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See detailInterozeption bei Depersonalisations-/Derealisationsstörung: veränderte Repräsentation afferenter Körpersignale auf Ebene des Kortex und des Hirnstamms
Schulz, André UL; Matthey, J. H.; Köster, S. et al

in Kubiak, T.; Wessa, M.; Witthöft, M. (Eds.) et al 15. Kongress der Deutschen Gesellschaft für Verhaltensmedizin und Verhaltensmodifikation - Abstractband (2016)

Die Depersonalisations-/Derealisationsstörung (DPD) ist durch eine subjektiv erlebte Distanz von Emotionen, sowie von Empfindungen des eigenen Körpers charakterisiert. Während viele neurophysiologische ... [more ▼]

Die Depersonalisations-/Derealisationsstörung (DPD) ist durch eine subjektiv erlebte Distanz von Emotionen, sowie von Empfindungen des eigenen Körpers charakterisiert. Während viele neurophysiologische Befunde ein verändertes Emotionserleben stützen, gibt es bislang keine neurophysiologischen Korrelate für eine veränderte Interozeption bei DPD. 27 Patienten mit DPD, sowie 27 gesunde Kontrollprobanden absolvierten zwei Herzschlagwahrnehmungstests: eine Herzschlagzählaufgabe (Schandry) und einen Test, bei dem zwischen Herzschlägen und exterozeptiven Signalen diskriminiert werden musste (Whitehead). Außerdem absolvierten die Probanden zwei psychophysiologische Verfahren, die interozeptive Signalübermittlung reflektieren: (1.) Herzschlag- evozierte Potenziale (HEPs), Indikatoren für die kortikale Verarbeitung afferenter Signale vom kardiovaskulären System und (2.) die kardiale Modulation der Schreckreaktion (CMS), welche als Index für die Verarbeitung kardio-afferenter Signale auf Ebene des Hirnstamms gilt. In den Herzschlagwahrnehmungstests gab es keine Gruppenunterschiede zwischen Patienten mit DPD und gesunden Kontrollprobanden, jedoch eine gegenläufige Tendenz beider Gruppen hinsichtlich der Genauigkeit über den Zeitverlauf (negative Lernkurve bei DPD). Bei der Kontrollgruppe zeigte sich ein intakter CMS-Effekt (geringere Schreckreaktionen während der frühen kardialen Phase), während sich bei den DPD-Patienten überhaupt kein CMS-Effekt beobachten ließ (Interaktion: p=.041). Ebenso wurden Gruppenunterschiede im HEP-Pattern beobachtet: gesunde Kontrollprobanden zeigten höhere HEP-Amplituden während der Aufmerksamkeitslenkung auf Körpersignale als während Ruhe. Dieser Effekt konnte bei DPD-Patienten nicht gefunden werden (Interaktion: p=.027). Die gegenläufigen Trends über den Zeitverlauf in verhaltensbasierten Indikatoren für Interozeption (Herzschlagwahrnehmung) bei DPD-Patienten gegenüber Kontrollprobanden impliziert, dass es Patienten weniger gut gelingt, ihre Aufmerksamkeit über längere Zeit auf Körperempfindungen zu fokussieren. Dieser Unterschied lässt sich auf veränderte Repräsentation afferenter Signale des kardiovaskulären Systems auf Hirnstammebene und auf kortikaler Ebene zurückführen. [less ▲]

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See detailDie Interozeption körperlicher Empfindungen bei somatoform gestörten Patienten
Vögele, Claus UL

in Margraf, J.; Neumer, S.; Rief, W. (Eds.) Somatoforme Störungen: Ätiologie, Diagnose und Therapie (1998)

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See detailInterozeption und Stress: die Psychophysiologie der bi-direktionalen Kommunikation auf der Hirn-Körper-Achse
Schulz, André UL

in Schächinger, H. (Ed.) Abstractband 43. Tagung Psychologie und Gehirn (2017)

Gehirn und Körper tauschen permanent Informationen aus. Interozeption, die Wahrnehmung von Körperprozessen, ist ein wichtiges Beispiel für aufsteigende Informationsübermittlung vom Körper zum Gehirn ... [more ▼]

