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Peer Reviewed
See detailEvaluation of Different Optimization Techniques in the Design of Ad Hoc Injection Networks
Dorronsoro, Bernabé UL; Danoy, Grégoire UL; Bouvry, Pascal UL et al

in special session on Parallel and Grid Computing for Optimization as part of The 2008 International Conference High Performance Computing & Simulation (HPCS008) and in conjunction with The 22nd European Conference on Modeling and Simulation (ECMS 2008). (2008)

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See detailEvaluation of End-To-End Learning for Autonomous Driving: The Good, the Bad and the Ugly
Varisteas, Georgios UL; Frank, Raphaël UL; Sajadi Alamdari, Seyed Amin UL et al

in 2nd International Conference on Intelligent Autonomous Systems, Singapore, Feb. 28 to Mar. 2, 2019 (2019, March 01)

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See detailEvaluation of ERA-Interim for tropospheric delay and water vapour estimation in different climate zones using ground-based GNSS observations
Ahmed, Furqan; Hunegnaw, Addisu UL; Teferle, Felix Norman UL et al

Poster (2017, April 27)

Tropospheric delay and integrated water vapour (IWV) derived from climate reanalysis models, such as that of the European Centre for Medium-range Weather Forecasts (ECMWF) namely the ECMWF ReAnalysis ... [more ▼]

Tropospheric delay and integrated water vapour (IWV) derived from climate reanalysis models, such as that of the European Centre for Medium-range Weather Forecasts (ECMWF) namely the ECMWF ReAnalysis-Interim (ERA-Interim), are widely used in many geodetic and atmospheric applications. Therefore, it is of interest to assess the quality of these reanalysis products using available observations. Observations from Global Navigation Satellite Systems (GNSS) are, as of now, available for a period of over 2 decades and their global availability make it possible to validate the zenith total delay (ZTD) and IWV obtained from climate reanalysis models in different geographical and climatic regions. In this study, a 5-year long homogeneously reprocessed GNSS data set based on double differenced positioning strategy and containing over 400 globally distributed ground-based GNSS stations has been used as a reference to validate the ZTD estimates obtained from the ERA-Interim climate reanalysis model in 25 different climate zones. It has been studied how the difference between the ERA-Interim ZTD and the GNSS-derived ZTD varies with respect to the different climate zones as well as the topographic variations in a particular climate zone. Periodicity in the ZTD residuals in different climate zones has been analyzed. Furthermore, the variation of the ZTD differences with respect to latitude has been presented. Finally, for one GNSS station in each of the 25 climate zones, IWV derived from ERA-Interim has been compared to the IWV derived using GNSS observations. [less ▲]

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See detailEvaluation of GNSS as a Tool for Monitoring Tropospheric Water Vapour
Ahmed, Furqan UL

Bachelor/master dissertation (2010)

Global Navigation Satellite Systems have the potential to become a significant tool in climate research ... [more ▼]

Global Navigation Satellite Systems have the potential to become a significant tool in climate research due to the fact that GNSS data can be processed in order to estimate the propagation delay experienced by the signal in atmosphere. If the ground pressure and temperature is known, the signal propagation path delay can be related to the amount of water vapour in the atmosphere. This thesis project focuses on the evaluation of GNSS as a tool for atmospheric water vapour estimation. In the first part of the project, various GNSS data processing software packages were compared by processing the same set of data and performing a statistical comparison of the estimates of zenith total delay obtained by each package. The software packages compared are GIPSY‐OASIS, Bernese GNSS Processing Software, GAMIT and magicGNSS. Also different strategies and methods, such as double‐differencing and precise point positioning,  are  investigated.  The  output from the  packages  is  validated  using  delay measurements obtained from ECMWF and RCA numerical models. It was observed that the output from climate models agrees with that from the software packages and the output from various software packages have a similarity between each other within 3 millimeters. In the second part of the project, simulations of new GNSS are carried out using in‐house software developed at Chalmers and SP Technical Research Institute of Sweden in order to investigate new methods and possible future improvements. The effect of local errors on atmospheric delay estimates from GPS, GLONASS and Galileo was studied through simulations. A hypothetical system formed by combination of the constellations of GPS, GLONASS and Galileo was also simulated and it was found to be least susceptible to local errors. Simulations were performed by varying some Keplerian orbital elements for Galileo system and it was observed that an orbit inclination between 60 degree and 65 degree would have been optimum for Galileo system. [less ▲]

