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See detailMit Guerilla zum Prototypen
Rohles, Björn UL

Article for general public (2019)

Little money, little time and still a great user experience? That sounds too good to be true. But the Guerilla-style UX design process promises exactly that. Part 2 of my series on Guerilla-UX is ... [more ▼]

Little money, little time and still a great user experience? That sounds too good to be true. But the Guerilla-style UX design process promises exactly that. Part 2 of my series on Guerilla-UX is dedicated to exploring user needs, brainstorming, and prototyping. [less ▲]

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See detail„Mit Herz, Fuß, Mund und ganzem Körper“ – Sprachen lehren und lernen mit Drama und Theater
Weyer, Dany UL

Speeches/Talks (2018)

Drama- und Theaterübungen eröffnen besonders im (Fremd-)Sprachenunterricht vielfältige lernförderliche Bedingungen. Im aktiven und kollaborativen Prozess des Theater-Spielens können authentische Sprech ... [more ▼]

Drama- und Theaterübungen eröffnen besonders im (Fremd-)Sprachenunterricht vielfältige lernförderliche Bedingungen. Im aktiven und kollaborativen Prozess des Theater-Spielens können authentische Sprech- und Schreibanlässe integriert, unterschiedliche Themen, Texte und Persönlichkeiten erkundet, sowie Sprache(n) mit dem ganzen Körper erfahren werden. Konkrete Beispiele haben in diesem Workshop verdeutlicht, wie spielerisch und gruppenorientiert an die Mehrsprachigkeit herangeführt werden kann. [less ▲]

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See detailMit Kindern Konflikte bewältigen
Steffgen, Georges UL; de Boer, Claudia

in Ministère de la Famille et de l'Intégration; Entente des Foyers de Jour; Syndicat des Villes et Communes luxembourgeoises (Eds.) et al Maisons Relais pour Enfants - Le manuel - Das Handbuch (2009)

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See detailMit Komplexität umgehen lernen: Welche Vorteile bieten computerbasierte Problemlöseszenarien in der Sensibilisierung für typische Probleme im Verstehen und Steuern komplexer Systeme?
Sonnleitner, Philipp UL; König, Ariane UL; Sikharulidze, Tea UL

Scientific Conference (2018, April)

Unbestreitbare Herausforderung der heutigen Zeit, ist der Umgang mit zunehmend komplexeren Systemen. Dem regelmäßigen Ruf, die dafür benötigten Fähigkeiten und mentalen Einstellungen bereits in Schule und ... [more ▼]

Unbestreitbare Herausforderung der heutigen Zeit, ist der Umgang mit zunehmend komplexeren Systemen. Dem regelmäßigen Ruf, die dafür benötigten Fähigkeiten und mentalen Einstellungen bereits in Schule und Studium zu trainieren (bspw. Vester, 2012), folgten - wohl auch aufgrund mangelnder Optionen – kaum Konsequenzen. Der vorliegende Beitrag diskutiert nun die Möglichkeit, vereinfachte aber dynamische Problemlöseszenarien mit weniger (System)Variablen und einfacheren (System)Effekten aber dafür hoch reliablen Performanzindizes für Trainingszwecke im Umgang mit Komplexität einzusetzen. Auf Basis dreier studentischer Kohorten eines Kurses zum Themenkomplex Nachhaltigkeit an der Universität Luxemburg (N=97), wurde erstmals evaluiert, welche Lernerfahrungen mit einem solchen Szenario gemacht und möglich werden. Die Ergebnisse zeigen, dass nicht nur zuverlässig verschiedene Problemlösestrategien erfasst werden, sondern das auch zwischen „aktiven“ und „reflektiven“ StudentInnen unterschieden werden kann, welche unterschiedlich erfolgreich mit den Szenarien umgehen. Die diagnostizierten typischen kognitiven Fehler im Umgang mit den Problemen und die dokumentierten Emotionen der StudienteilnehmerInnen zeigen das große (zukünftige) Potenzial dieser Szenarien. [less ▲]

