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See detailEpigenetics in Parkinson's Disease
Pavlou, Maria Angeliki UL; Outeiro, Tiago

in Neuroepigenomics in Aging and Disease (2017)

Parkinson's disease (PD) is a highly complex neurodegenerative disorder with a multifactorial origin. Although several cellular mechanisms and genes have been implicated in the onset and progression of ... [more ▼]

Parkinson's disease (PD) is a highly complex neurodegenerative disorder with a multifactorial origin. Although several cellular mechanisms and genes have been implicated in the onset and progression of the disease, the precise molecular underpinnings of the disease remain unclear. In this context, epigenetic modulation of gene expression by environmental factors is emerging as an important mechanism in PD and in other neurodegenerative disorders. Thus, epigenetic mechanisms, such as DNA methylation, histone modifications and altered microRNA expression, have been under intense investigation due to their possible involvement in PD. Epigenetic modulation is responsible for inducing differential gene expression, a phenomenon which is essential throughout life in order to regulate multiple cellular responses such as development, cellular fate commitment and adaptation to the environment. Disturbances of a balanced gene expression can, therefore, have detrimental effects. Environmental factors can challenge the establishment and maintenance of epigenetic modifications and could thereby fill the gap in our further understanding of origin and/or progression of neurodegenerative diseases. In this chapter, we focus on the role of epigenetics in PD. [less ▲]

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See detailEpigenetik und Entwicklung: Drei Kontrollmodelle
Valsiner, Jaan UL

in Richter, Jörg Thomas; Lux, Vanessa (Eds.) Kulturen der Epigenetik: Verebt, codiert, übertragen (2014)

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See detailEpipolar visual servoing for multirobot distributed consensus
Montijano, E.; Thunberg, Johan UL; Hu, X. et al

in IEEE Transaction on Robotics (2013), 29(5), 1212-1225

In this paper, we give a distributed solution to the problem of making a team of nonholonomic robots reach consensus about their orientations using monocular cameras. We consider a scheme where the ... [more ▼]

In this paper, we give a distributed solution to the problem of making a team of nonholonomic robots reach consensus about their orientations using monocular cameras. We consider a scheme where the motions of the robots are decided using nearest-neighbor rules. Each robot is equipped with a camera and can only exchange visual information with a subset of the other robots. The main contribution of this paper is a new controller that uses the epipoles that are computed from the images provided by neighboring robots, eventually reaching consensus in their orientations without the necessity of directly observing each other. In addition, the controller only requires a partial knowledge of the calibration of the cameras in order to achieve the desired configuration. We also demonstrate that the controller is robust to changes in the topology of the network and we use this robustness to propose strategies to reduce the computational load of the robots. Finally, we test our controller in simulations using a virtual environment and with real robots moving in indoor and outdoor scenarios. [less ▲]

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See detailEpistemic Nonconceptualism. Nonconceptual Content and the Justification of Perceptual Beliefs
Orlando, Andy UL

Doctoral thesis (2019)

The questions whether the content of perception is nonconceptual and, if so, whether it can serve as the justificatory basis for perceptual beliefs have been at the epicentre of wide-ranging debates in ... [more ▼]

The questions whether the content of perception is nonconceptual and, if so, whether it can serve as the justificatory basis for perceptual beliefs have been at the epicentre of wide-ranging debates in recent philosophy of mind and epistemology. The present dissertation will set out to answer these matters. It will be argued that the content of perception is not necessarily conceptual, i.e. a specific understanding of nonconceptual content will be laid out and defended. Starting from the presentation and criticism of conceptualism, it will be concluded that the arguments brought forth against nonconceptualism can successfully be met. A specific version of nonconceptualism will be developed on this basis and will serve as the necessary framework for the remainder of the discussion. Flowing from these arguments, this specific version of nonconceptualism will be taken to task by clarifying, analysing and specifying its epistemological commitments and options. Several problem sets will have to be introduced and evaluated, such as the divide between externalists and internalists, the phenomena surrounding epistemic defeaters and examinations pertaining to reasoning, specifically whether experiences could be the output states of inferential processes. These reflections will not only provide a more in-depth investigation of some of the most pressing epistemological questions surrounding nonconceptual content, but will also allow for a seamless transition into the problem of which specific epistemological theory best bears out the epistemological role of nonconceptual content. Specifically, disjunctivism, capacity approaches and phenomenal conservatism will be assessed as to their capacity to vindicate nonconceptual content. Phenomenal conservatism will be identified as the theory that best integrates nonconceptualism. While phenomenal conservatism will thus be defended, the closing sections of the present dissertation will mainly focus on questions surrounding rationality. Indeed, if perception and/ or perceptual experiences could be classified as rational, or more accurately put, if arguments pertaining to the evaluability of a perceptual experience’s aetiology are tenable, it can reasonably be asked whether phenomenal conservatism can satisfactorily meet this challenge. Ultimately, it will be concluded that there is room for a specific notion of nonconceptual content as the justificatory basis for basic perceptual beliefs. [less ▲]

