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See detailThe Notch ligand Jagged1 is required for inner ear sensory development.
Kiernan, A. E.; Ahituv, N.; Fuchs, H. et al

in Proceedings of the National Academy of Sciences of the United States of America (2001), 98(7), 3873-8

Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance, although how these sensory regions become specified remains unknown. Each sensory ... [more ▼]

Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance, although how these sensory regions become specified remains unknown. Each sensory region is populated by two cell types, the mechanosensory hair cell and the supporting cell, which are arranged in a mosaic in which each hair cell is surrounded by supporting cells. The proposed mechanism for creating the sensory mosaic is lateral inhibition mediated by the Notch signaling pathway. However, one of the Notch ligands, Jagged1 (Jag1), does not show an expression pattern wholly consistent with a role in lateral inhibition, as it marks the sensory patches from very early in their development--presumably long before cells make their final fate decisions. It has been proposed that Jag1 has a role in specifying sensory versus nonsensory epithelium within the ear [Adam, J., Myat, A., Roux, I. L., Eddison, M., Henrique, D., Ish-Horowicz, D. & Lewis, J. (1998) Development (Cambridge, U.K.) 125, 4645--4654]. Here we provide experimental evidence that Notch signaling may be involved in specifying sensory regions by showing that a dominant mouse mutant headturner (Htu) contains a missense mutation in the Jag1 gene and displays missing posterior and sometimes anterior ampullae, structures that house the sensory cristae. Htu/+ mutants also demonstrate a significant reduction in the numbers of outer hair cells in the organ of Corti. Because lateral inhibition mediated by Notch predicts that disruptions in this pathway would lead to an increase in hair cells, we believe these data indicate an earlier role for Notch within the inner ear. [less ▲]

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See detailNotch signaling modulates the activation of microglial cells
Grandbarbe, Luc UL; Michelucci, Alessandro UL; Heurtaux, Tony UL et al

in Glia (2007), 55(15), 1519-30

The Notch signaling pathway plays a crucial role in specifying cellular fate in metazoan development by regulating communication between adjacent cells. Correlative studies suggested an involvement of ... [more ▼]

The Notch signaling pathway plays a crucial role in specifying cellular fate in metazoan development by regulating communication between adjacent cells. Correlative studies suggested an involvement of Notch in hematopoietic cell development. Here, we report that the Notch pathway is expressed and active in microglial cells. During inflammatory activation, the transcription of the Notch down-stream effector Hes1 is downregulated. When Notch1 transcription in microglia is inhibited, an upregulation of the expression of pro-inflammatory cytokines is observed. Notch stimulation in activated microglia, using a soluble form of its ligand Jagged1, induces a decrease in pro-inflammatory cytokines secretion and nitric oxide production as well as an increase in phagocytic activity. Notch-stimulation is accompanied by an increase in the rate of STAT3 phosphorylation and nuclear translocation. Our results show that the Notch pathway plays an important role in the control of inflammatory reactions in the CNS. [less ▲]

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See detailA note about covariance function and their propagation
Weigelt, Matthias UL

Diverse speeches and writings (2005)

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See detailNote comparate sulla nuova articolazione dei rapporti fra contratto collettivo e contratto individuale in Francia
Ratti, Luca UL

in Lassandari, Andrea; Martelloni, Federico; Tullini, Patrizia (Eds.) et al La contrattazione collettiva nello spazio economico globale (2017)

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See detailNote d’observations, “Roj TV” entre ordre public et principe du pays d’origine
Cole, Mark UL

in Revue du Droit des Technologies de l'Information [= RDTI] (2012), 47

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See detailNote on A. Barbour’s paper on Stein’s method for diffusion approximations
Kasprzak, Mikolaj UL; Duncan, Andrew; Vollmer, Sebastian

in Electronic Communications in Probability (2017)

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See detailA note on Chow's entropy functional for the Gauss curvature flow
Guo, Hongxin UL; Philipowski, Robert UL; Thalmaier, Anton UL

in Comptes Rendus de l'Académie des Sciences. Série I. Mathématique (2013), 351(21-22), 833-835

Based on the entropy formula for the Gauss curvature flow introduced by Bennett Chow, we define an entropy functional which is monotone along the unnormalized flow and whose critical point is a shrinking ... [more ▼]

Based on the entropy formula for the Gauss curvature flow introduced by Bennett Chow, we define an entropy functional which is monotone along the unnormalized flow and whose critical point is a shrinking self-similar solution. [less ▲]

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See detailA note on clean technology adoption and its influence on tradeable emission permit prices
Sanin, Maria Eugenia; Zanaj, Skerdilajda UL

in Environmental & Resource Economics (2011), 48(4), 561-567

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See detailA Note on Compatibility and Entry in a Circular Model of Product Differentiation
Jonard, Nicolas UL; Schenk, Eric

in Economics Bulletin (2004), 12

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See detailNote on duopolistic vertical restraints
Irmen, Andreas UL

in European Economic Review (1997), 41(8), 1559-1567

No abstract is available for this item.

