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See detailFunctional PLS regression with functional response: the basis expansion approach
Preda, Christian; Schiltz, Jang UL

in Proceedings of the 14th Applied Stochastic Models and Data Analysis Conference (2011)

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See detailFunctional relevance of ceruloplasmin mutations in Parkinson's disease.
Hochstrasser, Helmine; Tomiuk, Jurgen; Walter, Uwe et al

in FASEB Journal (2005), 19(13), 1851-3

Increased iron levels of the substantia nigra and the discovery of ceruloplasmin mutations in patients with Parkinson's disease (PD) imply impaired iron metabolism in this neurodegenerative disorder ... [more ▼]

Increased iron levels of the substantia nigra and the discovery of ceruloplasmin mutations in patients with Parkinson's disease (PD) imply impaired iron metabolism in this neurodegenerative disorder. Ceruloplasmin has ferroxidase activity oxidizing iron(II) to iron(III). In the present study, we analyzed the amount of ceruloplasmin, iron, ferritin, and transferrin and the ceruloplasmin ferroxidase activity in serum of patients with the diagnosis of PD carrying the ceruloplasmin mutations I63T, D544E, and R793H. The impact of these missense mutations on the biosynthesis of holo-ceruloplasmin was investigated in cell culture experiments. Functional relevance was found for the ceruloplasmin mutations I63T and D544E. In vivo, the I63T mutation resulted in half the normal ceruloplasmin concentration and markedly reduced ferroxidase activity in serum from a heteroallelic PD patient. In cell culture, the I63T glycosylphosphatidylinositol (GPI)-linked ceruloplasmin isoform was retained in the endoplasmatic reticulum of human embryonic kidney cells. Furthermore, the D544E polymorphism resulted in significantly reduced serum ceruloplasmin levels and ferroxidase activity in heteroallelic patients and in expression of mainly apo-ceruloplasmin in cell culture. Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD. [less ▲]

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See detailFunctionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens.
Burckert, Jean-Philippe; Dubois, Axel R. S. X.; Faison, William J. et al

in Frontiers in immunology (2017), 8

The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this ... [more ▼]

The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers for tracing back infections, measuring vaccine immunogenicity, and perhaps ultimately allow the reconstruction of the immunological history of an individual. Here, we immunized groups of transgenic rats expressing human Ig against tetanus toxoid (TT), Modified Vaccinia virus Ankara (MVA), measles virus hemagglutinin and fusion proteins expressed on MVA, and the environmental carcinogen benzo[a]pyrene, coupled to TT. We showed that these antigens impose a selective pressure causing the Ig heavy chain (IgH) repertoires of the rats to converge toward the expression of antibodies with highly similar IgH CDR3 amino acid sequences. We present a computational approach, similar to differential gene expression analysis, that selects for clusters of CDR3s with 80% similarity, significantly overrepresented within the different groups of immunized rats. These IgH clusters represent antigen-induced IgH signatures exhibiting stereotypic amino acid patterns including previously described TT- and measles-specific IgH sequences. Our data suggest that with the presented methodology, transgenic Ig rats can be utilized as a model to identify antigen-induced, human IgH signatures to a variety of different antigens. [less ▲]

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See detailThe functionally defined right occipital and fusiform "face areas" discriminate novel from visually familiar faces
Rossion, Bruno; Schiltz, Christine UL; Crommelinck, Marc

in NeuroImage (2003), 19(3), 877-883

Neuroimaging (PET and fMRI) studies have identified a set of brain areas responding more to faces than to other object categories in the visual extrastriate cortex of humans. This network includes the ... [more ▼]

