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See detailDeterminants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.
Lehmann, Ute; Sommer, Ulrike; Smyczek, Tanya et al

in Cellular Signalling (2006), 18(1), 40-9

In recent years, the elucidation of the structures of many signalling molecules has allowed new insights into the molecular mechanisms that govern signal transduction events. In the field of cytokine ... [more ▼]

In recent years, the elucidation of the structures of many signalling molecules has allowed new insights into the molecular mechanisms that govern signal transduction events. In the field of cytokine signalling, the solved structures of cytokine/receptor complexes and of key components involved in signal transduction such as STAT factors or the tyrosine phosphatase SHP2 have broadened our understanding of the molecular basis of the signalling events and provided key information for the rational design of therapeutic approaches to modulate or block cytokine signal transduction. Unfortunately, no structural data on the intracellular parts of cytokine receptors are available. The exact molecular mechanism underlying one of the first steps in signal transduction, namely the recruitment of signalling components to the cytoplasmic parts of cytokine receptors, remains elusive. Here we investigated possible mechanisms underlying the different potency of the STAT3-activating motifs of gp130 after IL-6 stimulation. Our data indicate that the extent of STAT3 activation by the different receptor motifs is not influenced by structural features such as contacts between the two gp130 chains. In addition, the proximity of the negatively regulating motif around tyrosine Y759 to the different STAT3-recruiting motifs does not seem to be responsible for their differential capacity to activate STAT3. However, the potency of a specific motif to activate STAT3 directly reflects the affinity for the binding of STAT3 to this motif. [less ▲]

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See detailDéterminants individuels et territoriaux des navettes internes ou transfrontalières des actifs résidant en France
Pigeron-Piroth, Isabelle UL; Le Texier, Marion; Belkacem, Rachid et al

in Espace, Populations, Sociétés (2018), 2017(3), 1-30

This article focuses on the individual and territorial determinants of cross-border commuting from France to its neighbouring countries. We seek to identify whether cross-border commuting is a distinct ... [more ▼]

This article focuses on the individual and territorial determinants of cross-border commuting from France to its neighbouring countries. We seek to identify whether cross-border commuting is a distinct form of commuting, especially whether it differs for an active resident from commuting outside his/her reference functional urban area. We use individual data from the 2013 census and characterize the territory at the municipal scale in order to capture the relative polarisation of residential places within the national urban system. From our multinomial logistic models applied to the whole France or the border fringe, we find that gender, age, education, type and sector of activity, as well as the location of the commune with respect to employment poles in France, explain similarly the commute of active individuals towards another urban area in France and across the border. However, the effect is more intensive for cross-border commuting. After controlling the impact of the different neighbouring countries, we still clearly identify a different behaviour from elastic migrants in border areas and an effect of the distance to the border and of the job density on the cross-border commutes. [less ▲]

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See detailDeterminants of Academic Self-Concept
Niepel, Christoph UL

Presentation (2016, September 13)

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See detailDeterminants of bank efficiency: Evidence from a semi-parametric mathodology
Papanikolaou, Nikolaos UL; Delis, Manthos

in Managerial Finance (2009), 35(3), 260-275

Purpose – This paper aims to analyze bank efficiency into a number of bank-specific, industryspecific and macroeconomic determinants. Design/methodology/approach – The authors follow a semi-parametric two ... [more ▼]

Purpose – This paper aims to analyze bank efficiency into a number of bank-specific, industryspecific and macroeconomic determinants. Design/methodology/approach – The authors follow a semi-parametric two-stage methodology, where productive efficiency is derived via a non-parametric technique in the first stage and then the scores obtained are linked to a series of determinants of bank efficiency, using a double bootstrapping procedure. Findings – Overall, it is found that the banking sectors of almost all the sample countries show a gradual improvement in their efficiency levels. The model used shows that a number of determinants like bank size, industry concentration and the investment environment have a positive impact on bank efficiency, which is not the case when standard Tobit models are employed. Research limitations/implications – The findings have important implications for the relevance of well-known hypotheses that refer to the performance of the banking sectors, like the structure conduct-performance and the efficient structure hypotheses. These implications are not necessarily verified when past conventional econometric methodologies are used. Practical implications – The paper offers new insights to policy makers, bank managers and practitioners on the relevance of a number of driving factors of bank efficiency that might help them to improve the performance of the banking system and enhance the quality of services provided. Originality/value – This is the first paper in the bank efficiency literature that employs a semiparametric two-stage model, which relaxes several deficiencies of previous two-stage empirical approaches thus, offering a solution to the many problematic features of standard censored regressions. [less ▲]

