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See detailDifferential and Twistor Geometry of the Quantum Hopf Fibration
Brain, Simon UL; Landi, Giovanni

in Communications in Mathematical Physics (2012), 315(2), 489-530

Detailed reference viewed: 92 (0 UL)
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See detailDifferential binding of IgG and IgA antibodies to antigenic determinants of bovine serum albumin
Hilger, C.; Grigioni, F.; De Beaufort, Carine UL et al

in Clinical and Experimental Immunology (2001), 123(3), 387-394

The aim of this study was to investigate the recognition pattern of bovine serum albumin (BSA), a major dietary protein by serum IgG and IgA antibodies. Anti-BSA IgG and IgA antibodies were measured by ... [more ▼]

The aim of this study was to investigate the recognition pattern of bovine serum albumin (BSA), a major dietary protein by serum IgG and IgA antibodies. Anti-BSA IgG and IgA antibodies were measured by ELISA technique in 3 different cohorts: 578 unselected persons, 84 new-onset insulin-dependent diabetes mellitus (IDDM) patients and 103 atopic persons. In order to characterize the recognition pattern of the different BSA domains, recombinant BSA and recombinant fragments covering the 3 BSA domains were produced. BSA digestion was monitored in simulated gastric fluid experiments by means of domain specific monoclonal antibodies. IgG and IgA antibody titres to native BSA were highest in DDM patients. The three major BSA domains were equally well recognized by IgG antibodies of the three cohorts. Interestingly all three study groups showed a dissociation of their IgG and IgA antibody response to the first BSA domain. The ratio of IgG to IgA antibodies recognizing this domain was 93%/42% in controls, 92%/37% in IDDM patients and 80%/47% in atopic persons. In simulated gastric fluid experiments, the first BSA domain was the first to become undetectable to specific monoclonal antibodies during digestion. In conclusion humoral IgG and IgA antibodies recognize the major BSA domains with different frequencies. The N-terminal domain of BSA, the first to be degraded during simulated gastric digestion is less well recognized by IgA antibodies. This suggests that early digestion is negatively correlated to the IgA antibody response and that the IgA response associated to the gut associated lymphoid tissue (GALT) and the systemic IgG antibody responses are independent. [less ▲]

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See detailDifferential Calculus on Z_2^n Supermanifolds
Covolo, Tiffany; Kwok, Stephen UL; Poncin, Norbert UL

E-print/Working paper (2016)

Detailed reference viewed: 129 (14 UL)
See detailDifferential classical conditioning of heterotopic noxious counterstimulation-induced hypoalgesia
Scheuren, Raymonde; Anton, Fernand UL; Michaux, Gilles

Poster (2011)

Detailed reference viewed: 77 (1 UL)
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See detailDIFFERENTIAL EFFECTS OF IL-6-TYPE CYTOKINES, THEIR INTERPLAY WITH HYPOXIA AND RESULTING EFFECTS ON THE METABOLISM
Zimmer, Andreas David UL

Doctoral thesis (2015)

IL-6-type cytokines signal mainly via the Jak/STAT pathway using the common receptor chain gp130. They are implicated in various biological processes such as differentiation, apoptosis, tissue ... [more ▼]

IL-6-type cytokines signal mainly via the Jak/STAT pathway using the common receptor chain gp130. They are implicated in various biological processes such as differentiation, apoptosis, tissue regeneration and proliferation. However, one of their main functions is the regulation of inflammatory processes, especially the initial induction of an inflammatory response. They hereby exert key steps in the onset as well as in the termination of an inflammation and in the promotion of the shift from the innate to the adaptive immune response. In hepatocellular carcinoma (HCC) IL-6 has been identified as a key factor in the onset as well as in the progression of this cancer. In this study we first investigated the effects of the IL-6-type cytokine IL-27 on hepatic cells. By evaluating IL-27 signalling in several HCC cell lines as well as hepatic cells, we could demonstrate that IL-27 does, in contrary to other IL-6-type cytokines, activate STAT1 and STAT3. A transcriptional and protein read-out of STAT3 was not found in hepatic cells. Thus, IL-27 exerts interferon γ-like functions only in the liver. Interestingly, we could further show that the IL-27 signalling can still be repressed by the canonical IL-6-type cytokine feedback regulator SOCS3, following a pre-stimulation with other IL-6-type cytokines. The second part of this thesis focused on the effects of the IL-6-type cytokine Oncostatin M (OSM) on the cellular metabolism. We hereby evaluated to which extent OSM-mediated STAT3 activation can induce a Warburg-like, highly glycolytic, metabolic phenotype under normoxia. OSM induced the expression of HIF-1α, a key factor mediating the shift to a highly glycolytic phenotype, in several HCC cell lines and immortalized hepatocytes. In the non-neoplastic hepatocyte cell line, PH5CH8, this led to the induction of a more glycolytic metabolic phenotype. The observed changes in these immortalized hepatocytes did not fully resemble the metabolic state seen under hypoxia, since mainly the observed induction of PDK1 seems to explain the effect. Overall we could not observe strong effects on glycolytic enzymes or other canonical HIF-1α target genes involved in metabolism, on a transcriptional or protein expression level in the investigated cells. Interestingly we found that HIF-1α does not seem to be mediating all the early adaptions of the cellular metabolism to hypoxia. The early inhibition of the pyruvate dehydrogenase complex could be shown to be independent of the HIF-1α-mediated up-regulation of the pyruvate dehydrogenase kinase 1, but might rather be induced by reactive oxygen species, created during the switch from normoxia to hypoxia. In summary we could show that in the liver IL-27 exerts interferon γ-like effects. Additionally, cytokine-activated STAT3 does not per se induce a glycolytic metabolic phenotype and HIF-1α is not necessary for some of the early adaptions of the cellular metabolism to hypoxia. [less ▲]

