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See detailExpression of the plasma membrane Ca2+-ATPase in myogenic cells.
Hammes, A.; Oberdorf-Maass, S.; Jenatschke, S. et al

in The Journal of biological chemistry (1996), 271(48), 30816-22

To study the physiological function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in intact cells, L6 myogenic cell lines stably overexpressing the human PMCA isoform 4CI (= human PMCA ... [more ▼]

To study the physiological function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in intact cells, L6 myogenic cell lines stably overexpressing the human PMCA isoform 4CI (= human PMCA isoform 4b) were generated. Several independent L6 clones and controls stably transfected with the empty expression vector were analyzed in detail. The resting cytosolic calcium level in hPMCA4CI-overexpressing muscle cells (measured by the Fura-2 method) was significantly reduced by 20-30% compared with controls. This was shown in a cytosolic window of 1322 single cells (p < 0.01). Furthermore, the differentiation process of these cells was remarkably accelerated compared with control myoblasts and parental nontransfected L6 cells as assessed by multinucleated myotube formation and creatine phosphokinase activity elevation. After 4 and 6 days of differentiation, PMCA-overexpressing L6 cells from four independent clones displayed a 3- and 4-fold higher creatine phosphokinase activity compared with controls (n = 5, p < 0.02). These results may extend the concept of the function of the PMCA from simple prevention of calcium overload to an active involvement in intracellular calcium regulation with potentially important consequences for cellular functions. [less ▲]

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See detailExpression pattern suggests a role of MiR399 in the regulation of the cellular response to local Pi increase during arbuscular mycorrhizal symbiosis.
Branscheid, Anja; Sieh, Daniela; Pant, Bikram Datt et al

in Molecular plant-microbe interactions : MPMI (2010), 23(7), 915-26

Many plants improve their phosphate (Pi) availability by forming mutualistic associations with arbuscular mycorrhizal (AM) fungi. Pi-repleted plants are much less colonized by AM fungi than Pi-depleted ... [more ▼]

Many plants improve their phosphate (Pi) availability by forming mutualistic associations with arbuscular mycorrhizal (AM) fungi. Pi-repleted plants are much less colonized by AM fungi than Pi-depleted plants. This indicates a link between plant Pi signaling and AM development. MicroRNAs (miR) of the 399 family are systemic Pi-starvation signals important for maintenance of Pi homeostasis in Arabidopsis thaliana and might also qualify as signals regulating AM development in response to Pi availability. MiR399 could either represent the systemic low-Pi signal promoting or required for AM formation or they could act as counter players of systemic Pi-availability signals that suppress AM symbiosis. To test either of these assumptions, we analyzed the miR399 family in the AM-capable plant model Medicago truncatula and could experimentally confirm 10 novel MIR399 genes in this species. Pi-depleted plants showed increased expression of mature miR399 and multiple pri-miR399, and unexpectedly, levels of five of the 15 pri-miR399 species were higher in leaves of mycorrhizal plants than in leaves of nonmycorrhizal plants. Compared with nonmycorrhizal Pi-depleted roots, mycorrhizal roots of Pi-depleted M. truncatula and tobacco plants had increased Pi contents due to symbiotic Pi uptake but displayed higher mature miR399 levels. Expression levels of MtPho2 remained low and PHO2-dependent Pi-stress marker transcript levels remained high in these mycorrhizal roots. Hence, an AM symbiosis-related signal appears to increase miR399 expression and decrease PHO2 activity. MiR399 overexpression in tobacco suggested that miR399 alone is not sufficient to improve mycorrhizal colonization supporting the assumption that, in mycorrhizal roots, increased miR399 are necessary to keep the MtPho2 expression and activity low, which would otherwise increase in response to symbiotic Pi uptake. [less ▲]

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See detailExpression patterns of cardiac aging in Drosophila.
Cannon, Leah; Zambon, Alexander C.; Cammarato, Anthony et al

in Aging cell (2017), 16(1), 82-92

Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila ... [more ▼]

Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks, benefit from many tools to easily manipulate their genome, and their heart has significant genetic and phenotypic similarities to the human heart. Here, we performed a cardiac-specific gene expression study on aging Drosophila and carried out a comparative meta-analysis with published rodent data. Pathway level transcriptome comparisons suggest that age-related, extra-cellular matrix remodeling and alterations in mitochondrial metabolism, protein handling, and contractile functions are conserved between Drosophila and rodent hearts. However, expression of only a few individual genes similarly changed over time between and even within species. We also examined gene expression in single fly hearts and found significant variability as has been reported in rodents. We propose that individuals may arrive at similar cardiac aging phenotypes via dissimilar transcriptional changes, including those in transcription factors and micro-RNAs. Finally, our data suggest the transcription factor Odd-skipped, which is essential for normal heart development, is also a crucial regulator of cardiac aging. [less ▲]

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See detailExpression patterns of L-plastin isoform in normal and carcinomatous breast tissues.
Lapillonne, A.; Coue, O.; Friederich, Evelyne UL et al

in Anticancer research (2000), 20(5A), 3177-82

Plastins are members of a family of actin-binding proteins which exhibit a tissue-specific expression pattern. L-plastin, which is specifically expressed in hematopoietic cell lineage, has been proposed ... [more ▼]

Plastins are members of a family of actin-binding proteins which exhibit a tissue-specific expression pattern. L-plastin, which is specifically expressed in hematopoietic cell lineage, has been proposed to be involved in the control of cell adhesion and motility. This protein is also frequently expressed in cell lines derived from mammary solid tumors and therefore might be involved in cancer invasion and metastasis. We have analysed plastin expression in normal and carcinomatous breast tissues in vivo by immunohistochemistry and immunoblotting approaches using specific plastin isoform antibodies. L-plastin was not detected in normal epithelial cells of the mammary gland whereas a staining of myoepithelial cells was observed in 50% of the cases. In breast carcinomas, a significant immunostaining of malignant epithelial cells was observed in 4 of the 29 cases analysed (13.8%). No correlation between L-plastin expression and tumor size, histological grade or lymph node status was observed. In contrast, L-plastin was found expressed in 4 of the 11 estrogen and progesterone receptors negative tumors (p = 0.039). The potential role of plastin expression in the tumor process is discussed. [less ▲]

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See detailExpressionistische Alpen-Passion. Pazifistische Idealisierung der Schweiz bei Yvan Goll und anderen
Wiegmann, Eva UL

in Gätje, Hermann; Singh, Sikander (Eds.) Konjunktionen. Yvan Goll im Diskurs der Moderne (2017)

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See detailExpressionistische Lyrik als Kulturpolitik
Dembeck, Till UL

in Lubkoll, Christine; Illi, Manuel; Hampel, Anna (Eds.) Politische Literatur. Begriffe – Debatten – Aktualität (2018)

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See detailExpressions & relations mathématiques élémentaires
Korvers, Stéphane UL

Learning material (2016)

Ce texte introduit les outils de base des mathématiques que sont les expressions algébriques et numériques. Les nombres réels, les opérations sur les nombres, les moyennes, les sommes partielles de ... [more ▼]

Ce texte introduit les outils de base des mathématiques que sont les expressions algébriques et numériques. Les nombres réels, les opérations sur les nombres, les moyennes, les sommes partielles de termes de suites particulières, les polynômes ou la factorisation des expressions algébriques sont à compter parmi les thèmes abordés. La structure des notes vise à accompagner le lecteur au travers de ces éléments théoriques et à lui permettre de développer ses compétences mathématiques par la réalisation des nombreux exercices proposés. [less ▲]

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See detailExpressive incoherence and alexithymia in autism spectrum disorder
Pinto Costa, Andreia UL; Steffgen, Georges UL; Samson, Andrea C.

in Journal of Autism and Developmental Disorders (2017)

Expressive incoherence can be implicated in socio-emotional communicative problems in autism spectrum disorder (ASD). The present study examined expressive incoherence in 37 children with ASD and 41 ... [more ▼]