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See detailThe determinants of bootstrap financing in crises: evidence from entrepreneurial ventures in the COVID-19 pandemic
Block, Jörn; Fisch, Christian UL; Hirschmann, Mirko UL

in Small Business Economics (2022), 58(2), 867-885

Bootstrap financing refers to measures that entrepreneurial ventures undertake to preserve liquidity (e.g., reducing expenses, collecting receivables, delaying payments, preselling). Prior research shows ... [more ▼]

Bootstrap financing refers to measures that entrepreneurial ventures undertake to preserve liquidity (e.g., reducing expenses, collecting receivables, delaying payments, preselling). Prior research shows that bootstrap financing is an important enabler for the growth of resource-constrained early-stage ventures. However, little is known about the use of bootstrap financing in crises, during which the preservation of liquidity is particularly salient. We investigate the determinants of bootstrap financing in the 2020 COVID-19 crisis using a sample of 17,046 German entrepreneurial ventures. We formulate hypotheses about the determinants of bootstrap financing from a necessity, human capital, and opportunity cost perspective. Among others, our results show that the severity of the crisis for the venture, the level of private consumption, and self-employment experience are positively associated with an increased use of bootstrap financing measures. Our study contributes to the literature on bootstrap financing and illuminates how entrepreneurial ventures maintain liquidity in crises. [less ▲]

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See detailDeterminants of caregiving-related esteem among informal caregivers in Luxembourg, two years after their care-recipients’ stroke.
Bucki, Barbara UL; Spitz, Elisabeth; Baumann, Michèle UL

in Psychology and Health (2011), 26(suppl 2), 86

Mental health promotion policies are concerned by informal caregivers’ (ICs) suffering. What are the determinants of ICs’ caregiving-related esteem? Methods: (a) Crosssectional study. (b)62 Luxemburgish ... [more ▼]

Mental health promotion policies are concerned by informal caregivers’ (ICs) suffering. What are the determinants of ICs’ caregiving-related esteem? Methods: (a) Crosssectional study. (b)62 Luxemburgish ICs of stroke-survivors 2-year-post-event. (c)Variables: oCaregiver Reaction Assessment’s (CRA) five dimensions: caregiving-related esteem (dependent variable), impact of caregiving on health, impact on finances, impact on schedule, lack of family support, oCaregiver Satisfaction with Community Services scale, oLeisure/ couple changes/social repercussions scores. (d) Regressions adjusted on ICs’ sex and age. (e)Multiple regression including significant factors. Findings: (a) Caregiving-related esteem is determined by social repercussions (p¼0.002**), changes in couples (p¼0.004**), impact on health (p¼0.004**) and three CSCS’ dimensions: confidence (p¼0.012*), problem management (p¼0.034*) and information about stroke (p¼0.040*). (b) ICs with high caregiving related esteem (R2 adjusted¼0.275) are weakly impacted on their own health ( ¼ 0.39; p¼0.011*) and on their couple life ( ¼ 0.36; p¼0.026*). Discussion: Support programs centred on ICs’ caregiving-related esteem can reinforce ICs’ health capability. [less ▲]

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See detailThe determinants of CoCo bond prices
Wolff, Christian UL

E-print/Working paper (2015)

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See detailThe Determinants of CoCo Bond Prices
Wolff, Christian UL; Abed Masror Khah, Sara UL; Vermaelen, Theo

in Journal of Derivatives (2019)

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See detailDeterminants of cognitive decline in a large cross-national study using machine learning
Leist, Anja UL

in Innovation in Aging (2018, November), 2(S1), 244

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See detailDeterminants of Excess Worker Turnover in Luxembourg
Bertinelli, Luisito UL; Cardi, Olivier; Pamukçu, Teorman et al

in International Journal of Manpower (2009), 30(3), 253-268

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See detailDeterminants of Individual Occupational Careers in the 21st Century – Why Complex Problem Solving Matters Beyond General Mental Ability
Mainert, Jakob UL; Kretzschmar, André UL; Müller, Jonas UL et al

Scientific Conference (2014, August 27)

The OECD (2010) views problem solving as essential for lifelong learning. Recently, the 2012 PISA cycle administered domain-general problems, which featured the complexity of the structure, dynamics and ... [more ▼]