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See detailEvaluation of heat transfer on a backward acting grate
Peters, Bernhard UL; Džiugys

in MECHANIKA (2014), 20

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Peer Reviewed
See detailAn evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae
Wilkening, Stefan; Lin, Gen; Fritsch, Emilie S. et al

in Genetics (2014), 196(3), 853-65

Dissecting the molecular basis of quantitative traits is a significant challenge and is essential for understanding complex diseases. Even in model organisms, precisely determining causative genes and ... [more ▼]

Dissecting the molecular basis of quantitative traits is a significant challenge and is essential for understanding complex diseases. Even in model organisms, precisely determining causative genes and their interactions has remained elusive, due in part to difficulty in narrowing intervals to single genes and in detecting epistasis or linked quantitative trait loci. These difficulties are exacerbated by limitations in experimental design, such as low numbers of analyzed individuals or of polymorphisms between parental genomes. We address these challenges by applying three independent high-throughput approaches for QTL mapping to map the genetic variants underlying 11 phenotypes in two genetically distant Saccharomyces cerevisiae strains, namely (1) individual analysis of >700 meiotic segregants, (2) bulk segregant analysis, and (3) reciprocal hemizygosity scanning, a new genome-wide method that we developed. We reveal differences in the performance of each approach and, by combining them, identify eight polymorphic genes that affect eight different phenotypes: colony shape, flocculation, growth on two nonfermentable carbon sources, and resistance to two drugs, salt, and high temperature. Our results demonstrate the power of individual segregant analysis to dissect QTL and address the underestimated contribution of interactions between variants. We also reveal confounding factors like mutations and aneuploidy in pooled approaches, providing valuable lessons for future designs of complex trait mapping studies. [less ▲]

Detailed reference viewed: 70 (1 UL)
Peer Reviewed
See detailEvaluation of intensive blood glucose control using glargine in diabetic cats
Roomp, Kirsten UL; Rand, J.S.

in Journal of Veterinary Internal Medicine (2008), 22(3), 790

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Peer Reviewed
See detailEvaluation of intervention strategies for a road link in the Netherlands
Adey, Bryan Tyrone; Lethanh, Nam; Hartmann, Andreas et al

in Built Environment Project and Asset Management (2014), 4(2), 180-198

Purpose – The purpose of this paper is to investigate the use of the impact hierarchy and the optimization model to determine the optimal intervention strategy for a road link composed of multiple objects ... [more ▼]

Purpose – The purpose of this paper is to investigate the use of the impact hierarchy and the optimization model to determine the optimal intervention strategy for a road link composed of multiple objects. The paper focusses on the results of a case study of intervention project on A20 road link in Rotterdam, the Netherlands. Design/methodology/approach – The study was a case study research. It describes briefly the impact hierarchy and its link to the optimization model, and then focussed on analyzing the results obtained from running the model. In order to understand the influence of various factors affecting the results of optimization, sensitivity analysis was performed. Findings – The proposed hierarchy is suitable to be used to support the determination of optimal intervention strategies (OISs) for public road. From the case study, it was also realized that optimal intervention strategy can be changed due to not only intervention costs incurred by the owner, but also due to the setup of traffic configuration during the execution of interventions since the impacts incurred to users, directly affected public, and indirectly affected public are significantly different from one traffic configuration to the others. The optimal intervention strategy also depends greatly on the factors of deterioration during the operation of the infrastructure objects. Research limitations/implications – In the impact hierarchy, some impact factors are difficult to be quantified, e.g., the long-term economic impacts on the region where having intervention projects. The use of only exponential function for impacts could be oversimplified the actual behavior of the impacts. Other functional form should be investigated to be used within the framework of the optimization model. Practical implications – The proposed hierarchy and the optimization model could be used in practical situation for determination of OISs for multiple objects within a road link. Originality/value – This paper contributes to the body of knowledge of stakeholder analysis in the field of infrastructure asset management. It also gives a guideline and tool for infrastructure administrators to select the OISs for their infrastructure network. [less ▲]

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Peer Reviewed
See detailEvaluation of laser braze-welded dissimilar Al-Cu joints
Schmalen, Pascal Guy UL; Plapper, Peter UL

in Physics Procedia (2016), 83

The thermal joining of Aluminum and Copper is a promising technology towards automotive battery manufacturing. The dissimilar metals Al-Cu are difficult to weld due to their different physicochemical ... [more ▼]

