Results: By a large-scale analysis on epithelial plasticity, we highlighted miR-203 and its molecular link with SNAI1 and the miR-200 family, key regulators of epithelial homeostasis. During SNAI1-induced EMT in MCF7 breast cancer cells, miR-203 and miR-200 family members were repressed in a timely correlated manner. Importantly, miR-203 repressed endogenous SNAI1, forming a double negative miR203/SNAI1 feedback loop. We integrated this novel miR203/SNAI1 with the known miR200/ZEB feedback loops to construct an a priori EMT core network. Dynamic simulations revealed stable epithelial and mesenchymal states, and underscored the crucial role of the miR203/SNAI1 feedback loop in state transitions underlying epithelial plasticity. Conclusion: By combining computational biology and experimental approaches, we propose a novel EMT core network integrating two fundamental negative feedback loops, miR203/SNAI1 and miR200/ZEB. Altogether our analysis implies that this novel EMT core network could function as a switch controlling epithelial cell plasticity during differentiation and cancer progression. [less ▲]

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See detailA novel numerical integration technique over arbitrary polygons
Natarajan, Sundararajan; Mahapatra, D Roy; Bordas, Stéphane UL et al

Scientific Conference (2009, April)

In this paper, a new numerical integration technique [1] on arbitrary polygons is presented. The polygonal do- main is mapped conformally to the unit disk using Schwarz-Christoffel mapping [2] and a ... [more ▼]

In this paper, a new numerical integration technique [1] on arbitrary polygons is presented. The polygonal do- main is mapped conformally to the unit disk using Schwarz-Christoffel mapping [2] and a midpoint quadrature rule defined on the unit circle is used. This method eliminates the need for a two level isoparametric mapping usuall required [3]. Moreover the positivity of the Jacobian is guaranteed. We present numerical results for a few benchmark problems in the context of polygonal finite elements that show the effectiveness of the method. [less ▲]

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See detailNovel Opportunities by Laser Welding of Dissimilar Materials
Schiry, Marc UL; Plapper, Peter UL

in Proceedings of International Conference on Competitive Manufacturing COMA'19 (2019, January)

The Laser Technology Competence Centre (LTCC) of the University of Luxembourg provides skills in joining material combinations, which are considered being non-weld able with traditional methods or at ... [more ▼]

The Laser Technology Competence Centre (LTCC) of the University of Luxembourg provides skills in joining material combinations, which are considered being non-weld able with traditional methods or at least challenging to join (e.g. Copper and Aluminium, Aluminium and Polyamide (PA), Titanium and PEEK, steel and tungsten hard alloy). Related accomplishments include minimal intermetallic compounds, convincing mechanical and superior electrical properties of the laser-welded specimen. With defined spatial and temporal modulation of the laser beam, an accurately defined temperature profile is created on the lower side of the upper material in the two dimensional directions, which enable joining of dissimilar materials in overlap configurations, despite challenging thermal properties. To weld butt-joint geometries with minimal heat affected volume, the temperature profiles were expanded in the third dimension, which can be achieved through controlled laser energy guidance. The scientific methods to accomplish these convincing results are explained, with selected industrial use cases ranging from automotive industry, energy storage, and medical implants. An outlook with unsolved challenges is intended to ignite discussions about upcoming research topics. [less ▲]

Detailed reference viewed: 69 (7 UL)
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See detailA novel optimization approach to estimating kinetic parameters of the enzymatic hydrolysis of corn stover
Qi, Fenglei UL; Wright, Mark

in AIMS Energy (2016), 4(1), 52-67

Detailed reference viewed: 98 (3 UL)
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See detailNovel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
Radtke, S.; Hermanns, H. M.; Haan, Claude UL et al

in Journal of Biological Chemistry (2002), 277(13), 11297-305

The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and ... [more ▼]