Neuroimaging (PET and fMRI) studies have identified a set of brain areas responding more to faces than to other object categories in the visual extrastriate cortex of humans. This network includes the middle lateral fusiform gyrus (the fusiform face area, or FFA) as well as the inferior occipital gyrus (occipital face area, OFA). The exact functions of these areas in face processing remain unclear although it has been argued that their primary function is to distinguish faces from nonface object categories-"face detection"-or also to discriminate among faces, irrespective of their visual familiarity to the observer. Here, we combined the data from two previous positron emission tomography (PET) studies to show that the functionally defined face areas are involved in the automatic discrimination between unfamiliar faces and familiar faces. Consistent with previous studies, a face localizer contrast (faces-objects) revealed bilateral activation in the middle lateral fusiform gyrus (FFA, BA37) and in the right inferior occipital cortex (OFA, BA19). Within all the regions of the right hemisphere, larger levels of activation were found for unfamiliar as compared to familiar faces. These results suggest that the very same areas involved in categorizing faces at the basic or individual level, play a role in differentiating familiar faces from new faces, showing an overlap between visual and presemantic mnesic representations of faces in the right hemisphere. [less ▲]

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See detailFunctions of hepatitis C virus non-structural protein 2
Dentzer, Thomas UL

Doctoral thesis (2010)

An estimated 170 million people are infected with hepatitis C virus (HCV). 15-30% of HCV-induced chronic hepatitis progresses to cirrhosis within years to decades after infection, and 3-4% of them will ... [more ▼]

An estimated 170 million people are infected with hepatitis C virus (HCV). 15-30% of HCV-induced chronic hepatitis progresses to cirrhosis within years to decades after infection, and 3-4% of them will develop hepatocellular carcinoma. There is no vaccine available, and current HCV therapy of pegylated interferon-! in combination with ribavirin leads to a sustained response only in about 50% of infected patients. The HCV non-structural protein NS2 (MW 23 kDa) is a dimeric multifunctional hydrophobic protein with an essential but poorly understood role in infectious virus production. The N terminal region of NS2 interacts with membranes whereas the Cterminal region, together with the N-terminal third of NS3, forms the NS2-3 protease. NS2 is not required for RNA synthesis, although cleavage at the NS2/3 junction is necessary for replication. Further, NS2 has been shown to interact with a number of viral and host proteins; it has been reported to activate transcription factors, inhibit apoptosis, and is a substrate for host kinase phosphorylation and proteosomic degradation. NS2 determinants and their respective function in the HCV life cycle were investigated. Based on the crystal structure of the post-cleavage form of the NS2 protease domain, we mutated conserved features and analyzed the effects of these changes on polyprotein processing, replication, and infectious virus production. We found that mutations around the protease active site inhibit viral RNA replication by preventing NS2/3 cleavage. Supplementary assays indicated a dimerization defect for these mutant constructs, which prevented cleavage and RNA replication. In contrast, alterations in the dimer interface and at the C-terminal region did not affect replication, NS2 stability, or NS2 protease activity, but decreased infectious virus production. Analysis of the NS2/3 cleavage site revealed an additional function for several residues besides cleavage, notably in infectious virus production. A more comprehensive deletion and mutagenesis analysis of the C-terminal end of NS2 revealed the importance of its C-terminal residue in infectious particle production. Structural data suggests that the C-terminal leucine is locked in the active site, and mutation or deletion of this residue could therefore alter the NS2 folding and disrupt potential protein-protein interactions important for infectious particle production. Further, we established an NS2- 3 interaction model based on the solved NS2pro and NS3 crystal structures and assessed the importance of proximal residues for viral propagation. We were able to show genetic interactions between the viral proteins NS2 and E1 as well as NS2 and NS3. Additionally a pull down assay of strep-tagged NS2 followed by a mass spectrometry analysis divulged the physical interactions between NS2-E2, and NS2- NS3. Numerous host cell proteins could be identified to interact with NS2, involved in various pathways such as membrane trafficking, actin/myosin interactions or actin polymerization. In this study we dissected the residues of NS2 involved in its multiple essential roles and interactions in the HCV life cycle and established NS2 as a new viable target for HCV-specific inhibitors for future anti-viral therapeutics. [less ▲]

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See detailFunctions on Probabilistic Graphical Models
Ignac, Tomasz UL; Sorger, Ulrich UL

in Proceedings of the International Multiconference on Computer Science and Information Technology IMCSIT 2009 (2009)

