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See detailMutation Testing Strategies using Mutant Classification
Papadakis, Mike UL; Le Traon, Yves UL

in Abstract book of 28th Symposium On Applied Computing (2013)

Detailed reference viewed: 150 (4 UL)
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See detailMutation-based Generation of Software Product Line Test Configurations
Henard, Christopher UL; Papadakis, Mike UL; Le Traon, Yves UL

in Symposium on Search-Based Software Engineering (SSBSE 2014) (2014)

Detailed reference viewed: 112 (4 UL)
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See detailMutationen im VSP13D-Gen verursachen eine oftmals frühkindliche spastische Ataxie
Grünewald, Anne UL

in DGNeurologie (2018), 1(1), 58-59

Detailed reference viewed: 83 (0 UL)
See detailLes mutations de la société française : les grandes questions économiques et sociales
Castel, Robert; Chauvel, Louis UL; et, al.

Book published by La découverte (2013)

Detailed reference viewed: 145 (16 UL)
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See detailMutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A.; Marcil, M.; Clee, S. M. et al

in Nature Genetics (1999), 22(4), 336-45

Detailed reference viewed: 198 (15 UL)
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See detailMutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.
Rakovic, Aleksandar; Grünewald, Anne UL; Kottwitz, Jan et al

in PloS one (2011), 6(3), 16746

PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and ... [more ▼]

PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy.Here, we investigated the impact of mutations in endogenous PINK1 and Parkin on the ubiquitination of mitochondrial fusion and fission factors and the mitochondrial network structure. Treating control fibroblasts with mitochondrial membrane potential (Deltapsi) inhibitors or H(2)O(2) resulted in ubiquitination of Mfn1/2 but not of OPA1 or Fis1. Ubiquitination of Mitofusins through the PINK1/Parkin pathway was observed within 1 h of treatment. Upon combined inhibition of Deltapsi and the ubiquitin proteasome system (UPS), no ubiquitination of Mitofusins was detected. Regarding morphological changes, we observed a trend towards increased mitochondrial branching in PD patient cells upon mitochondrial stress.For the first time in PD patient-derived cells, we demonstrate that mutations in PINK1 and Parkin impair ubiquitination of Mitofusins. In the presence of UPS inhibitors, ubiquitinated Mitofusin is deubiquitinated by the UPS but not degraded, suggesting that the UPS is involved in Mitofusin degradation. [less ▲]

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See detailMutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease.
Grossmann, Dajana UL; Berenguer, Clara UL; Bellet, Marie Estelle et al

in Antioxidants & redox signaling (2019)

OBJECTIVE: The outer mitochondrial membrane protein Miro1 is a crucial player in mitochondrial dynamics and calcium homeostasis. Recent evidence indicated that Miro1 mediates calcium-induced mitochondrial ... [more ▼]

OBJECTIVE: The outer mitochondrial membrane protein Miro1 is a crucial player in mitochondrial dynamics and calcium homeostasis. Recent evidence indicated that Miro1 mediates calcium-induced mitochondrial shape transition (MiST), which is a prerequisite for the initiation of mitophagy. Moreover, altered Miro1 protein levels have emerged as a shared feature of monogenic and sporadic Parkinson's disease (PD), but, so far, no disease-associated variants in RHOT1 have been identified. RESULTS: Here, for the first time, we describe heterozygous RHOT1 mutations in two PD patients (het c.815G>A; het c.1348C>T) and identified mitochondrial phenotypes with reduced mitochondrial mass in patient-derived cellular models. Both mutations lead to decreased ER-mitochondrial contact sites and calcium dyshomeostasis. As a consequence, energy metabolism was impaired, which in turn lead to increased mitophagy. CONCLUSION: In summary, our data support the role of Miro1 in maintaining calcium homeostasis and mitochondrial quality control in PD. [less ▲]

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See detailMutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes
Schubert, Julian; Siekierska, Aleksandra; Langlois, Melanie UL et al

in Nature Genetics (2014), 46(12), 1327-32

Febrile seizures affect 2–4% of all children1 and have a strong genetic component2. Recurrent mutations in three main genes (SCN1A, SCN1B and GABRG2)3, 4, 5 have been identified that cause febrile ... [more ▼]

Febrile seizures affect 2–4% of all children1 and have a strong genetic component2. Recurrent mutations in three main genes (SCN1A, SCN1B and GABRG2)3, 4, 5 have been identified that cause febrile seizures with or without epilepsy. Here we report the identification of mutations in STX1B, encoding syntaxin-1B6, that are associated with both febrile seizures and epilepsy. Whole-exome sequencing in independent large pedigrees7, 8 identified cosegregating STX1B mutations predicted to cause an early truncation or an in-frame insertion or deletion. Three additional nonsense or missense mutations and a de novo microdeletion encompassing STX1B were then identified in 449 familial or sporadic cases. Video and local field potential analyses of zebrafish larvae with antisense knockdown of stx1b showed seizure-like behavior and epileptiform discharges that were highly sensitive to increased temperature. Wild-type human syntaxin-1B but not a mutated protein rescued the effects of stx1b knockdown in zebrafish. Our results thus implicate STX1B and the presynaptic release machinery in fever-associated epilepsy syndromes. [less ▲]

