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See detailLe ministre du culte, personne ordinaire
Riassetto, Isabelle UL; Woerhling, Jean-Marie

in Messner, Francis; Woerhling, Jean-Marie; Prélot, Pierre-Henri (Eds.) et al Traité de droit français des religions (2013)

Detailed reference viewed: 40 (3 UL)
See detailLe Minitel. L'enfance numérique de la France
Schafer, Valerie UL; Thierry, Benjamin G.

Book published by Nuvis (2012)

Une synthèse consacrée au Minitel, depuis sa naissance au début des années 1980 jusqu'à sa disparition, programmée le 30 juin 2012.

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See detailUne minorité de citoyens reste nostalgique
Paravantis, Spero UL

E-print/Working paper (2016)

Au cours de l’automne 1991, les républiques constituantes de l’Union soviétique proclamaient, l’une après l’autre, leur indépendance. Il y a 25 ans, avec la création de la Communauté des États ... [more ▼]

Au cours de l’automne 1991, les républiques constituantes de l’Union soviétique proclamaient, l’une après l’autre, leur indépendance. Il y a 25 ans, avec la création de la Communauté des États indépendants (CEI), la superpuissance URSS a cessé d’exister d’un jour à l’autre. Dr. Spero S.Z. Paravantis de l’Université du Luxembourg revient sur ce grand chapitre de l’histoire. [less ▲]

Detailed reference viewed: 43 (6 UL)
See detailA minority pulls the sample mean: on the individual prevalence of robust group-level cognitive phenomena - the instance of the SNARC effect
Cipora, Krzysztof; van Dijck, Jean-Philippe; Georges, Carrie UL et al

Presentation (2019, January)

Detailed reference viewed: 8 (1 UL)
See detailMinors as victims of cross-border human trafficking in Europe
Simonato, Michele UL

Presentation (2014, April)

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See detailMinors of Boolean functions with respect to clique functions and hypergraph homomorphisms
Lehtonen, Erkko UL; Nešetřil, Jaroslav

in European Journal of Combinatorics (2010), 31(8), 1981-1995

Each clone C on a fixed base set A induces a quasi-order on the set of all operations on A by the following rule: f is a C-minor of g if f can be obtained by substituting operations from C for the ... [more ▼]

Each clone C on a fixed base set A induces a quasi-order on the set of all operations on A by the following rule: f is a C-minor of g if f can be obtained by substituting operations from C for the variables of g. By making use of a representation of Boolean functions by hypergraphs and hypergraph homomorphisms, it is shown that a clone C on {0,1} has the property that the corresponding C-minor partial order is universal if and only if C is one of the countably many clones of clique functions or the clone of self-dual monotone functions. Furthermore, the C-minor partial orders are dense when C is a clone of clique functions. [less ▲]

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See detailMint Centrality: A Centrality Measure for the Bitcoin Transaction Graph
Fiz Pontiveros, Beltran UL; Steichen, Mathis UL; State, Radu UL

Poster (2019, May 17)

In this work, we consider the graph of confirmed transactions in Bitcoin. Understanding this graph is essential to discern the different economic activities conducted by the pseudonymous actors. In ... [more ▼]

In this work, we consider the graph of confirmed transactions in Bitcoin. Understanding this graph is essential to discern the different economic activities conducted by the pseudonymous actors. In addition to traditional graph analysis methods, new metrics need to be engineered specifically for the bitcoin transaction graph. Hence, we propose a new centrality measure named mint centrality. The measure uses the inherent tree structure of transactions in bitcoin and their relation to the corresponding set of coinbase transactions, and can be evaluated with linear complexity. We evaluate the mint centrality on the first 200,000 blocks of the public bitcoin blockchain. [less ▲]

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See detailMinUS: Mining User Similarity with Trajectory Patterns
Chen, Xihui; Kordy, Piotr; Lu, Ruipeng et al

in Proceedings of 17th European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML/PKDD) (2014)