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See detailFunctions, divergence and clinical value of TAp73 isoforms in cancer.
Logotheti, Stella; Pavlopoulou, Athanasia; Galtsidis, Sotirios UL et al

in Cancer and Metastasis Reviews (2013), 32(3-4), 511534

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See detailThe fund Synthetic Index : An alternative benchmark for mutual funds
Terraza, Virginie UL; Razafitombo, Hery

in Bankers, Markets, Investors [=BMI] (2011), 114

Evaluation of the performance of investment funds is a topic of considerable interest to practitioners and academic researchers. Performance indicators of fi nancial places have for long posed interesting ... [more ▼]

Evaluation of the performance of investment funds is a topic of considerable interest to practitioners and academic researchers. Performance indicators of fi nancial places have for long posed interesting challenges with regards to funds investors, but also to legal regulators authorities. The two major issues that need to be addressed in any performance study are how to choose an appropriate benchmark for comparison and how to adjust a fund’s return for risk. Indeed, investors desire information about representative market indexes as a norm to evaluate the performance of their portfolios. MSCI Indexes are frequently used by institutional investors around the world as benchmarks to decide allocation of funds across asset classes and regions. Despite this wide acceptance, MSCI country index has in its original application a number of drawbacks and limitations. The main problems can be traced to the presence of usual biases, such as sampling, survivorship and instant history biases (Fung and Shieh, 2002), involving problems into the aggregation procedure. Thus, one can explain why certain fi nancial places are less representative, specifi cally for funds distribution places. Some results also indicate problems related to misclassifi cation in mutual funds (Sharpe, 1992). Each of these phenomena can have a signifi cant impact on international diversifi cation for fund managers. Based on these empirical fi ndings, Ferreira, Miguel and Ramos (2007) examine cross-country mutual fund performance using several alternative benchmark models including a domestic and an international version of the Carhart (1997) four-factor model. Using multiple regressions, they obtain signifi cant determinants explaining funds performance, like the funds size, the fees, the management style… . In this article, we contribute to the existing discussion on alternative benchmarks to compare fi nancial places, by conducting an analysis on funds time variation structure. Contrary to previous literature, we propose to use directly the information contained in the NAV to extract performance characteristics of funds. Then, each domiciliation place is compared by constructing a fund synthetic index that will capture the time structure of mutual fund performance. Usual statistical approach consists to estimate fi nancial returns of each fund in each country, which involves dealing with huge data sets that may cause the calculation processes to become slow and cumbersome and the results diffi cult to be interpreted and used in further applications. To reduce data sets, and give conclusions for each fi nancial place, indicators of the mean of fund’s returns can be used. Then one can identify classes of domicile funds that are subject to common properties. But this classical approach, gives only approximate results because it is based on an aggregation of average performance and risk and a boxplot statistical format. The construction of fund synthetic portfolio avoids this issue. First, it avoids the logic of representativity through market capitalization that is often diffi cult to apply to the mutual fund universe. Second, it is based on factor analysis techniques to generate indexes that are able to capture a very large fraction of the information. More precisely, it permits to take into account the common properties of fund returns relative to their domicile while keeping the maximum of information given by the original data. Indeed, it may be very useful to use a transformation to form a simplifi ed data set retaining the characteristics of the original data set. Principal component analysis, abbreviated as PCA, is a method of statistical analysis useful in data reduction and interpretation of multivariate data sets by identifying factors of common behavior such that not much of the contained information is lost. In our context, we use this method to derive portfolio weights in order to construct a synthetic portfolio of each fi nancial place. For that, we propose to replace the matrix of returns and to derive an index which keeps the global representation of each fi nancial place. [less ▲]

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See detailFundamental asymmetric lamb wave ( a0 ) interaction with rectangular notch using elastodynamic finite integration technique (EFIT)
Rappel, Hussein UL; Yousefi-Koma, Aghli

Scientific Conference (2013, May 07)

Fundamental asymmetric lamb wave’s interactions with rectangular notches in a steel plate are investigated in this paper. Elastodynamic finite integration technique previously mainly used to study wave ... [more ▼]

