Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailA meta-analysis of the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

in Language, Education and Diversity Conference (2015, November)

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

Detailed reference viewed: 65 (2 UL)
See detailA meta-analysis of the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

Scientific Conference (2014, June)

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

Detailed reference viewed: 58 (2 UL)
Full Text
See detailA meta-analysis of the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

in International Congress on Education, Innovation and Learning Technologies (2014, July)

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

Detailed reference viewed: 56 (2 UL)
Full Text
Peer Reviewed
See detailA meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure.
Mamas, Mamas A.; Caldwell, Jane C.; Chacko, Sanoj et al

in European journal of heart failure (2009), 11(7), 676-83

AIMS: Atrial fibrillation (AF) is one of the commonest sustained arrhythmias in chronic heart failure (CHF), although the prognostic implications of the presence of AF in CHF remain controversial. We have ... [more ▼]

AIMS: Atrial fibrillation (AF) is one of the commonest sustained arrhythmias in chronic heart failure (CHF), although the prognostic implications of the presence of AF in CHF remain controversial. We have therefore performed this meta-analysis to study the effects of the presence of AF on mortality in CHF patients. METHODS AND RESULTS: A systematic MEDLINE search for all randomized trials and observational studies in which the influence of AF on CHF mortality was investigated and meta-analysis of the mortality data was performed. A total of 16 studies were identified of which 7 were randomized trials and 9 were observational studies including 30,248 and 23,721 patients, respectively. An adjusted meta-analysis of the data revealed that the presence of AF is associated with an adverse effect on total mortality with an odds ratio (OR) of 1.40 [95% confidence interval (CI) 1.32-1.48, P < 0.0001] in randomized trials and an OR of 1.14 (95% CI 1.03-1.26, P < 0.05) in observational studies. This increase in mortality associated with the presence of AF was observed in subgroups of CHF patients with both preserved and impaired left ventricular (LV) systolic function. CONCLUSION: In conclusion, meta-analysis of 16 studies involving 53,969 patients suggests that the presence of AF is associated with an adverse prognosis in CHF irrespective of LV systolic function. [less ▲]

Detailed reference viewed: 104 (0 UL)
Full Text
Peer Reviewed
See detailA Meta-Analysis of Viewing Time Measures of Sexual Interest in Children
Schmidt, Alexander F. UL; Babchishin, Kelly M.; Lehmann, Robert J. B.

in Archives of Sexual Behavior (in press)

Due to unobtrusiveness and ease of implementation, viewing time (VT) measures of sexual interest in children have sparked increasing research interest in forensic contexts over the last two decades. The ... [more ▼]

Due to unobtrusiveness and ease of implementation, viewing time (VT) measures of sexual interest in children have sparked increasing research interest in forensic contexts over the last two decades. The current study presents two meta-analyses of VT measures adapted to assess pedophilic interest to determine their discrimination between sexual offenders against children (SOC) and non-SOC groups as well as convergent validity (associations with other measures of sexual interest in children). On average, VT measures showed moderate discrimination between criterion groups (fixed-effect d = 0.60, 95% CI [0.51, 0.68], N = 2,705, k = 14) and significant convergent validity with self-reports, penile plethysmography, Implicit Association Tests and offence behavioral measures ranging from r =.18 to r = .38. VT measures, however, provided better discrimination for adults (fixed-effect d = 0.78, 95% CI [0.64, 0.92]) than adolescent samples (fixed-effect d = 0.50, 95% CI [0.40, 0.61]), Qbetween = 9.37, p = .002. Moreover, using pedophilic difference scores within adult samples substantially increased VT measures’ validity (fixed-effect d = 1.03, 95% CI [0.82, 1.25], N = 414, k = 7). Results are discussed in terms of their theoretical and applied implications for forensic contexts. [less ▲]

