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In a model of neuropathic pain (chronic constriction injury, CCI) we ... [more ▼]BACKGROUND: Altered hypothalamo-pituitary-adrenal (HPA) axis activity may be accompanied by a modulation of pain sensitivity. In a model of neuropathic pain (chronic constriction injury, CCI) we investigated the onset and maintenance of mechanical allodynia/hyperalgesia and the expression of biochemical mediators potentially involved in spinal cell modulation in two rat strains displaying either hypo- (Lewis-LEW) or hyper- (Fischer 344-FIS) reactivity of the HPA axis. RESULTS: Mechanical pain thresholds and plasmatic corticosterone levels were assessed before and during periods of 4 or 21 days following CCI surgery. At the end of the respective protocols, the mRNA expression of glial cell markers (GFAP and Iba1) and glutamate transporters (EAAT3 and EAAT2) were examined. We observed a correlation between the HPA axis reactivity and the pain behavior but not as commonly described in the literature; LEW rats seemed to be less sensitive than FIS from 4 to 14 days after the CCI surgery when looking at the mechanical allodynia/hyperalgesia. However, the biochemical spinal markers expression we observed is conflicting. CONCLUSION: We did not find a specific causal relation between the pain behavior and the glial cell activation or the expression of the glutamate transporters, suggesting that the interaction between the HPA axis and the spinal activation pattern is more complex in a context of neuropathic pain. [less ▲]Detailed reference viewed: 147 (5 UL) Differential operator algebras on compact Riemann surfacesSchlichenmaier, Martin in Generalized Symmetries in Physics, Clausthal 1993 (1994)Detailed reference viewed: 35 (0 UL) Differential physiological effects during tonic painful hand immersion tests using hot and ice waterStreff, Anouk; Kuehl, Linn; Michaux, Gilles et alin European Journal of Pain (2010), 14(3), 266-272Detailed reference viewed: 582 (1 UL) Differential relations between facets of complex problem solving and students’ immigration backgroundSonnleitner, Philipp ; Brunner, Martin; Keller, Ulrich et alin Journal of Educational Psychology (2014), Advance online publicationWhereas the assessment of complex problem solving (CPS) has received increasing attention in the context of international large-scale assessments, its fairness in regard to students’ cultural background ... [more ▼]Whereas the assessment of complex problem solving (CPS) has received increasing attention in the context of international large-scale assessments, its fairness in regard to students’ cultural background has gone largely unexplored. On the basis of a student sample of ninth-graders (N = 299), including a representative number of immigrant students (N = 127), the present study evaluated (1) whether CPS can be assessed fairly among students with or without immigration background and (2) whether achievement differences between these groups exist. Results showed that fair assessment of CPS is possible using the Genetics Lab, a computer-based microworld that incorporates game-like characteristics and multilingual-friendly features. Immigrant students were generally outperformed by their non-immigrant peers, but performance differences can largely be explained by differential enrollment in lower academic tracks. Interestingly, CPS scales were less affected by students’ educational background than a traditional paper-pencil-based reasoning scale. Moreover, a fine-grained analysis of different facets of CPS showed that irrespective of the academic track, immigrant students demonstrated a more efficient task exploration behavior than their native peers (d = .26). In sum, this might point to the potential of computer-based assessment of CPS to identify otherwise hidden cognitive potential in immigrant students. [less ▲]Detailed reference viewed: 221 (35 UL) Differentially Private Neighborhood-based Recommender SystemsWang, Jun ; Tang, Qiangin IFIP Information Security & Privacy Conference (2017, May)Privacy issues of recommender systems have become a hot topic for the society as such systems are appearing in every corner of our life. In contrast to the fact that many secure multi-party computation ... [more ▼]Privacy issues of recommender systems have become a hot topic for the society as such systems are appearing in every corner of our life. In contrast to the fact that many secure multi-party computation protocols have been proposed to prevent information leakage in the process of recommendation computation, very little has been done to restrict the information leakage from the recommendation results. In this paper, we apply the differential privacy concept to neighborhood-based recommendation methods (NBMs) under a probabilistic framework. We first present a solution, by directly calibrating Laplace noise into the training process, to differential-privately find the maximum a posteriori parameters similarity. Then we connect differential privacy to NBMs by exploiting a recent observation that sampling