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See detailA new model selection criterion for finite mixture models
Schiltz, Jang UL

in Proceedings of the 62nd ISI World Statistics Congress (2019, August 20)

Detailed reference viewed: 27 (0 UL)
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See detailA new modeling approach for the biobjective exact optimization of satellite payload configuration
Kieffer, Emmanuel UL; Danoy, Grégoire UL; Bouvry, Pascal UL et al

in International Transactions in Operational Research (2017)

Detailed reference viewed: 162 (17 UL)
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See detailA New Modelling Framework over Temporal Graphs for Collaborative Mobility Recommendation Systems
Toader, Bogdan UL; Moawad, Assaad UL; Fouquet, François UL et al

in A New Modelling Framework over Temporal Graphs for Collaborative Mobility Recommendation Systems (2018, March 15)

Over the years, collaborative mobility proved to be an important but challenging component of the smart cities paradigm. One of the biggest challenges in the smart mobility domain is the use of data ... [more ▼]

Over the years, collaborative mobility proved to be an important but challenging component of the smart cities paradigm. One of the biggest challenges in the smart mobility domain is the use of data science as an enabler for the implementation of large scale transportation sharing solutions. In particular, the next generation of Intelligent Transportation Systems (ITS) requires the combination of artificial intelligence and discrete simulations when exploring the effects of whatif decisions in complex scenarios with millions of users. In this paper, we address this challenge by presenting an innovative data modelling framework that can be used for ITS related problems. We demonstrate that the use of graphs and time series in multi-dimensional data models can satisfy the requirements of descriptive and predictive analytics in real-world case studies with massive amounts of continuously changing data. The features of the framework are explained in a case study of a complex collaborative mobility system that combines carpooling, carsharing and shared parking. The performance of the framework is tested with a large-scale dataset, performing machine learning tasks and interactive realtime data visualization. The outcome is a fast, efficient and complete architecture that can be easily deployed, tested and used for research as well in an industrial environment. [less ▲]

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See detailNew models to study the cross-talk between the protein repair L-isoaspartyl methyltransferase and cell signalling
Soliman, Remon UL

Doctoral thesis (2017)

Isomerization of L-aspartyl and L-asparaginyl residues to form L-isoaspartyl residues in proteins is one type of protein damage that can occur under physiological conditions and can potentially lead to ... [more ▼]

Isomerization of L-aspartyl and L-asparaginyl residues to form L-isoaspartyl residues in proteins is one type of protein damage that can occur under physiological conditions and can potentially lead to conformational change, loss of function and enhanced protein degradation. Protein L-isoaspartyl methyltransferase (PCMT or PIMT) is a repair enzyme, which allows the reconversion of L-isoaspartyl residues to L-aspartyl residues in protein. Although the catalytic function of PCMT is known, its physiological roles remain less well understood. Pcmt1 gene knockout in mice leads for example, via molecular mechanisms that remain mostly obscure, to activation of insulin/IGF-1 and MAPK signalling pathways in the brain, and premature death due to massive epileptic seizure events. In this doctoral research project, we have used both mammalian cells and zebrafish models to investigate the impact of PCMT deficiency on insulin/IGF-1, MAPK and calcium signalling as well as how PCMT may be involved in epilepsy. In mammalian cells we used shRNA and CRISPR/Cas9 technology to reduce or completely silence PCMT expression, with the main objective being to mimic, in cell culture, the activation of the IGF-1 and MAPK signalling pathways observed in Pcmt1 knockout mice in the hope to thereby increase the chances to elucidate the underlying molecular mechanisms. In zebrafish we used an antisense morpholino-based strategy to knock down both PCMT homologs and thereby establish a new whole organism model to further study the physiological functions of PCMT, more particularly in the brain. Our results indicate that insulin/IGF-1 signalling is not affected by PCMT knockdown or knockout in mammalian cells whereas a time-dependent MAPK pathway activation could be detected in a Pcmt1 knockout mouse hippocampal cell line. In zebrafish, we showed that the two PCMT homologs Pcmt and Pcmtl (Pcmt/l) possess isoaspartyl methyltransferase activity. In pcmt/l knockdown (or morphant) zebrafish larvae we did not detect abnormal electrical activity in the brain, but we identified movement impairment and strongly perturbed brain calcium fluxes. Abnormal calcium responses were also observed in the Pcmt1 knockout mouse hippocampal cell line. We concluded that the interplay between PCMT and growth signalling pathways is highly dependent on experimental model and may not be amenable to investigation in cell culture. Importantly, our results clearly show that PCMT plays a pivotal role in calcium signalling and suggest that PCMT-dependent repair mechanisms may be important to prevent calcium-related neurological disorders. [less ▲]