Gehirn und Körper tauschen permanent Informationen aus. Interozeption, die Wahrnehmung von Körperprozessen, ist ein wichtiges Beispiel für aufsteigende Informationsübermittlung vom Körper zum Gehirn. Stress wiederum kann als prototypisch für absteigende Informationen vom Gehirn zum Körper gesehen werden. Eine Veränderung der Kommunikation auf der Hirn-Körper-Achse kann zur Entstehung körperlicher Symptome bei psychischen Störungen führen. Neueste Theorien zu Interozeption weisen darauf hin, dass es sich nicht um ein uniformes Konstrukt handelt, sondern in die Facetten ‚Bewusstheit‘ (Awareness), ‚Sensibilität‘ (Sensibility), ‚Genauigkeit‘ (Accuracy) und ZNS-Repräsentation afferenter Körpersignale separiert werden kann. Körperliche Symptome können aus der selektiven Veränderung weniger Facetten entstehen. Stress kann differenziert werden in psychologische (selbstberichteten Stress), sowie physiologische Komponenten, wie die Aktivität der beiden physiologischen Stressachsen, des autonomen Nervensystems und der HPA-Achse. In diesem Symposium werden erstmals Erkenntnisse zum Zusammenhang von Interozeption und Stress auf allen Beobachtungsebenen integriert. Zunächst werden Zusammenhänge von akuter Stressreaktivität und –Erholung mit ‚Interozeptiver Genauigkeit‘ bei gesunden Probanden diskutiert (van Dyck/Luxemburg). Anschließend werden Erkenntnisse zu chronischem Stress, ‚Interozeptiver Bewusstheit‘ und gesundheitlichen Beschwerden bei Angestellten präsentiert (Trojan/Landau). Danach wird die ZNS-Repräsentation von Körpersignalen und ‚Interozeptive Genauigkeit‘ bei Kindern und Jugendlichen besprochen (Mai/Ulm), da sich das Jugendalter als entwicklungsbedingte Phase besonderer Stressvulnerabilität erweist. Im der folgenden Studie wird ‚Interozeptive Genauigkeit‘, Stressbelastung und –reaktivität bei Erwachsenen mit einer Trennungserfahrung der Eltern im Kindesalter als Stressor untersucht (Schaan/Luxemburg). Abschließend werden Daten zu ZNS-Repräsentation von Körpersignalen und HPA-Achsenaktivität bei posttraumatischer Belastungsstörung präsentiert (Müller/Heidelberg). Letztlich wird eine Synthese der Einzelbefunde in eine erweiterte Theorie zu Interozeption und Stress diskutiert. [less ▲]

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See detailInterozeptive Genauigkeit: Ein methodischer Vergleich von zwei Heartbeat Tracking Paradigmen
Haciahmet, C.; Opdensteinen, K.; Schaan, L. et al

in Kirschbaum, C. (Ed.) 45. Jahrestagung Psychologie und Gehirn - Abstractband (2019)

Diese Arbeit untersucht zwei Herzschlagwahrnehmungsaufgaben mit unterschiedlichen Verarbeitungsmodi - Heartbeat Tracking Task (HTT; Schandry, 1981) und adaptierter Heartbeat Tracking Task (aHTT; adaptiert ... [more ▼]