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See detailMit Lingscape auf Pad in der Stadt. Ein Schulprojekt zu gesellschaftlicher Mehrsprachigkeit in Windhoek
Purschke, Christoph UL; Trusch, Kerstin

in Marten, Heiko; Ziegler, Evelyn (Eds.) Linguistic Landscapes im deutschsprachigen Kontext: Forschungsperspektiven, Methoden und Anwendungsmöglichkeiten im Unterricht und Sprachmarketing (in press)

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See detailMit oder gegen den Strom? Postwachstumsplanung in der Fishbowl
Lamker, Christian; Schulze Dieckhoff, Viola; Grotefels, Susan et al

in PND online (2019), 2018(2), 1-10

Detailed reference viewed: 55 (2 UL)
See detailMit Postern die Welt erkunden
Andersen, Katja Natalie UL

Scientific Conference (2016, February 18)

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See detailMit und ohne Netz - Fotovoltaik-Anlagen in Deutschland und Andalusien
Helfer, Malte UL

in Geographie heute : Themen, Modelle, Materialien für die Unterrichtspraxis aller Sekundarstufen (2001), (6), 36-39

Detailed reference viewed: 56 (3 UL)
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See detail"Mit vereinten Kräften voran". Social Development in einem Kooperationsprojekt einer transnationaeln NGO und einer loken NGO.
Schröder, Christian UL

in Homfeldt, Hans Günther (Ed.) Soziale Arbeit als Entwicklungszusammenarbeit (2011)

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See detailMit Video einen mikroanalytischen Blick auf gemeinsam konstruierte Lernprozesse von Kindern richten
Sujbert, Monika UL; Sunnen, Patrick UL; Arend, Béatrice UL et al

in Kopp, B.; Martschinke, S.; Munser-Kiefer, M. (Eds.) et al Individuelle Förderung und Lernen in der Gemeinschaft. Jahrbuch Grundschulforschung. Bd. 17 (2014)

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See detailMitarbeiterführung und Social-Media-Nutzung im Führungsalltag von Generation-Y-Führungskräften - Eine explorative Analyse mittels Mixed-Methods-Ansatz
Feltes, Florian UL

Doctoral thesis (2016)

The topic of this thesis is the qualitative and quantitative evaluation of leadership behaviour and therefore the leadership style of Generation Y (GenY) considering the use of social media in day-to-day ... [more ▼]

The topic of this thesis is the qualitative and quantitative evaluation of leadership behaviour and therefore the leadership style of Generation Y (GenY) considering the use of social media in day-to-day management. It examines the question of how GenY leaders lead and how they use social media in this context. It explores the topic based on a sequential mixed methods approach of qualitative interviews and a quantitative online questionnaire. Using the qualitative content analysis, it examines 25 qualitative interviews concerning the following aspects: leadership behaviour of generation Y, generation-based differences in the leadership and different strength of leadership styles, influence of contextual factors like hierarchies, sector and company size on the leadership style and use of social media, use of social media on day-to-day management, and, finally, connections between applied leadership styles and social media usage of GenY leaders. The findings and tendencies were then verified in an online questionnaire. The results of the online questionnaire [self-evaluation of leaders (N=406), bottom-up evaluation by employees (N=622)] show a significant discrepancy between the leaders’ statements and those of the employees. However, there are clear results and tendencies that confirm the findings of the qualitative study. It was established that GenY leaders show characteristics of task-oriented, person-oriented, transactional and transformational leadership. GenY leadership is characterised by clear outcome orientation, flat hierarchies and feedback. The use of social media varies considerably, depending for example on the context in which the leader works, e. g. sector and level of management. In summary, it can be stated that there is a connection between the strength of the leadership style and the usage of social media in day-to-day management. [less ▲]

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See detailMitgliederrückgang und Organisationsstrategien deutscher Gewerkschaften
Ebbinghaus, Bernhard UL; Göbel, Claudia

in Schroeder, Wolfgang (Ed.) Handbuch Arbeitgeber- und Wirtschaftsverbände in Deutschland (2014)