from the scaled posterior distribution of a Bayesian model results in provably differentially private systems. Our experiments show that both solutions allow promising accuracy with a modest privacy budget, and the second solution yields better accuracy if the sampling asymptotically converges. We also compare our solutions to the recent differentially private matrix factorization (MF) recommender systems, and show that our solutions achieve better accuracy when the privacy budget is reasonably small. This is an interesting result because MF systems often offer better accuracy when differential privacy is not applied. [less ▲]Detailed reference viewed: 225 (17 UL) Differentials on graph complexesKhoroskhin, Anton; Willwacher, Thomas; Zivkovic, Marko in Advances in Mathematics (2017), 307We study the cohomology of complexes of ordinary (non-decorated) graphs, introduced by M. Kontsevich. We construct spectral sequences converging to zero whose first page contains the graph cohomology. In ... [more ▼]We study the cohomology of complexes of ordinary (non-decorated) graphs, introduced by M. Kontsevich. We construct spectral sequences converging to zero whose first page contains the graph cohomology. In particular, these spectral sequences may be used to show the existence of an infinite series of previously unknown and provably non-trivial cohomology classes, and put constraints on the structure of the graph cohomology as a whole. [less ▲]Detailed reference viewed: 170 (12 UL) Differentials on graph complexes II: hairy graphsKhoroshkin, Anton; Willwacher, Thomas; Zivkovic, Marko in Letters in Mathematical Physics (2017), 107(10), 17811797We study the cohomology of the hairy graph complexes which compute the rational homotopy of embedding spaces, generalizing the Vassiliev invariants of knot theory. We provide spectral sequences converging ... [more ▼]We study the cohomology of the hairy graph complexes which compute the rational homotopy of embedding spaces, generalizing the Vassiliev invariants of knot theory. We provide spectral sequences converging to zero whose first pages contain the hairy graph cohomology. Our results yield a way to construct many nonzero hairy graph cohomology classes out of (known) non-hairy classes by studying the cancellations in those sequences. This provide a first glimpse at the tentative global structure of the hairy graph cohomology. [less ▲]Detailed reference viewed: 134 (5 UL) Differentials on graph complexes III: hairy graphs and deleting a vertexZivkovic, Marko in Letters in Mathematical Physics (2018)We continue studying the cohomology of the hairy graph complexes which compute the rational homotopy of embedding spaces, generalizing the Vassiliev invariants of knot theory, after the second part in ... [more ▼]We continue studying the cohomology of the hairy graph complexes which compute the rational homotopy of embedding spaces, generalizing the Vassiliev invariants of knot theory, after the second part in this series. In that part we have proven that the hairy graph complex HGC_{m,n} with the extra differential is almost acyclic for even m. In this paper, we give the expected same result for odd m. As in the previous part, our results yield a way to construct many hairy graph cohomology classes by the waterfall mechanism also for odd m. However, the techniques are quite different. The main tool used in this paper is a new differential, deleting a vertex in non-hairy Kontsevich’s graphs, and a similar map for hairy vertices. We hope that the new differential can have further applications in the study of Kontsevich’s graph cohomology. Namely it is conjectured that the Kontsevich’s graph complex with deleting a vertex as an extra differential is acyclic. [less ▲]Detailed reference viewed: 157 (12 UL) Differentiated integration in the Eurozone: new challenges for the EU legal orderLacchi, Clelia Presentation (2014, October)Detailed reference viewed: 70 (9 UL) Differentiated SH-SY5Y Cells as PD Model for Mitochondrial Dysfunction: From Whole Genome Sequencing to an Educated Design of High-Throughput ExperimentsAntony, Paul ; Krishna, Abhimanyu ; May, Patrick et alPoster (2013)Objectives: Mitochondrial dysfunction is a cellular hallmark of Parkinson's disease (PD) and energetic stress of dopaminergic neurons appears to be a physiological risk factor for mitochondrial ... [more ▼]Objectives: Mitochondrial dysfunction is a cellular hallmark of Parkinson's disease (PD) and energetic stress of dopaminergic neurons appears to be a physiological risk factor for mitochondrial dysfunction. It is however challenging to assess the high variety of factors regulating mitochondrial physiology in living neurons in a high throughput manner. To overcome this bottleneck, we established an analysis platform, using the neuroblastoma cell line SH-SY5Y. For the first time ever we have characterized the SH-SY5Y cell line in an integrated whole genome, transcriptome, and proteome approach. In addition, we show that neuronal differentiation improves the physiological properties of this experimental model