Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailExpanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants.
Thiele, Ines UL; Vo, Thuy D.; Price, Nathan D. et al

in Journal of Bacteriology (2005), 187(16), 5818-30

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the ... [more ▼]

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the revised genome annotation and new experimental data. This reconstruction, iIT341 GSM/GPR, represents a detailed review of the current literature about H. pylori as it integrates biochemical and genomic data in a comprehensive framework. In total, it accounts for 341 metabolic genes, 476 intracellular reactions, 78 exchange reactions, and 485 metabolites. Novel features of iIT341 GSM/GPR include (i) gene-protein-reaction associations, (ii) elementally and charge-balanced reactions, (iii) more accurate descriptions of isoprenoid and lipopolysaccharide metabolism, and (iv) quantitative assessments of the supporting data for each reaction. This metabolic reconstruction was used to carry out in silico deletion studies to identify essential and conditionally essential genes in H. pylori. A total of 128 essential and 75 conditionally essential metabolic genes were identified. Predicted growth phenotypes of single knockouts were validated using published experimental data. In addition, in silico double-deletion studies identified a total of 47 synthetic lethal mutants involving 67 different metabolic genes in rich medium. [less ▲]

Detailed reference viewed: 128 (2 UL)
Full Text
Peer Reviewed
See detailExpanding spaces of participation: insights from an infrastructural project in rural Nepal
Cima, Ottavia UL

in Geographica Helvetica (2015), 70(4), 353-361

The spread of participatory development worldwide has multiplied opportunities for local population to engage in paid and unpaid development activities. However, scholars have pointed out that ... [more ▼]

The spread of participatory development worldwide has multiplied opportunities for local population to engage in paid and unpaid development activities. However, scholars have pointed out that participatory approaches bear the risk of strengthening unequal social structures, despite their emphasis on democratisation and inclusion. This paper investigates the case of a Swiss-funded infrastructural project in rural Nepal, analysing the role of participatory spaces in the dynamics of development resource capture. The empirical material collected suggests that, although participatory development has created more opportunities for social mobility, these opportunities are not necessarily open to everyone. In the case studied, the transformational potential of participation is only partially fulfilled. [less ▲]

Detailed reference viewed: 60 (0 UL)
Full Text
Peer Reviewed
See detailExpanding the field of science education: A conversation with Ken Tobin
Siry, Christina UL

in Eurasia Journal of Mathematics, Science and Technology Education (2009), 5(3), 197-208

This paper focuses on a conversation with Dr. Kenneth Tobin, which took place in June 2009 at The Graduate Center of the City University of New York (CUNY), where he is Presidential Professor in the Urban ... [more ▼]

This paper focuses on a conversation with Dr. Kenneth Tobin, which took place in June 2009 at The Graduate Center of the City University of New York (CUNY), where he is Presidential Professor in the Urban Education Program. Our purpose was to focus on Ken’s career in science education, and to discuss the past, present, and future of his research interests. During our conversation, we explored the various trajectories of his career, focusing on the ways in which his research has evolved through the years. Further, Ken shared his thoughts on the field of science education, and provided salient advice for early career scholars. This manuscript includes an introductory summary of Ken’s career achievements to this point, a record of our conversation (the audio-recording can be downloaded at the journal’s website) and a list of selected publications that highlight Ken’s key works. [less ▲]

Detailed reference viewed: 116 (1 UL)
Full Text
Peer Reviewed
See detailExpanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations
SALA, Stefano; Van troys, Marleen; Medves, Sandrine et al

in Journal of Proteome Research (2017), doi: 10.1021/acs.jproteome.7b00034

Detailed reference viewed: 139 (15 UL)
Full Text
Peer Reviewed
See detailExpanding the use of spectral libraries in proteomics.
Deutsch, Eric W.; Perez-Riverol, Yasset; Chalkley, Robert J. et al

in Journal of proteome research (2018)

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass ... [more ▼]

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass spectrometry spectral libraries. Their use in proteomics is growing slowly, but there are multiple challenges in the field that must be addressed to further increase the adoption of spectral libraries and related techniques. The primary bottlenecks are the paucity of high quality and comprehensive libraries and the general difficulty of adopting spectral library searching into existing workflows. There are several existing spectral library formats, but none capture a satisfactory level of metadata; therefore a logical next improvement is to design a more advanced, Proteomics Standards Initiative-approved spectral library format that can encode all of the desired metadata. The group discussed a series of metadata requirements organized into three designations of completeness or quality, tentatively dubbed bronze, silver, and gold. The metadata can be organized at four different levels of granularity: at the collection (library) level, at the individual entry (peptide ion) level, at the peak (fragment ion) level, and at the peak annotation level. Strategies for encoding mass modifications in a consistent manner and the requirement for encoding high-quality and commonly-seen but as-yet-unidentified spectra were discussed. The group also discussed related topics, including strategies for comparing two spectra, techniques for generating representative spectra for a library, approaches for selection of optimal signature ions for targeted workflows, and issues surrounding the merging of two or more libraries into one. We present here a review of this field and the challenges that the community must address in order to accelerate the adoption of spectral libraries in routine analysis of proteomics datasets. [less ▲]