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See detailMitigating flash crowd effect using connected vehicle technology
Grzybek, Agata UL; Danoy, Grégoire UL; Bouvry, Pascal UL et al

in Vehicular Communications (2015), 2(4),

A Flash Crowd Effect (FCE) occurs when in the case of non-recurring congestion a large portion of drivers follows similar re-routing advice. Consequently, congestion is transferred from one road to ... [more ▼]

A Flash Crowd Effect (FCE) occurs when in the case of non-recurring congestion a large portion of drivers follows similar re-routing advice. Consequently, congestion is transferred from one road to another. Coping with the FCE is challenging, especially if the congestion results from a temporary loss of capacity (e.g. due to a traffic incident). The existing route guidance systems do not address FCE, as they either do not consider the effects of guidance on the rest of the road network, or predict link travel times based on the number of vehicles travelling on the link, which in the case of the loss of capacity is unreliable. We demonstrate that the FCE can be addressed in a distributed way with Vehicle-to-Vehicle (V2V) communication provided by Connected Vehicle (CV) technology. The proposed in-vehicle TrafficEQ system provides vehicles with mixed route guidance strategy—i.e. a route is autonomously chosen by the vehicle with a probability that is inversely proportional to the latest reported travel time on the route. Real-time travel time information is crowd-sourced by TrafficEQ users. Using realistic simulations of incident-related capacity drops on a classic two-route highway example and a realistic urban road network, we demonstrate that TrafficEQ can address the FCE by reducing travel time oscillations among the alternative routes. The system's drawbacks—in particular the occasional necessity of providing incentives to follow the guidance—are discussed. [less ▲]

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See detailMitigating the Effects of Equivalent Mutants with Mutant Classification Strategies
Papadakis, Mike UL; Delamaro, Eduardo Márcio; Le Traon, Yves UL

in Science of Computer Programming (2014), 95

Mutation Testing has been shown to be a powerful technique in detecting software faults. Despite this advantage, in practice there is a need to deal with the equivalent mutants’ problem. Automatically ... [more ▼]

Mutation Testing has been shown to be a powerful technique in detecting software faults. Despite this advantage, in practice there is a need to deal with the equivalent mutants’ problem. Automatically detecting equivalent mutants is an undecidable problem. Therefore, identifying equivalent mutants is cumbersome since it requires manual analysis, resulting in unbearable testing cost. To overcome this difficulty, researchers suggested the use of mutant classification, an approach that aims at isolating equivalent mutants automatically. From this perspective, the present paper establishes and empirically assesses possible mutant classification strategies. A conducted study reveals that mutant classification isolates equivalent mutants effectively when low quality test suites are used. However, it turns out that as the test suites evolve, the benefit of this practice is reduced. Thus, mutant classification is only fruitful in improving test suites of low quality and only up to a certain limit. To this end, empirical results show that the proposed strategies provide a cost-effective solution when they consider a small number of live mutants, i.e., 10-12. At this point they kill 92% of all the killable mutants. [less ▲]

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See detailMitochondrial Defects and Neurodegeneration in Mice Overexpressing Wild Type or G399S Mutant HtrA2
Casadei, Nicolas; Sood, Poonan; Ulrich, Thomas et al

in Human Molecular Genetics (2016), 25(3), 459-71

The protease HtrA2 has a protective role inside mitochondria, but promotes apoptosis under stress. We previously identified the G399S HtrA2 mutation in Parkinson's disease (PD) patients and reported ... [more ▼]