The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family. Upon heterologous expression of the OSMR in several cell lines, we observed that its surface expression was significantly enhanced by coexpression of the Janus kinases Jak1, Jak2, and Tyk2 but not Jak3. Chimeric receptors consisting of the extracellular region of the interleukin-5 receptor beta chain and the transmembrane and intracellular part of the OSMR were similarly up-regulated on the plasma membrane when Jak1 was coexpressed. The overall expression level of these constructs did not change significantly, but Jak1 coexpression increased the amount of endoglycosidase H-resistant, fully processed OSMR chimeras. Using mutated receptor and Jak1 constructs, we were able to demonstrate that association of Jak1 with the membrane proximal region of the receptor, but not its kinase activity, is necessary for this effect. Moreover, deletion of the OSMR box1/2 region also resulted in an improved surface expression indicating that this region may contain a signal preventing efficient receptor surface expression in the absence of associated Jaks. Finally we demonstrate that in Jak1-deficient cells, the endogenous OSMR is significantly down-regulated, an effect that can be reversed by transient expression of Jak1 in these cells. [less ▲]

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See detailNovel similarity invariant for space curves using turning angles and its application to object recognition
Aouada, Djamila UL; Krim, Hamid

in IEEE International Conference on Acoustics, Speech and Signal Processing, 2009. ICASSP 2009 (2009)

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See detailNovel SLC9A6 mutations in two families with Christianson syndrome.
Riess, A.; Rossier, E.; Krüger, Rejko UL et al

in Clinical genetics (2013), 83(6), 596-7

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See detailA Novel Stacked Slotted Bow-Tie Antenna Element at 11.7 GHz
Moonshiram, Anusha UL; Marso, Michel UL

in NNGT International Journal on Networking and Communication (2015), 4

This paper reveals a novel stacked slotted bow-tie antenna element with a large bandwidth resonating at 11.7 GHz for satellite TV broadcasts. The simple, cost effective antenna is built on common ... [more ▼]

This paper reveals a novel stacked slotted bow-tie antenna element with a large bandwidth resonating at 11.7 GHz for satellite TV broadcasts. The simple, cost effective antenna is built on common dielectrics and is a layered version of the popular patch antenna. It is shaped in a bow-tie and converted into the slotted version in order to increase the antenna radiating surface. The dual polarized antenna element offers a large directivity of 7.2 dBi in the farfield direction. It is terminated with a coplanar waveguide feedline which is ideal to preserve its large bandwidth in an antenna array configuration. In order to appreciate its results and its design simplicity, a comparison of its S-parameters, radiation patterns, E-fields and H-fields are made with five other popular elements at the center frequency of 11.7 GHz. [less ▲]

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See detailA novel TIMP3 mutation associated with a retinitis pigmentosa-like phenotype
DeBenedictis, Meghan; Gindzin, Yosef; Glaab, Enrico UL et al

in Ophthalmic Genetics (in press)

Sorsby Fundus Dystrophy is an inherited macular degeneration caused by pathogenic variants in the TIMP3 gene. In this study we describe a father and son initially diagnosed with retinitis pigmentosa of ... [more ▼]

Sorsby Fundus Dystrophy is an inherited macular degeneration caused by pathogenic variants in the TIMP3 gene. In this study we describe a father and son initially diagnosed with retinitis pigmentosa of unknown genetic origin. More recent genetic testing of the patients, identified a novel c.410A>G; p.Tyr137Cys variant of uncertain clinical significance in the Tissue Inhibitor of Metalloproteinase-3 (TIMP3) gene. The atypical clinical findings led us to compare the theoretical molecular effects of this variant on the TIMP3 protein structure and interactions with other proteins using homology modeling and machine learning predictions. [less ▲]

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See detailNovel Two-Bit Adaptive Delta Modulation Algorithms
Peric, Zoran; Denic, Bojan; Despotovic, Vladimir UL

in Informatica (2019), 30(1), 117-134

This paper introduces two novel algorithms for the 2-bit adaptive delta modulation, namely 2-bit hybrid adaptive delta modulation and 2-bit optimal adaptive delta modulation. In 2-bit hybrid adaptive ... [more ▼]

This paper introduces two novel algorithms for the 2-bit adaptive delta modulation, namely 2-bit hybrid adaptive delta modulation and 2-bit optimal adaptive delta modulation. In 2-bit hybrid adaptive delta modulation, the adaptation is performed both at the frame level and the sample level, where the estimated variance is used to determine the initial quantization step size. In the latter algorithm, the estimated variance is used to scale the quantizer codebook optimally designed assuming Laplace distribution of the input signal. The algorithms are tested using speech signal and compared to constant factor delta modulation, continuously variable slope delta modulation and instantaneously adaptive 2-bit delta modulation, showing that the proposed algorithms offer higher performance and significantly wider dynamic range. [less ▲]