Detailed reference viewed: 150 (2 UL)
Full Text
Peer Reviewed
See detailA meta-analysis on resting state high-frequency heart rate variability in Bulimia Nervosa
Peschel, Stephanie K.V.; Feeling, Nicole R.; Vögele, Claus UL et al

in European Eating Disorders Review (2016), 24(5), 355-365

Objective: Autonomic nervous system (ANS) function is altered in eating disorders. We aimed to quantify differences in resting state vagal activity, indexed by high-frequency heart rate variability (HF ... [more ▼]

Objective: Autonomic nervous system (ANS) function is altered in eating disorders. We aimed to quantify differences in resting state vagal activity, indexed by high-frequency heart rate variability (HF-HRV) comparing patients with bulimia nervosa (BN) and healthy controls. Methods: A systematic search of the literature to identify studies eligible for inclusion and meta-analytical methods were applied. Meta-regression was used to identify potential covariates. Results: 8 studies reporting measures of resting HF-HRV in individuals with BN (n=137) and controls (n=190) were included. Random-effects meta-analysis revealed a sizeable main effect (Z=2.22, p=.03; Hedge’s g=0.52, 95%CI[0.06;0.98]) indicating higher resting state vagal activity in individuals with BN. Meta-regression showed that BMI and medication intake are significant covariates. Discussion: Findings suggest higher vagal activity in BN at rest, particularly in un-medicated samples with lower body mass index. Potential mechanisms underlying these findings and implications for routine clinical care are discussed. [less ▲]

Detailed reference viewed: 187 (2 UL)
Full Text
Peer Reviewed
See detailA meta-analysis on the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

in Review of Educational Research (2015), 85(1), 92-128

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

Detailed reference viewed: 81 (5 UL)
Full Text
Peer Reviewed
See detailMeta-Argumentation part 1
Boella, Guido UL; Gabbay, Dov M. UL; van der Torre, Leon UL et al

in Studia Logica (2009)

In this paper, we introduce the methodology and techniques of meta-argumentation to model argumentation. The methodology of meta-argumentation instantiates Dung’s abstract argumentation theory with an ... [more ▼]

In this paper, we introduce the methodology and techniques of meta-argumentation to model argumentation. The methodology of meta-argumentation instantiates Dung’s abstract argumentation theory with an extended argumentation theory, and is thus based on a combination of the methodology of instantiating abstract arguments, and the methodology of extending Dung’s basic argumentation frameworks with other relations among abstract arguments. The technique of meta-argumentation applies Dung’s theory of abstract argumentation to itself, by instantiating Dung’s abstract arguments with meta-arguments using a technique called flattening. We characterize the domain of instantiation using a representation technique based on soundness and completeness. Finally, we distinguish among various instantiations using the technique of specification languages. [less ▲]

Detailed reference viewed: 32 (0 UL)
Full Text
Peer Reviewed
See detailA meta-model of access control in a fibred security language
Barker, Steve; Guido, Boella; Gabbay, Dov M. UL et al

in Studia Logica (2009), 92(3), 437-477

The issue of representing access control requirements continues to demand significant attention. The focus of researchers has traditionally been on developing particular access control models and policy ... [more ▼]

The issue of representing access control requirements continues to demand significant attention. The focus of researchers has traditionally been on developing particular access control models and policy specification languages for particular applications. However, this approach has resulted in an unnecessary surfeit of models and languages. In contrast, we describe a general access control model and a logic-based specification language from which both existing and novel access control models may be derived as particular cases and from which several approaches can be developed for domain-specific applications. We will argue that our general framework has a number of specific attractions and an implication of our work is to encourage a methodological shift from a study of the particulars of access control to its generalities. [less ▲]

Detailed reference viewed: 84 (0 UL)
Full Text
Peer Reviewed
See detailLe méta-principe de l’Etat social (Sozialstaat) dans la jurisprudence de la Cour constitutionnelle fédérale allemande
Heuschling, Luc UL

in Burgorgue-Larsen, Laurence (Ed.) La justice sociale saisie par les juges en Europe (2013)