The protease HtrA2 has a protective role inside mitochondria, but promotes apoptosis under stress. We previously identified the G399S HtrA2 mutation in Parkinson's disease (PD) patients and reported mitochondrial dysfunction in vitro. Mitochondrial dysfunction is a common feature of PD and related to neurodegeneration. Complete loss of HtrA2 has been shown to cause neurodegeneration in mice. However, the full impact of HtrA2 overexpression or the G399S mutation is still to be determined in vivo. Here, we report the first HtrA2 G399S transgenic mouse model. Our data suggest that the mutation has a dominant-negative effect. We also describe a toxic effect of wild-type (WT) HtrA2 overexpression. Only low overexpression of the G399S mutation allowed viable animals and we suggest that the mutant protein is likely unstable. This is accompanied by reduced mitochondrial respiratory capacity and sensitivity to apoptotic cell death. Mice overexpressing WT HtrA2 were viable, yet these animals have inhibited mitochondrial respiration and significant induction of apoptosis in the brain leading to motor dysfunction, highlighting the opposing roles of HtrA2. Our data further underscore the importance of HtrA2 as a key mediator of mitochondrial function and its fine regulatory role in cell fate. The location and abundance of HtrA2 is tightly controlled and, therefore, human mutations leading to gain- or loss of function could provide significant risk for PD-related neurodegeneration. [less ▲]

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See detailMitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons.
Grünewald, Anne UL; Rygiel, Karolina A.; Hepplewhite, Philippa D. et al

in Annals of Neurology (2016), 79(3), 366-378

OBJECTIVE: To determine the extent of respiratory chain abnormalities and investigate the contribution of mitochondrial DNA (mtDNA) to the loss of respiratory chain complexes (CI-IV) in the substantia ... [more ▼]

OBJECTIVE: To determine the extent of respiratory chain abnormalities and investigate the contribution of mitochondrial DNA (mtDNA) to the loss of respiratory chain complexes (CI-IV) in the substantia nigra (SN) of idiopathic Parkinson disease (IPD) patients at the single-neuron level. METHODS: Multiple-label immunofluorescence was applied to postmortem sections of 10 IPD patients and 10 controls to quantify the abundance of CI-IV subunits (NDUFB8 or NDUFA13, SDHA, UQCRC2 and COXI), and mitochondrial transcription factors (TFAM and TFB2M) relative to mitochondrial mass (Porin and GRP75) in dopaminergic neurons. To assess the involvement of mtDNA in respiratory chain deficiency in IPD, SN neurons, isolated with laser-capture microdissection, were assayed for mtDNA deletions, copy number and presence of transcription/replication-associated 7S DNA employing a triplex real-time PCR assay. RESULTS: While mitochondrial mass was unchanged in single SN neurons from IPD patients, we observed a significant reduction in the abundances of CI and II subunits. At single-cell level, CI and II deficiencies were correlated in patients. The CI deficit concomitantly occurred with low abundances of the mtDNA transcription factors TFAM and TFB2M, which also initiate transcription-primed mtDNA replication. Consistent with this, real-time PCR analysis revealed fewer transcription/replication-associated mtDNA molecules and an overall reduction in mtDNA copy number in patients. This effect was more pronounced in single IPD neurons with severe complex I deficiency. INTERPRETATION: Respiratory chain dysfunction in IPD neurons not only involves CI, but also extends to CII. These deficiencies are possibly a consequence of the interplay between nDNA and mtDNA-encoded factors mechanistically connected via TFAM. This article is protected by copyright. All rights reserved. [less ▲]

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See detailMitochondrial morphology provides a mechanism for energy buffering at synapses
Garcia, Guadalupe Clara UL; Bartol, Thomas M.; Phan, Sebastien A. et al

E-print/Working paper (2019)

Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these ... [more ▼]

Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based dynamic model using three-dimensional morphologies from electron microscopy tomography which considers the molecular dynamics of the main ATP production components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor space dependence when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness. [less ▲]

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See detailMitochondrial morphology provides a mechanism for energy buffering at synapses.
Garcia, Guadalupe Clara UL; Bartol, Thomas M.; Phan, Sébastien et al

in Scientific reports (2019), 9

Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these ... [more ▼]

Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based multiscale model that integrates three-dimensional morphologies from electron microscopy tomography with the molecular dynamics of the main ATP producing components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor spatial effects when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness. IM [less ▲]

Detailed reference viewed: 42 (0 UL)