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See detailLe médium nomade du logogramme et du logoneige de Christian Dotremont
PELARD, Emmanuelle UL

in Revue Proteus. Cahiers des théories de l'art (2010), 1

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See detailMedium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay
Siddiqui, Farid A.; Parkkola, Hanna; Manoharan, Ganesh Babu UL et al

in SLAS Discovery (2019)

The protein-folding chaperone Hsp90 enables the maturation and stability of various oncogenic signaling proteins and is thus pursued as a cancer drug target. Folding in particular of protein kinases is ... [more ▼]

The protein-folding chaperone Hsp90 enables the maturation and stability of various oncogenic signaling proteins and is thus pursued as a cancer drug target. Folding in particular of protein kinases is assisted by the co-chaperone Cdc37. Several inhibitors against the Hsp90 ATP-binding site have been developed. However, they displayed significant toxicity in clinical trials. By contrast, the natural product conglobatin A has an exceptionally low toxicity in mice. It targets the protein–protein interface (PPI) of Hsp90 and Cdc37, suggesting that interface inhibitors have an interesting drug development potential. In order to identify inhibitors of the Hsp90/Cdc37 PPI, we have established a mammalian cell lysate-based, medium-throughput amenable split Renilla luciferase assay. This assay employs N-terminal and C-terminal fragments of Renilla luciferase fused to full-length human Hsp90 and Cdc37, respectively. We expect that our assay will allow for the identification of novel Hsp90/Cdc37 interaction inhibitors. Such tool compounds will help to evaluate whether the toxicity profile of Hsp90/Cdc37 PPI inhibitors is in general more favorable than that of ATP-competitive Hsp90 inhibitors. Further development of such tool compounds may lead to new classes of Hsp90 inhibitors with applications in cancer and other diseases. [less ▲]

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See detailMedizinische Eingriffe und Operationsstress
Vögele, Claus UL

in Bengel, J.; Jerusalem, M. (Eds.) Handbuch der Gesundheitspsychologie und Medizinischen Psychologie (2009)

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See detailMedizinische Klassifikationen: ICD-10, ICIDH, ICF und DSM 5
Limbach-Reich, Arthur UL; Pitsch, Hans-Jürgen

in Limbach-Reich, Arthur (Ed.) Inklusive Diagnostik. Möglichkeiten und Perspektiven einer qualitativ-quantitativen Diagnostik aus Sicht der Sonder- und Regelpädagogik in Praxis, Wissenschaft und Forschung. (2014)

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See detailMedizinstudenten und ihre Berufsperspektiven - In welcher Facharztrichtung, wo und wie wollen sie arbeiten?
Heinz, Andreas UL; Jacob, Rüdiger

in Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz (2012), 55(2), 245-253

This article presents selected results from a nationwide online survey in Germany asking medical students about their occupational perspectives and expectations: what kind of specialization are they ... [more ▼]

This article presents selected results from a nationwide online survey in Germany asking medical students about their occupational perspectives and expectations: what kind of specialization are they inclined to, where do they want to work, and under what conditions? We sent an email to all the students at 34 of 36 faculties of medicine, asking them to partake in the survey. Through 9 July 2010, 12,518 students answered, which is 15.7% of all 79,929 students enrolled in medicine. One central result is that general medicine—compared to the current situation — will have significant problems in recruiting young medical professionals, if the preferences of the students do not change. In addition, we found spatial disparities: students consider Berlin and Hamburg, urban areas in Southern Germany and the Ruhr Area as attractive places to work, whereas economically underdeveloped rural areas in both Eastern and Western Germany are highly unattractive. So especially So especially those regions will face the problem of recruiting a sufficient number of general practitioners. One strategy to solve this problem could be to recruit young adults for medical school from these rural locations, because there is also a clear tendency that students study close to their home and later also want to work there. [less ▲]

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See detailMedlineRanker: flexible ranking of biomedical literature.
Fontaine, Jean-Fred; Barbosa Da Silva, Adriano UL; Schaefer, Martin et al

in Nucleic acids research (2009), 37(Web Server issue), 141-6

The biomedical literature is represented by millions of abstracts available in the Medline database. These abstracts can be queried with the PubMed interface, which provides a keyword-based Boolean search ... [more ▼]

The biomedical literature is represented by millions of abstracts available in the Medline database. These abstracts can be queried with the PubMed interface, which provides a keyword-based Boolean search engine. This approach shows limitations in the retrieval of abstracts related to very specific topics, as it is difficult for a non-expert user to find all of the most relevant keywords related to a biomedical topic. Additionally, when searching for more general topics, the same approach may return hundreds of unranked references. To address these issues, text mining tools have been developed to help scientists focus on relevant abstracts. We have implemented the MedlineRanker webserver, which allows a flexible ranking of Medline for a topic of interest without expert knowledge. Given some abstracts related to a topic, the program deduces automatically the most discriminative words in comparison to a random selection. These words are used to score other abstracts, including those from not yet annotated recent publications, which can be then ranked by relevance. We show that our tool can be highly accurate and that it is able to process millions of abstracts in a practical amount of time. MedlineRanker is free for use and is available at http://cbdm.mdc-berlin.de/tools/medlineranker. [less ▲]

