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See detailExistence of nontrivial solutions of linear functional equations.
Kiss, Gergely UL; Varga, Adrienn

in Aequationes Mathematicae (2014), 88(1-2), 151162

We investigate the existence of a solution of linear functional equations.

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See detailExistence of Positive Steady States for Mass Conserving and Mass-Action Chemical Reaction Networks with a Single Terminal-Linkage Class
Fleming, Ronan MT UL; Akle, Santiago; Dalal, Onkar et al

in arXiv preprint arXiv:1105.2359 (2013)

We establish that mass conserving, single terminal-linkage networks of chemical reactions admit positive steady states regardless of network deficiency and the choice of reaction rate constants. This ... [more ▼]

We establish that mass conserving, single terminal-linkage networks of chemical reactions admit positive steady states regardless of network deficiency and the choice of reaction rate constants. This result holds for closed systems without material exchange across the boundary, as well as for open systems with material exchange at rates that satisfy a simple sufficient and necessary condition. Our proof uses a fixed point of a novel convex optimization formulation to find the steady state behavior of chemical reaction networks that satisfy the law of mass-action kinetics. A fixed point iteration can be used to compute these steady states, and we show that it converges for weakly reversible homogeneous systems. We report the results of our algorithm on numerical experiments. [less ▲]

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See detailDie Exklusion von Schüler/innen mit sonderpädagogischem Förderbedarf. Ein Beitrag zur Debatte um nationale Bildungsstandards und die Schule für alle
Pfahl, Lisa; Powell, Justin J W UL

in Gemeinsam Leben : Zeitschrift für Integrative Erziehung (2005), (10), 68-78

Aktuelle bildungspolitische Reformbemühungen zielen darauf, eine Erhöhung der schulischen Leistungen zu bewirken und messbare Kompetenzen weiter zu entwickeln. Dabei wird die Selektion von Schüler/innen ... [more ▼]

Aktuelle bildungspolitische Reformbemühungen zielen darauf, eine Erhöhung der schulischen Leistungen zu bewirken und messbare Kompetenzen weiter zu entwickeln. Dabei wird die Selektion von Schüler/innen mit sonderpädagogischem Förderbedarf durch die Institution Schule und die Frage nach der Chancengleichheit eines segregierenden Schulsystems eher selten thematisiert. Statt solcher "Strukturfragen" stehen die Forderungen nach nationalen Bildungsstandards, Ganztagsschulen und der Kultushoheit der Bundesländer im Mittelpunkt der Diskussion. Die Idee einer individuellen Förderung von Schüler/innen, evtl. sogar in einer Schule für alle, wird seit PISA 2003 zunehmend Gegenstand der gesellschaftlichen Diskussion. Jedoch bleiben sonderpädagogische Förderprogramme trotz deren Spezialisierung auf solche individualisierte Unterrichtsformen, unberücksichtigt. Anhand zweier unterschiedlicher Ansätze in der Bildungsforschung - biographische Analysen und gesellschaftshistorische Vergleiche - werden die Autoren aufzeigen, dass die weitgehende Nicht-Berücksichtigung des sonderpädagogischen Bereichs in der allgemeinen Bildungsforschung die Scheiternserfahrungen von Kindern und Jugendlichen mit sonderpädagogischem Förderungsbedarf ausblendet, und die (inter)nationalen Ergebnisse von PISA, sowie die ermittelten - oder zu ermittelnden - "nationalen Bildungsstandards" verzerrt. Gerade die Situation von Kindern und Jugendlichen mit sonderpädagogischem Förderbedarf an Sonderschulen unterstreicht die Wichtigkeit der aktuellen Diskussion um eine Schule für alle. Eine solche Schulform wäre ohne diese Schüler/innen lediglich eine weitere exkludierende Schulform, denn Schulen ohne behinderte Kinder ist keine normalen Schulen. [less ▲]

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See detailExogenous covert shift of attention without the ability to plan eye movements.
Masson, Nicolas UL; Andres, Michael; Pereira, Sarah Carneiro et al

in Current biology : CB (2020), 30(18), 1032-1033

The automatic allocation of attention to a salient stimulus in the visual periphery (e.g., a traffic light turning red) while maintaining fixation elsewhere (e.g., on the car ahead) is referred to as ... [more ▼]

The automatic allocation of attention to a salient stimulus in the visual periphery (e.g., a traffic light turning red) while maintaining fixation elsewhere (e.g., on the car ahead) is referred to as exogenous covert shift of attention (ECSA). An influential explanation is that ECSA results from the programming of a saccadic eye movement toward the stimulus of interest [1,2], although the actual movement may be withheld if needed. In this paper, however, we report evidence of ECSA in the paralyzed axis of three individuals with either horizontal or vertical congenital gaze paralysis, including for stimuli appearing at locations that cannot be foveated through head movements. This demonstrates that ECSA does not require programming either eye or head movements and calls for a re-examination of the oculomotor account. [less ▲]