Detailed reference viewed: 164 (9 UL)
See detailExpanding traditional enforcement designs to actors across the public-private divide: the example of criminal law
Blount, Kelly UL

in Studies on Enforcement in Multilevel Regulatory Systems (2022)

Detailed reference viewed: 20 (0 UL)
Full Text
Peer Reviewed
See detailExpansion and inequality of educational opportunity: a comparative study
Bar-Haim, Eyal UL; Shavit, Yossi

in Research in Social Stratification and Mobility (2013), 31

Detailed reference viewed: 138 (3 UL)
See detailExpansion nach Belgien als Verwaltungstätigkeit: der Kölner Beamte Franz Thedieck im NS
Brüll, Christoph UL

Scientific Conference (2019, June 28)

Detailed reference viewed: 150 (1 UL)
Full Text
Peer Reviewed
See detailExpansion of a Fermi cloud in the BCS-BEC crossover
Diana, Giovanni UL; Manini, Nicola; Salasnich, Luca

in Physical Review. A (2006), 73(6), 065601

We study the free expansion of a dilute two-component Fermi gas with attractive interspecies interaction in the BCS-BEC crossover. We apply a time-dependent parameter-free density-functional theory by ... [more ▼]

We study the free expansion of a dilute two-component Fermi gas with attractive interspecies interaction in the BCS-BEC crossover. We apply a time-dependent parameter-free density-functional theory by using two choices of the equation of state: an analytic formula based on Monte Carlo data and the mean-field equation of state resulting from the extended BCS equations. The calculated axial and transverse radii and the aspect ratio of the expanding cloud are compared to experimental data on vapors of 6 Li atoms. Remarkably, the mean-field theory shows a better agreement with the experiments than the theory based on the Monte Carlo equation of state. Both theories predict a measurable dependence of the aspect ratio on expansion time and on scattering length. [less ▲]

Detailed reference viewed: 147 (1 UL)
Full Text
Peer Reviewed
See detailExpansion ohne Kontraktion? Krieg und Militär als ‚Zeichen und Werkzeug der Vereinigung der ganzen Welt‘
Kolnberger, Thomas UL

in Feldbauer, Peter; Hödl, Gerald; Lehners, Jean-Paul (Eds.) Rhythmen der Globalisierung – Expansion und Kontraktion zwischen dem 13. und 20. Jahrhundert (2009)

Detailed reference viewed: 60 (0 UL)
Peer Reviewed
See detailExpansions of the Instant. Disruptions of Time in Contemporary German Literature
Pause, Johannes UL

in Koch, Lars; Nanz, Tobias; Pause, Johannes (Eds.) Disruption in the Arts. Textual, Visual, and Performative Strategies for Analyzing Societal Self-Descriptions (2018)

Detailed reference viewed: 91 (0 UL)
Full Text
Peer Reviewed
See detailExpectation Shock in Education: Utilising Industry SERVQUAL to Enhance Student Perception of STEAM and STEAM Careers
Houghton, Tony; Lavicza, Zsolt; Weinhandl, Robert et al

in International Journal of Technology Enhanced Learning (in press)

In industry, an Expectation Shock occurs when a customer has a post-experience Perception that greatly exceeds their prior Expectation. In our study, the customers are students and teachers. An ... [more ▼]

In industry, an Expectation Shock occurs when a customer has a post-experience Perception that greatly exceeds their prior Expectation. In our study, the customers are students and teachers. An Expectation shock might occur when, for example, a student ‘just did not expect to find STEAM so interesting’. The objective of this research was to determine how Expectation Shock might be used in schools to enhance student Perception of STEAM and STEAM careers. It was found that Expectation shock in the form of Hothousing intensive, collaborative workshops can be used in schools to greatly enhance student Perception of STEAM and STEAM careers and give them experience of Industry practice valuable for their future careers. Educational practice should focus on enhancing student or teacher Perception rather than stated Importance. It is essential to examine Perception post-experience versus prior Expectation to identify benefits (or not) from the activity. [less ▲]