Expressive incoherence can be implicated in socio-emotional communicative problems in autism spectrum disorder (ASD). The present study examined expressive incoherence in 37 children with ASD and 41 typically developing (TD) children aged 3–13 years old during a frustration task. The role of alexithymia in expressive incoherence was also assessed. Compared to TD children, children with ASD had higher expressive incoherence, such as more neutral and positive emotion expressions during negative behaviors, but not in the expression of negative emotions during positive behaviors. Further analyses revealed that alexithymia moderated the expressions of positive emotions during negative behaviors. These results suggest that children with ASD may benefit from interventions targeting alexithymia to increase emotional coherence, which may improve socio-emotional communication. [less ▲]

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See detailExpressiveness modulo Bisimilarity of Regular Expressions with Parallel Composition
Baeten, J.; Luttik, B.; Muller, Tim UL et al

in Proc. 17th International Workshop on Expressiveness in Concurrency (2010)

The languages accepted by finite automata are precisely the languages denoted by regular expressions. In contrast, finite automata may exhibit behaviours that cannot be described by regular expressions up ... [more ▼]

The languages accepted by finite automata are precisely the languages denoted by regular expressions. In contrast, finite automata may exhibit behaviours that cannot be described by regular expressions up to bisimilarity. In this paper, we consider extensions of the theory of regular expressions with various forms of parallel composition and study the effect on expressiveness. First we prove that adding pure interleaving to the theory of regular expressions strictly increases its expressiveness up to bisimilarity. Then, we prove that replacing the operation for pure interleaving by ACP-style parallel composition gives a further increase in expressiveness. Finally, we prove that the theory of regular expressions with ACP-style parallel composition and encapsulation is expressive enough to express all finite automata up to bisimilarity. Our results extend the expressiveness results obtained by Bergstra, Bethke and Ponse for process algebras with (the binary variant of) Kleene's star operation. [less ▲]

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See detailExtend the Concept of Public Key Encryption with Delegated Search
Tang, Qiang UL; Ma, Hua; Chen, Xiaofeng

in Computer Journal (2015), 58(4), 11

We revisit the concept of public key encryption with delegated keyword search (PKEDS), a concept proposed by Ibraimi et al. A PKEDS scheme allows a receiver to authorize a third-party server to search in ... [more ▼]

We revisit the concept of public key encryption with delegated keyword search (PKEDS), a concept proposed by Ibraimi et al. A PKEDS scheme allows a receiver to authorize a third-party server to search in two ways: either according to a message chosen by the server itself or according to a trapdoor sent by the receiver.We first show some observations on the primitive formulation and the proposed PKEDS scheme by Ibraimi et al. and point out that the single-server setting may limit the application of this primitive. We then extend the concept to the multiple-server setting and present a new security model. We finally propose a new PKEDS scheme, which is proven secure, and compare it with that by Ibraimi et al. [less ▲]

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See detailExtended Adjacency and Scale-dependent Graph Fourier Transform via Diffusion Distances
Elias, Vitor R.M.; Alves Martins, Wallace UL; Werner, Stefan

in IEEE Transactions on Signal and Information Processing over Networks (2020)

This paper proposes the augmentation of the adjacency model of networks for graph signal processing. It is assumed that no information about the network is available, apart from the initial adjacency ... [more ▼]

This paper proposes the augmentation of the adjacency model of networks for graph signal processing. It is assumed that no information about the network is available, apart from the initial adjacency matrix. In the proposed model, additional edges are created according to a Markov relation imposed between nodes. This information is incorporated into the extended-adjacency matrix as a function of the diffusion distance between nodes. The diffusion distance measures similarities between nodes at a certain diffusion scale or time, and is a metric adopted from diffusion maps. Similarly, the proposed extended-adjacency matrix depends on the diffusion scale, which enables the definition of a scale-dependent graph Fourier transform. We conduct theoretical analyses of both the extended adjacency and the corresponding graph Fourier transform and show that different diffusion scales lead to different graph-frequency perspectives. At different scales, the transform discriminates shifted ranges of signal variations across the graph, revealing more information on the graph signal when compared to traditional approaches. The scale-dependent graph Fourier transform is applied for anomaly detection and is shown to outperform the conventional graph Fourier transform. [less ▲]

