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See detailExpression patterns of cardiac aging in Drosophila.
Cannon, Leah; Zambon, Alexander C.; Cammarato, Anthony et al

in Aging cell (2017), 16(1), 82-92

Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila ... [more ▼]

Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks, benefit from many tools to easily manipulate their genome, and their heart has significant genetic and phenotypic similarities to the human heart. Here, we performed a cardiac-specific gene expression study on aging Drosophila and carried out a comparative meta-analysis with published rodent data. Pathway level transcriptome comparisons suggest that age-related, extra-cellular matrix remodeling and alterations in mitochondrial metabolism, protein handling, and contractile functions are conserved between Drosophila and rodent hearts. However, expression of only a few individual genes similarly changed over time between and even within species. We also examined gene expression in single fly hearts and found significant variability as has been reported in rodents. We propose that individuals may arrive at similar cardiac aging phenotypes via dissimilar transcriptional changes, including those in transcription factors and micro-RNAs. Finally, our data suggest the transcription factor Odd-skipped, which is essential for normal heart development, is also a crucial regulator of cardiac aging. [less ▲]

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See detailExpression patterns of L-plastin isoform in normal and carcinomatous breast tissues.
Lapillonne, A.; Coue, O.; Friederich, Evelyne UL et al

in Anticancer research (2000), 20(5A), 3177-82

Plastins are members of a family of actin-binding proteins which exhibit a tissue-specific expression pattern. L-plastin, which is specifically expressed in hematopoietic cell lineage, has been proposed ... [more ▼]

Plastins are members of a family of actin-binding proteins which exhibit a tissue-specific expression pattern. L-plastin, which is specifically expressed in hematopoietic cell lineage, has been proposed to be involved in the control of cell adhesion and motility. This protein is also frequently expressed in cell lines derived from mammary solid tumors and therefore might be involved in cancer invasion and metastasis. We have analysed plastin expression in normal and carcinomatous breast tissues in vivo by immunohistochemistry and immunoblotting approaches using specific plastin isoform antibodies. L-plastin was not detected in normal epithelial cells of the mammary gland whereas a staining of myoepithelial cells was observed in 50% of the cases. In breast carcinomas, a significant immunostaining of malignant epithelial cells was observed in 4 of the 29 cases analysed (13.8%). No correlation between L-plastin expression and tumor size, histological grade or lymph node status was observed. In contrast, L-plastin was found expressed in 4 of the 11 estrogen and progesterone receptors negative tumors (p = 0.039). The potential role of plastin expression in the tumor process is discussed. [less ▲]

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See detailExpressionistische Alpen-Passion. Pazifistische Idealisierung der Schweiz bei Yvan Goll und anderen
Wiegmann, Eva UL

in Gätje, Hermann; Singh, Sikander (Eds.) Konjunktionen. Yvan Goll im Diskurs der Moderne (2017)

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See detailExpressionistische Lyrik als Kulturpolitik
Dembeck, Till UL

in Lubkoll, Christine; Illi, Manuel; Hampel, Anna (Eds.) Politische Literatur. Begriffe – Debatten – Aktualität (2018)

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See detailExpressions & relations mathématiques élémentaires
Korvers, Stéphane UL

Learning material (2016)

Ce texte introduit les outils de base des mathématiques que sont les expressions algébriques et numériques. Les nombres réels, les opérations sur les nombres, les moyennes, les sommes partielles de ... [more ▼]

Ce texte introduit les outils de base des mathématiques que sont les expressions algébriques et numériques. Les nombres réels, les opérations sur les nombres, les moyennes, les sommes partielles de termes de suites particulières, les polynômes ou la factorisation des expressions algébriques sont à compter parmi les thèmes abordés. La structure des notes vise à accompagner le lecteur au travers de ces éléments théoriques et à lui permettre de développer ses compétences mathématiques par la réalisation des nombreux exercices proposés. [less ▲]

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See detailExpressive incoherence and alexithymia in autism spectrum disorder
Pinto Costa, Andreia UL; Steffgen, Georges UL; Samson, Andrea C.

in Journal of Autism and Developmental Disorders (2017)

Expressive incoherence can be implicated in socio-emotional communicative problems in autism spectrum disorder (ASD). The present study examined expressive incoherence in 37 children with ASD and 41 ... [more ▼]

