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See detailEvaluation of heat transfer on a backward acting grate
Peters, Bernhard UL; Džiugys

in MECHANIKA (2014), 20

Detailed reference viewed: 134 (10 UL)
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See detailAn evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae
Wilkening, Stefan; Lin, Gen; Fritsch, Emilie S. et al

in Genetics (2014), 196(3), 853-65

Dissecting the molecular basis of quantitative traits is a significant challenge and is essential for understanding complex diseases. Even in model organisms, precisely determining causative genes and ... [more ▼]

Dissecting the molecular basis of quantitative traits is a significant challenge and is essential for understanding complex diseases. Even in model organisms, precisely determining causative genes and their interactions has remained elusive, due in part to difficulty in narrowing intervals to single genes and in detecting epistasis or linked quantitative trait loci. These difficulties are exacerbated by limitations in experimental design, such as low numbers of analyzed individuals or of polymorphisms between parental genomes. We address these challenges by applying three independent high-throughput approaches for QTL mapping to map the genetic variants underlying 11 phenotypes in two genetically distant Saccharomyces cerevisiae strains, namely (1) individual analysis of >700 meiotic segregants, (2) bulk segregant analysis, and (3) reciprocal hemizygosity scanning, a new genome-wide method that we developed. We reveal differences in the performance of each approach and, by combining them, identify eight polymorphic genes that affect eight different phenotypes: colony shape, flocculation, growth on two nonfermentable carbon sources, and resistance to two drugs, salt, and high temperature. Our results demonstrate the power of individual segregant analysis to dissect QTL and address the underestimated contribution of interactions between variants. We also reveal confounding factors like mutations and aneuploidy in pooled approaches, providing valuable lessons for future designs of complex trait mapping studies. [less ▲]

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See detailEvaluation of intensive blood glucose control using glargine in diabetic cats
Roomp, Kirsten UL; Rand, J.S.

in Journal of Veterinary Internal Medicine (2008), 22(3), 790

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See detailEvaluation of intervention strategies for a road link in the Netherlands
Adey, Bryan Tyrone; Lethanh, Nam; Hartmann, Andreas et al

in Built Environment Project and Asset Management (2014), 4(2), 180-198

Purpose – The purpose of this paper is to investigate the use of the impact hierarchy and the optimization model to determine the optimal intervention strategy for a road link composed of multiple objects ... [more ▼]

Purpose – The purpose of this paper is to investigate the use of the impact hierarchy and the optimization model to determine the optimal intervention strategy for a road link composed of multiple objects. The paper focusses on the results of a case study of intervention project on A20 road link in Rotterdam, the Netherlands. Design/methodology/approach – The study was a case study research. It describes briefly the impact hierarchy and its link to the optimization model, and then focussed on analyzing the results obtained from running the model. In order to understand the influence of various factors affecting the results of optimization, sensitivity analysis was performed. Findings – The proposed hierarchy is suitable to be used to support the determination of optimal intervention strategies (OISs) for public road. From the case study, it was also realized that optimal intervention strategy can be changed due to not only intervention costs incurred by the owner, but also due to the setup of traffic configuration during the execution of interventions since the impacts incurred to users, directly affected public, and indirectly affected public are significantly different from one traffic configuration to the others. The optimal intervention strategy also depends greatly on the factors of deterioration during the operation of the infrastructure objects. Research limitations/implications – In the impact hierarchy, some impact factors are difficult to be quantified, e.g., the long-term economic impacts on the region where having intervention projects. The use of only exponential function for impacts could be oversimplified the actual behavior of the impacts. Other functional form should be investigated to be used within the framework of the optimization model. Practical implications – The proposed hierarchy and the optimization model could be used in practical situation for determination of OISs for multiple objects within a road link. Originality/value – This paper contributes to the body of knowledge of stakeholder analysis in the field of infrastructure asset management. It also gives a guideline and tool for infrastructure administrators to select the OISs for their infrastructure network. [less ▲]

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See detailEvaluation of laser braze-welded dissimilar Al-Cu joints
Schmalen, Pascal Guy UL; Plapper, Peter UL

in Physics Procedia (2016), 83

The thermal joining of Aluminum and Copper is a promising technology towards automotive battery manufacturing. The dissimilar metals Al-Cu are difficult to weld due to their different physicochemical ... [more ▼]