The OECD (2010) views problem solving as essential for lifelong learning. Recently, the 2012 PISA cycle administered domain-general problems, which featured the complexity of the structure, dynamics and interconnections of variables, and intransparency of the situation. This emphasis on domain-general problems expresses a paradigmatic shift to lifelong learning. In an attempt towards an integrative process theory of CPS, Fischer, Greiff and Funke (2012) portray knowledge acquisition and knowledge application as the core processes of CPS, which are distinguishable from classical cognitive ability (Dörner, 1986). These core processes are assessed in research via innovative computer-based microworlds. These microworlds simulate complex problems, which share features with real world problems, require knowledge acquisition and knowledge application for a successful task completion and offer a wide range of tasks and approaches (Greiff, Holt, et al., 2013; Greiff, Fischer, et al., 2013). Initiatives looking for the facilitation of so-called 21st century skills (e.g., Griffin, McGaw, & Care, 2012; National Research Council, 2012a; OECD, 2013a, 2013b) strongly relate CPS to demands for professional development as resulting from shifts towards non-routine problem solving and communication tasks in the working lives of adults (e.g., successfully adapting towards IT-depending occupations; Autor, Levy, & Murnane, 2003). So far, the application of CPS in research and practice has mainly been restricted to primary and secondary education. Lifespan or educational research on the role of transversal cognitive skills such as CPS for learning later in life is scarce at best and adult education practice fails to fully tap into the requirements of a working reality (Smith & Reio, 2006), which is defined by uncertainties, contradictions, and dynamic changes. CPS is considered to be important for lifelong learning and occupational success, but underrepresented in research and practice. As a consequence, adult education’s mission to provide opportunities for career preparation (e.g., Gianakos, 1996) and intellectual growth (Perry, 1999) seem to be at risk. Hence, the research goals in this study are to (1) enlarge the understanding for determinants of occupational career indicators (e.g. lifelong learning efforts) and eventually (2) encourage the inclusion of CPS on the adult educational research and practice agenda. Our research goals are built on a rich research fundus of the impact of GMA on professional development (e.g., Schmidt & Hunter, 1998) and promising results on the predictive validity of CPS for academic achievement (e.g., Schweizer, Wüstenberg, & Greiff, 2013; Sonnleitner, Keller, Martin, & Brunner, 2013; Wüstenberg, Greiff, & Funke, 2012) and occupational performance (Abele et al., 2012; Danner et al., 2011). Hence, the targeted constructs are GMA, and CPS as a transversal cognitive skill in occupational careers and professional development. [less ▲]

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See detailDeterminants of individual occupational careers in the 21st century. Does complex problem solving matter beyond general mental ability?
Mainert, Jakob UL; Kretzschmar, André UL; Neubert, Jonas UL et al

Scientific Conference (2015, May 21)

Purpose Complex problem solving (CPS) describes the interaction with dynamic and nonroutine tasks, and has been included in PISA 2012 as a factor for employability. This study examines whether CPS can ... [more ▼]

Purpose Complex problem solving (CPS) describes the interaction with dynamic and nonroutine tasks, and has been included in PISA 2012 as a factor for employability. This study examines whether CPS can also contribute to the prediction of career advancement in jobs beyond general mental ability (GMA) as one of the best predictors. Design/Methodology Using latent structural equation modeling (SEM), we analyzed a sample of technicians, service/trade workers, and assemblers (n=245) at a German automotive company. A computer-based assessment measured participants' CPS and GMA levels. The dependent variables were the participants’ job level (ISCO-08) and professional training days. Results CPS and GMA both correlated significantly with career advancement (from .18 to .26, all p < .01). The models showed good fit and indicated that CPS explained incremental variance in one of two indicators (β = .14 for trainings, p < .05; ΔR2 = .02) in comparison with GMA alone (β = .24, p < 0.01; R2= .06). Limitations Analyses did not include processes information from CPS assessment as potential advantage. The company-based sample and cross-sectional data restrict inferences. Research Implications Our findings suggest positive relations between CPS and career advancement even when controlling for GMA. Hence, CPS could be a valuable addition for the study of careers and personnel selection test batteries. Originality/Value The first evaluation of CPS in career research gave a general indication of an as-yet-to-be-defined role of CPS, especially when considering the task characteristics compared to complex and demanding jobs, and process data available through CPS. [less ▲]

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See detailThe determinants of International Mobility of Students
Ragot, Lionel; Noel, Romain; Beine, Michel UL

in Economics of Education Review (2014), 41(C), 40-54

This paper analyzes the determinants of the choice of location of international students. Building on the documented trends in international migration of students, we identify the various factors ... [more ▼]