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See detailA New Multi-Lateral Filter for Real-Time Depth Enhancement
Garcia Becerro, Frederic UL; Aouada, Djamila UL; Mirbach, Bruno et al

in 8th IEEE International Conference on Advanced Video and Signal-Based Surveillance (2011)

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See detailNew Multilinear Maps over the Integers
Coron, Jean-Sébastien UL; Lepoint, Tancrede; Tibouchi, Mehdi

in Proceedings of Crypto 2015 (2015)

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See detailA new national flag for Luxembourg Struggeling over identity in a small multilingual society
Fehlen, Fernand UL

in Cultural Identities and National Borders (2009)

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See detailA new one point quadrature rule over arbitrary star convex polygon/polyhedron
Natarajan, Sundararajan; Francis, Amrita; Atroshchenko, Elena et al

E-print/Working paper (n.d.)

The Linear Smoothing (LS) scheme \cite{francisa.ortiz-bernardin2017} ameliorates linear and quadratic approximations over convex polytopes by employing a three-point integration scheme. In this work, we ... [more ▼]

The Linear Smoothing (LS) scheme \cite{francisa.ortiz-bernardin2017} ameliorates linear and quadratic approximations over convex polytopes by employing a three-point integration scheme. In this work, we propose a linearly consistent one point integration scheme which possesses the properties of the LS scheme with three integration points but requires one third of the integration computational time. The essence of the proposed technique is to approximate the strain by the smoothed nodal derivatives that are determined by the discrete form of the divergence theorem. This is done by the Taylor's expansion of the weak form which facilitates the evaluation of the smoothed nodal derivatives acting as stabilization terms. The smoothed nodal derivatives are evaluated only at the centroid of each integration cell. These integration cells are the simplex subcells (triangle/tetrahedron in two and three dimensions) obtained by subdividing the polytope. The salient feature of the proposed technique is that it requires only $n$ integrations for an $n-$ sided polytope as opposed to $3n$ in~\cite{francisa.ortiz-bernardin2017} and $13n$ integration points in the conventional approach. The convergence properties, the accuracy, and the efficacy of the LS with one point integration scheme are discussed by solving few benchmark problems in elastostatics. [less ▲]

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See detailNew opportunities by laser joining of dissimilar materials
Plapper, Peter UL

Scientific Conference (2020, February 13)

The presentation gives an overview about research projects at UL related to laser welding of dissimilar materials. Literature reference at the end enables the reader to dig deeper in case some specific ... [more ▼]

The presentation gives an overview about research projects at UL related to laser welding of dissimilar materials. Literature reference at the end enables the reader to dig deeper in case some specific projects are of interest. [less ▲]

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See detailA New Optimization Tool for Mega-Constellation Design and its Application to Trunking Systems
Kisseleff, Steven UL; Shankar, Bhavani UL; Spano, Danilo UL et al

in 37th International Communications Satellite Systems Conference (ICSSC), Japan, October 2019 (2019, November)

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See detailNew Orleans tijdens orkaan Katrina
Van Baars, Stefan UL

in Land+Water (2007)

New Orleans kent een grote overeenstemming met delen van Nederland. Het is een delta, het ligt gedeeltelijk lager dan zeeniveau en het kent ook een dubbele bedreiging: zowel van de zee als van de rivieren ... [more ▼]

New Orleans kent een grote overeenstemming met delen van Nederland. Het is een delta, het ligt gedeeltelijk lager dan zeeniveau en het kent ook een dubbele bedreiging: zowel van de zee als van de rivieren. In de zomer van 2005 werd New Orleans zwaar getroffen door orkaan Katrina. In het verleden zijn er al vaker overstromingen geweest, maar nooit zo ernstig als deze keer. De beelden hiervan zijn over de hele wereld gegaan. In dit artikel wordt beschreven wat er mis ging. Omdat de situatie van New Orleans in meerdere opzichten op Nederland lijkt kunnen uit deze ramp lessen worden getrokken die wellicht ook voor Nederland toepasbaar zijn. [less ▲]