Detailed reference viewed: 108 (2 UL)
Peer Reviewed
See detailMetabolic fate of desomorphine elucidated using rat urine, pooled human liver preparations, and human hepatocyte cultures as well as its detectability using standard urine screening approaches.
Richter, Lilian H. J.; Kaminski, Yeda Rumi; Noor, Fozia UL et al

in Analytical and bioanalytical chemistry (2016), 408(23), 6283-94

Desomorphine is an opioid misused as "crocodile", a cheaper alternative to heroin. It is a crude synthesis product homemade from codeine with toxic byproducts. The aim of the present work was to ... [more ▼]

Desomorphine is an opioid misused as "crocodile", a cheaper alternative to heroin. It is a crude synthesis product homemade from codeine with toxic byproducts. The aim of the present work was to investigate the metabolic fate of desomorphine in vivo using rat urine and in vitro using pooled human liver microsomes and cytosol as well as human liver cell lines (HepG2 and HepaRG) by Orbitrap-based liquid chromatography-high resolution-tandem mass spectrometry or hydrophilic interaction liquid chromatography. According to the identified metabolites, the following metabolic steps could be proposed: N-demethylation, hydroxylation at various positions, N-oxidation, glucuronidation, and sulfation. The cytochrome P450 (CYP) initial activity screening revealed CYP3A4 to be the only CYP involved in all phase I steps. UDP-glucuronyltransferase (UGT) initial activity screening showed that UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B15, and UGT2B17 formed desomorphine glucuronide. Among the tested in vitro models, HepaRG cells were identified to be the most suitable tool for prediction of human hepatic phase I and II metabolism of drugs of abuse. Finally, desomorphine (crocodile) consumption should be detectable by all standard urine screening approaches mainly via the parent compound and/or its glucuronide assuming similar kinetics in rats and humans. [less ▲]

Detailed reference viewed: 51 (0 UL)
Peer Reviewed
See detailMetabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells.
Strigun, Alexander; Noor, Fozia UL; Pironti, Alejandro et al

in Journal of biotechnology (2011), 155(3), 299-307

Verapamil has been shown to inhibit glucose transport in several cell types. However, the consequences of this inhibition on central metabolism are not well known. In this study we focused on verapamil ... [more ▼]

Verapamil has been shown to inhibit glucose transport in several cell types. However, the consequences of this inhibition on central metabolism are not well known. In this study we focused on verapamil induced changes in metabolic fluxes in a murine atrial cell line (HL-1 cells). These cells were adapted to serum free conditions and incubated with 4 muM verapamil and [U-(1)(3)C(5)] glutamine. Specific extracellular metabolite uptake/production rates together with mass isotopomer fractions in alanine and glutamate were implemented into a metabolic network model to calculate metabolic flux distributions in the central metabolism. Verapamil decreased specific glucose consumption rate and glycolytic activity by 60%. Although the HL-1 cells show Warburg effect with high lactate production, verapamil treated cells completely stopped lactate production after 24 h while maintaining growth comparable to the untreated cells. Calculated fluxes in TCA cycle reactions as well as NADH/FADH(2) production rates were similar in both treated and untreated cells. This was confirmed by measurement of cell respiration. Reduction of lactate production seems to be the consequence of decreased glucose uptake due to verapamil. In case of tumors, this may have two fold effects; firstly depriving cancer cells of substrate for anaerobic glycolysis on which their growth is dependent; secondly changing pH of the tumor environment, as lactate secretion keeps the pH acidic and facilitates tumor growth. The results shown in this study may partly explain recent observations in which verapamil has been proposed to be a potential anticancer agent. Moreover, in biotechnological production using cell lines, verapamil may be used to reduce glucose uptake and lactate secretion thereby increasing protein production without introduction of genetic modifications and application of more complicated fed-batch processes. [less ▲]