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See detailExome-wide analysis of mutational burden in patients with typical and atypical Rolandic Epilepsy
Bobbili, Dheeraj Reddy UL; Lal, Dennis; May, Patrick UL et al

in European Journal of Human Genetics (2018)

Rolandic Epilepsy (RE) is the most common focal epilepsy in childhood. To date no hypothesis-free exome-wide mutational screen has been conducted for RE and Atypical RE (ARE). Here we report on whole ... [more ▼]

Rolandic Epilepsy (RE) is the most common focal epilepsy in childhood. To date no hypothesis-free exome-wide mutational screen has been conducted for RE and Atypical RE (ARE). Here we report on whole-exome sequencing of 194 unrelated patients with RE/ARE and 567 ethnically matched population controls. We identified an exome-wide significantly enriched burden for deleterious and loss-of-function variants only for the established RE/ARE gene GRIN2A. The statistical significance of the enrichment disappeared after removing ARE patients. For several disease-related gene-sets, an odds ratio > 1 was detected for loss-of-function variants. [less ▲]

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See detailExpanded coverage of non-targeted LC-HRMS using atmospheric pressure chemical ionization: a case study with ENTACT mixtures.
Singh, Randolph UL; Chao, Alex; Phillips, Katherine A. et al

in Analytical and Bioanalytical Chemistry (2020)

Non-targeted analysis (NTA) is a rapidly evolving analytical technique with numerous opportunities to improve and expand instrumental and data analysis methods. In this work, NTA was performed on eight ... [more ▼]

Non-targeted analysis (NTA) is a rapidly evolving analytical technique with numerous opportunities to improve and expand instrumental and data analysis methods. In this work, NTA was performed on eight synthetic mixtures containing 1264 unique chemical substances from the U.S. Environmental Protection Agency’s Non-Targeted Analysis Collaborative Trial (ENTACT). These mixtures were analyzed by atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) using both positive and negative polarities for a total of four modes. Out of the 1264 ENTACT chemical substances, 1116 were detected in at least one ionization mode, 185 chemicals were detected using all four ionization modes, whereas 148 were not detected. Forty-four chemicals were detected only by APCI, and 181 were detected only by ESI. Molecular descriptors and physicochemical properties were used to assess which ionization type was preferred for a given compound. One ToxPrint substructure (naphthalene group) was found to be enriched in compounds only detected using APCI, and eight ToxPrints (e.g., several alcohol moieties) were enriched in compounds only detected using ESI. Examination of physicochemical parameters for ENTACT chemicals suggests that those with higher aqueous solubility preferentially ionized by ESI−. While ESI typically detects a larger number of compounds, APCI offers chromatograms with less background, fewer co-elutions, and additional chemical space coverage, suggesting both should be considered for broader coverage in future NTA research. [less ▲]

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See detailExpanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants.
Thiele, Ines UL; Vo, Thuy D.; Price, Nathan D. et al

in Journal of Bacteriology (2005), 187(16), 5818-30

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the ... [more ▼]

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the revised genome annotation and new experimental data. This reconstruction, iIT341 GSM/GPR, represents a detailed review of the current literature about H. pylori as it integrates biochemical and genomic data in a comprehensive framework. In total, it accounts for 341 metabolic genes, 476 intracellular reactions, 78 exchange reactions, and 485 metabolites. Novel features of iIT341 GSM/GPR include (i) gene-protein-reaction associations, (ii) elementally and charge-balanced reactions, (iii) more accurate descriptions of isoprenoid and lipopolysaccharide metabolism, and (iv) quantitative assessments of the supporting data for each reaction. This metabolic reconstruction was used to carry out in silico deletion studies to identify essential and conditionally essential genes in H. pylori. A total of 128 essential and 75 conditionally essential metabolic genes were identified. Predicted growth phenotypes of single knockouts were validated using published experimental data. In addition, in silico double-deletion studies identified a total of 47 synthetic lethal mutants involving 67 different metabolic genes in rich medium. [less ▲]

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See detailExpanding spaces of participation: insights from an infrastructural project in rural Nepal
Cima, Ottavia UL

in Geographica Helvetica (2015), 70(4), 353-361

The spread of participatory development worldwide has multiplied opportunities for local population to engage in paid and unpaid development activities. However, scholars have pointed out that ... [more ▼]