Fundamental asymmetric lamb wave’s interactions with rectangular notches in a steel plate are investigated in this paper. Elastodynamic finite integration technique previously mainly used to study wave propagation in elastic media is adopted to study lamb wave interaction with defects. Simulation examples are presented to illustrate the reflection and transmission coefficients’ variations with defect’s height, for both symmetric and asymmetric modes. Results show as the depth of notch increases reflection coefficients for both symmetric mode and asymmetric mode increase. However, when the depth of notch increases transmission coefficient for asymmetric mode decreases which means the main part of transmitted energy is carried by symmetric mode generated when the fundamental asymmetric mode interacts with defect. This simulation could be a valuable tool for the research of lamb wave’s applications in nondestructive testing (NDT) field, as the problem of lamb wave interaction with discontinuities can be used to study defect sizing problem. [less ▲]

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See detailFundamental limits to helical edge conductivity due to sphin-phonon scattering
Groenendijk, Solofo UL; Dolcetto; Schmidt, Thomas UL

in Physical Review. B, Condensed Matter (2018), 97

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See detailThe Fundamental Right to Data Protection of Blockchain Users seen through the Applicability of the GDPR
Jolly, Loren UL

in Borges, Georg; Sorge, Christoph (Eds.) IT Law and Legal Informatics (in press)

The aim of this chapter is to highlight the different issues that one faces when trying to ensure the fundamental right to data protection of blockchain users. The provisions of the General Data ... [more ▼]

The aim of this chapter is to highlight the different issues that one faces when trying to ensure the fundamental right to data protection of blockchain users. The provisions of the General Data Protection Regulation are used as an example of the difficulties. Here, two principal issues are addressed: issues regarding the addressees of the General Data Protection Regulation's provisions and issues regarding the qualification and treatment of data available on permissionless and permissioned blockchains. Finally, this article highlights the consequences that these uncertainties may have on the protection of users’ fundamental rights and the necessity to ensure legal certainty through additional guidance from the European legislator or upcoming case-law. [less ▲]

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See detailFundamental rights and constitutional identity(ies): limits or parameters of the EU constitutional governance?
Zinonos, Panagiotis UL

in Grigoriou, Panos (Ed.) European Governance & Sovereignty (2019)

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See detailFundamental rights protection between Strasbourg and Luxembourg: Extending Transnational ne bis in idem Across Administrative and Criminal Procedures
Ligeti, Katalin UL

in Ligeti, Katalin; Robinson, Gavin; ELI (European Law Institute) (Eds.) Preventing and Resolving Conflicts of Jurisdiction in EU Criminal Law (2018)

This chapter analyses the conceptual roots of extended ne bis in idem protection and, in particular, how the concept of ‘criminal charge’ developed by the ECtHR impacts the interpretative outcomes of the ... [more ▼]

This chapter analyses the conceptual roots of extended ne bis in idem protection and, in particular, how the concept of ‘criminal charge’ developed by the ECtHR impacts the interpretative outcomes of the CJEU and the ECtHR respectively. The chapter will then present the specific case law of the two Courts on extended ne bis in idem, including the latest developments, and will offer an assessment of the consequences of this jurisprudence for transnational cases in the Area of Freedom, Security and Justice (AFSJ). In particular, the transnational application of extended ne bis in idem requires a reconceptualisation and rethinking of the legal framework for preventing and resolving conflicts of criminal jurisdiction in the AFSJ. [less ▲]

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See detailFundamental Solutions and Dual Boundary Element Method for Crack Problems in Plane Cosserat Elasticity
Atroshchenko, Elena; Bordas, Stéphane UL

in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (2014)

In this paper, both singular and hypersingular fundamental solutions of plane Cosserat elasticity are derived and given in a ready-to-use form. The hypersingular fundamental solutions allow to formulate ... [more ▼]