Expressive incoherence can be implicated in socio-emotional communicative problems in autism spectrum disorder (ASD). The present study examined expressive incoherence in 37 children with ASD and 41 typically developing (TD) children aged 3–13 years old during a frustration task. The role of alexithymia in expressive incoherence was also assessed. Compared to TD children, children with ASD had higher expressive incoherence, such as more neutral and positive emotion expressions during negative behaviors, but not in the expression of negative emotions during positive behaviors. Further analyses revealed that alexithymia moderated the expressions of positive emotions during negative behaviors. These results suggest that children with ASD may benefit from interventions targeting alexithymia to increase emotional coherence, which may improve socio-emotional communication. [less ▲]

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See detailExpressiveness modulo Bisimilarity of Regular Expressions with Parallel Composition
Baeten, J.; Luttik, B.; Muller, Tim UL et al

in Proc. 17th International Workshop on Expressiveness in Concurrency (2010)

The languages accepted by finite automata are precisely the languages denoted by regular expressions. In contrast, finite automata may exhibit behaviours that cannot be described by regular expressions up ... [more ▼]

The languages accepted by finite automata are precisely the languages denoted by regular expressions. In contrast, finite automata may exhibit behaviours that cannot be described by regular expressions up to bisimilarity. In this paper, we consider extensions of the theory of regular expressions with various forms of parallel composition and study the effect on expressiveness. First we prove that adding pure interleaving to the theory of regular expressions strictly increases its expressiveness up to bisimilarity. Then, we prove that replacing the operation for pure interleaving by ACP-style parallel composition gives a further increase in expressiveness. Finally, we prove that the theory of regular expressions with ACP-style parallel composition and encapsulation is expressive enough to express all finite automata up to bisimilarity. Our results extend the expressiveness results obtained by Bergstra, Bethke and Ponse for process algebras with (the binary variant of) Kleene's star operation. [less ▲]

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See detailExtend the Concept of Public Key Encryption with Delegated Search
Tang, Qiang UL; Ma, Hua; Chen, Xiaofeng

in Computer Journal (2015), 58(4), 11

We revisit the concept of public key encryption with delegated keyword search (PKEDS), a concept proposed by Ibraimi et al. A PKEDS scheme allows a receiver to authorize a third-party server to search in ... [more ▼]

We revisit the concept of public key encryption with delegated keyword search (PKEDS), a concept proposed by Ibraimi et al. A PKEDS scheme allows a receiver to authorize a third-party server to search in two ways: either according to a message chosen by the server itself or according to a trapdoor sent by the receiver.We first show some observations on the primitive formulation and the proposed PKEDS scheme by Ibraimi et al. and point out that the single-server setting may limit the application of this primitive. We then extend the concept to the multiple-server setting and present a new security model. We finally propose a new PKEDS scheme, which is proven secure, and compare it with that by Ibraimi et al. [less ▲]

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See detailAn Extended Cooperative Adaptive Cruise Control (CACC) Algorithm for Efficient Energy Consumption & Traffic Density Formulation
Bayar, Bilgehan; Sajadi Alamdari, Seyed Amin UL; Viti, Francesco UL et al

in Traffic Flow Theory and Characteristics Committee (AHB45) 2016 Summer Meeting, Sydney, Australia, 2016 (2016, July 02)

Electric transportation, one of the most promising technologies of the century, can contribute to a greener environment as it is emission-free and sustainable. Although this technology promises a clean ... [more ▼]