Detailed reference viewed: 54 (0 UL)
Full Text
Peer Reviewed
See detailMetabolic network analysis integrated with transcript verification for sequenced genomes.
Manichaikul, Ani; Ghamsari, Lila; Hom, Erik F. Y. et al

in Nature Methods (2009), 6(8), 589-592

With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we ... [more ▼]

With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we describe a systems-level methodology bridging metabolic network reconstruction with experimental verification of enzyme encoding open reading frames. Our quantitative and predictive metabolic model and its associated cloned open reading frames provide useful resources for metabolic engineering. [less ▲]

Detailed reference viewed: 84 (4 UL)
Full Text
Peer Reviewed
See detailMetabolic networks are NP-hard to reconstruct.
Nikoloski, Zoran; Grimbs, Sergio; May, Patrick UL et al

in Journal of Theoretical Biology (2008), 254(4), 807-16

High-throughput data from various omics and sequencing techniques have rendered the automated metabolic network reconstruction a highly relevant problem. Our approach reflects the inherent probabilistic ... [more ▼]

High-throughput data from various omics and sequencing techniques have rendered the automated metabolic network reconstruction a highly relevant problem. Our approach reflects the inherent probabilistic nature of the steps involved in metabolic network reconstruction. Here, the goal is to arrive at networks which combine probabilistic information with the possibility to obtain a small number of disconnected network constituents by reduction of a given preliminary probabilistic metabolic network. We define automated metabolic network reconstruction as an optimization problem on four-partite graph (nodes representing genes, enzymes, reactions, and metabolites) which integrates: (1) probabilistic information obtained from the existing process for metabolic reconstruction from a given genome, (2) connectedness of the raw metabolic network, and (3) clustering of components in the reconstructed metabolic network. The practical implications of our theoretical analysis refer to the quality of reconstructed metabolic networks and shed light on the problem of finding more efficient and effective methods for automated reconstruction. Our main contributions include: a completeness result for the defined problem, polynomial-time approximation algorithm, and an optimal polynomial-time algorithm for trees. Moreover, we exemplify our approach by the reconstruction of the sucrose biosynthesis pathway in Chlamydomonas reinhardtii. [less ▲]

Detailed reference viewed: 77 (1 UL)
Full Text
Peer Reviewed
See detailMetabolic Networks, Chapter 10
da Silva, Marcio Rosa; Sun, Jibin; Ma, HongWu et al

in Junker, Björn H.; Schreiber, Falk (Eds.) Analysis of Biological Networks (2007)

Detailed reference viewed: 235 (2 UL)
Full Text
Peer Reviewed
See detailMetabolic outcomes in young children with type 1 diabetes differ between treatment centers: the Hvidoere Study in Young Children 2009
De Beaufort, Carine UL; Lange, K.; Swift, P.G. et al

in Pediatric Diabetes (2012), 14(6), 422-428

Objective: To investigate whether center differences in glycemic control are present in prepubertal children <11 yr with type 1 diabetes mellitus. Research Design and Methods: This cross-sectional study ... [more ▼]