The thermal joining of Aluminum and Copper is a promising technology towards automotive battery manufacturing. The dissimilar metals Al-Cu are difficult to weld due to their different physicochemical characteristics and the formation of intermetallic compounds (IMC), which have reduced mechanical and electric properties. There is a critical thickness of the IMCs where the favored mechanical properties of the base material can be preserved. The laser braze welding principle uses a position and power oscillated laser-beam to reduce the energy input and the intermixture of both materials and therefore achieves minimized IMCs thickness. The evaluation of the weld seam is important to improve the joint performance and enhance the welding process. This paper is focused on the characterization and quantification of the IMCs. Mechanical, electrical and metallurgical methods are presented and performed on Al1050 and SF-Cu joints and precise weld criteria are developed. [less ▲]

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See detailAn evaluation of low-cost consumer-grade UAS systems for 3D reality capture
Backes, Dietmar UL; Teasdale, Oliver; Eloff, Jacques

Poster (2016, September 22)

During the last years, small lightweight and low cost remotely piloted aerial systems (RPAS) commonly referred as Drones have rapidly developed into capable low-cost Unmanned Aerial Systems (UAS). Fuelled ... [more ▼]

During the last years, small lightweight and low cost remotely piloted aerial systems (RPAS) commonly referred as Drones have rapidly developed into capable low-cost Unmanned Aerial Systems (UAS). Fuelled by a vibrant community of scientists, professionals and hobby enthusiasts enabling technologies have matured quickly, and prices of consumer grade as well as semi-professional systems fell sharply. Especially multirotor vertical take-off and landing (VTOL) UAS have proven to be versatile and flexible platforms which can be equipped with a range of sensors capable of capturing aerial data for a variety of 2D and 3D mapping applications. Consumer grade, low weight systems as the DJI Phantom or 3DR Solo have a limited payload and can carry low weight action cameras like the GoPro Hero models which are capable of collecting video as well as still RGB and near-infrared imagery. Applying traditional Photogrammetric methods to imagery from low-cost UAS systems proved complex and impractical in the past. However modern the state-of-the-art structure from motion algorithms implemented in off the shelf software packages (sometimes referred as new Photogrammetry), cloud processing environments and available via open source libraries promise to generate dense 3D point clouds, textured models and orthomosaics in high quality and without much effort. How accurate and how reliable are data products generated from such systems? Expanding from a preliminary study (BACKES & TEASDALE 2015) we review the every progressing capabilities and features of COTS (commercial of the shelf) user and semi-professional UAS systems under the aspects of deployable sensors, ease of use, reliability as well as safety. We show the workflow from flight planning, data collection to dense pointclould matching using a range of software products. The resulting point clouds are evaluated and benchmarked using a highly accurate and dense reference data acquired via geodetic terrestrial survey and Laserscanning. The results of this evaluations allow conclusions on the current accuracy capabilities of this such low-cost systems. [less ▲]

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See detailAn Evaluation of New Estimates from GPS, GRACE and Load Models compared to SLR
Lavalee, D.; Moore, P.; Clarke, Peter J. et al

in Geophysical Research Letters (2010), (37), 5-6

Changes in J2, resulting from past and present changes in Earth’s climate, are traditionally observed by Satellite Laser ranging (SLR). Assuming an elastic Earth, it is possible to infer changes in J2 ... [more ▼]

Changes in J2, resulting from past and present changes in Earth’s climate, are traditionally observed by Satellite Laser ranging (SLR). Assuming an elastic Earth, it is possible to infer changes in J2 from changes in Earth’s shape observed by GPS. We compare estimates of non‐secular J2 changes from GPS, SLR, GRACE, and a load model. The GPS and SLR annual signals agree but are different (16%) to the load model. Subtraction of the load model removes the annual variation from GPS, SLR, and GRACE, and the semi‐annual variation in GPS. The GPS and SLR long‐term signals are highly correlated, but GPS is better correlated with the loading model. Subtraction of the load model removes the 1998 anomaly from the GPS J2 series but not completely from the SLR J2 series, suggesting that the SLR anomaly may not be entirely due to mass re‐distribution as has been presumed. [less ▲]

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See detailEvaluation of PGM2007A by comparison with globally and locally estimated gravity solutions from CHAMP
Weigelt, Matthias UL; Sneeuw, N.; Keller, W.

in Newton's Bulletin (2009), 4

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See detailEvaluation of plasma membrane calcium/calmodulin-dependent ATPase isoform 4 as a potential target for fertility control.
Cartwright, Elizabeth J.; Neyses, Ludwig UL

in Handbook of experimental pharmacology (2010), (198), 79-95

The array of contraceptives currently available is clearly inadequate and does not meet consumer demands since it is estimated that up to a quarter of all pregnancies worldwide are unintended. There is ... [more ▼]