Electric transportation, one of the most promising technologies of the century, can contribute to a greener environment as it is emission-free and sustainable. Although this technology promises a clean transportation style, it also has some drawbacks. One of the most significant one is cruising range, which needs to be addressed sustainably. The most eco-friendly solution is decreasing energy consumption by addressing driving behaviour. This can be achieved by taking the advantage of implementing an advancing vehicle automation technology which controls vehicles using a driver-assistance system such as Eco-Cruise Control (Eco-CC). Variety of systems already exist in the literature and a little known advanced version Eco-Adaptive Cruise Control (Eco-ACC) systems are developed as well. The next step of the vehicle automation is vehicle cooperation and information sharing, so-called Cooperative Adaptive Cruise Control (CACC). It is already developed and tested by various researcher. However, the largest deal of existing studies focus on assessing the performance in terms of safety, possible contributions to the energy consumption is not taken into account. This study covers the extension of Cooperative Adaptive Cruise Control systems while aiming to provide an energy efficient extended control algorithm to increase the energy efficiency and battery usage for electric vehicles. An energy efficient control algorithm is aimed to be derived to decrease the consumption of the vehicle. Cruising velocities and vehicle positions are received from the leading vehicles and accordingly traction force is adjusted to achieve efficient energy consumption. By providing vehicle to vehicle (V2V) communication tighter spacing gaps, lower time headway, are aimed to obtain while traffic disturbances are damped, whereas in the cases ACC applications amplify the disturbance. Traffic density formula is introduced by using V2V communication which might be useful for ADAS and ITS framework. As a result, increase in traffic stability, density, and reduction in the total energy consumption is expected. Moreover, possible reductions in air drag with tighter spacing gaps may lead reduction in energy consumption. For the energy calculations and the validation of the proposed method, vehicle dynamics and energy consumption of an electric car is formulated, which has completely different characteristics and limitations than combustion engine cars. Hence the study aims to provide additional understanding of behaviour of a fleet of CACC-equipped electric vehicles. Even though the proposed control algorithm is developed for Electric Vehicles, it can be extended to other vehicle types based on their energy consumption characteristics and vehicle dynamics. [less ▲]

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See detailAn extended coordinate descent method for distributed anticipatory network traffic control
Rinaldi, Marco UL; Tampère, C. M. J.

in Transportation Research. Part B : Methodological (2015), 80

Anticipatory optimal network control can be defined as the practice of determining the set of control actions that minimizes a network-wide objective function, so that the consequences of this action are ... [more ▼]

Anticipatory optimal network control can be defined as the practice of determining the set of control actions that minimizes a network-wide objective function, so that the consequences of this action are taken in consideration not only locally, on the propagation of flows, but globally, taking into account the user's routing behavior. Such an objective function is, in general, defined and optimized in a centralized setting, as knowledge regarding the whole network is needed in order to correctly compute it. This is a strong theoretical framework but, in practice, reaching a level of centralization sufficient to achieve said optimality is very challenging. Furthermore, even if centralization was possible, it would exhibit several shortcomings, with concerns such as computational speed (centralized optimization of a huge control set with a highly nonlinear objective function), reliability and communication overhead arising.The main aim of this work is to develop a decomposed heuristic descent algorithm that, demanding the different control entities to share the same information set, attains network-wide optimality through separate control actions. © 2015 Elsevier Ltd. [less ▲]

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See detailDie Extended Discrete Element Method (XDEM) als integraler Ansatz für reagierende Mehrphasenströmungen
Peters, Bernhard UL; Amir, Mahmoudi

in 26. Deutscher Flammentag Verbrennung und Feuerung (2013, September)

Eine Großzahl technischer Anwendungen wie beispielsweise in der pharmazeutischen Industrie, Nahrungsmittelindustrie, Bergbau, Verfahrenstechnik oder Energiegewinnung durch Verbrennung von Feststoffen ... [more ▼]

Eine Großzahl technischer Anwendungen wie beispielsweise in der pharmazeutischen Industrie, Nahrungsmittelindustrie, Bergbau, Verfahrenstechnik oder Energiegewinnung durch Verbrennung von Feststoffen enthalten neben einer gasförmigen oder fluiden Phase eine diskrete Phase in Form von Partikeln oder Feststoffen. Diese Anwendungen lassen sich sehr vorteilhaft mit dem innovativen Konzept der Extended Discrete Element Method (XDEM) numerisch beschreiben. Hierbei werden die einzelnen Partikel über den dynamischen Zustand (Position und Orientierung) und den thermodynamischen Zustand (Temperatur und Spezies) diskret beschrieben, wo hingegen die Gas- oder Flüssigphase über kontinuumsmechanische Ansätze der Computational Fluid Dynamics (CFD) berechnet wird. Beide Phasen – diskret und kontinuumsmechanisch – sind durch Austausch von Stoff, Wärme und Impuls gekoppelt, was damit eine detaillierte Auflösung der Phasen für CFD-Gesamtrechnungen ermöglicht. Dieser Ansatz wurde angewendet, um den Reaktionsprozess während der Pyrolyse von Holz in einem Festbettreaktor zu berechnen. [less ▲]

