11th. World Congress on Computational Mechanics (WCCM XI)

Scientific Conference (2014, July 23)

12th FIEP European Congress 2017

Diverse speeches and writings (2016)

Congress title: “Changes in Childhood and Adolescence: Current Challenges for Physical Education”

13.9 heures est une période de résonance des océans atlantique et indien - Thèse annexe

Dissertation and these (1993)

14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.

in Molecular Brain Research (2002), 108(1-2), 33-9

Mutations in alpha-synuclein have been identified in some rare families with autosomal dominant Parkinson's disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 ... [more ▼]

Mutations in alpha-synuclein have been identified in some rare families with autosomal dominant Parkinson's disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 proteins and binds to 14-3-3 proteins and to its ligands. We therefore investigated whether 14-3-3 proteins are also involved in the pathogenesis of PD. Here we demonstrate that 14-3-3 proteins are colocalized with Lewy bodies in PD. We investigated the 14-3-3 eta (YWHAH) gene by mutation analysis and association studies as it maps to human chromosome 22q12.1-q13.1, a region which has been recently implicated in PD and carried out immunohistochemical studies of Lewy bodies with two different 14-3-3 eta antibodies. In 358 sporadic and familial PD patients, disease causing mutations were not identified. Furthermore, association studies with intragenic polymorphisms do not provide evidence for an involvement of 14-3-3 eta in the pathogenesis of PD. In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit. [less ▲]

150 ans de chemins de fer luxembourgeois (1859-2009). De la fin d'un isolement au début d'une mobilité durable

in 150 Joer Eisebunn zu Lëtzebuerg, 1859 - 2009 (2009)

16 GHz Bandwidth MSM Photodetector and 45/85 GHz fT/fmax HEMT Prepared on an Identical InGaAs/InP Layer Structure

in Electronics Letters (1996), 32

17 The epidemiology and immunogenetics of IDDM in Italian-heritage populations. Diabetes Epidemiology Research International (DERI) Study Group

in Diabetes/Metabolism Reviews (1990), 6

17beta-estradiol prevents programmed cell death in cardiac myocytes.

in Biochemical and biophysical research communications (2000), 268(1), 192-200

The cardioprotective effects of estrogens are clearly established. However, the underlying mechanisms are poorly understood. Because programmed cell death (apoptosis) probably contributes to the loss of ... [more ▼]

The cardioprotective effects of estrogens are clearly established. However, the underlying mechanisms are poorly understood. Because programmed cell death (apoptosis) probably contributes to the loss of cardiac myocytes in heart failure and because estrogens prevent apoptosis in breast cancer cells, we investigated whether the loss of cardiac myocytes by programmed cell death could be prevented by physiological doses of 17beta-estradiol. Apoptosis of cultured cardiac myocytes was induced by staurosporine. 17beta-estradiol (10 nM) had an antiapoptotic effect as determined by morphological analysis, vital staining using the Hoechst dye 33342 and terminal transferase dUTP nick-end labeling (TUNEL). As a potential mechanism for the antiapoptotic effect of 17beta-estradiol we found a reduced activity of the ICE-like protease caspase-3 in hormone-treated myocytes. Furthermore, inhibition of apoptosis by estradiol was associated with a reduced activity of NF-kappaB transcription factors, particularly p65/RelA and p50. To our knowledge, these data provide the first indication that 17beta-estradiol in physiological concentrations inhibits apoptosis in cardiac myocytes. The antiapoptotic effect of estrogens might contribute to the known cardioprotective effect of estrogens and provides a starting point for the development of future treatment options. [less ▲]

Das 18. Jahrhundert: eine Beschleunigung

in Hausberger, Bernd; Lehners, Jean-Paul (Eds.) Die Welt im 18. Jahrhundert. (2011)

1839 ou comment le Luxembourg s'est inventé son anniversaire

Article for general public (2014)