The array of contraceptives currently available is clearly inadequate and does not meet consumer demands since it is estimated that up to a quarter of all pregnancies worldwide are unintended. There is, therefore, an overwhelming global need to develop new effective, safe, ideally non-hormonal contraceptives for both male and female use. The contraceptive field, unlike other areas such as cancer, has a dearth of new targets. We have addressed this issue and propose that isoform 4 of the plasma membrane calcium ATPase is a potentially exciting novel target for fertility control. The plasma membrane calcium ATPase is a ubiquitously expressed calcium pump whose primary function in the majority of cells is to extrude calcium to the extracellular milieu. Two isoforms of this gene family, PMCA1 and PMCA4, are expressed in spermatozoa, with PMCA4 being the predominant isoform. Although this gene is ubiquitously expressed, its function is highly tissue-specific. Genetic deletion of PMCA4, in PMCA4 knockout mice, led to 100% infertility specifically in the male mutant mice due to a selective defect in sperm motility. It is important to note that the gene deletion did not affect normal mating characteristics in these mice. This phenotype was mimicked in wild-type sperm treated with the non-specific PMCA inhibitor 5-(and 6-) carboxyeosin diacetate succinimidyl ester; a proof-of-principle that inhibition of PMCA4 has potential importance in the control of fertility. This review outlines the potential for PMCA4 to be a novel target for fertility control by acting to inhibit sperm motility. It will outline the characteristics that make this target drugable and will describe methodologies to identify and validate novel inhibitors of this target. [less ▲]

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See detailEvaluation of potassium chloride emissions applying the Discrete Particle Method (DPM)
Peters, Bernhard UL; Smula, Joanna UL

in Computers & Chemical Engineering (2011)

Detailed reference viewed: 87 (3 UL)
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See detailEvaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes
Lal, Dennis; Reinthaler, Eva; Dejanovic et al

in PLoS ONE (2016)

Objective The SCN1A gene, coding for the voltage-gated Na+ channel alpha subunit NaV1.1, is the clinically most relevant epilepsy gene. With the advent of high-throughput next-generation sequencing ... [more ▼]

Objective The SCN1A gene, coding for the voltage-gated Na+ channel alpha subunit NaV1.1, is the clinically most relevant epilepsy gene. With the advent of high-throughput next-generation sequencing, clinical laboratories are generating an ever-increasing catalogue of SCN1A variants. Variants are more likely to be classified as pathogenic if they have already been identified previously in a patient with epilepsy. Here, we critically re-evaluate the pathogenicity of this class of variants in a cohort of patients with common epilepsy syndromes and subsequently ask whether a significant fraction of benign variants have been misclassified as pathogenic. Methods We screened a discovery cohort of 448 patients with a broad range of common genetic epilepsies and 734 controls for previously reported SCN1A mutations that were assumed to be disease causing. We re-evaluated the evidence for pathogenicity of the identified variants using in silico predictions, segregation, original reports, available functional data and assessment of allele frequencies in healthy individuals as well as in a follow up cohort of 777 patients. Results and Interpretation We identified 8 known missense mutations, previously reported as pathogenic, in a total of 17 unrelated epilepsy patients (17/448; 3.80%). Our re-evaluation indicates that 7 out of these 8 variants (p.R27T; p.R28C; p.R542Q; p.R604H; p.T1250M; p.E1308D; p.R1928G; NP_001159435.1) are not pathogenic. Only the p.T1174S mutation may be considered as a genetic risk factor for epilepsy of small effect size based on the enrichment in patients (P = 6.60 x 10−4; OR = 0.32, fishers exact test), previous functional studies but incomplete penetrance. Thus, incorporation of previous studies in genetic counseling of SCN1A sequencing results is challenging and may produce incorrect conclusions. [less ▲]

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See detailEvaluation of RDS/Peripherin and ROM1 as candidate genes in generalised progressive retinal atrophy and exclusion of digenic inheritance
Runte, Maren UL; Dekomien, Gabriele; Epplen, Jörg T

in Animal Genetics (2000), 31(3), 223-227

Detailed reference viewed: 57 (1 UL)
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See detailAn evaluation of real-time troposphere estimation based on GNSS Precise Point Positioning
Ding, Wenwu; Teferle, Felix Norman UL; Kazmierski, Kamil et al

in Journal of Geophysical Research: Atmospheres (2017), 122(5), 2779--2790

It is anticipated that the performance of real-time (RT) GNSS meteorology can be further improved by incorporating observations from multiple Global Navigation Satellite System (GNSS), including GPS ... [more ▼]