Detailed reference viewed: 47 (2 UL)
Full Text
Peer Reviewed
See detailExpectation: Personalized Explainable Artificial Intelligence for Decentralized Agents with Heterogeneous Knowledge
Calvaresi, Davide; Ciatto, Giovanni; Najjar, Amro UL et al

in Calvaresi, Davide; Najjar, Amro; Winikoff, Michael (Eds.) et al Explainable and Transparent AI and Multi-Agent Systems - Third International Workshop, EXTRAAMAS 2021, Virtual Event, May 3-7, 2021, Revised Selected Papers (2021)

Explainable AI (XAI) has emerged in recent years as a set of techniques and methodologies to interpret and explain machine learning (ML) predictors. To date, many initiatives have been proposed ... [more ▼]

Explainable AI (XAI) has emerged in recent years as a set of techniques and methodologies to interpret and explain machine learning (ML) predictors. To date, many initiatives have been proposed. Nevertheless, current research efforts mainly focus on methods tailored to specific ML tasks and algorithms, such as image classification and sentiment analysis. However, explanation techniques are still embryotic, and they mainly target ML experts rather than heterogeneous end-users. Furthermore, existing solutions assume data to be centralised, homogeneous, and fully/continuously accessible—circumstances seldom found altogether in practice. Arguably, a system-wide perspective is currently missing. The project named “Personalized Explainable Artificial Intelligence for Decentralized Agents with Heterogeneous Knowledge” (Expectation) aims at overcoming such limitations. This manuscript presents the overall objectives and approach of the Expectation project, focusing on the theoretical and practical advance of the state of the art of XAI towards the construction of personalised explanations in spite of decentralisation and heterogeneity of knowledge, agents, and explainees (both humans or virtual). To tackle the challenges posed by personalisation, decentralisation, and heterogeneity, the project fruitfully combines abstractions, methods, and approaches from the multi-agent systems, knowledge extraction / injec- tion, negotiation, argumentation, and symbolic reasoning communities. [less ▲]

Detailed reference viewed: 103 (9 UL)
Full Text
Peer Reviewed
See detailExpectations of mutual support and care in the light of migration
Albert, Isabelle UL; Ferring, Dieter UL; Barros Coimbra, Stephanie UL et al

Scientific Conference (2015, September 08)

As first generation immigrants are currently approaching retirement age in many European countries, intergenerational solidarity within the context of acculturation gains high importance. However, most ... [more ▼]

As first generation immigrants are currently approaching retirement age in many European countries, intergenerational solidarity within the context of acculturation gains high importance. However, most research on intergenerational relations in ageing families so far has not drawn special attention to migrant families. The aim of the present study was to investigate similarities and differences in the expectations about intergenerational support in a sample of n = 48 Luxembourgish (68.8% female) and n = 36 Portuguese (60.5% female) adult children and at least one of their parents. Luxembourgish adult children were on average M = 25.90 (SD = 5.74) years old, Portuguese M = 27.28 (SD = 6.49). A total of 58.3% of Portuguese adult children were born in Luxembourg; the remainder was born in Portugal but had grown up in Luxembourg. For all participants, both parents were still alive and were living in the Grand-Duchy. Whereas Luxembourgish and Portuguese adult children did not differ regarding family cohesion and expected support from parents toward children, Portuguese participants reported higher expectations of support from adult children toward their ageing parents. More Portuguese than Luxembourgish parents indicated they would like to live with their children in case of need, whereas more Luxembourgish parents preferred to live in a residential home. Nonetheless, no differences between adult children of both national groups were found regarding filial anxiety about future care of parents. Results are discussed in the framework of an integrative model on intergenerational family relations in the light of migration and ageing. This model takes several aspects into account that might have an impact on different needs, tasks and resources of the individual and the family depending on different family cultures, the larger cultural context in which family relations are embedded as well as significant events over the life-span (such as migration history). [less ▲]

Detailed reference viewed: 350 (11 UL)
See detailExpected and Unexpected Consequences of the Educational Expansion in Europe and the US Theoretical approaches and empirical findings in comparative perspective
Hadjar, Andreas UL; Becker, Rolf

Book published by Haupt Verlag (2009)

A main mechanism behind the change in European and North American societies in the second half of the 20th century is the educational expansion, i.e. the increase in educational opportunities and the ... [more ▼]

A main mechanism behind the change in European and North American societies in the second half of the 20th century is the educational expansion, i.e. the increase in educational opportunities and the higher demand for education. Whereas other abstract social processes like modernization have been widely theorized in social science literature, the educational expansion and its consequences in particular have not been well studied. Therefore the main aim of this compilation is to deal with the question of whether the demands of the educational reforms have been fulfilled and which other consequences the educational expansion has had. This book will focus on consequences of the educational expansion for individuals and their life courses as well as for the social structure and other societal areas such as culture and politics. Aspects that will be analysed in the light of educational expansion include participation in education, educational inequalities, labour market outcomes, educational returns, and gender differences as well as crime, life expectancy, and lifestyles. Countries analysed in the book include West European countries like Germany, France, Italy and Spain, East European countries (Hungary, Poland, and the Czech Republic) as well as the US. [less ▲]