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See detailMedroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats.
Arias-Loza, Paula Anahi; Hu, Kai; Schafer, Andreas et al

in Hypertension (2006), 48(5), 994-1001

Controversial results obtained from human and animal studies on the prevention of heart disease by estrogens and progestins warrant a better understanding of nuclear hormone receptor function and ... [more ▼]

Controversial results obtained from human and animal studies on the prevention of heart disease by estrogens and progestins warrant a better understanding of nuclear hormone receptor function and interaction. To address this issue and taking into account that effects of synthetic progestins are not only referable to action through the progesterone receptor but may also be mediated by other steroid receptors, we characterized cardiovascular function and inflammatory gene expression in aldosterone salt-treated rats on long-term administration of 17beta-estradiol, medroxyprogesterone acetate, and drospirenone, a new progestogen exhibiting antimineralocorticoid activity. The complex pattern of cardiovascular injury in ovariectomized Wistar rats induced by chronic aldosterone infusion plus a high-salt diet was significantly attenuated in sham-ovariectomized rats and by coadministration of 17beta-estradiol in ovariectomized animals after 8 weeks of continuous treatment. The beneficial role of 17beta-estradiol on blood pressure, cardiac hypertrophy, vascular osteopontin expression, perivascular fibrosis, and impaired NO-dependent relaxation of isolated aortic rings was completely abrogated by coadministration of medroxyprogesterone acetate. In contrast, drospirenone was either neutral or additive to 17beta-estradiol in protecting against aldosterone salt-induced cardiovascular injury and inflammation. The current results support the hypothesis of complex interactions among estrogen, progesterone, glucocorticoid, androgen, and mineralocorticoid receptor signaling in cardiovascular injury and inflammation. Novel progestins, such as drospirenone, confer superior effects compared with medroxyprogesterone acetate in a model of aldosterone-induced heart disease because of its antimineralocorticoid properties. [less ▲]

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See detailMedusa: A tool for exploring and clustering biological networks.
Pavlopoulos, Georgios A.; Hooper, S. D.; Sifrim, A. et al

in BMC Research Notes (2011), 4(1), 384

Background: Biological processes such as metabolic pathways, gene regulation or protein-protein interactions are often represented as graphs in systems biology. The understanding of such networks, their ... [more ▼]

Background: Biological processes such as metabolic pathways, gene regulation or protein-protein interactions are often represented as graphs in systems biology. The understanding of such networks, their analysis, and their visualization are today important challenges in life sciences. While a great variety of visualization tools that try to address most of these challenges already exists, only few of them succeed to bridge the gap between visualization and network analysis. Findings: Medusa is a powerful tool for visualization and clustering analysis of large-scale biological networks. It is highly interactive and it supports weighted and unweighted multi-edged directed and undirected graphs. It combines a variety of layouts and clustering methods for comprehensive views and advanced data analysis. Its main purpose is to integrate visualization and analysis of heterogeneous data from different sources into a single network. Conclusions: Medusa provides a concise visual tool, which is helpful for network analysis and interpretation. Medusa is offered both as a standalone application and as an applet written in Java. It can be found at: https:// sites.google.com/site/medusa3visualization. [less ▲]

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See detailMeer pedagogiek in de lerarenopleiding?
Biesta, Gert UL

in Tijdschrift voor lerarenopleiders (1998), 19(2), 69-74

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See detailMeet the editor session for the European Journal of Psychological Assessment
Greiff, Samuel UL; Ziegler, M.

Speeches/Talks (2017)

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See detailMeet-in-the-Middle Attacks and Structural Analysis of Round-Reduced PRINCE
Derbez, Patrick UL; Perrin, Léo Paul UL

in Leander, Gregor (Ed.) Fast Software Encryption - 22nd International Workshop, FSE 2015, Istanbul, March 8-11, 2015 (2015, March)

NXP Semiconductors and its academic partners challenged the cryptographic community with finding practical attacks on the block cipher they designed, PRINCE. Instead of trying to attack as many rounds as ... [more ▼]