In this paper, both singular and hypersingular fundamental solutions of plane Cosserat elasticity are derived and given in a ready-to-use form. The hypersingular fundamental solutions allow to formulate the analogue of Somigliana stress identity, which can be used to obtain the stress and couple stress fields inside the domain from the boundary values of the displacements, microrotation and stress and couple stress tractions. Using these newly derived fundamental solutions, the boundary integral equations of both types are formulated and solved by the boundary element method. Simultaneous use of both types of the equations (approach known as the dual BEM) allows to treat problems where parts of the boundary are overlapping, such as crack problems, and to do this for general geometry and loading conditions. The high accuracy of the boundary element method for both types of equations is demonstrated for a number of benchmark problems, including a Griffith crack problem and a plate with an edge crack. The detailed comparison of the BEM-results and the analytical solution for a Griffith crack is given, particularly, in terms of stress and couple stress intensity factors, as well as the crack opening displacements and microrotations on the crack faces. A modified method for computing the couple stress intensity factors is also proposed and evaluated. Finally, the asymptotic behavior of the solution to the Cosserat crack problems, in the vicinity of the crack tip is analyzed. [less ▲]

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See detailFundamental solutions and dual boundary element methods for fracture in plane Cosserat elasticity
Atroshchenko, Elena; Bordas, Stéphane UL

in Proceedings of the Royal Society a-Mathematical Physical and Engineering Sciences (2015), 471(2179),

In this paper, both singular and hypersingular fundamental solutions of plane Cosserat elasticity are derived and given in a ready-to-use form. The hypersingular fundamental solutions allow to formulate ... [more ▼]

In this paper, both singular and hypersingular fundamental solutions of plane Cosserat elasticity are derived and given in a ready-to-use form. The hypersingular fundamental solutions allow to formulate the analogue of Somigliana stress identity, which can be used to obtain the stress and couple-stress fields inside the domain from the boundary values of the displacements, microrotation and stress and couple-stress tractions. Using these newly derived fundamental solutions, the boundary integral equations of both types are formulated and solved by the boundary element method. Simultaneous use of both types of equations (approach known as the dual boundary element method (BEM)) allows problems where parts of the boundary are overlapping, such as crack problems, to be treated and to do this for general geometry and loading conditions. The high accuracy of the boundary element method for both types of equations is demonstrated for a number of benchmark problems, including a Griffith crack problem and a plate with an edge crack. The detailed comparison of the BEM results and the analytical solution for a Griffith crack and an edge crack is given, particularly in terms of stress and couple-stress intensity factors, as well as the crack opening displacements and microrotations on the crack faces and the angular distributions of stresses and couple-stresses around the crack tip. [less ▲]

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See detailFundamental studies in nanosciences at the Institute of Electronics, Microelectronics, and Nanotechnology (IEMN)
Allan, G.; Barbet, S.; Coffinier, Y. et al

in International Journal of Nanotechnology (2008), 5(6-8), 631-648

This paper gives an overview over the fundamental research in nanosciences at the Institute of Electronics, Microelectronics and Nanotechnology (IEMN). We present some highlights from the numerical ... [more ▼]

This paper gives an overview over the fundamental research in nanosciences at the Institute of Electronics, Microelectronics and Nanotechnology (IEMN). We present some highlights from the numerical simulation of the electronic structure of nanowires and nanotubes, the charge spectroscopy of Si nanoparticles and C nanotubes, the scanning tunnelling spectroscopy of semiconductor quantum dots, to research in surface science for bio-screening. [less ▲]

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See detailFundamentalismus und Terrorismus - Versuch eines Resümees
Kolnberger, Thomas UL

Article for general public (2008)

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See detailFundamentality and Time's Arrow
Loew, Christian UL

in Philosophy of Science (2018), 85(3), 483-500

The distribution of matter in our universe is strikingly time asymmetric. Most famously, the Second Law of Thermodynamics says that entropy tends to increase toward the future but not toward the past. But ... [more ▼]

The distribution of matter in our universe is strikingly time asymmetric. Most famously, the Second Law of Thermodynamics says that entropy tends to increase toward the future but not toward the past. But what explains this time-asymmetric distribution of matter? In this paper, I explore the idea that time itself has a direction by drawing from recent work on grounding and metaphysical fundamentality. I will argue that positing such a direction of time, in addition to time-asymmetric boundary conditions (such as the so-called "past hypothesis"), enables a better explanation of the thermodynamic asymmetry than is available otherwise. [less ▲]

Detailed reference viewed: 324 (2 UL)