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See detailThe epistemic role of experience
Hofmann, Frank UL

Presentation (2012, June 12)

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See detailEpistemic virtues and values
Hofmann, Frank UL

in Henning, Tim; Schweikard, David (Eds.) Knowledge, Virtue, and Action (2013)

Plato’s Meno problem is the problem of why knowledge is better than true belief which is not knowledge. The paper studies the account of this surplus value of knowledge that recent reliabilist virtue ... [more ▼]

Plato’s Meno problem is the problem of why knowledge is better than true belief which is not knowledge. The paper studies the account of this surplus value of knowledge that recent reliabilist virtue epistemologists like John Greco and Ernest Sosa have proposed: knowledge is true belief from epistemic virtue. I reconstruct the master argument which subsumes the epistemic case under the general case of success from virtue. Five accounts of (epistemic) virtue are presented and discussed critically. The result is that only the fifth account – the refined dispositionalist account of virtue, based on an idea of J.J. Thomson – is viable, for the purposes of accounting for the surplus value of knowledge along the lines of the master argument. However, there is at least one remaining question, namely, of why success from virtue has surplus value in general. [less ▲]

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See detailDie epistemischen Motoren des Kinos.
Pause, Johannes UL

in Gradinari, Irina; Muller, Dorit; Pause, Johannes (Eds.) Wissensraum Film. (2014)

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See detailEpistemología social y ‘la razón’ para la escolarización
Popkewitz, Thomas S. UL

in Espinosa, Julieta; Robert, André (Eds.) Epistemología social y pensamiento crítico. Pensar la educación de otra manera (2014)

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See detailEpistemological, critical and reflexive gymnastics: constructing research in "former Yugoslavia" in the face of the coloniality of knowledge
Blondel, Cyril UL

in Aiken, Gerald Taylor; Button, Cat (Eds.) Over-researched places (in press)

This article is a story narrating the evolution of my own reflections during my Ph.D.: “Planning at the Borders of European Peripheries: The Serbia/Croatia Borderland and the EU Cooperation and ... [more ▼]

This article is a story narrating the evolution of my own reflections during my Ph.D.: “Planning at the Borders of European Peripheries: The Serbia/Croatia Borderland and the EU Cooperation and Reconciliation Injunctions” (Ph.D. thesis, Tours, Université François-Rabelais, 2016). Using auto-ethnographic methods, this article demonstrates a conviction, the necessity to engage with a reflexive and critical approach, before, during, and after the production of research. I show first how I built the thesis’ epistemological approach, by progressively deconstructing classical theoretical frameworks (nationalist, postsocialist, post-Yugoslav). I expose and discuss then the outcomes of such a reflexivity, in particular how I gradually became conscious of the coloniality of (my) knowledge. These mental gymnastics allowed me to occasionally overcome – but regularly report on – the limits of my research, but also to recognize the unsurpassibility of certain aspects of my work connected to the situation in which I stated and conducted it. Reflecting on epistemological reflexivity contributes to clarifying scientific (in)validity of research, and better situates researcher’s arguments, their position and positionality. [less ▲]

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See detailEpistemologie der Gewalt. Der italienische Polizeifilm.
Pause, Johannes UL

in Montage AV (2014), 23(1), 63-79

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See detailEpistemology in German Idealism
Heidemann, Dietmar UL

in Moyar, D. (Ed.) The Routledge Companion to Nineteenth Century Philosophy (2010)