Detailed reference viewed: 197 (1 UL)
Full Text
Peer Reviewed
See detailExpected Running Time of Parallel Evolutionary Algorithms on Unimodal Pseudo-Boolean Functions over Small-World Networks
Muszynski, Jakub UL; Varrette, Sébastien UL; Bouvry, Pascal UL

in Proc. of the IEEE Congress on Evolutionary Computation (CEC'2013) (2013)

This paper proposes a theoretical and experimental analysis of the expected running time for an elitist parallel Evolutionary Algorithm (pEA) based on an island model executed over small-world networks ... [more ▼]

This paper proposes a theoretical and experimental analysis of the expected running time for an elitist parallel Evolutionary Algorithm (pEA) based on an island model executed over small-world networks. Our study assumes the resolution of optimization problems based on unimodal pseudo-boolean funtions. In particular, for such function with d values, we improve the previous asymptotic upper bound for the expected parallel running time from O(d√n) to O(d log n). This study is a first step towards the analysis of influence of more complex network topologies (like random graphs created by P2P networks) on the runtime of pEAs. A concrete implementation of the analysed algorithm have been performed on top of the ParadisEO framework and run on the HPC platform of the University of Luxembourg (UL). Our experiments confirm the expected speed- up demonstrated in this article and prove the benefit that pEA can gain from a small-world network topology. [less ▲]

Detailed reference viewed: 151 (1 UL)
Full Text
Peer Reviewed
See detailExpediting in Two-Echelon Spare Parts Inventory Systems
Drent, Melvin UL; Arts, Joachim UL

in Manufacturing and Service Operations Management (2021), 23(6), 1431-1448

We consider a two-echelon spare parts inventory system consisting of one central warehouse and multiple local warehouses. Each warehouse keeps multiple types of repairable parts to maintain several types ... [more ▼]

We consider a two-echelon spare parts inventory system consisting of one central warehouse and multiple local warehouses. Each warehouse keeps multiple types of repairable parts to maintain several types of capital goods. The local warehouses face Poisson demand and are replenished by the central warehouse. We assume that unsatisfied demand is backordered at all warehouses. Furthermore, we assume deterministic lead times for the replenishments of the local warehouses. The repair shop at the central warehouse has two repair options for each repairable part: a regular repair option and an expedited repair option. Both repair options have stochastic lead times. Irrespective of the repair option, each repairable part uses a certain resource for its repair. Assuming a dual-index policy at the central warehouse and base stock control at the local warehouses, an exact and efficient evaluation procedure for a given control policy is formulated. To find an optimal control policy, we look at the minimization of total investment costs under constraints on both the aggregate mean number of backorders per capital good type and the aggregate mean fraction of repairs that are expedited per repair resource. For this non-linear non-convex integer programming problem, we develop a greedy heuristic and an algorithm based on decomposition and column generation. Both solution approaches perform very well with average optimality gaps of 1.56 and 0.23 percent, respectively, across a large test bed of industrial size. Based on a case study at Netherlands Railways, we show how managers can significantly reduce the investment in repairable spare parts when dynamic repair policies are leveraged to prioritize repair of parts whose inventory is critically low. [less ▲]

Detailed reference viewed: 715 (128 UL)
See detailL’expérience américaine de l’enseignement transétatique du droit
Cuniberti, Gilles UL

in Ancel, Pascal; Heuschling, Luc (Eds.) La transnationalisation de l’enseignement du droit (2016)

Detailed reference viewed: 42 (1 UL)
Peer Reviewed
See detailExperience Design for Digital Cultural Heritage
Morse, Christopher UL

Scientific Conference (2019, September)

The experience of visiting museums has evolved to extend beyond the walls of the institutions themselves into digital spaces, where online galleries, exhibitions, and virtual tours invite audiences to ... [more ▼]

The experience of visiting museums has evolved to extend beyond the walls of the institutions themselves into digital spaces, where online galleries, exhibitions, and virtual tours invite audiences to explore arts and culture from their personal devices. However, generating interest from the public around these platforms remains a challenge, and the digital experience rarely compares to an in-person visit. Building on research that demonstrates the effectiveness of emotional design as a way to generate public engagement with physical museum spaces and exhibitions, this project adopts a user-centered design approach to develop novel experiences around digitized museum collections. [less ▲]

Detailed reference viewed: 87 (6 UL)
Peer Reviewed
See detail«L'expérience du paysage»
Roelens, Nathalie UL

in Poésie et description (1999)

Detailed reference viewed: 46 (1 UL)