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See detailMutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.
Wortmann, Saskia B.; Vaz, Frederic M.; Gardeitchik, Thatjana et al

in Nature genetics (2012), 44(7), 797-802

Using exome sequencing, we identify SERAC1 mutations as the cause of MEGDEL syndrome, a recessive disorder of dystonia and deafness with Leigh-like syndrome, impaired oxidative phosphorylation and 3 ... [more ▼]

Using exome sequencing, we identify SERAC1 mutations as the cause of MEGDEL syndrome, a recessive disorder of dystonia and deafness with Leigh-like syndrome, impaired oxidative phosphorylation and 3-methylglutaconic aciduria. We localized SERAC1 at the interface between the mitochondria and the endoplasmic reticulum in the mitochondria-associated membrane fraction that is essential for phospholipid exchange. A phospholipid analysis in patient fibroblasts showed elevated concentrations of phosphatidylglycerol-34:1 (where the species nomenclature denotes the number of carbon atoms in the two acyl chains:number of double bonds in the two acyl groups) and decreased concentrations of phosphatidylglycerol-36:1 species, resulting in an altered cardiolipin subspecies composition. We also detected low concentrations of bis(monoacyl-glycerol)-phosphate, leading to the accumulation of free cholesterol, as shown by abnormal filipin staining. Complementation of patient fibroblasts with wild-type human SERAC1 by lentiviral infection led to a decrease and partial normalization of the mean ratio of phosphatidylglycerol-34:1 to phosphatidylglycerol-36:1. Our data identify SERAC1 as a key player in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. [less ▲]

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See detailMutations, défis, gestes symboliques et recettes miracles
Scuto, Denis UL

Article for general public (2016)

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See detailMutli-Frame Super-Resolution by Enhanced Shift & Add
Al Ismaeil, Kassem UL; Aouada, Djamila UL; Mirbach, Bruno et al

in 8th International Symposium on Image and Signal Processing and Analysis (2013)

A critical step in multi-frame super-resolution is the registration of frames based on their motion. We improve the performance of current state-of-the-art super-resolution techniques by proposing a more ... [more ▼]

A critical step in multi-frame super-resolution is the registration of frames based on their motion. We improve the performance of current state-of-the-art super-resolution techniques by proposing a more robust and accurate registration as early as in the initialization stage of the high resolution estimate. Indeed, we solve the limitations on scale and motion inherent to the classical Shift & Add approach by upsampling the low resolution frames up to the super-resolution factor prior to estimating motion or to median filtering. This is followed by an appropriate selective optimization, leading to an enhanced Shift & Add. Quantitative and qualitative evaluations have been conducted at two levels; the initial estimation and the final optimized super-resolution. Results show that the proposed algorithm outperforms existing state-of-art methods. [less ▲]

Detailed reference viewed: 149 (16 UL)
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See detailDie Muttergottesoktave im Wandel der Zeit
Kmec, Sonja UL

in Jungblut, Marie-Paule; Pauly, Michel; Reif, Heinz (Eds.) Luxemburg, eine Stadt in Europa (2015)

Detailed reference viewed: 91 (17 UL)
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See detailMutterschutz als Prävention. Überlegungen zu einem neugefundenen Text Pestalozzis
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter : Zeitschrift für pädagogische Historiographie (2000), 6(1), 42-44

Detailed reference viewed: 35 (0 UL)
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See detailMuttersprachliche Mehrsprachigkeit: Batty Weber (1860-1940) und die Mischkultur in Luxemburg
Millim, Anne-Marie UL

in Glesener, Jeanne; Roelens, Nathalie; Sieburg, Heinz (Eds.) Das Paradigma der Interkulturalität: Themen und Positionen in europöischen Literaturwissenschaften (2017)

Ein Großteil der wissenschaftlichen Publikationen der letzten zwanzig Jahre zum Thema Mehrsprachigkeit in Luxemburg stellt Webers Konzept der Mischkultur zu Recht als Pfeiler von nationalen Kulturtheorien ... [more ▼]