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See detailEpitaxial Cu2ZnSnSe4 thin films and devices
Redinger, Alex UL; Groiss, Heiko; Sendler, Jan UL et al

in Thin Solid Films (2014)

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See detailEpitaxial Cu2ZnSnSe4 thin films and devices
Redinger, Alex UL; Groiss, Heiko; Sendler, Jan UL et al

in THIN SOLID FILMS (2015), 582

Epitaxial Cu2ZnSnSe4 (CZTSe) thin films have been grown via high temperature coevaporation on GaAs(001). Electron backscattering diffraction confirms epitaxy in a wide compositional range. Different ... [more ▼]

Epitaxial Cu2ZnSnSe4 (CZTSe) thin films have been grown via high temperature coevaporation on GaAs(001). Electron backscattering diffraction confirms epitaxy in a wide compositional range. Different secondary phases are present in the epitaxial layer. The main secondary phases are Cu2SnSe3 and ZnSe which grow epitaxially on top of the CZTSe. Transmission electron microscopy measurements show that the epitaxial CZTSe grows predominantly parallel to the c-direction. Epitaxial CZTSe solar cells with a maximum power conversion efficiency of 2.1\%, an open-circuit voltage of 223 mV and a current density of 16 mA/cm(2) are presented. (C) 2014 Elsevier B.V. All rights reserved. [less ▲]

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See detailEpitaxial growth of very large grain bicrystalline Cu(In, Ga)Se2 thin films by a hybrid sputtering method
Hall, Allen J.; Hebert, Daman; Lei, C. et al

in Applied Physics Letters (2008), 103(8), 083540-1

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See detailEpitexte: a) Kommentar/Interpretation
Dembeck, Till UL; Neumann, Florian

in Binczek, Natalie; Dembeck, Till; Schäfer, Jörgen (Eds.) Handbuch Medien der Literatur (2013)

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See detailEpitexte: Begriffsexplikation
Dembeck, Till UL

in Binczek, Natalie; Dembeck, Till; Schäfer, Jörgen (Eds.) Handbuch Medien der Literatur (2013)

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See detailEpithelial factors: modulation of the airway smooth muscle tone
Bertrand, C.; Tschirhart, Eric UL

in Fundamental & Clinical Pharmacology (1993), 7(6), 261-73

The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These ... [more ▼]

The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also metabolize some of the inflammatory mediators. Epithelial damage is a consistent feature of some respiratory conditions, but whether or not such damage contributes to airway disease is for the moment unknown. This review summarizes the literature on the known and proposed roles of the epithelium in the modulation of the airway smooth muscle tone. [less ▲]

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See detailEpithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis
Bertrand, C.; Tschirhart, Eric UL; Landry, Y.

in Immunopharmacology (1992), 22(2), 115-25

The role of prostanoids and platelet-activating factor (PAF) was studied in the in vitro response of guinea pig trachea to immunochallenge according to the presence or the absence of the epithelial layer ... [more ▼]

The role of prostanoids and platelet-activating factor (PAF) was studied in the in vitro response of guinea pig trachea to immunochallenge according to the presence or the absence of the epithelial layer and to the sensitization procedure leading to the preferential synthesis of immunoglobulin E (IgE) or immunoglobulin G (IgG) antibodies. Indomethacin, a cyclooxygenase inhibitor, potentiated the antigen-induced contractions both in IgE and IgG models, suggesting the involvement of relaxant prostaglandins (PGs), independently of the presence of the airway epithelium. UK-38485, a thromboxane synthetase inhibitor, did not modify the tracheal response to antigen in the IgE model. However, this compound enhanced the maximum contractile response to antigen of the intact tracheal strips of IgG-sensitized guinea pig, but reduced the contractile response of the epithelium-free tracheal strips. Two potent non-structurally related PAF antagonists, Ro 19-3704 and BN 52021, reduced antigen-induced contraction of the epithelium-free tracheal strips in the IgE model. In contrast, these compounds did not affect the contractile responses of the preparations in the IgG model. These results suggest the selective implication of thromboxane A2 and PAF, in IgG- and IgE-mediated guinea pig anaphylaxis respectively. Finally, these results indicate that thromboxane A2 (TXA2) and PAF are potent inducers of epithelium-derived mediators. [less ▲]

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