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See detail"A Noble Animal" : Animalische und andere Tiere in D. H. Lawrence' "St. Mawr"
Kohns, Oliver UL

in Doll, Martin; Kohns, Oliver (Eds.) Politische Tiere : Zoologie des Kollektiven (2017)

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See detailA phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling
Gebruers, E.; Cordero-Maldonado, M. L.; Gray, A. I. et al

in PLoS ONE (2013), 8(12),

Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin. We carried out a ... [more ▼]

Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin. We carried out a zebrafish-based phenotypic screen of over 3000 plant-derived secondary metabolite extracts with the goal of identifying novel small-molecule modulators of the BMP and Wnt signaling pathways. One of the bioactive plant extracts identified in this screen - Jasminum gilgianum, an Oleaceae species native to Papua New Guinea - induced ectopic tails during zebrafish embryonic development. As ectopic tail formation occurs when BMP or non-canonical Wnt signaling is inhibited during the tail protrusion process, we suspected a constituent of this extract to act as a modulator of these pathways. A bioassay-guided isolation was carried out on the basis of this zebrafish phenotype, identifying para-coumaric acid methyl ester (pCAME) as the active compound. We then performed an in-depth phenotypic analysis of pCAME-treated zebrafish embryos, including a tissue-specific marker analysis of the secondary tails. We found pCAME to synergize with the BMP-inhibitors dorsomorphin and LDN-193189 in inducing ectopic tails, and causing convergence-extension defects in compound-treated embryos. These results indicate that pCAME may interfere with non-canonical Wnt signaling. Inhibition of Jnk, a downstream target of Wnt/PCP signaling (via morpholino antisense knockdown and pharmacological inhibition with the kinase inhibitor SP600125) phenocopied pCAME-treated embryos. However, immunoblotting experiments revealed pCAME to not directly inhibit Jnk-mediated phosphorylation of c-Jun, suggesting additional targets of SP600125, and/or other pathways, as possibly being involved in the ectopic tail formation activity of pCAME. Further investigation of pCAME's mechanism of action will help determine this compound's pharmacological utility. © 2013 Gebruers et al. [less ▲]

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See detailL'a priori, l'a posteriori, le pur et le non pur chez Christian Wolff et ses maîtres
Neveu, Sébastien Adrien Charles UL

Doctoral thesis (2014)

This work tries at first, in a structural part, to understand the coherence and to estimate the solidity of the " marriage between the reason and the experience " that Christian Wolff tried to establish ... [more ▼]

This work tries at first, in a structural part, to understand the coherence and to estimate the solidity of the " marriage between the reason and the experience " that Christian Wolff tried to establish in philosophy, by means of the concepts of a priori, of a posteriori, the pure and the not pure. It demonstrates while this "alliance" is not bearable and engenders an important tension in the whole of its thought, what engenders a historic crisis concerning the metaphysics, the crisis ending historically in the criticism of Kant. In a more historic, second part, this work tries to go back up at the origin of the use of these concepts (a priori, a posteriori, pure and not pure) at the predecessors of Wolff (Tschirnhaus, Leibniz, Weigel, Sturm, Agricola, Descartes, Ramus, etc.) to establish that the concept of pure reason is far from making the unanimity in the classic thought, that it stirs up controversy and that it is in complete opposition with the Aristotelian and scholastic tradition. This work thus allows in the end to question a history of the official philosophy based on the classic interpretation stemming from Kant. [less ▲]

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See detailA propos de la taille des villes. Population agglomérée - population dispersée à l'aube du XIXe siècle
Leboutte, René UL

in Le réseau urbain en Belgique dans une perspective historique (1350-1850). Une approche statistique et dynamique (1992)

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See detailA propos de Life time contracts
Hiez, David UL

in Revue Trimestrielle de Droit Civil (2014), 4

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See detailA propos des souvenirs de guerre de Jean Hamilius
Scuto, Denis UL

Article for general public (2015)

Weekly column on contemporary history ("L'histoire du temps présent") in Luxembourg newspaper Tageblatt, here on Mémoires of banker and liberal politician Jean Hamilius, "Luxemburg im Wandel der Zeiten"

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See detailA propos du principe de primauté
Neframi, Eleftheria UL

in Schneider, Catherine (Ed.) Le traité de Lisbonne. Reconfiguration ou déconstitutionnalisation de l’Union européenne ? (2009)

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See detailÀ propos...
Scuto, Denis UL

Article for general public (2018)

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See detailA quoi les jeunes adultes en Suisse aspirent pour leur avenir?
Samuel, Robin UL; Bergman, Manfred Max

Article for general public (2015)

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See detailA rendszerváltás és a büntetőjog
Ligeti, Katalin UL

in Kulcsár, K.; Bayer, J. (Eds.) Magyar Tudománytár (2003)

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See detailÅ snakke 'pedagogikk' til 'education': Internasjonalisering og problemet med konseptuell hegemoni i studiet av pedagogikk.
Biesta, Gert UL

in Norsk Pedagogisk Tidskrift (2013), 97(3), 172-184

I lys av internasjonaliseringen av den anglo-amerikanske konstruksjonen av feltet «education», presenterer og diskuterer artikkelen problemet med konseptuell hegemoni i pedagogisk forskning. Ved å drøfte ... [more ▼]