The thermal joining of Aluminum and Copper is a promising technology towards automotive battery manufacturing. The dissimilar metals Al-Cu are difficult to weld due to their different physicochemical characteristics and the formation of intermetallic compounds (IMC), which have reduced mechanical and electric properties. There is a critical thickness of the IMCs where the favored mechanical properties of the base material can be preserved. The laser braze welding principle uses a position and power oscillated laser-beam to reduce the energy input and the intermixture of both materials and therefore achieves minimized IMCs thickness. The evaluation of the weld seam is important to improve the joint performance and enhance the welding process. This paper is focused on the characterization and quantification of the IMCs. Mechanical, electrical and metallurgical methods are presented and performed on Al1050 and SF-Cu joints and precise weld criteria are developed. [less ▲]

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See detailAn evaluation of low-cost consumer-grade UAS systems for 3D reality capture
Backes, Dietmar UL; Teasdale, Oliver; Eloff, Jacques

Poster (2016, September 22)

During the last years, small lightweight and low cost remotely piloted aerial systems (RPAS) commonly referred as Drones have rapidly developed into capable low-cost Unmanned Aerial Systems (UAS). Fuelled ... [more ▼]

During the last years, small lightweight and low cost remotely piloted aerial systems (RPAS) commonly referred as Drones have rapidly developed into capable low-cost Unmanned Aerial Systems (UAS). Fuelled by a vibrant community of scientists, professionals and hobby enthusiasts enabling technologies have matured quickly, and prices of consumer grade as well as semi-professional systems fell sharply. Especially multirotor vertical take-off and landing (VTOL) UAS have proven to be versatile and flexible platforms which can be equipped with a range of sensors capable of capturing aerial data for a variety of 2D and 3D mapping applications. Consumer grade, low weight systems as the DJI Phantom or 3DR Solo have a limited payload and can carry low weight action cameras like the GoPro Hero models which are capable of collecting video as well as still RGB and near-infrared imagery. Applying traditional Photogrammetric methods to imagery from low-cost UAS systems proved complex and impractical in the past. However modern the state-of-the-art structure from motion algorithms implemented in off the shelf software packages (sometimes referred as new Photogrammetry), cloud processing environments and available via open source libraries promise to generate dense 3D point clouds, textured models and orthomosaics in high quality and without much effort. How accurate and how reliable are data products generated from such systems? Expanding from a preliminary study (BACKES & TEASDALE 2015) we review the every progressing capabilities and features of COTS (commercial of the shelf) user and semi-professional UAS systems under the aspects of deployable sensors, ease of use, reliability as well as safety. We show the workflow from flight planning, data collection to dense pointclould matching using a range of software products. The resulting point clouds are evaluated and benchmarked using a highly accurate and dense reference data acquired via geodetic terrestrial survey and Laserscanning. The results of this evaluations allow conclusions on the current accuracy capabilities of this such low-cost systems. [less ▲]

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Peer Reviewed
See detailAn Evaluation of New Estimates from GPS, GRACE and Load Models compared to SLR
Lavalee, D.; Moore, P.; Clarke, Peter J. et al

in Geophysical Research Letters (2010), (37), 5-6

Changes in J2, resulting from past and present changes in Earth’s climate, are traditionally observed by Satellite Laser ranging (SLR). Assuming an elastic Earth, it is possible to infer changes in J2 ... [more ▼]

Changes in J2, resulting from past and present changes in Earth’s climate, are traditionally observed by Satellite Laser ranging (SLR). Assuming an elastic Earth, it is possible to infer changes in J2 from changes in Earth’s shape observed by GPS. We compare estimates of non‐secular J2 changes from GPS, SLR, GRACE, and a load model. The GPS and SLR annual signals agree but are different (16%) to the load model. Subtraction of the load model removes the annual variation from GPS, SLR, and GRACE, and the semi‐annual variation in GPS. The GPS and SLR long‐term signals are highly correlated, but GPS is better correlated with the loading model. Subtraction of the load model removes the 1998 anomaly from the GPS J2 series but not completely from the SLR J2 series, suggesting that the SLR anomaly may not be entirely due to mass re‐distribution as has been presumed. [less ▲]

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Peer Reviewed
See detailEvaluation of PGM2007A by comparison with globally and locally estimated gravity solutions from CHAMP
Weigelt, Matthias UL; Sneeuw, N.; Keller, W.