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See detail»Mir gesinn eis dono op facebook« – Mediale (Selbst-)Inszenierungen luxemburgischer Jugendlicher als virtuelle Identitätskonstruktionen
Belling, Luc UL

in Wille, Christian; Reckinger, Rachel; Kmec, Sonja (Eds.) et al Räume und Identitäten in Grenzregionen Politiken – Medien – Subjekte (2014)

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See detail“Mir gesinn eis dono op facebook” – (Self-)Stagings of Luxembourg Teenagers in Social Media as Virtual Identity Constructions.
Belling, Luc UL

in Wille, Christian; Reckinger, Rachel; Kmec, Sonja (Eds.) et al Spaces and Identities in Border Regions. Politics – Media – Subjects. (2016)

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See detail"Mir wëlle bleiwe wat mir sinn" - mee ween ass "mir"?
Kmec, Sonja UL

Conference given outside the academic context (2018)

Detailed reference viewed: 55 (4 UL)
See detailMir wëlle bleiwe wat mir waren … Zur Konstruktion einer Luxemburger Nationalgeschichte
Pauly, Michel UL

in Gräf, Holger; Jendorff, Alexander; Monnet, Pierre (Eds.) Land – Geschichte – Identität. Geschichtswahrnehmung und Geschichtskonstruktion im 19. und 20. Jahrhundert – eine historiographische Bestandsaufnahme (2016)

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See detailMiR-128 represses L1 retrotransposition by binding directly to L1 RNA
Hamdorf, Matthias UL; Idica, A.; Zisoulis, D. G. et al

in Nature Structural and Molecular Biology (2015), 22(10), 824-831

Long interspersed element 1 (LINE-1 or L1) retrotransposons compose 17% of the human genome. Active L1 elements are capable of replicative transposition (mobilization) and can act as drivers of genetic ... [more ▼]

Long interspersed element 1 (LINE-1 or L1) retrotransposons compose 17% of the human genome. Active L1 elements are capable of replicative transposition (mobilization) and can act as drivers of genetic diversity. However, this mobilization is mutagenic and may be detrimental to the host, and therefore it is under strict control. Somatic cells usually silence L1 activity by DNA methylation of the L1 promoter. In hypomethylated cells, such as cancer cells and induced pluripotent stem cells (iPSCs), a window of opportunity for L1 reactivation emerges, and with it comes an increased risk of genomic instability and tumorigenesis. Here we show that miR-128 represses new retrotransposition events in human cancer cells and iPSCs by binding directly to L1 RNA. Thus, we have identified and characterized a new function of microRNAs: mediating genomic stability by suppressing the mobility of endogenous retrotransposons. © 2015 Nature America, Inc. All rights reserved. [less ▲]

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See detailmiR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.
Roser, Anna-Elisa; Caldi Gomes, Lucas; Halder, Rashi UL et al

in Molecular Therapy: Nucleic Acids (2018)

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See detailmiR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers
Vetter, G.; Saumet, A.; Moes, Michèle UL et al

in Oncogene (2016), 35(5), 670

Epithelial to mesenchymal transition (EMT) is a key step toward metastasis. MCF7 breast cancer cells conditionally expressing the EMT master regulator SNAI1 were used to identify early expressed microRNAs ... [more ▼]

Epithelial to mesenchymal transition (EMT) is a key step toward metastasis. MCF7 breast cancer cells conditionally expressing the EMT master regulator SNAI1 were used to identify early expressed microRNAs (miRNAs) and their targets that may contribute to the EMT process. Potential targets of miRNAs were identified by matching lists of in silico predicted targets and of inversely expressed mRNAs. MiRNAs were ranked based on the number of predicted hits, highlighting miR-661, a miRNA with so far no reported role in EMT. MiR-661 was found required for efficient invasion of breast cancer cells by destabilizing two of its predicted mRNA targets, the cell-cell adhesion protein Nectin-1 and the lipid transferase StarD10, resulting, in turn, in the downregulation of epithelial markers. Reexpression of Nectin-1 or StarD10 lacking the 3'-untranslated region counteracted SNAI1-induced invasion. Importantly, analysis of public transcriptomic data from a cohort of 295 well-characterized breast tumor specimen revealed that expression of StarD10 is highly associated with markers of luminal subtypes whereas its loss negatively correlated with the EMT-related, basal-like subtype. Collectively, our non-a priori approach revealed a nonpredicted link between SNAI1-triggered EMT and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome. [less ▲]