for studying mitochondrial dysfunction in PD. Methods: Whole genome sequencing, RNA-Seq, qRT-PCR, MS, FRET using Voltage sensing proteins, Immunofluorescence, cytometry, and live cell imaging. Results: The integrated molecular characterization of SH-SY5Y uncovers the level of molecular network integrity and hence the relevance of this cell line for targeted studies in selected molecular processes. Furthermore, we dissect changes in mitochondrial and energetic stress factors during the process of neuronal differentiation. Conclusions: In terms of both morphology and energetic stress response, differentiated SH-SY5Y cells are more similar to dopaminergic neurons than their undifferentiated precursors. Thanks to dividing progenitors and the short duration of differentiation, combined with the use of specific endpoints analysed with high-content microscopy, our platform paves the route for high throughput experiments on a neuronal cell culture model for PD. Our genomic characterization and expression profiling of SH-SY5Y cells furthermore helps guiding the experimental design and interpretation of such studies. [less ▲]Detailed reference viewed: 529 (55 UL) Differentiating $\sigma$-fields for Gaussian and shifted Gaussian processesDarses, Sébastien; Nourdin, Ivan ; Peccati, Giovanni in Stochastics (2009), 81(1), 79--97Detailed reference viewed: 139 (1 UL) Differentiating between static and complex problems: A theoretical framework and its empirical validationStadler, Matthias ; Niepel, Christoph ; Greiff, Samuel in Intelligence (2019), 72Detailed reference viewed: 67 (3 UL) Differentiating equality? The different advancement in the protected grounds in the case law of the Court of JusticeZaccaroni, Giovanni in Rossi, Lucia Serena; Casolari, Federico (Eds.) The principle of equality under EU law (2017)Detailed reference viewed: 94 (6 UL) Differentiating Equality? The different advancements in the protected grounds in the case law of the Court of JusticeZaccaroni, Giovanni Presentation (2015, May 18)Detailed reference viewed: 50 (0 UL) The differentiation of hypoelliptic diffusion semigroupsArnaudon, Marc; Thalmaier, Anton in Don Burkholder: A Collection of Articles in His Honor (2012)Detailed reference viewed: 405 (40 UL) The differentiation of hypoelliptic diffusion semigroupsArnaudon, Marc; Thalmaier, Anton in Illinois Journal of Mathematics (2010), 54(4), 1285-1311Detailed reference viewed: 156 (5 UL) Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell cultureLucumi Moreno, Edinson ; Hachi, Siham ; Hemmer, Kathrin et alin Lab on a Chip - Miniaturisation for Chemistry and Biology (2015), 15Detailed reference viewed: 595 (55 UL) Differentiation of primary CNS lymphoma and glioblastoma using Raman spectroscopy and machine learning algorithmsKlamminger, Gilbert Georg; Klein, Karoline; Mombaerts, Laurent et alin Free Neuropathology (2021), 2Objective and Methods: Timely discrimination between primary CNS lymphoma (PCNSL) and glioblastoma is crucial for diagnostics and therapy, but most importantly also determines the intraoperative surgical ... [more ▼]Objective and Methods: Timely discrimination between primary CNS lymphoma (PCNSL) and glioblastoma is crucial for diagnostics and therapy, but most importantly also determines the intraoperative surgical course. Advanced radiological methods allow this to a certain extent but ultimately, biopsy is still necessary for final diagnosis. As an upcoming method that enables tissue analysis by tracking changes in the vibrational state of molecules via inelastic scattered photons, we used Raman Spectroscopy (RS) as a label free method to examine specimens of both tumor entities intraoperatively, as well as postoperatively in formalin fixed paraffin embedded (FFPE) samples. Results: We applied and compared statistical performance of linear and nonlinear machine learning algorithms (Logistic Regression, Random Forest and XGBoost), and found that Random Forest classification distinguished the two tumor entities with a balanced accuracy of 82,4% in intraoperative tissue condition and with 94% using measurements of distinct tumor areas on FFPE tissue. Taking a deeper insight into the spectral properties of the tumor entities, we describe different tumor-specific Raman shifts of interest for classification. Conclusions: Due to our findings, we propose RS as an additional tool for fast and non-destructive, perioperative tumor tissue discrimination, which may augment treatment options at an early stage. RS may further serve as a useful additional tool for neuropathological diagnostics with little requirements for tissue integrity. [less ▲]Detailed reference viewed: 49 (2 UL) Différentiation sur les espaces de Sobolev généralisésSchiltz, Jang Presentation (2000, November 25)Detailed reference viewed: 39 (0 UL) Differentiation Tests for the Mean Shape and the Mean Variance of Renal Tumours appearing in early ChildhoodGiebel, Stefan; Schenk, Jens-Peter; Schiltz, Jang in Lechevallier, Yves; Saporta, Gilbert (Eds.) Proceedings of COMPSTAT'2010 (2010)Detailed reference viewed: 19 (5 UL)