Diese Arbeit untersucht zwei Herzschlagwahrnehmungsaufgaben mit unterschiedlichen Verarbeitungsmodi - Heartbeat Tracking Task (HTT; Schandry, 1981) und adaptierter Heartbeat Tracking Task (aHTT; adaptiert nach Melloni et al., 2013) - welche Interozeptive Genauigkeit (IG) anhand des Vergleichs von objektiver und selbst-berichteter Herzrate erfassen (Garfinkel et al., 2015). Die Paradigmen unterscheiden sich hinsichtlich des mentalen Zählens (HTT) und motorischen Tappings (aHTT) von kardiovaskulären Empfindungen. Tapping wird in Biofeedback-Studien zur Verbesserung der IG angewendet (Ring et al., 2015), bislang jedoch kaum mit mentalem Zählen verglichen. 74 gesunde Versuchspersonen (MAlter = 22.66, SDAlter = 2.74, 49 Frauen) bearbeiteten den HTT und den aHTT. Die IGScores des HTT waren im Durchschnitt signifikant höher als im aHTT (t(73) = 2.73, p = .01, d = .28). Bei einem Cut-Off von IG = 0.70 konnten 37 gute Herzschlagwahrnehmer/innen im HTT und 27 gute Herzschlagwahrnehmer/innen im aHTT klassifiziert werden. Auch im Selbstbericht zur eigenen Herzschlagwahrnehmungsfähigkeit, zeigte sich bei den Probanden ein höheres Konfidenzrating im HTT als im aHTT (MHTT = 5.00, SD = 2.04; MaHTT = 3.88, SD = 1.77; Z(74) = -5.24, p < .01, d = .59). Zusammenfassend weisen die Ergebnisse auf eine bessere Herzschlagwahrnehmung im HTT hin, sowohl bezüglich der IG-Scores als auch im Selbstbericht. Eine Erklärung für die niedrigeren Interozeptionswerte im aHTT könnte sein, dass die sensorische und motorische Interferenz der Tapping-Aufgaben mit der Detektion von afferenten Herzsensationen konkurrieren, weshalb der salientere Tapping-Stimulus den Aufmerksamkeitsfokus von internalen Prozessen ablenkt (Pennebaker & Hoover, 1984). Zukünftige Studien sollten prüfen, welche spezifischen Einsatzmöglichkeiten sich für HTT und aHTT anbieten, hinsichtlich einer akkuraten und ökonomischen Erfassung von IG. [less ▲]

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See detailInterozeptive Sensitivität bei Bulimia Nervosa und Binge-Eating-Störung
Van Dyck, Zoé UL; Schulz, André UL; Blechert, J. et al

in Kaiser, J.; Fiebach, C. (Eds.) 41. Tagung Psychologie und Gehirn - Abstracts der Beiträge (2015)

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See detailInterphases, gelation, vitrication, porous glasses and the generalized Cauchy relation: epoxy/silica nanocomposites
Philipp, Martine UL; Müller, Ulrich UL; Jiménez Riobóo, R. J. et al

in New Journal of Physics (2009), 11(2), 023015

The generalized Cauchy relation (gCR) of epoxy/silica nanocomposites does not show either the chemically induced sol–gel transition or the chemically induced glass transition in the course of ... [more ▼]

The generalized Cauchy relation (gCR) of epoxy/silica nanocomposites does not show either the chemically induced sol–gel transition or the chemically induced glass transition in the course of polymerization. Astonishingly, by varying the silica nanoparticles’ concentration between 0 and 25 vol%in the composites, the Cauchy parameter A of the gCR remains universal and can be determined from the pure epoxy’s elastic moduli. Air-filled porous silica glasses are considered as models for percolated silica particles. A longitudinal modulus versus density representation evidences the aforementioned transition phenomena during polymerization of the epoxy/silica nanocomposites. The existence of optically and mechanically relevant interphases is discussed. [less ▲]

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See detailThe Interplay between Active Ageing and Silver Economy – a QCA Analysis
Tkalec, Igor UL

in Cahiers RESUME (2017)

Ageing, the most salient policy challenge of the 21st century, can convert into an economic venture. In order to grasp this aspiration, this paper examines the interplay between active ageing and the ... [more ▼]

Ageing, the most salient policy challenge of the 21st century, can convert into an economic venture. In order to grasp this aspiration, this paper examines the interplay between active ageing and the demand side of the silver economy from both national and the EU perspective. The goal is to configure a combination of policies recommended by the active ageing framework that ameliorates silver consumption. Qualitative comparative analysis (QCA) demonstrated that the intersection between higher public health care spending, active social life, achieving employment targets and retirement before or at statutory retirement age constitutes a sufficient combination to exploit the potential of the silver economy. Therefore, the active ageing framework theoretically underpins the silver. However, the argument is not empirically compelling because only a minor proportion of the EU member states have actively engaged in the exploitation of the silver economy potential. [less ▲]