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See detailUna mirada al MERCOSUR desde la Corte Suprema de Justicia de la Nación. Comentario al fallo Bio Sidus
Pena, Mariana UL

in Revista de Doctrina Judicial (2013), 35

Comentario al Fallo Bio Sidus. Envío de una opinión consultiva al Tribunal Permanente de Revisión del MERCOSUR sobre la compatibilidad con el Tratado de Asunción de la percepción de derechos de ... [more ▼]

Comentario al Fallo Bio Sidus. Envío de una opinión consultiva al Tribunal Permanente de Revisión del MERCOSUR sobre la compatibilidad con el Tratado de Asunción de la percepción de derechos de exportación sobre mercaderías originarias de un Estado Parte del MERCOSUR y destinadas a otro Estado Parte. [less ▲]

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See detailMiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties
Schmitt, Martina; Margue, Christiane UL; Behrmann, Iris UL et al

in Current Molecular Medicine (2012), 13(4), 572-585

MicroRNAs (miRNAs) are ubiquitously expressed small, non-coding RNAs that negatively regulate gene expression at a post-transcriptional level. So far, over 1000 miRNAs have been identified in human cells ... [more ▼]

MicroRNAs (miRNAs) are ubiquitously expressed small, non-coding RNAs that negatively regulate gene expression at a post-transcriptional level. So far, over 1000 miRNAs have been identified in human cells and their diverse functions in normal cell homeostasis and many different diseases have been thoroughly investigated during the past decade. MiR-29, one of the most interesting miRNA families in humans to date, consists of three mature members miR-29a, miR-29b and miR-29c, which are encoded in two genetic clusters. Members of this family have been shown to be silenced or down-regulated in many different types of cancer and have subsequently been attributed predominantly tumor-suppressing properties, albeit exceptions have been described where miR-29s have tumor-promoting functions. MiR-29 targets expression of diverse proteins like collagens, transcription factors, methyltransferases and others, which may partake in abnormal migration, invasion or proliferation of cells and may favor development of cancer. Furthermore, members of the miR-29 family can be activated by interferon signaling, which suggests a role in the immune system and in host-pathogen interactions, especially in response to viral infections. In this review, we summarize current knowledge on the genomic organization and regulation of the miR-29 family and we provide an overview of its implication in cancer suppression and promotion as well as in host immune responses. The numerous remarkable properties of these miRNAs and their often altered expression patterns might make the miR-29 family promising biomarkers and therapeutic targets for various diseases in future. © 2013 Bentham Science Publishers. [less ▲]

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See detailMiRNAs and neural stem cells: a team to treat Parkinson's disease?
Palm, Thomas; Bahnassawy, Lamia A; Schwamborn, Jens Christian UL

in RNA Biology (2012), 9(6), 720-30

Parkinson's disease (PD) is a common neurodegenerative disorder with no proven neuroprotective or neurorestorative therapies. During disease progression, degeneration of dopaminergic neurons of the ... [more ▼]

Parkinson's disease (PD) is a common neurodegenerative disorder with no proven neuroprotective or neurorestorative therapies. During disease progression, degeneration of dopaminergic neurons of the central nervous system occurs. Therefore, therapies that either aim on the inhibition of this degeneration or on the replacement of the degenerated neurons are needed. On the one hand, arrest of degeneration might be achievable through specific inhibition of disease associated genes like alpha-Synuclein or Leucine rich repeat kinase 2 (LRRK2). On the other hand, based on neural stem cells that bear the ability to generate new dopaminergic neurons, replacement of degenerated cells could be accomplished. Since both approaches can be regulated by micro-RNAs, these molecules have an enormous therapeutic potential. In this review, we will focus on the neurobiological and neurodegenerative implications of miRNAs and highlight their role in stem cell fate decisions. Finally, we will discuss their potential as therapeutic agents and targets for Parkinson's disease. [less ▲]