The spread of participatory development worldwide has multiplied opportunities for local population to engage in paid and unpaid development activities. However, scholars have pointed out that participatory approaches bear the risk of strengthening unequal social structures, despite their emphasis on democratisation and inclusion. This paper investigates the case of a Swiss-funded infrastructural project in rural Nepal, analysing the role of participatory spaces in the dynamics of development resource capture. The empirical material collected suggests that, although participatory development has created more opportunities for social mobility, these opportunities are not necessarily open to everyone. In the case studied, the transformational potential of participation is only partially fulfilled. [less ▲]

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See detailExpanding the field of science education: A conversation with Ken Tobin
Siry, Christina UL

in Eurasia Journal of Mathematics, Science & Technology Education (2009), 5(3), 197-208

This paper focuses on a conversation with Dr. Kenneth Tobin, which took place in June 2009 at The Graduate Center of the City University of New York (CUNY), where he is Presidential Professor in the Urban ... [more ▼]

This paper focuses on a conversation with Dr. Kenneth Tobin, which took place in June 2009 at The Graduate Center of the City University of New York (CUNY), where he is Presidential Professor in the Urban Education Program. Our purpose was to focus on Ken’s career in science education, and to discuss the past, present, and future of his research interests. During our conversation, we explored the various trajectories of his career, focusing on the ways in which his research has evolved through the years. Further, Ken shared his thoughts on the field of science education, and provided salient advice for early career scholars. This manuscript includes an introductory summary of Ken’s career achievements to this point, a record of our conversation (the audio-recording can be downloaded at the journal’s website) and a list of selected publications that highlight Ken’s key works. [less ▲]

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See detailExpanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations
SALA, Stefano; Van troys, Marleen; Medves, Sandrine et al

in Journal of Proteome Research (2017), doi: 10.1021/acs.jproteome.7b00034

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See detailExpanding the use of spectral libraries in proteomics.
Deutsch, Eric W.; Perez-Riverol, Yasset; Chalkley, Robert J. et al

in Journal of proteome research (2018)

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass ... [more ▼]

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass spectrometry spectral libraries. Their use in proteomics is growing slowly, but there are multiple challenges in the field that must be addressed to further increase the adoption of spectral libraries and related techniques. The primary bottlenecks are the paucity of high quality and comprehensive libraries and the general difficulty of adopting spectral library searching into existing workflows. There are several existing spectral library formats, but none capture a satisfactory level of metadata; therefore a logical next improvement is to design a more advanced, Proteomics Standards Initiative-approved spectral library format that can encode all of the desired metadata. The group discussed a series of metadata requirements organized into three designations of completeness or quality, tentatively dubbed bronze, silver, and gold. The metadata can be organized at four different levels of granularity: at the collection (library) level, at the individual entry (peptide ion) level, at the peak (fragment ion) level, and at the peak annotation level. Strategies for encoding mass modifications in a consistent manner and the requirement for encoding high-quality and commonly-seen but as-yet-unidentified spectra were discussed. The group also discussed related topics, including strategies for comparing two spectra, techniques for generating representative spectra for a library, approaches for selection of optimal signature ions for targeted workflows, and issues surrounding the merging of two or more libraries into one. We present here a review of this field and the challenges that the community must address in order to accelerate the adoption of spectral libraries in routine analysis of proteomics datasets. [less ▲]

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See detailExpansion and inequality of educational opportunity: a comparative study
Bar-Haim, Eyal UL; Shavit, Yossi

in Research in Social Stratification and Mobility (2013), 31

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See detailExpansion nach Belgien als Verwaltungstätigkeit: der Kölner Beamte Franz Thedieck im NS
Brüll, Christoph UL

Scientific Conference (2019, June 28)

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See detailExpansion of a Fermi cloud in the BCS-BEC crossover
Diana, Giovanni UL; Manini, Nicola; Salasnich, Luca

in Physical Review A (2006), 73(6), 065601

We study the free expansion of a dilute two-component Fermi gas with attractive interspecies interaction in the BCS-BEC crossover. We apply a time-dependent parameter-free density-functional theory by ... [more ▼]

We study the free expansion of a dilute two-component Fermi gas with attractive interspecies interaction in the BCS-BEC crossover. We apply a time-dependent parameter-free density-functional theory by using two choices of the equation of state: an analytic formula based on Monte Carlo data and the mean-field equation of state resulting from the extended BCS equations. The calculated axial and transverse radii and the aspect ratio of the expanding cloud are compared to experimental data on vapors of 6 Li atoms. Remarkably, the mean-field theory shows a better agreement with the experiments than the theory based on the Monte Carlo equation of state. Both theories predict a measurable dependence of the aspect ratio on expansion time and on scattering length. [less ▲]

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See detailExpansion ohne Kontraktion? Krieg und Militär als ‚Zeichen und Werkzeug der Vereinigung der ganzen Welt‘
Kolnberger, Thomas UL

in Feldbauer, Peter; Hödl, Gerald; Lehners, Jean-Paul (Eds.) Rhythmen der Globalisierung – Expansion und Kontraktion zwischen dem 13. und 20. Jahrhundert (2009)