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See detailAn Extended Cooperative Adaptive Cruise Control (CACC) Algorithm for Efficient Energy Consumption & Traffic Density Formulation
Bayar, Bilgehan; Sajadi Alamdari, Seyed Amin UL; Viti, Francesco UL et al

in Traffic Flow Theory and Characteristics Committee (AHB45) 2016 Summer Meeting, Sydney, Australia, 2016 (2016, July 02)

Electric transportation, one of the most promising technologies of the century, can contribute to a greener environment as it is emission-free and sustainable. Although this technology promises a clean ... [more ▼]

Electric transportation, one of the most promising technologies of the century, can contribute to a greener environment as it is emission-free and sustainable. Although this technology promises a clean transportation style, it also has some drawbacks. One of the most significant one is cruising range, which needs to be addressed sustainably. The most eco-friendly solution is decreasing energy consumption by addressing driving behaviour. This can be achieved by taking the advantage of implementing an advancing vehicle automation technology which controls vehicles using a driver-assistance system such as Eco-Cruise Control (Eco-CC). Variety of systems already exist in the literature and a little known advanced version Eco-Adaptive Cruise Control (Eco-ACC) systems are developed as well. The next step of the vehicle automation is vehicle cooperation and information sharing, so-called Cooperative Adaptive Cruise Control (CACC). It is already developed and tested by various researcher. However, the largest deal of existing studies focus on assessing the performance in terms of safety, possible contributions to the energy consumption is not taken into account. This study covers the extension of Cooperative Adaptive Cruise Control systems while aiming to provide an energy efficient extended control algorithm to increase the energy efficiency and battery usage for electric vehicles. An energy efficient control algorithm is aimed to be derived to decrease the consumption of the vehicle. Cruising velocities and vehicle positions are received from the leading vehicles and accordingly traction force is adjusted to achieve efficient energy consumption. By providing vehicle to vehicle (V2V) communication tighter spacing gaps, lower time headway, are aimed to obtain while traffic disturbances are damped, whereas in the cases ACC applications amplify the disturbance. Traffic density formula is introduced by using V2V communication which might be useful for ADAS and ITS framework. As a result, increase in traffic stability, density, and reduction in the total energy consumption is expected. Moreover, possible reductions in air drag with tighter spacing gaps may lead reduction in energy consumption. For the energy calculations and the validation of the proposed method, vehicle dynamics and energy consumption of an electric car is formulated, which has completely different characteristics and limitations than combustion engine cars. Hence the study aims to provide additional understanding of behaviour of a fleet of CACC-equipped electric vehicles. Even though the proposed control algorithm is developed for Electric Vehicles, it can be extended to other vehicle types based on their energy consumption characteristics and vehicle dynamics. [less ▲]

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See detailAn extended coordinate descent method for distributed anticipatory network traffic control
Rinaldi, Marco UL; Tampère, C. M. J.

in Transportation Research. Part B : Methodological (2015), 80

Anticipatory optimal network control can be defined as the practice of determining the set of control actions that minimizes a network-wide objective function, so that the consequences of this action are ... [more ▼]

Anticipatory optimal network control can be defined as the practice of determining the set of control actions that minimizes a network-wide objective function, so that the consequences of this action are taken in consideration not only locally, on the propagation of flows, but globally, taking into account the user's routing behavior. Such an objective function is, in general, defined and optimized in a centralized setting, as knowledge regarding the whole network is needed in order to correctly compute it. This is a strong theoretical framework but, in practice, reaching a level of centralization sufficient to achieve said optimality is very challenging. Furthermore, even if centralization was possible, it would exhibit several shortcomings, with concerns such as computational speed (centralized optimization of a huge control set with a highly nonlinear objective function), reliability and communication overhead arising.The main aim of this work is to develop a decomposed heuristic descent algorithm that, demanding the different control entities to share the same information set, attains network-wide optimality through separate control actions. © 2015 Elsevier Ltd. [less ▲]