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See detailThe Interplay between Educational Achievement, Occupational Success, and Well-Being
Samuel, Robin UL; Bergman, Manfred Max; Hupka-Brunner, Sandra

in Social Indicators Research (2013), 111(1), 75-96

Many studies have examined the effect of life events, education, and income on well-being. Conversely, research concerning well-being as a predictor of life course outcomes is sparse. Diener’s suggestion ... [more ▼]

Many studies have examined the effect of life events, education, and income on well-being. Conversely, research concerning well-being as a predictor of life course outcomes is sparse. Diener’s suggestion “to inquire about the effects of well-being on future behavior and success” has, with some exceptions, not yet come to fruition. This article contributes to this body of research. We conceptualize and analyze the interplay between educational achievement, occupational success, and well-being as a complex process. The relationship between these domains is examined drawing on a structure-agency framework derived from Bourdieu and Social Comparison Theory. Social comparison between adolescents and their parents is suggested to be the mechanism explaining the effects of successful and unsuccessful intergenerational transmission of educational achievement and occupational success on well-being. It is further argued that well-being may serve as an individual resource by fostering educational and occupational outcomes. Panel data from the Transition from Education to Employment (TREE) project, a Swiss PISA 2000 follow-up study, was used. The interplay between well-being and successful and unsuccessful intergenerational transfer of educational attainment was analyzed in an autoregressive cross-lagged mixture model framework. Social comparison was found to be related to well-being, while well-being proved to significantly increase the probability of successful intergenerational transfer of educational attainment. [less ▲]

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See detailThe Interplay between Educational Success, Well-Being, and Gender
Samuel, Robin UL

Presentation (2012)

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See detailThe Interplay between Educational Success, Well-Being, and Gender
Samuel, Robin UL

Scientific Conference (2011)

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See detailThe Interplay between Language and Numbers in Bilinguals
Van Rinsveld, Amandine UL

Presentation (2013, June)

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See detailThe interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans
Khare, Shilpi; Linster, Carole UL; Clarke, Steven G.

in PLoS ONE (2011), 6(6), 20850

The protein L-isoaspartyl-O-methyltransferase functions to initiate the repair of isomerized aspartyl and asparaginyl residues that spontaneously accumulate with age in a variety of organisms ... [more ▼]

The protein L-isoaspartyl-O-methyltransferase functions to initiate the repair of isomerized aspartyl and asparaginyl residues that spontaneously accumulate with age in a variety of organisms. Caenorhabditis elegans nematodes lacking the pcm-1 gene encoding this enzyme display a normal lifespan and phenotype under standard laboratory growth conditions. However, significant defects in development, egg laying, dauer survival, and autophagy have been observed in pcm-1 mutant nematodes when deprived of food and when exposed to oxidative stress. Interestingly, overexpression of this repair enzyme in both Drosophila and C. elegans extends adult lifespan under thermal stress. In this work, we show the involvement of the insulin/insulin-like growth factor-1 signaling (IIS) pathway in PCM-1-dependent lifespan extension in C. elegans. We demonstrate that reducing the levels of the DAF-16 downstream transcriptional effector of the IIS pathway by RNA interference reduces the lifespan extension resulting from PCM-1 overexpression. Using quantitative real-time PCR analysis, we show the up-regulation of DAF-16-dependent stress response genes in the PCM-1 overexpressor animals compared to wild-type and pcm-1 mutant nematodes under mild thermal stress conditions. Additionally, similar to other long-lived C. elegans mutants in the IIS pathway, including daf-2 and age-1 mutants, PCM-1 overexpressor adult animals display increased resistance to severe thermal stress, whereas pcm-1 mutant animals survive less long under these conditions. Although we observe a higher accumulation of damaged proteins in pcm-1 mutant nematodes, the basal level of isoaspartyl residues detected in wild-type animals was not reduced by PCM-1 overexpression. Our results support a signaling role for the protein L-isoaspartyl methyltransferase in lifespan extension that involves the IIS pathway, but that may be independent of its function in overall protein repair. [less ▲]