Objective: To investigate whether center differences in glycemic control are present in prepubertal children <11 yr with type 1 diabetes mellitus. Research Design and Methods: This cross-sectional study involved 18 pediatric centers worldwide. All children, <11 y with a diabetes duration ≥12 months were invited to participate. Case Record Forms included information on clinical characteristics, insulin regimens, diabetic ketoacidosis (DKA), severe hypoglycemia, language difficulties, and comorbidities. Hemoglobin A1c (HbA1c) was measured centrally by liquid chromatography (DCCT aligned, range: 4.4-6.3%; IFFC: 25-45 mmol/mol). Results: A total of 1133 children participated (mean age: 8.0 ± 2.1 y; females: 47.5%, mean diabetes duration: 3.8 ± 2.1 y). HbA1c (overall mean: 8.0 ± 1.0%; range: 7.3-8.9%) and severe hypoglycemia frequency (mean 21.7 events per 100 patient-years), but not DKA, differed significantly between centers (p < 0.001 resp. p = 0.179). Language difficulties showed a negative relationship with HbA1c (8.3 ± 1.2% vs. 8.0 ± 1.0%; p = 0.036). Frequency of blood glucose monitoring demonstrated a significant but weak association with HbA1c (r = -0.17; p < 0.0001). Although significant different HbA1c levels were obtained with diverse insulin regimens (range: 7.3-8.5%; p < 0.001), center differences remained after adjusting for insulin regimen (p < 0.001). Differences between insulin regimens were no longer significant after adjusting for center effect (p = 0.199). Conclusions: Center differences in metabolic outcomes are present in children <11 yr, irrespective of diabetes duration, age, or gender. The incidence of severe hypoglycemia is lower than in adolescents despite achieving better glycemic control. Insulin regimens show a significant relationship with HbA1c but do not explain center differences. Each center's effectiveness in using specific treatment strategies remains the key factor for outcome. [less ▲]

Detailed reference viewed: 69 (0 UL)
Peer Reviewed
See detailMetabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry: Metabolic Profiling of Neurotransmitters by GC-MS
Jäger, Christian UL; Hiller, Karsten UL; Buttini, Manuel UL

in Auwerx, Johan; Ackerman, Susan L.; Brown, Stephen D. (Eds.) et al Current Protocols in Mouse Biology (2016)

Detailed reference viewed: 137 (11 UL)
Full Text
Peer Reviewed
See detailMetabolic Profiling as Well as Stable Isotope Assisted Metabolic and Proteomic Analysis of RAW 264.7 Macrophages Exposed to Ship Engine Aerosol Emissions: Different Effects of Heavy Fuel Oil and Refined Diesel Fuel.
Sapcariu, Sean UL; Kanashova, Tamara; Dilger, Marco et al

in PloS one (2016), 11(6), 0157964

Exposure to air pollution resulting from fossil fuel combustion has been linked to multiple short-term and long term health effects. In a previous study, exposure of lung epithelial cells to engine ... [more ▼]

Exposure to air pollution resulting from fossil fuel combustion has been linked to multiple short-term and long term health effects. In a previous study, exposure of lung epithelial cells to engine exhaust from heavy fuel oil (HFO) and diesel fuel (DF), two of the main fuels used in marine engines, led to an increased regulation of several pathways associated with adverse cellular effects, including pro-inflammatory pathways. In addition, DF exhaust exposure was shown to have a wider response on multiple cellular regulatory levels compared to HFO emissions, suggesting a potentially higher toxicity of DF emissions over HFO. In order to further understand these effects, as well as to validate these findings in another cell line, we investigated macrophages under the same conditions as a more inflammation-relevant model. An air-liquid interface aerosol exposure system was used to provide a more biologically relevant exposure system compared to submerged experiments, with cells exposed to either the complete aerosol (particle and gas phase), or the gas phase only (with particles filtered out). Data from cytotoxicity assays were integrated with metabolomics and proteomics analyses, including stable isotope-assisted metabolomics, in order to uncover pathways affected by combustion aerosol exposure in macrophages. Through this approach, we determined differing phenotypic effects associated with the different components of aerosol. The particle phase of diluted combustion aerosols was found to induce increased cell death in macrophages, while the gas phase was found more to affect the metabolic profile. In particular, a higher cytotoxicity of DF aerosol emission was observed in relation to the HFO aerosol. Furthermore, macrophage exposure to the gas phase of HFO leads to an induction of a pro-inflammatory metabolic and proteomic phenotype. These results validate the effects found in lung epithelial cells, confirming the role of inflammation and cellular stress in the response to combustion aerosols. [less ▲]

Detailed reference viewed: 113 (1 UL)