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See detailDie Extended Discrete Element Method (XDEM) als integraler Ansatz für reagierende Mehrphasenströmungen
Peters, Bernhard UL; Amir, Mahmoudi

in 26. Deutscher Flammentag Verbrennung und Feuerung (2013, September)

Eine Großzahl technischer Anwendungen wie beispielsweise in der pharmazeutischen Industrie, Nahrungsmittelindustrie, Bergbau, Verfahrenstechnik oder Energiegewinnung durch Verbrennung von Feststoffen ... [more ▼]

Eine Großzahl technischer Anwendungen wie beispielsweise in der pharmazeutischen Industrie, Nahrungsmittelindustrie, Bergbau, Verfahrenstechnik oder Energiegewinnung durch Verbrennung von Feststoffen enthalten neben einer gasförmigen oder fluiden Phase eine diskrete Phase in Form von Partikeln oder Feststoffen. Diese Anwendungen lassen sich sehr vorteilhaft mit dem innovativen Konzept der Extended Discrete Element Method (XDEM) numerisch beschreiben. Hierbei werden die einzelnen Partikel über den dynamischen Zustand (Position und Orientierung) und den thermodynamischen Zustand (Temperatur und Spezies) diskret beschrieben, wo hingegen die Gas- oder Flüssigphase über kontinuumsmechanische Ansätze der Computational Fluid Dynamics (CFD) berechnet wird. Beide Phasen – diskret und kontinuumsmechanisch – sind durch Austausch von Stoff, Wärme und Impuls gekoppelt, was damit eine detaillierte Auflösung der Phasen für CFD-Gesamtrechnungen ermöglicht. Dieser Ansatz wurde angewendet, um den Reaktionsprozess während der Pyrolyse von Holz in einem Festbettreaktor zu berechnen. [less ▲]

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See detailThe extended discrete element method (XDEM) applied to drying of a packed bed
Peters, Bernhard UL; Besseron, Xavier UL; Estupinan Donoso, Alvaro Antonio UL et al

in Industrial Combustion (2014), 14

A vast number of engineering applications involve physics not solely of a single domain but of several physical phenomena, and therefore are referred to as multi-physical. As long as the phenomena ... [more ▼]

A vast number of engineering applications involve physics not solely of a single domain but of several physical phenomena, and therefore are referred to as multi-physical. As long as the phenomena considered are to be treated by either a continuous (i.e. Eulerian) or discrete (i.e. Lagrangian) approach, numerical solution methods may be employed to solve the problem. However, numerous challenges in engineering exist and evolve; those include modelling a continuous and discrete phase simultaneously, which cannot be solved accurately by continuous or discrete approaches only. Problems that involve both a continuous and a discrete phase are important in applications as diverse as the pharmaceutical industry, the food processing industry, mining, construction, agricultural machinery, metals manufacturing, energy production and systems biology. A novel technique referred to as Extended Discrete Element Method (XDEM) has been developed that offers a significant advancement for coupled discrete and continuous numerical simulation concepts. XDEM extends the dynamics of granular materials or particles as described through the classical discrete element method (DEM) to include additional properties such as the thermodynamic state or stress/strain for each particle coupled to a continuous phase such as a fluid flow or a solid structure. Contrary to a continuum mechanics concept, XDEM aims at resolving the particulate phase through the various processes attached to particles. While DEM predicts the spatial-temporal position and orientation for each particle, XDEM additionally estimates properties such as the internal temperature and/or species distribution during drying, pyrolysis or combustion of solid fuel material such as biomass in a packed bed. These predictive capabilities are further extended by an interaction with fluid flow by heat, mass and momentum transfer and the impact of particles on structures. © International Flame Research Foundation, 2014. [less ▲]

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See detailThe Extended Discrete Element Method (XDEM) as a Flexible and Advanced Tool in Multi-physics Applications
Peters, Bernhard UL

in 26th International Symposium on Transport Phenomena (2015)

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See detailThe extended discrete element method (XDEM) for multi-physics applications
Peters, Bernhard UL

in Scholarly Journal of Engineering Research (2013)

Detailed reference viewed: 111 (18 UL)