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See detailA note on internationalisation, internationalism and language teaching and learning
Byram, Michael UL

in The Language Learning Journal (2012), 40(3), 375-381

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See detailA note on minors determined by clones of semilattices
Lehtonen, Erkko UL

in Novi Sad Journal of Mathematics (2010), 40(3), 75-81

The C-minor partial orders determined by the clones generated by a semilattice operation (and possibly the constant operations corresponding to its identity or zero elements) are shown to satisfy the ... [more ▼]

The C-minor partial orders determined by the clones generated by a semilattice operation (and possibly the constant operations corresponding to its identity or zero elements) are shown to satisfy the descending chain condition. [less ▲]

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See detailA Note on Stein’s Overreaction Puzzle
Lin, Yuehao; Lehnert, Thorsten UL

in Decisions in Economics and Finance (2020), 43(1), 269-276

Recently, Christoffersen et al. (2013) argue that the overreaction puzzle of Stein (1989) can be explained by a variance-dependent pricing kernel. In this note, we challenge this view. Our theoretical ... [more ▼]

Recently, Christoffersen et al. (2013) argue that the overreaction puzzle of Stein (1989) can be explained by a variance-dependent pricing kernel. In this note, we challenge this view. Our theoretical results are in line with their argument that the variance under risk-neutral measure is more persistent than the variance under physical measure due to a negative variance risk premium. But our results do not support their argument that the more persistent variance is able to qualitatively explain Stein’s findings. We show theoretically that the persistence of the volatility cannot amplify the movements of long-term variance to short-term fluctuations in variance, and, therefore, conclude that Stein’s overreaction puzzle is still unsolved. [less ▲]

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See detailA note on successive oligopolies and vertical mergers
GABSZEWICZ, Jean; Zanaj, Skerdilajda UL

in Communications & Stratégies (2007), 68

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See detailA Note on the Bivariate Coppersmith Theorem
Coron, Jean-Sébastien UL; Kirichenko, Alexey; Tibouchi, Mehdi UL

in Journal of Cryptology (2013), 26(2), 246-250

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See detailA Note on the Characterization of the Neoclassical Production Function
Irmen, Andreas UL; Maussner, Alfred

in Macroeconomic Dynamics (2016)

We study production functions with capital and labor as arguments that exhibit positive, yet diminishing marginal products and constant returns to scale. We show that such functions satisfy the Inada ... [more ▼]

We study production functions with capital and labor as arguments that exhibit positive, yet diminishing marginal products and constant returns to scale. We show that such functions satisfy the Inada conditions if i) both inputs are essential and ii) an unbounded quantity of either input leads to unbounded output. This allows for an alternative characterization of the neoclassical production function that altogether dispenses with the Inada conditions. While this proposition generalizes to the case of n > 2 factors of production its converse does not hold: 2n Inada conditions do not imply that each factor is essential. [less ▲]

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See detailA Note on the Characterization of the Neoclassical Production Function
Irmen, Andreas UL

in Macroeconomic Dynamics (2017)

We study production functions with capital and labor as arguments that exhibit positive, yet diminishing marginal products and constant returns to scale. We show that such functions satisfy the Inada ... [more ▼]

We study production functions with capital and labor as arguments that exhibit positive, yet diminishing marginal products and constant returns to scale. We show that such functions satisfy the Inada conditions if (i) both inputs are essential and (ii) an unbounded quantity of either input leads to unbounded output. This allows for an alternative characterization of the neoclassical production function that altogether dispenses with the Inada conditions. Although this proposition generalizes to the case of n > 2 factors of production, its converse does not hold: 2n Inada conditions do not imply that each factor is essential. [less ▲]

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See detailA note on the environmental impact of Bertrand and Cournot duopolies
Tampieri, Alessandro UL; Lambertini, Luca

in Economia Politica: journal of analytical and institutional economics (2014), 31

Detailed reference viewed: 33 (0 UL)