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See detailmiRNAs in ancient tissue specimens of the Tyrolean Iceman
Keller, Andreas; Kreis, Stephanie UL; Leidinger, Petra et al

in Molecular Biology and Evolution (2016), 34(4), 793-801

The analysis of nucleic acids in ancient samples is largely limited to DNA. Small noncoding RNAs (microRNAs) are known to be evolutionary conserved and stable. To gain knowledge on miRNAs measured from ... [more ▼]

The analysis of nucleic acids in ancient samples is largely limited to DNA. Small noncoding RNAs (microRNAs) are known to be evolutionary conserved and stable. To gain knowledge on miRNAs measured from ancient samples, we profiled microRNAs in cryoconserved mummies. First, we established the approach on a World War One warrior, the “Kaiserj€ager”, which has been preserved for almost one century. Then, we profiled seven ancient tissue specimens including skeletal muscle, stomach mucosa, stomach content and two corpus organ tissues of the 5,300-year-old copper age mummy Iceman and compared these profiles to the presence of organ-specific miRNAs in modern tissues. Our analyses suggest the presence of specific miRNAs in the different Iceman’s tissues. Of 1,066 analyzed human miRNAs, 31 were discovered across all biopsies and 87 miRNAs were detected only in a single sample. To check for potential microbiological contaminations, all miRNAs detected in Iceman samples and not present in ancient samples were mapped to 14,582 bacterial and viral genomes. We detected few hits (3.9% of miRNAs compared with 3.6% of miRNAs). Interestingly, the miRNAs with higher abundance across all ancient tissues were significantly enriched for Guanine (P value of 10–13) and Cytosine (P value of 10–7). The same pattern was observed for modern tissues. Comparing miRNAs measured from ancient organs to modern tissue patterns highlighted significant similarities, e.g., formiRNAs present in themuscle. Our first comprehensive analysis of microRNAs in ancient human tissues indicates that these stable molecules can be detected in tissue specimens after 5,300 years. [less ▲]

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See detailThe miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster
Pichler, Sabrina; Gu, Wei UL; Hartl, Daniela et al

in Neurobiology of Aging (2016), 50

MicroRNAs (miRNAs) are small noncoding RNA molecules, with essential functions in RNA silencing and post-transcriptional regulation of gene expression. miRNAs appear to regulate the development and ... [more ▼]

MicroRNAs (miRNAs) are small noncoding RNA molecules, with essential functions in RNA silencing and post-transcriptional regulation of gene expression. miRNAs appear to regulate the development and function of the nervous system. Alterations of miRNA expression have been associated with Alzheimer's disease (AD). To characterize the AD miRNA signature, we examined genome-wide miRNA and mRNA expression patterns in the temporal cortex of AD and control samples. We validated our miRNA results by semiquantitative real-time polymerase chain reaction (PCR) in independent prefrontal cortex. Furthermore, we separated gray and white matter brain sections to identify the cellular origin of the altered miRNA expression. We observed genome-wide downregulation of hsa-miR-132-3p and hsa-miR-212-3p in AD with a stronger decrease in gray matter AD samples. We further identified 10 differently expressed transcripts achieving genome-wide levels of significance. Significantly deregulated miRNAs and mRNAs were correlated and examined for potential binding sites (in silico). This miRNome-wide study in AD provides supportive evidence and corroborates an important contribution of miR-132/212 and corresponding target mRNAs to the pathogenesis of AD. [less ▲]

Detailed reference viewed: 116 (5 UL)