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See detailA New Parallel Asynchronous Cellular Genetic Algorithm for Scheduling in Grids
Pinel, Frédéric UL; Dorronsoro, Bernabé UL; Bouvry, Pascal UL

in Parallel & Distributed Processing, Workshops and Phd Forum (IPDPSW), 2010 IEEE International Symposium on (2010)

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See detailA New Parallel Multi-objective Cooperative Coevolutionary Algorithm Based on SPEA2
Dorronsoro, Bernabé UL; Cañero, J. Alberto UL; Danoy, Grégoire UL et al

in ALIO-INFORMS Joint International Meeting 2010 (2010)

We present in this work a new multi-objective cooperative coevolutionary algorithm based on SPEA2 (called CCSPEA2). In this algorithm, we split the solution chromosome into 4 different parts of the same ... [more ▼]

We present in this work a new multi-objective cooperative coevolutionary algorithm based on SPEA2 (called CCSPEA2). In this algorithm, we split the solution chromosome into 4 different parts of the same size, and 4 islands are optimizing every single partial solution by using SPEA2. For evaluating the solutions, the islands are sharing their best partial solutions. As a result, CCSPEA2 outperforms SPEA2 in most of tested problems. [less ▲]

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See detailA new Pax gene, Pax-9, maps to mouse chromosome 12.
Wallin, J.; Mizutani, Y.; Imai, K. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1993), 4(7), 354-8

Members of the Pax gene family have recently been shown to play important roles in mouse embryogenesis. Of eight so far characterized Pax genes, three have been associated with mouse developmental mutants ... [more ▼]

Members of the Pax gene family have recently been shown to play important roles in mouse embryogenesis. Of eight so far characterized Pax genes, three have been associated with mouse developmental mutants. Here we report the cloning of a new Pax gene, Pax-9. Most of the DNA sequence encoding the highly conserved paired domain has been determined and compared with previously known paired domains. This comparison classifies Pax-9 as a member of the same subgroup as Pax-1/undulated. By analysis of the segregation of a Pax-9 restriction fragment length polymorphism and a large number of simple sequence length polymorphisms in an interspecific C57BL/6 x Mus musculus mollosinus backcross, Pax-9 was mapped close to the D12Nds1 locus on the proximal part of Chromosome (Chr) 12. [less ▲]

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See detailThe New PCA' s Rules for Arbitration and their Relevance to Disputes Arising from Erroneous Navigational Signals
Loukakis, Andreas UL

Scientific Conference (2014, September 30)

This contribution seeks to address the issues of damage and dispute resolution for erroneous navigational signals from a different perspective, particularly under a newly adopted legal mechanism: The ... [more ▼]

This contribution seeks to address the issues of damage and dispute resolution for erroneous navigational signals from a different perspective, particularly under a newly adopted legal mechanism: The Permanent Court of Arbitration’ s (PCA) Optional Rules for Disputes Relating to Outer Space Activities. One interesting provision contained within these rules is article 1. Article 1 par. 1 provides that “the Outer Space Rules can be adopted by consent as the rules between any parties whatever their nature...”. Furthermore, the last sentence of article 1 stipulates that “the characterization of the dispute as relating to Outer Space is not necessary for jurisdiction under these rules…”. Hence, one would argue that the scope of application -both personal and material- of the PCA rules is quite broad, depending exclusively on the will and the consent of the parties. In light of this broad scope of application of the new PCA rules, the paper will examine their relevance for disputes in the field of Global Navigational Satellite Systems. Additionally, it will assess the practical chances of success of this new legal instrument for potential GNSS related disputes. [less ▲]

Detailed reference viewed: 119 (18 UL)
See detailA New Perspective on Nonmonotonic Logics
Gabbay, Dov M. UL; Schlechta, Karl

Book published by Springer (2016)

Detailed reference viewed: 100 (0 UL)
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See detailA New Perspective on the Luxembourgish Genitive
Döhmer, Caroline UL

in Germanic Genitives (in press)

Detailed reference viewed: 390 (7 UL)