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See detailExpansions of the Instant. Disruptions of Time in Contemporary German Literature
Pause, Johannes UL

in Koch, Lars; Nanz, Tobias; Pause, Johannes (Eds.) Disruption in the Arts. Textual, Visual, and Performative Strategies for Analyzing Societal Self-Descriptions (2018)

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See detailExpectations of mutual support and care in the light of migration
Albert, Isabelle UL; Ferring, Dieter UL; Barros Coimbra, Stephanie UL et al

Scientific Conference (2015, September 08)

As first generation immigrants are currently approaching retirement age in many European countries, intergenerational solidarity within the context of acculturation gains high importance. However, most ... [more ▼]

As first generation immigrants are currently approaching retirement age in many European countries, intergenerational solidarity within the context of acculturation gains high importance. However, most research on intergenerational relations in ageing families so far has not drawn special attention to migrant families. The aim of the present study was to investigate similarities and differences in the expectations about intergenerational support in a sample of n = 48 Luxembourgish (68.8% female) and n = 36 Portuguese (60.5% female) adult children and at least one of their parents. Luxembourgish adult children were on average M = 25.90 (SD = 5.74) years old, Portuguese M = 27.28 (SD = 6.49). A total of 58.3% of Portuguese adult children were born in Luxembourg; the remainder was born in Portugal but had grown up in Luxembourg. For all participants, both parents were still alive and were living in the Grand-Duchy. Whereas Luxembourgish and Portuguese adult children did not differ regarding family cohesion and expected support from parents toward children, Portuguese participants reported higher expectations of support from adult children toward their ageing parents. More Portuguese than Luxembourgish parents indicated they would like to live with their children in case of need, whereas more Luxembourgish parents preferred to live in a residential home. Nonetheless, no differences between adult children of both national groups were found regarding filial anxiety about future care of parents. Results are discussed in the framework of an integrative model on intergenerational family relations in the light of migration and ageing. This model takes several aspects into account that might have an impact on different needs, tasks and resources of the individual and the family depending on different family cultures, the larger cultural context in which family relations are embedded as well as significant events over the life-span (such as migration history). [less ▲]

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See detailExpected and Unexpected Consequences of the Educational Expansion in Europe and the US Theoretical approaches and empirical findings in comparative perspective
Hadjar, Andreas UL; Becker, Rolf

Book published by Haupt Verlag (2009)

A main mechanism behind the change in European and North American societies in the second half of the 20th century is the educational expansion, i.e. the increase in educational opportunities and the ... [more ▼]

A main mechanism behind the change in European and North American societies in the second half of the 20th century is the educational expansion, i.e. the increase in educational opportunities and the higher demand for education. Whereas other abstract social processes like modernization have been widely theorized in social science literature, the educational expansion and its consequences in particular have not been well studied. Therefore the main aim of this compilation is to deal with the question of whether the demands of the educational reforms have been fulfilled and which other consequences the educational expansion has had. This book will focus on consequences of the educational expansion for individuals and their life courses as well as for the social structure and other societal areas such as culture and politics. Aspects that will be analysed in the light of educational expansion include participation in education, educational inequalities, labour market outcomes, educational returns, and gender differences as well as crime, life expectancy, and lifestyles. Countries analysed in the book include West European countries like Germany, France, Italy and Spain, East European countries (Hungary, Poland, and the Czech Republic) as well as the US. [less ▲]

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See detailExpected Running Time of Parallel Evolutionary Algorithms on Unimodal Pseudo-Boolean Functions over Small-World Networks
Muszynski, Jakub UL; Varrette, Sébastien UL; Bouvry, Pascal UL

in Proc. of the IEEE Congress on Evolutionary Computation (CEC'2013) (2013)

This paper proposes a theoretical and experimental analysis of the expected running time for an elitist parallel Evolutionary Algorithm (pEA) based on an island model executed over small-world networks ... [more ▼]

This paper proposes a theoretical and experimental analysis of the expected running time for an elitist parallel Evolutionary Algorithm (pEA) based on an island model executed over small-world networks. Our study assumes the resolution of optimization problems based on unimodal pseudo-boolean funtions. In particular, for such function with d values, we improve the previous asymptotic upper bound for the expected parallel running time from O(d√n) to O(d log n). This study is a first step towards the analysis of influence of more complex network topologies (like random graphs created by P2P networks) on the runtime of pEAs. A concrete implementation of the analysed algorithm have been performed on top of the ParadisEO framework and run on the HPC platform of the University of Luxembourg (UL). Our experiments confirm the expected speed- up demonstrated in this article and prove the benefit that pEA can gain from a small-world network topology. [less ▲]

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