This paper analyzes the determinants of the choice of location of international students. Building on the documented trends in international migration of students, we identify the various factors associated to the attraction of migrants as well as the costs of moving abroad. Using new data capturing the number of students from a large set of origin countries studying in a set of 13 OECD countries, we assess the importance of the various factors identified in the theory. We find support for a significant network effect in the migration of students, a result so far undocumented in the literature. We also find a significant role for cost factors such as housing prices and for attractiveness variables such as the reported quality of universities. In contrast, we do not find an important role for registration fees. [less ▲]

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See detailThe Determinants of National Pride of Ethnic and Immigrant Minorities in Europe
Cebotari, Victor UL

in Nationalism and Ethnic Politics (2015), 21(3), 269-288

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See detailDeterminants of Self-Stigma in People with Parkinson's Disease: A Mixed Methods Scoping Review
Hanff, Anne-Marie UL; Leist, Anja UL; Fritz, Joëlle UL et al

in Journal of Parkinson's Disease (2021)

Background: Self-stigma in people with Parkinson's disease (PD) can substantially impact quality of life and possibilities for social participation. An integrative analysis of determinants of self-stigma ... [more ▼]

Background: Self-stigma in people with Parkinson's disease (PD) can substantially impact quality of life and possibilities for social participation. An integrative analysis of determinants of self-stigma has been lacking. Objective: We sought to explore which complementary insights from qualitative and quantitative studies, as well as from expert consultation, could be gained. Methods: An established mixed methods study design was employed to first conduct a mixed methods scoping review of published qualitative and quantitative literature, and then consult with experts to arrive at an exhaustive list of determinants of self-stigma after a thematic synthesis. Results: A total of 87 unique determinants of self-stigma were identified. Quantitative studies and expert consultations mainly identified personal determinants of people with self-stigma (e.g., age, anxiety, or apathy). In contrast, qualitative studies identified social situations associated with self-stigma (e.g., joint meals of people with typical PD with others). Notably, self-stigma of people with PD was found to be particularly salient in unfamiliar places, at the working place or in contact with people without PD. Across methods, cognitive impairment, tremor, and abnormal walk and unsteady gait, respectively, were associated with self-stigma. Conclusion: The mixed method study design yielded complementary insights, but also factors commonly associated with self-stigma across methods. Future prioritization exercises may gain further insights into self-stigma of people with PD. Facilitating social encounters by both addressing needs of affected people and raising knowledge and public awareness may improve quality of life in people with PD [less ▲]

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See detailDeterminants over graded-commutative algebras, a categorical viewpoint
Covolo, Tiffany UL; Michel, Jean-Philippe

E-print/Working paper (2016)

We generalize linear superalgebra to higher gradings and commutation factors, given by arbitrary abelian groups and bicharacters. Our central tool is an extension, to monoidal categories of modules, of ... [more ▼]

We generalize linear superalgebra to higher gradings and commutation factors, given by arbitrary abelian groups and bicharacters. Our central tool is an extension, to monoidal categories of modules, of the Nekludova-Scheunert faithful functor between the categories of graded-commutative and supercommutative algebras. As a result we generalize (super-)trace, determinant and Berezinian to graded matrices over graded-commutative algebras. For instance, on homogeneous quaternionic matrices, we obtain a lift of the Dieudonné determinant to the skew-field of quaternions. [less ▲]

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See detailDétermination de l'accélération de la pesanteur pour la balance du watt du LNE
Merlet, Sébastien; Gillot, Pierre; Farah, Tristan et al

in Revue Française de Métrologie (2014), 36(2014-4), 11-27

The “watt balance” project aims at linking the kilogram definition to the Planck constant. The weighing of the mass involved requires a determination of the acceleration g with an uncertainty better than ... [more ▼]

The “watt balance” project aims at linking the kilogram definition to the Planck constant. The weighing of the mass involved requires a determination of the acceleration g with an uncertainty better than 10-8. This work aims at determining g with an atomic gravimeter and a dedicated gravimetric site. [less ▲]

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See detailLa détermination de l'âge des jeunes demandeurs de protection internationale
Silga, Janine UL; Anibaldi, Johnny

in Chaouche, Fatima; Gerkrath, Jörg; Silga, Janine (Eds.) et al Droit d'Asile au Grand-Duché de Luxembourg - Guide pratique (2019)

Detailed reference viewed: 82 (7 UL)