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See detailThe extended discrete element method (XDEM) applied to drying of a packed bed
Peters, Bernhard UL; Besseron, Xavier UL; Estupinan Donoso, Alvaro Antonio UL et al

in Industrial Combustion (2014), 14

A vast number of engineering applications involve physics not solely of a single domain but of several physical phenomena, and therefore are referred to as multi-physical. As long as the phenomena ... [more ▼]

A vast number of engineering applications involve physics not solely of a single domain but of several physical phenomena, and therefore are referred to as multi-physical. As long as the phenomena considered are to be treated by either a continuous (i.e. Eulerian) or discrete (i.e. Lagrangian) approach, numerical solution methods may be employed to solve the problem. However, numerous challenges in engineering exist and evolve; those include modelling a continuous and discrete phase simultaneously, which cannot be solved accurately by continuous or discrete approaches only. Problems that involve both a continuous and a discrete phase are important in applications as diverse as the pharmaceutical industry, the food processing industry, mining, construction, agricultural machinery, metals manufacturing, energy production and systems biology. A novel technique referred to as Extended Discrete Element Method (XDEM) has been developed that offers a significant advancement for coupled discrete and continuous numerical simulation concepts. XDEM extends the dynamics of granular materials or particles as described through the classical discrete element method (DEM) to include additional properties such as the thermodynamic state or stress/strain for each particle coupled to a continuous phase such as a fluid flow or a solid structure. Contrary to a continuum mechanics concept, XDEM aims at resolving the particulate phase through the various processes attached to particles. While DEM predicts the spatial-temporal position and orientation for each particle, XDEM additionally estimates properties such as the internal temperature and/or species distribution during drying, pyrolysis or combustion of solid fuel material such as biomass in a packed bed. These predictive capabilities are further extended by an interaction with fluid flow by heat, mass and momentum transfer and the impact of particles on structures. © International Flame Research Foundation, 2014. [less ▲]

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See detailThe Extended Discrete Element Method (XDEM) as a Flexible and Advanced Tool in Multi-physics Applications
Peters, Bernhard UL

in 26th International Symposium on Transport Phenomena (2015)

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See detailThe Extended Discrete Element Method (XDEM) for Multi-Physics Applications
Peters, Bernhard UL

Scientific Conference (2013)

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See detailThe extended discrete element method (XDEM) for multi-physics applications
Peters, Bernhard UL

in Scholarly Journal of Engineering Research (2013)

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See detailThe extended discrete element method (XDEM) for multi-physics applications
Peters, Bernhard UL

in Scholarly Journal of Engineering Research (2013), 2

The Extended Discrete Element Method (XDEM) is a novel numerical simulation technique that extends the dynamics of granular materials or particles as described through the classical Discrete Element ... [more ▼]

The Extended Discrete Element Method (XDEM) is a novel numerical simulation technique that extends the dynamics of granular materials or particles as described through the classical Discrete Element Method (DEM) by additional properties such as the thermodynamic state, stress/strain, or electromagnetic field for each particle coupled to a continuum phase such as fluid flow or solid structures. Contrary to a continuum mechanics concept, XDEM aims at resolving the particulate phase through the various processes attached to particles, while DEM predicts the special-temporal position and orientation for each particle; XDEM additionally estimates properties such as the internal temperature and/or species distribution. These predictive capabilities are further extended by an interaction to fluid flow by heat, mass and momentum transfer and impact of particles on structures. These superior features as compared to traditional and pure continuum mechanic approaches are highlighted by predicted examples of relevant engineering applications. [less ▲]

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See detailDie Extended Discrete Element Method (XDEM) für multiphysikalische Anwendungen
Peters, Bernhard UL; Besseron, Xavier UL; Estupinan Donoso, Alvaro Antonio UL et al

Scientific Conference (2013)

A vast number of engineering applications include a continuous and discrete phase simultaneously, and therefore, cannot be solved accurately by continuous or discrete approaches only. Problems that ... [more ▼]