NXP Semiconductors and its academic partners challenged the cryptographic community with finding practical attacks on the block cipher they designed, PRINCE. Instead of trying to attack as many rounds as possible using attacks which are usually impractical despite being faster than brute-force, the challenge invites cryptographers to find practical attacks and encourages them to actually implement them. In this paper, we present new attacks on round-reduced PRINCE including the ones which won the challenge in the 6 and 8-round categories --- the highest for which winners were identified. Our first attacks rely on a meet-in-the-middle approach and break up to 10 rounds of the cipher. We also describe heuristic methods we used to find practical SAT-based and differential attacks. Finally, we also present an analysis of the cycle structure of the internal rounds of PRINCE leading both to a low complexity distinguisher for 4-round PRINCE-core and an alternative representation of the cipher valid in particular contexts and which highlights, in this cases, a poor diffusion. [less ▲]

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See detailMeeting Designers Where They Are: Using Industry Events as a Research Venue for HCI and Design Methods Development
Lockton, Dan; Lallemand, Carine UL

Scientific Conference (2020)

There is much work in the CHI community about the ‘industry-academia divide’, and how to bridge it. One key crossover between HCI/UX scientists and practitioners is the development and use of tools and ... [more ▼]

There is much work in the CHI community about the ‘industry-academia divide’, and how to bridge it. One key crossover between HCI/UX scientists and practitioners is the development and use of tools and methods—boundary objects between academia and practice. Among other forms of collaboration, there is an underdeveloped opportunity for academics to make use of industry events (conferences, meetups, design jams) as a research venue in the context of tool and method development. This paper describes three cases from work in academia-industry engagement over the last decade, in which workshops or experiments have been run at industry events as a way of trialling and developing tools directly with practitioners. We discuss advantages of this approach and extract key insights and practical implications, highlighting how the CHI community might use this method more widely, gathering relevant research outcomes while contributing to knowledge exchange between academia and practice. [less ▲]

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See detailMeeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium
Laurent, Louise; Abdel-Mageed, Asim; Adelson, P. David et al

in Journal of Extracellular Vesicles (2015), 4

Extracellular RNAs (exRNAs) have been identified in all tested biofluids and have been associated with a variety of extracellular vesicles, ribonucleoprotein complexes and lipoprotein complexes. Much of ... [more ▼]

Extracellular RNAs (exRNAs) have been identified in all tested biofluids and have been associated with a variety of extracellular vesicles, ribonucleoprotein complexes and lipoprotein complexes. Much of the interest in exRNAs lies in the fact that they may serve as signalling molecules between cells, their potential to serve as biomarkers for prediction and diagnosis of disease and the possibility that exRNAs or the extracellular particles that carry them might be used for therapeutic purposes. Among the most significant bottlenecks to progress in this field is the lack of robust and standardized methods for collection and processing of biofluids, separation of different types of exRNA-containing particles and isolation and analysis of exRNAs. The Sample and Assay Standards Working Group of the Extracellular RNA Communication Consortium is a group of laboratories funded by the U.S. National Institutes of Health to develop such methods. In our first joint endeavour, we held a series of conference calls and in-person meetings to survey the methods used among our members, placed them in the context of the current literature and used our findings to identify areas in which the identification of robust methodologies would promote rapid advancements in the exRNA field. [less ▲]

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See detailMeeting the Challenges of Critical and Extreme Dependability and Security
Verissimo, Paulo UL; Volp, Marcus UL; Decouchant, Jérémie UL et al

in Proceedings of the 22nd Pacific Rim International Symposium on Dependable Computing (2017)

The world is becoming an immense critical information infrastructure, with the fast and increasing entanglement of utilities, telecommunications, Internet, cloud, and the emerging IoT tissue. This may ... [more ▼]

The world is becoming an immense critical information infrastructure, with the fast and increasing entanglement of utilities, telecommunications, Internet, cloud, and the emerging IoT tissue. This may create enormous opportunities, but also brings about similarly extreme security and dependability risks. We predict an increase in very sophisticated targeted attacks, or advanced persistent threats (APT), and claim that this calls for expanding the frontier of security and dependability methods and techniques used in our current CII. Extreme threats require extreme defenses: we propose resilience as a unifying paradigm to endow systems with the capability of dynamically and automatically handling extreme adversary power, and sustaining perpetual and unattended operation. In this position paper, we present this vision and describe our methodology, as well as the assurance arguments we make for the ultra-resilient components and protocols they enable, illustrated with case studies in progress. [less ▲]

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See detailMeeting the Lower Bound on Designing Set of Unimodular Sequences with Small Aperiodic/Periodic ISL
Alaee-Kerahroodi, Mohammad UL; Shankar, Bhavani; Mishra, Kumar Vijay et al

in 2019 20th International Radar Symposium (IRS) (2019)

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See detailMega columns with several reinforced steel profiles - experimental and numerical investigations
Bogdan, Teodora; Chrzanowski, Maciej UL

in Proceedings of the ASCCS 2018 Conference, Valencia, Spain, June 27-29, 2018 (2018, June)

Detailed reference viewed: 69 (6 UL)