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See detailNext-generation phenotyping using the parkin example: time to catch up with genetics.
Grünewald, Anne UL; Kasten, Meike; Ziegler, Andreas et al

in JAMA neurology (2013), 70(9), 1186-91

IMPORTANCE: Two decades of intense research have led to important insights into the pathophysiology of neurodegenerative diseases, with limited direct clinical impact. While next-generation sequencing has ... [more ▼]

IMPORTANCE: Two decades of intense research have led to important insights into the pathophysiology of neurodegenerative diseases, with limited direct clinical impact. While next-generation sequencing has emerged as a powerful research tool, we hypothesized that systematic exploitation of phenotypic data are lagging behind genetic advances. OBJECTIVES: To use the 15-year experience with parkin-associated Parkinson disease (PD) to evaluate type, quality, and quantity of genetic and phenotypic data and to elucidate clinical or genetic features impacting genetic testing and counseling. EVIDENCE REVIEW: We searched MEDLINE: (1998-2012) using the term parkin AND mutation for English publications about proved parkin-associated PD and at least minimal, individual clinical information excluding digenic cases, and redundant articles. This approach identified 877 articles, of which 196 described patients with PD with confirmed parkin mutations and 127 articles fulfilled our inclusion criteria. Information was extracted using predefined criteria and a consensus approach for questionable details. To evaluate study method differences, we devised a quality score representing the completeness of clinical, demographic, and genetic information. FINDINGS: In the data about 1184 patients, the quality score increased steadily and was driven exclusively by improvements in genetic analyses. By contrast, demographic and clinical content stagnated. The mean age at onset was 9 years lower in index patients with 2 mutant parkin alleles than in heterozygotes. Genotype-phenotype correlation was observed for the number of mutated alleles and dystonia. By contrast, dementia was rare in all parkin-mutation carriers (<3%), despite long disease duration. CONCLUSIONS AND RELEVANCE: Notwithstanding large gaps in phenotypic information content, we identified dystonia and the absence of dementia as "red flags" to be incorporated in counseling guidelines. We propose mandatory minimal criteria for genotype-phenotype studies to facilitate the next breakthrough-following genetics-toward more personalized medicine for genetic conditions, extending well beyond the parkin example. [less ▲]

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See detailThe Nexus between Science and Industry: Evidence from Faculty Inventions
Czarnitzki, Dirk; Hussinger, Katrin UL; Schneider, Cedric

in Journal of Technology Transfer (2012)

Knowledge transfer from science to industry has been shown to be beneficial for the corporate partner. In order to get a better understanding of the reasons behind these positive effects, this study ... [more ▼]

Knowledge transfer from science to industry has been shown to be beneficial for the corporate partner. In order to get a better understanding of the reasons behind these positive effects, this study focuses on the junction of science and industry by comparing characteristics of academic inventions that are transferred to industry and those staying in the public sector. Academic inventions are identified via patent applications of German academic scientists. We find that academic patents assigned to corporations are more likely to enable firms reaping short term rather than, possibly more uncertain, long-run returns, in contrast to patents that stay in the public sector. Firms also strive for academic inventions with a high blocking potential in technology markets. Academic patents issued to corporations appear to reflect less complex inventions as compared to inventions that are patented by the public science sector. [less ▲]

Detailed reference viewed: 103 (6 UL)
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See detail«Nez à nez avec l'humour»
Roelens, Nathalie UL

in Poétique (1992)

Detailed reference viewed: 54 (1 UL)
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See detailThe NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
Maus, F.; Sakry, D.; Biname, F. et al

in PLoS ONE (2015), 10(9), 0137311

The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte ... [more ▼]

The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress resulting in cell death in white matter after hypoxic or ischemic insults of premature infants and destruction of OPC in some types of Multiple Sclerosis lesions. Here we show that the NG2 proteoglycan binds OMI/HtrA2, a mitochondrial serine protease which is released from damaged mitochondria into the cytosol in response to stress. In the cytosol, OMI/HtrA2 initiates apoptosis by proteolytic degradation of anti-apoptotic factors. OPC in which NG2 has been downregulated by siRNA, or OPC from the NG2-knockout mouse show an increased sensitivity to oxidative stress evidenced by increased cell death. The proapoptotic protease activity of OMI/HtrA2 in the cytosol can be reduced by the interaction with NG2. Human glioma expressing high levels of NG2 are less sensitive to oxidative stress than those with lower NG2 expression and reducing NG2 expression by siRNA increases cell death in response to oxidative stress. Binding of NG2 to OMI/HtrA2 may thus help protect cells against oxidative stress-induced cell death. This interaction is likely to contribute to the high chemo- and radioresistance of glioma. [less ▲]

Detailed reference viewed: 106 (5 UL)
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See detailNiccolò Machiavelli, Mandragola, éd. Antonio Stäuble, Firenze: Cesati Editore 2004
Cicotti, Claudio UL

in Zeitschrift für Romanische Philologhie (2008), 124(2), 384-386

Detailed reference viewed: 35 (1 UL)
See detailNicht die Emotion ist unprofessionell, sondern die Welt, in der sie existiert.
Baudson, Tanja Gabriele UL

Article for general public (2015)

Detailed reference viewed: 14 (0 UL)
See detailNicht-heterosexuelle Identitäten in der empirisch-psychologischen Forschung
Niepel, Christoph UL

Presentation (2013, May 21)

Detailed reference viewed: 22 (4 UL)
See detailNicht-heterosexuelle Identitäten: Empirisch-psychologische Betrachtungen
Niepel, Christoph UL

in Schneider, M.; Diehl, M. (Eds.) Gender, Queer und Fetisch – Konstruktion von Identität und Begehren (2011)

Detailed reference viewed: 29 (1 UL)
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See detailDas Nicht-Sagbare thematisieren
Hesse, Markus UL

Article for general public (2019)

Der Beitrag thematisiert das Verhältnis von Wissenschaft und Politik im Allgemeinen sowie in Luxemburg, insbesondere mit Blick auf Geographie und Raumplanung.