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See detailThe Interplay between Relationships, Roles and Objects
Boella, Guido UL; van der Torre, Leon UL

in Proceedings of FSEN09 (2009)

In this paper we study the interconnection between relationships and roles. We start from the patterns used to introduce relationships in object oriented languages, and we show how the role model proposed ... [more ▼]

In this paper we study the interconnection between relationships and roles. We start from the patterns used to introduce relationships in object oriented languages, and we show how the role model proposed in powerJava can be used to define roles. In particular, we focus on how to implement roles in an abstract way in objects representing relationships, and to specify the interconnections between the roles. Abstract roles cannot be instantiated. To participate in a relationship, objects have to extend the abstract roles of the relationship. Only when roles are implemented in the objects offering them, they can be instantiated, thus allowing another object to play those roles. [less ▲]

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See detailInterplay of chemical structure and magnetic order coupling at the interface between Cr2O3 and Fe3O4 in hybrid nanocomposites
Otero-Lorenzo, Ruth; Weber, Mads C.; Thomas, Pamela A. et al

in Physical Chemistry Chemical Physics (2014), 16(40), 22337-22342

Hybrid nanocomposites based on ferrimagnetic (FiM) Fe3O4 and magnetoelectric antiferromagnetic (AFM) Cr2O3 nanocrystals were synthesized to offer a particular three-dimensional (3D) interface between the ... [more ▼]

Hybrid nanocomposites based on ferrimagnetic (FiM) Fe3O4 and magnetoelectric antiferromagnetic (AFM) Cr2O3 nanocrystals were synthesized to offer a particular three-dimensional (3D) interface between the two oxides. This interface favours an intermixing process (demonstrated by combining Raman spectroscopy and magnetization measurements) that determines the final magnetic behavior. [less ▲]

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See detailThe interplay of deliberative legitimacy, constituent power and constitutional form
Burks, Deven UL

Scientific Conference (2019, May 21)

Enhanced legitimacy is a driving force behind deliberative innovations (Fung 2015, Curato and Böker 2016). This is no less the case for constitutional deliberative innovations. Assessing deliberative ... [more ▼]

Enhanced legitimacy is a driving force behind deliberative innovations (Fung 2015, Curato and Böker 2016). This is no less the case for constitutional deliberative innovations. Assessing deliberative constitutionalism’s success in generating legitimacy necessitates a better grasp of the distinct legitimacy standards which constitutional deliberative innovations may meet. Bound up with those standards is deliberative constitutionalism’s attempt to navigate the tension between politics and law, constituent power (CP) and constituted form (CF). How do factors of deliberative legitimacy interact with standard ways of modelling that tension? To answer this question, I proceed in three parts, the first of which maps ten factors of deliberative legitimacy at four levels: personal, interpersonal, institutional, and systemic. The second lays out four ways of modelling the tension between CP and CF from Loughlin and Walker (2007): the containment, mutual articulation, radical potential, and irritant models. The last part sets out to determine whether the four models directly or indirectly support or neglect the realization of the forms of deliberative legitimacy and casts in a different light from Parkinson (2016) the landscape of deliberative democracy and constitutions. I conclude that certain forms of deliberative legitimacy may be more sensitive to and better served by some models of CP and CF than by others. [less ▲]

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See detailInterplay of measles virus with early induced cytokines reveals different wild type phenotypes.
Kessler, Julia UL; Kremer, Jacques R.; Muller, Claude P.

in Virus Research (2011), 155(1), 195-202

Differential effects of measles virus (MV) on the innate immune response may influence virus spread and severity of disease. Using a representative panel of 22 MV strains including 14 different genotypes ... [more ▼]