It is anticipated that the performance of real-time (RT) GNSS meteorology can be further improved by incorporating observations from multiple Global Navigation Satellite System (GNSS), including GPS, GLONASS, Galileo, and BeiDou. In this paper, an operational RT system for extracting zenith troposphere delay (ZTD) using a modified version of the Precise Point Positioning With Integer and Zero-difference Ambiguity Resolution Demonstrator (PPP-WIZARD) was established. GNSS, including GPS, GLONASS, and Galileo, observation streams were processed using RT Precise Point Positioning (PPP) strategy based on RT satellite orbit/clock products from the Centre National d'Etudes Spatiales. An experiment covering 30 days was conducted, in which the observation streams of 20 globally distributed stations were processed. The initialization time and accuracy of the RT troposphere results using single-system and multisystem observations were evaluated. The effect of PPP ambiguity resolution was also evaluated. Results reveal that RT troposphere estimates based on single-system observations can both be applied in weather nowcasting, in which the GPS-only solution is better than the GLONASS-only solution. The performance can also be improved by PPP ambiguity resolution and utilizing GNSS observations. Specifically, we notice that ambiguity resolution is more effective in improving the accuracy of ZTD, whereas the initialization process can be better accelerated by GNSS observations. Combining all techniques, the RT troposphere results with an average accuracy of about 8 mm in ZTD can be achieved after an initialization process of approximately 8.5 min, which demonstrates superior results for applying GNSS observations and ambiguity resolution for RT meteorological applications. [less ▲]

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See detailAn Evaluation of Real-Time Zenith Total Delay Estimates
Ahmed, Furqan UL; Teferle, Felix Norman UL; Bingley, Richard

Poster (2012, December)

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See detailEvaluation of Resource-based App Repackaging Detection in Android
Gadyatskaya, Olga UL; Lezza, A.-L.; Zhauniarovich, Y.

in Proc. of NordSec (2016)

Android app repackaging threatens the health of application markets, as repackaged apps, besides stealing revenue for honest developers, are also a source of malware distribution. Techniques that rely on ... [more ▼]

Android app repackaging threatens the health of application markets, as repackaged apps, besides stealing revenue for honest developers, are also a source of malware distribution. Techniques that rely on visual similarity of Android apps recently emerged as a way to tackle the repackaging detection problem, as code-based detection techniques often fail in terms of effi ciency, and e ffectiveness when obfuscation is applied [19,21]. Among such techniques, the resource-based repackaging detection approach that compares sets of files included in apks has arguably the best performance [20,17,10]. Yet, this approach has not been previously validated on a dataset of repackaged apps. In this paper we report on our evaluation of the approach, and present substantial improvements to it. Our experiments show that the state-of-art tools applying this technique rely on too restrictive thresholds. Indeed, we demonstrate that a very low proportion of identical resource files in two apps is a reliable evidence for repackaging. Furthermore, we have shown that the Overlap similarity score performs better than the Jaccard similarity coe fficient used in previous works. By applying machine learning techniques, we give evidence that considering separately the included resource fi le types signi cantly improves the detection accuracy of the method. Experimenting with a balanced dataset of more than 2700 app pairs, we show that with our enhancements it is possible to achieve the F-measure of 0.9919. [less ▲]

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See detailEvaluation of school tasks in the light of sustainability education: Textbook research in science education in Luxembourgish primary schools
Andersen, Katja Natalie UL

in Environmental Education Research (2017), 24(9), 1301-1319

This article describes a research project that aimed to classify different types of sustainability-related school tasks in terms of two central approaches in primary school education: action-based and ... [more ▼]

This article describes a research project that aimed to classify different types of sustainability-related school tasks in terms of two central approaches in primary school education: action-based and task-based learning. Using a textbook analysis approach, the article clarifies implicit and explicit forms of sustainability education in school tasks in Luxembourgish science textbooks for Grades 1 to 6. The study uses a two-step analysis: first, scanning textbooks on content relating to sustainability; and, second, evaluating the teaching practices associated with this content apparent in the textbooks. Step one identifies the school tasks in which sustainability content is implicitly or explicitly addressed while step two analyzes which forms of action-based and task-based learning occur in these sustainability-related school tasks. Based on the results two claims can be made: first, that there is very little sustainability-related content in Luxembourgish primary science textbooks, and those topics raised mostly relate to sustainability only indirectly; secondly, action-based and task-based learning are undervalued in the context of sustainability-related school tasks; neither of the two was commonly found in school tasks in sustainability education. [less ▲]

Detailed reference viewed: 106 (9 UL)