A vast number of engineering applications include a continuous and discrete phase simultaneously, and therefore, cannot be solved accurately by continuous or discrete approaches only. Problems that involve both a continuous and a discrete phase are important in applications as diverse as pharmaceutical industry e.g. drug production, agriculture food and processing industry, mining, construction and agricultural machinery, metals manufacturing, energy production and systems biology. <br />A novel technique referred to as Extended Discrete Element Method (XDEM) is developed, that offers a significant advancement for coupled discrete and continuous numerical simulation concepts. XDEM treats the solid phase representing the particles and the fluidised phase usually a fluid phase or a structure as two distinguished phases that are coupled through heat, mass and momentum transfer. An outstanding feature of the numerical concept is that each particle is treated as an individual entity that is described by its thermodynamic state e.g. temperature and reaction progress and its position and orientation in time and space. The thermodynamic state includes one-dimensional and transient distributions of temperature and species within the particle and therefore, allows a detailed and accurate characterisation of the reaction progress in a fluidised bed. Thus, the proposed methodology provides a high degree of resolution ranging from scales within a particle to the continuum phase as global dimensions. <br />These superior features as compared to traditional and pure continuum mechanics approaches are applied to predict drying of wood particles in a packed bed and impact of particles on a membrane. Pre- heated air streamed through the packed bed, and thus, heated the particles with simultaneous evaporation of moisture. Water vapour is transferred into the gas phase at the surface of the particles and transported to the exit of the reactor. A rather inhomogeneous drying process in the upper part of the reactor with higher temperatures around the circumference of the inner reactor wall was observed. The latter is due to increased porosity in conjunction with higher mass flow rates than in the centre of the reactor, and thus, augmented heat transfer. A comparison of the weight loss over time agreed well with measurements. <br />Under the impact of falling particles the surface of a membrane deforms that conversely affects the motion of particles on the surface. Due to an increasing vertical deformation particles roll or slide down toward the bottom of the recess, where they are collected in a heap. Furthermore, during initial impacts deformation waves are predicted that propagate through the structure, and may, already indicate resonant effects already before a prototype is built. Hence, the Extended Discrete Element Method offers a high degree of resolution avoiding further empirical correlations and extends the knowledge into the underlying physics. Although most of the work load concerning CFD and FEM is arranged in the ANSYS workbench, a complete integration is intended that allows for a smooth workflow of the entire simulation environment. [less ▲]

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See detailExtended Discrete Element Method (XDEM) to Model Heterogeneous Reactions in Packed Beds
Hoffmann, Florian UL; Peters, Bernhard UL

in PARTEC - International Congress on Particle Technology (2013, April)

Packed beds, due to their high surface-area-to-volume-ratio, are widely used for chemical reactors, such as catalytic or pebble bed reactors, blast furnaces or as heat exchanging units. Depending on the ... [more ▼]

Packed beds, due to their high surface-area-to-volume-ratio, are widely used for chemical reactors, such as catalytic or pebble bed reactors, blast furnaces or as heat exchanging units. Depending on the mode of packing, structured or random, a different degree of heterogeneity is introduced. For stable and efficient process handling local quantities such as temperature or concentration of chemical species are of major interest. Direct measurement of such quantities has proven very difficult or unfeasable due to the morphology of the bed. Hence, numerical modeling can help to gain insights into inaccessible parts of such reactors. The objective of this contribution is to introduce a discrete numerical approach that describes heterogeneous reaction processes within packed and moving beds. The so-called Extended Discrete Element Method (XDEM) is used to account for convective heat and mass transfer within porous media. Both motion and chemical conversion of particulate material can be dealt with. A granular medium consists of an ensemble of particles of which each exhibits individual chemical and mechanical properties. Dynamics of solid particles is accounted for by the known discrete element approach. In addition physicochemical conversion of an individual particle like drying, gasification or redox reactions are accounted for by transient differential equations (species, energy, momentum) on a particle scale. Predictions include properties such as temperature and species distribution inside a particle. The general and modular formulation of the model allows for application to any chemical process involving heterogeneous reactions. Chemical interaction between multiple particles takes place through gaseous intermediates by heat and mass transfer. Computational Fluid Dynamics is applied for the gaseous continuum in the voidage between particles. The presented model can act as tool to gain valuable insights into chemical processes inside packed beds such as blast furnace iron making or gasification of biomass. It can serve as a toolbox for prediction, analysis and optimization of a variety of process parameters such as residence time, conversion progress, burden charging and gas flow patterns. As an example a section of the burden in a blast furnace is focused on. [less ▲]

Detailed reference viewed: 219 (8 UL)