Differential effects of measles virus (MV) on the innate immune response may influence virus spread and severity of disease. Using a representative panel of 22 MV strains including 14 different genotypes, we found that wild-type (wt) differ considerably in their sensitivity to type I interferon (IFN). The wt virus production was 2-47-fold lower in IFN-alpha treated Vero/hSLAM cells, whereas vaccine virus production was reduced only 2-3-fold. Sequence analysis of the MV-P/C/V gene, revealed no obvious amino acid mutations that correlated with the different phenotypes. Strains also widely differed in their ability to induce type I IFN, tumor necrosis factor (TNF) alpha and other cytokines in human A549/hSLAM cells. Some wt strains that were highly sensitive to type I IFN induced only low levels of these and other cytokines. In vitro wt strains that produced the 5' copy-back defective interfering RNAs (5'cb-diRNA) characterized by Shingai et al. (2007), induced high levels of cytokines that otherwise were only reached by vaccine strains. These 5'cb-diRNAs emerged only in virus cultures during multiple passaging and were not detectable in clinical samples of measles patients. These subgenomic RNAs are an important confounding parameter in passaged wt viruses which must be carefully assessed in all in vitro studies. The present data show that MV wt strains differ in their sensitivity and their ability to temper with the innate immune response, which may result in differences in virulence. [less ▲]

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See detailInterplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function
Nazarov, P. V. A; Reinsbach, Susanne UL; Muller, A. A et al

in Nucleic Acids Research (2013), 41(5), 2817-2831

MicroRNAs (miRNAs) are ubiquitously expressed small non-coding RNAs that, in most cases, negatively regulate gene expression at the posttranscriptional level. miRNAs are involved in fine-tuning ... [more ▼]

MicroRNAs (miRNAs) are ubiquitously expressed small non-coding RNAs that, in most cases, negatively regulate gene expression at the posttranscriptional level. miRNAs are involved in fine-tuning fundamental cellular processes such as proliferation, cell death and cell cycle control and are believed to confer robustness to biological responses. Here, we investigated simultaneously the transcriptional changes of miRNA and mRNA expression levels over time after activation of the Janus kinase/Signal transducer and activator of transcription (Jak/STAT) pathway by interferon-c stimulation of melanoma cells. To examine global miRNA and mRNA expression patterns, time-series microarray data were analysed. We observed delayed responses of miRNAs (after 24-48 h) with respect to mRNAs (12-24 h) and identified biological functions involved at each step of the cellular response. Inference of the upstream regulators allowed for identification of transcriptional regulators involved in cellular reactions to interferon-c stimulation. Linking expression profiles of transcriptional regulators and miRNAs with their annotated functions, we demonstrate the dynamic interplay of miRNAs and upstream regulators with biological functions. Finally, our data revealed network motifs in the form of feed-forward loops involving transcriptional regulators, mRNAs and miRNAs. Additional information obtained from integrating time-series mRNA and miRNA data may represent an important step towards understanding the regulatory principles of gene expression. © The Author(s) 2013. [less ▲]

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See detailThe interplay of personality and attitudes toward own aging across two decades of later life
Kornadt, Anna Elena UL; Siebert, Jelena S.; Wahl, Hans-Werner

in PLoS One (2019), 14(10),

Big Five personality traits are assumed to be linked with attitudes toward own aging. Since both constructs have central importance for the aging process, it is surprising that to our knowledge no study ... [more ▼]

Big Five personality traits are assumed to be linked with attitudes toward own aging. Since both constructs have central importance for the aging process, it is surprising that to our knowledge no study so far comprehensively addressed their mutual connection over time. We used data from the ILSE study, a longitudinal study capturing personality and attitudes toward own aging at four measurement occasions, spanning 20 years and including two participant cohorts in midlife (n = 501; born 1950–52) and later life (n = 500; born 1930–32). Dual latent change score models showed that personality was longitudinally related to change in attitudes toward own aging: Lower Neuroticism, higher Conscientiousness, and higher Openness predicted more positive attitudes, whereas the direction of the effect for Extraversion varied by time. Furthermore, the role of personality seems to be confined to certain sensitive periods in midlife and early old age. Contrary to our expectations, attitudes toward own aging had only marginal longitudinal impact on the Big Five. Our results shed light on the developmental co-dynamics of personality and subjective perceptions of aging across the second half of the lifespan. [less ▲]

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See detailInterpolable Formulas in Equilibrium Logic and Answer Set Programming
Gabbay, Dov M. UL; Pearce, David; Valverde, Agust In

in Journal of Artificial Intelligence Research (2014), abs/1401.3897

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