Detailed reference viewed: 48 (3 UL)
See detailEine nicht-sozialpädagogische Geschichte der Sozialpädagogik. Feldtheoretische Historiographie
Neumann, Sascha UL; Dollinger, Bernd; Schabdach, Michael

in Zugänge zur Geschichte von Sozialpädagogik und Sozialarbeit (2011)

Detailed reference viewed: 31 (1 UL)
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See detailNichtgleichgewichtsphänomene, Strukturbildung und Grenzflächeneinflüsse in netzwerkbildenden Systemen aus optischer und akustischer Sicht.
Philipp, Martine UL

Doctoral thesis (2009)

Isostructural phase transitions occurring under non-equilibrium conditions are investigated using technologically relevant epoxies. The evolution of the hypersonic and optical properties during the ... [more ▼]

Isostructural phase transitions occurring under non-equilibrium conditions are investigated using technologically relevant epoxies. The evolution of the hypersonic and optical properties during the genesis of the polymeric network leads to deeper insight into the chemically induced sol-gel transition and glass transition, as demonstrated e.g. by the elastic anharmonicity and the generalised Cauchy relation. During gelation the refractive index versus chemical conversion behaves in an unexpected manner, indicating that in addition to the mass density an excess polarisability seems to contribute to the optical polarisability. The clarification of the isostructural phase transitions is impeded by the demixing tendency of the epoxy components which leads to different types of epoxy inhomogeneities on the nano- to mesoscopic scale. Taking benefit from a sample arrangement where both epoxy components are layered, the spatio-temporal evolution of acoustic properties gives supplementary information about trans-interfacial transport and structure formation processes. Of special technological relevance, but also of fundamental interest, is the influence of nanoscopic disturbances placed into the epoxy matrix. So-called interphases surrounding the nanoparticles modify and complicate the epoxy network formation, leading to long-lived metastable morphologies and properties. The role of the mixing sequence of the epoxy resin, the hardener and the nanoparticles for the polymerised epoxy state and the transient states during network formation, as well as the isostructural phase transitions is further elucidated. [less ▲]

Detailed reference viewed: 81 (1 UL)
See detailNichtheterosexuelle Elternschaft: Forschungsfelder und Befunde
Niepel, Christoph UL

Presentation (2014, December 04)

Detailed reference viewed: 24 (1 UL)
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See detailNichts als Ärger. Zur Modifikation von Ärgerreaktionen im Leistungssport
Steffgen, Georges UL

in Leistungssport (1994), 24(3), 27-30

Ein Fußballspieler, der aufgrund seiner "Wut im Bauch" ein Revanchefoul begeht, oder ein anderer, der aufgrund seines Ärgers das Siegestor erzielt, sind Beispiele für höchst unterschiedliche Auswirkungen ... [more ▼]

Ein Fußballspieler, der aufgrund seiner "Wut im Bauch" ein Revanchefoul begeht, oder ein anderer, der aufgrund seines Ärgers das Siegestor erzielt, sind Beispiele für höchst unterschiedliche Auswirkungen der Emotion Ärger. Im Kontext leistungssportlichen Handelns wird von Sportlern, Trainern, Betreuern und Sportwissenschaftlern die leistungsfördernde Wirkung von Ärgererleben heftig diskutiert. Um die Kontroversen zu entschärfen, wird in diesem Beitrag eine psychologische Sichtweise zum Thema "Ärger" dargelegt. Die Gründe für eine Veränderung von Ärgerreaktionen, ein theoretischer Erklärungsansatz sowie ein Modifikationsprogramm des Ärgers werden hierzu vorgestellt. Ziel ist es, ein differenzierteres Bild der Veränderungsnotwendigkeiten und -möglichkeiten von Ärgerreaktionen aufzuzeigen. [less ▲]

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See detailNicola Dusi, Il cinema come traduzione, 2003
Tore, Gian Maria UL

in Nouveaux Actes Sémiotiques (2005), (98-100), 62-70

Detailed reference viewed: 59 (0 UL)
Peer Reviewed
See detailNicotinamid
De Beaufort, Carine UL

in Diabetes, prevention and therapy (1992), 6

Detailed reference viewed: 24 (0 UL)
Peer Reviewed
See detailnicotine effect on selective attention
Mancuso, Giovanna UL; Vandenberghe, Michelle

in Proceedings of the Low Countries Meeting (1997)

Detailed reference viewed: 12 (0 UL)
Peer Reviewed
See detailNicotine Interact With Gabaergic System: Behavioural Evidences?,
Mancuso, Giovanna UL; Tirelli, Ezio

in Pflügers Archiv : European Journal of Physiology (1996), 431(3),

Detailed reference viewed: 24 (1 UL)
See detailNIDISC Introduction and Committees
Bouvry, Pascal UL; Danoy, Grégoire UL; Seredynski, Franciszek et al

in Parallel and Distributed Processing Symposium Workshop (IPDPSW), 2015 IEEE International 2015-10-27 14:21:42 +0000 2015-10-27 14:21:42 +0000 (2015)

Detailed reference viewed: 87 (0 UL)
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See detailDer niedergelassene Arzt als Unternehmer: Die Rolle von Persönlichkeitsfaktoren im Zugang zu medizinischer Technologie
Geraudel, Mickaël UL; Gundolf, Katherine; Cesinger, Beate et al

in ZfKE: Zeitschrift für KMU und Entrepreneurship (2019), 67(3), 153-169

Detailed reference viewed: 69 (4 UL)