in Newton's Bulletin (2009), 4

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Peer Reviewed
See detailEvaluation of plasma membrane calcium/calmodulin-dependent ATPase isoform 4 as a potential target for fertility control.
Cartwright, Elizabeth J.; Neyses, Ludwig UL

in Handbook of experimental pharmacology (2010), (198), 79-95

The array of contraceptives currently available is clearly inadequate and does not meet consumer demands since it is estimated that up to a quarter of all pregnancies worldwide are unintended. There is ... [more ▼]

The array of contraceptives currently available is clearly inadequate and does not meet consumer demands since it is estimated that up to a quarter of all pregnancies worldwide are unintended. There is, therefore, an overwhelming global need to develop new effective, safe, ideally non-hormonal contraceptives for both male and female use. The contraceptive field, unlike other areas such as cancer, has a dearth of new targets. We have addressed this issue and propose that isoform 4 of the plasma membrane calcium ATPase is a potentially exciting novel target for fertility control. The plasma membrane calcium ATPase is a ubiquitously expressed calcium pump whose primary function in the majority of cells is to extrude calcium to the extracellular milieu. Two isoforms of this gene family, PMCA1 and PMCA4, are expressed in spermatozoa, with PMCA4 being the predominant isoform. Although this gene is ubiquitously expressed, its function is highly tissue-specific. Genetic deletion of PMCA4, in PMCA4 knockout mice, led to 100% infertility specifically in the male mutant mice due to a selective defect in sperm motility. It is important to note that the gene deletion did not affect normal mating characteristics in these mice. This phenotype was mimicked in wild-type sperm treated with the non-specific PMCA inhibitor 5-(and 6-) carboxyeosin diacetate succinimidyl ester; a proof-of-principle that inhibition of PMCA4 has potential importance in the control of fertility. This review outlines the potential for PMCA4 to be a novel target for fertility control by acting to inhibit sperm motility. It will outline the characteristics that make this target drugable and will describe methodologies to identify and validate novel inhibitors of this target. [less ▲]

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Peer Reviewed
See detailEvaluation of potassium chloride emissions applying the Discrete Particle Method (DPM)
Peters, Bernhard UL; Smula, Joanna UL

in Computers & Chemical Engineering (2011)

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Peer Reviewed
See detailEvaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes
Lal, Dennis; Reinthaler, Eva; Dejanovic et al

in PLoS ONE (2016)

Objective The SCN1A gene, coding for the voltage-gated Na+ channel alpha subunit NaV1.1, is the clinically most relevant epilepsy gene. With the advent of high-throughput next-generation sequencing ... [more ▼]

Objective The SCN1A gene, coding for the voltage-gated Na+ channel alpha subunit NaV1.1, is the clinically most relevant epilepsy gene. With the advent of high-throughput next-generation sequencing, clinical laboratories are generating an ever-increasing catalogue of SCN1A variants. Variants are more likely to be classified as pathogenic if they have already been identified previously in a patient with epilepsy. Here, we critically re-evaluate the pathogenicity of this class of variants in a cohort of patients with common epilepsy syndromes and subsequently ask whether a significant fraction of benign variants have been misclassified as pathogenic. Methods We screened a discovery cohort of 448 patients with a broad range of common genetic epilepsies and 734 controls for previously reported SCN1A mutations that were assumed to be disease causing. We re-evaluated the evidence for pathogenicity of the identified variants using in silico predictions, segregation, original reports, available functional data and assessment of allele frequencies in healthy individuals as well as in a follow up cohort of 777 patients. Results and Interpretation We identified 8 known missense mutations, previously reported as pathogenic, in a total of 17 unrelated epilepsy patients (17/448; 3.80%). Our re-evaluation indicates that 7 out of these 8 variants (p.R27T; p.R28C; p.R542Q; p.R604H; p.T1250M; p.E1308D; p.R1928G; NP_001159435.1) are not pathogenic. Only the p.T1174S mutation may be considered as a genetic risk factor for epilepsy of small effect size based on the enrichment in patients (P = 6.60 x 10−4; OR = 0.32, fishers exact test), previous functional studies but incomplete penetrance. Thus, incorporation of previous studies in genetic counseling of SCN1A sequencing results is challenging and may produce incorrect conclusions. [less ▲]

Detailed reference viewed: 202 (8 UL)
Peer Reviewed
See detailEvaluation of RDS/Peripherin and ROM1 as candidate genes in generalised progressive retinal atrophy and exclusion of digenic inheritance
Runte, Maren UL; Dekomien, Gabriele; Epplen, Jörg T

in Animal Genetics (2000), 31(3), 223-227

Detailed reference viewed: 57 (1 UL)