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See detailA novel two-color photodetector based on an InAlAs-InGaAs HEMT layer structure
Marso, Michel UL; Wolter, M.; Kordoš, P.

in IEEE Photonics Technology Letters (2004), 16 (2004)(11), 2541-2543

The spectral responsivity of an InAlAs–InGaAs metal–semiconductor–metal diode above a two-dimensional electron gas (2DEG) is investigated as a function of the applied bias. At low voltages, only the ... [more ▼]

The spectral responsivity of an InAlAs–InGaAs metal–semiconductor–metal diode above a two-dimensional electron gas (2DEG) is investigated as a function of the applied bias. At low voltages, only the InAlAs layer above the 2DEG contributes to the photocurrent, while the InGaAs channel layer is activated at higher bias. This results in a voltage-dependent spectral response of the photodetector. The ratio of the responsivities at 1300 and 850 nm changes from 0.03- at 1-V to 0.44- at 1.6-V bias. This property makes the device a candidate suitable to detect and to separate optical information originated both from the GaAs (850 nm) and in the InGaAs (1300, 1550 nm)-based optoelectronic technology. [less ▲]

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See detailUn novembre rouge à Bruxelles?
Majerus, Benoît UL

Article for general public (2018)

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See detailNow we are European! ”How did it get that way?”
Popkewitz, Thomas S. UL; Martins, Catarina

in Sisyphus : Journal of Education (2013), 1(1), 37-66

«The European» is given as a kind of person and as an autonomous subject in contemporary policy and research. The paper examines the role that the social and educational science technologies play in ... [more ▼]

«The European» is given as a kind of person and as an autonomous subject in contemporary policy and research. The paper examines the role that the social and educational science technologies play in constructing this new type of person. We first briefly explore the human sciences as historical practices that link the individual to the community. These practices are reassembled and examined descriptively in the second section which explores the making of the European as a particular kind of person from which nation and daily life are to be ordered. In the third and fourth sections, we discuss the cultural technologies of science in fabricating the European. These technologies are forging the memory of a common history that simultaneously erases, forgets, and realigns Europe’s internal differences so that Europe may become the «world champions» of global competition. At a different level are technologies of numbers and statistics mobilized in making the unity given to the European and from which to understand diversity and differences. [less ▲]

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See detailNozione di ciclo produttivo nella sicurezza degli appalti
Ratti, Luca UL

in Il Lavoro nella Giurisprudenza (2008)

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See detailNPD Projects in Search of Top Management Support: The Role of Team Leaders' Social Capital
Chollet, Barthelemy; Brion, Sébastien; Chauvet, Vincent et al

in M@n@gement (2012), 15(1), 43-75

A number of studies have found that the performance of NPD projects greatly depends on the support they get from top management. However, research into why some projects get more support than others has ... [more ▼]

A number of studies have found that the performance of NPD projects greatly depends on the support they get from top management. However, research into why some projects get more support than others has been limited. The present paper takes a political approach to NPD, in which top management support is considered to be a function of a project leader’s ability to influence decision processes through personal relationships. Mobilizing the bridging perspective of social capital, we argue that project leaders need both strong ties to high-ranking others and sparseness in their networks. Vertical strong ties bring direct support and solidarity, resulting in improved access to resources and priority over other projects; sparseness provides exposure to the full range of information and interpretations in the organization, resulting in a more accurate picture of the political landscape and thus enabling the implementation of an appropriate influence strategy. A PLS analysis of a sample of 73 French project leaders involved in NPD projects provided support for our hypotheses. Hence, we contribute to a very recent stream of research showing that the structural and relational dimensions of social capital are complementary. [less ▲]

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See detailNS-Zwangsarbeit im Raum Aachen
Krebs, Stefan UL

Scientific Conference (2019)

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See detailnsights from a Study on Decision Making in Enterprise Architecture
van der Linden, Dirk; Van Zee, Marc UL

in In Short Paper Proceedings of the 8th IFIP WG 8.1 Working Conference on the Practice of Enterprise Modeling (PoEM) (2015)

Detailed reference viewed: 34 (3 UL)