I lys av internasjonaliseringen av den anglo-amerikanske konstruksjonen av feltet «education», presenterer og diskuterer artikkelen problemet med konseptuell hegemoni i pedagogisk forskning. Ved å drøfte forskjellen mellom den engelskspråklige konstruksjonen «education» og den tyskspråklige konstruksjonen «Pädagogik», viser artikkelen hvordan en monokulturell tilnærming til pedagogikk – ved å ødelegge viktige og levedyktige alternativer – står i fare for å gjøre feltet meget sårbart. I forsøket på å gjøre distinksjonen mellom de to konstruksjonene tydelig, er det i oversettelsen av artikkelen systematisk benyttet begrepet «education» og kombinasjoner med «education» i tilknytning til den anglo-amerikanske konstruksjonen. «Pädagogik» og tyskspråklige begrep er brukt i tilknytning til den kontinentale konstruksjonen. Ellers er begrepene «pedagogikk» og «pedagogisk» brukt. [less ▲]

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See detailA spirituality of the good turn
Weber, Jean-Marie UL

Speeches/Talks (2017)

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See detailA survey on sustainability in ICT a computing perspective
Tantar, Alexandru-Adrian UL; Tantar, Emilia UL

in GECCO 2014 - Companion Publication of the 2014 Genetic and Evolutionary Computation Conference (2014)

The rise of the data centers industry, together with the emergence of large cloud computing that require large quantities of resources to be maintained, brought the need of providing a sustainable ... [more ▼]

The rise of the data centers industry, together with the emergence of large cloud computing that require large quantities of resources to be maintained, brought the need of providing a sustainable development process. Through this paper we aim to provide an introductory insight on the status and tools available to tackle this perspective within the evolutionary and genetic algorithms community. Existing advancement are also emphasized and perspectives outlined. [less ▲]

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See detailA szervezett bűnözés elleni fellépés állami eszközeiről
Ligeti, Katalin UL; Csúri, András

in Nagy, F. (Ed.) Festschrift für Mihály Vida (2006)

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See detailA training-resistant anomaly detection system
Muller, Steve UL; Lancrenon, Jean; Harpes, Carlo et al

in Computers & Security (2018), 76

Modern network intrusion detection systems rely on machine learning techniques to detect traffic anomalies and thus intruders. However, the ability to learn the network behaviour in real-time comes at a ... [more ▼]

Modern network intrusion detection systems rely on machine learning techniques to detect traffic anomalies and thus intruders. However, the ability to learn the network behaviour in real-time comes at a cost: malicious software can interfere with the learning process, and teach the intrusion detection system to accept dangerous traffic. This paper presents an intrusion detection system (IDS) that is able to detect common network attacks including but not limited to, denial-of-service, bot nets, intrusions, and network scans. With the help of the proposed example IDS, we show to what extent the training attack (and more sophisticated variants of it) has an impact on machine learning based detection schemes, and how it can be detected. © 2018 Elsevier Ltd [less ▲]

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See detailA wie Anfang
Heimböckel, Dieter UL

Article for general public (2012)

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See detailA-EKB-EA – Fragebogen zur Erfassung von Ambivalenz in Eltern-Kind-Beziehungen im Erwachsenenalter. Test Info.
Michels, Tom; Albert, Isabelle UL; Ferring, Dieter UL

in Focus Diagnostica (2011), 57 (1)

Ambivalenz in der Beziehung zu Mutter und Vater und anderen Familienmitgliedern stellt neben dem Solidaritätskonzept eine bedeutsame Dimension für die Beschreibung intergenerationeller Beziehungen dar ... [more ▼]

Ambivalenz in der Beziehung zu Mutter und Vater und anderen Familienmitgliedern stellt neben dem Solidaritätskonzept eine bedeutsame Dimension für die Beschreibung intergenerationeller Beziehungen dar. Psychologische Ambivalenz ist dabei definiert durch das gleichzeitige Auftreten von widersprüchlichen Motiven, Emotionen und Handlungstendenzen gegenüber einer Person. In der vorliegenden Studie wurde ein „Fragebogen zur Erfassung von Ambivalenz in Eltern-Kind-Beziehungen im Erwachsenenalter” entwickelt, der k = 23 Items umfasst und in einer Mutter- respektive Vaterversion vorliegt. Exploratorische und konfirmatorische Analysen in einer Stichprobe von N = 210 Personen jungen und mittleren Erwachsenenalters zeigten unterschiedliche zweifaktorielle Strukturen des Verfahrens für die Vater- und die Mutterversion. Es wurde weiter eine Kurzversion der Instrumente entwickelt, die Vergleiche zwischen elterlichen Beziehungen erlaubt. Die Prüfung der psychometrischen Kennwerte zeigte zufriedenstellende Reliabilitätsschätzungen; ebenso ergaben sich erste Hinweise auf eine substantielle kriterienbezogene Validität der Skalen. [less ▲]

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