Ein Großteil der wissenschaftlichen Publikationen der letzten zwanzig Jahre zum Thema Mehrsprachigkeit in Luxemburg stellt Webers Konzept der Mischkultur zu Recht als Pfeiler von nationalen Kulturtheorien und Identitätsmodellen hin. Der vorliegende Beitrag möchte zu einer differenzierteren Betrachtung des Artikels von 1909 im Kontext von Webers Gesamtwerk anregen und anhand der Quelle der Feuilletonserie Abreißkalender (1913-1940) deutlich machen, dass für Weber die Mischkultur keine permanente Identität bedeutete, sondern einen andauernden Prozess des Negoziierens, der Zueigenmachung, der Ablehnung, der Assimilierung und der Emanzipation von interkulturellen Elementen. Weber tritt zwar in diesem Text für die Wertschätzung der luxemburgischen Kultur ein, stellt aber im Laufe seiner journalistischen und literarischen Laufbahn selbst sprachliche Qualitätsstandarde auf, die, durch interkulturellen Vergleich, die Bildung, Kompetenz und Ausdrucksfähigkeit seiner Leser in Frage stellen. Wenn auch Weber seinen Identitätsbegriff nie an klar definierten binären Dichotomien von fremd und eigen festmacht, so fordert er doch wiederholt die einwandfreie Beherrschung mehrerer Standardsprachen, indem er klar zwischen Fehler und korrektem Gebrauch unterscheidet. Während die Mischung von französischen, deutschen und luxemburgischen Kulturelementen für Weber den verallgemeinerten Luxemburger ausmacht, stellt er sprachliche Interferenzen als Fehler dar. Diese Fehlerhaftigkeit ist stark kontextabhängig: im Sprachgebrauch der Bevölkerung stellt Weber Vermischungen von Sprachsystemen oft als Zeichen von Inkompetenz und Anmaßung dar aber im Bereich der Kunst zeugen sie, ihm zufolge, von Kreativität, Individualität und luxemburgischer Eigenart. Besonders in den ersten Jahren seines Feuilletons, ca. 1913 bis 1920, beschäftigt sich Weber mir linguistischen Notionen der Korrektheit, die in den 1930er Jahren stark an Bedeutung verlieren. In diesem Jahrzehnt sind Feuilletons, in denen Weber versucht das Kunstpotential der Luxemburger Literaten genau zu lokalisieren, häufig. [less ▲]

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See detailMutual entropy production in bipartite systems
Diana, Giovanni UL; Esposito, Massimiliano UL

in Journal of Statistical Mechanics : Theory and Experiment (2014)

It was recently shown by Barato et al (2013 Phys. Rev. E 87 042104) that the mutual information at the trajectory level of a bipartite Markovian system is not bounded by the entropy production. In the ... [more ▼]

It was recently shown by Barato et al (2013 Phys. Rev. E 87 042104) that the mutual information at the trajectory level of a bipartite Markovian system is not bounded by the entropy production. In the same way as Gaspard showed (2004 J. Stat. Phys. 117 599) that the entropy production is not directly related to the Shannon entropy at the trajectory level but is in fact equal to its difference from the so-called time-reversed Shannon entropy, we show in this paper that the difference between the mutual information and its time-reversed form is equal to the mutual entropy production (MEP), i.e. the difference between the full entropy production and that of the two marginal processes. Evaluation of the MEP is in general a difficult task due to non-Markovian effects. For bipartite systems, we provide closed expressions in various limiting regimes which we verify by numerical simulations. [less ▲]

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See detailMutual Funds' Returns from Providing Liquidity and Costs of Immediacy
Rinne, Kalle UL; Suominen, Matti UL

Scientific Conference (2014, October)

Detailed reference viewed: 25 (3 UL)
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See detailMutual Funds’ Returns from Providing Liquidity and Costs of Immediacy
Rinne, Kalle UL; Suominen, Matti UL

E-print/Working paper (2014)

We present evidence that some mutual funds systematically act as contrarian traders, and earn returns in the stock market by providing liquidity to investors that demand immediacy, while others ... [more ▼]

We present evidence that some mutual funds systematically act as contrarian traders, and earn returns in the stock market by providing liquidity to investors that demand immediacy, while others systematically realize costs of immediacy. On average, the mutual funds’ costs of immediacy exceed their returns from providing liquidity. The funds with outflows, flows that correlate with industry flows, high market beta funds, and funds highly exposed to the momentum strategy suffer the most in costs of immediacy. The mutual funds’ average underperformance can be explained with their costs of immediacy. Finally, the funds’ historical costs of immediacy predict their alphas. [less ▲]

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See detailMutual funds' returns from providing liquidity and costs of immediacy
Rinne, Kalle UL; Suominen, Matti UL

Scientific Conference (2014, May)

Detailed reference viewed: 11 (3 UL)
See detailMutual Funds’ Returns from Providing Liquidity and Costs of Immediacy
Rinne, Kalle UL; Suominen, Matti

Presentation (2012)

Detailed reference viewed: 13 (0 UL)
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See detailMutual Funds, Price Pressure and Index Option
Lehnert, Thorsten UL

in Journal of Derivatives (2016), 24(1), 30-46

Detailed reference viewed: 72 (3 UL)