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See detailDifferential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.
Grünewald, Anne UL; Gegg, M. E.; Taanman, J.-W. et al

in Experimental neurology (2009), 219(1), 266-73

Mutations of the PINK1 gene are a cause of autosomal recessive Parkinson's disease (PD). PINK1 encodes a mitochondrial kinase of unknown function which is widely expressed in both neuronal and non ... [more ▼]

Mutations of the PINK1 gene are a cause of autosomal recessive Parkinson's disease (PD). PINK1 encodes a mitochondrial kinase of unknown function which is widely expressed in both neuronal and non-neuronal cells. We have studied fibroblast cultures from four family members harbouring the homozygous p.Q456X mutation in PINK1, three of their wild-type relatives, one individual with the homozygous p.V170G mutation and five independent controls. Results showed bioenergetic abnormalities involving decreased activities of complexes I and IV along with increased activities of complexes II and III in the missense p.V170G mutant. There were increased basal levels of mitochondrial superoxide dismutase in these cells and an exaggerated increase of reduced glutathione in response to paraquat-induced free radical formation. Furthermore, swollen and enlarged mitochondria were observed in this sample. In the p.Q456X nonsense mutants, the respiratory chain enzymes were unaffected, but ATP levels were significantly decreased. These results confirm that mutations of PINK1 cause abnormal mitochondrial morphology, bioenergetic function and oxidative metabolism in human tissues but suggest that the biochemical consequences may vary between mutations. [less ▲]

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See detailDifferential entropy analysis of the IDEA block cipher
Biryukov, Alex UL; Nakahara, Jorge; Murat Yildirim, Hamdi

in Journal of Computational and Applied Mathematics (2014), 259(Part B), 561570

This paper describes a new cryptanalytic technique that combines differential cryptanalysis with Shannon entropy. We call it differential entropy (DE). The objective is to exploit the non-uniform ... [more ▼]

This paper describes a new cryptanalytic technique that combines differential cryptanalysis with Shannon entropy. We call it differential entropy (DE). The objective is to exploit the non-uniform distribution of output differences from a given mapping as a distinguishing tool in cryptanalysis. Our preferred target is the IDEA block cipher, since we detected significantly low entropy at the output of its multiplication operation. We looked to further extend this entropy analysis to larger components and for a number of rounds. We present key-recovery attacks on up to 2.5-round IDEA in the single-key model and without weak-key assumptions. [less ▲]

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See detailDifferential Evolution Algorithms with Cellular Populations
Dorronsoro, Bernabé UL; Bouvry, Pascal UL

in Lecture Notes in Computer Science (2011), 6239

Differential Evolution (DE) algorithms are efficient Evolutionary Algorithms (EAs) for the continuous optimization domain. There exist a large number of DE variants in the literature. In this paper, we ... [more ▼]

Differential Evolution (DE) algorithms are efficient Evolutionary Algorithms (EAs) for the continuous optimization domain. There exist a large number of DE variants in the literature. In this paper, we analyze the effect of adding a cellular structure to the population of some of the most outstanding existing ones. The original algorithms will be compared versus their equivalent versions with cellular population both in terms of accuracy and convergence speed. As a result, we conclude that the cellular versions of the algorithms perform, in general, better than the equivalent state-of-the-art ones in the two considered issues. [less ▲]

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See detailDifferential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed
Alt, Simone UL; Turner, Jonathan D.; Klok, Melanie D. et al

in Psychoneuroendocrinology (2010), 35(4), 544-56

Detailed reference viewed: 99 (2 UL)
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See detailDifferential Fault Attacks on Elliptic Curve Cryptosystems
Biehl, Ingrid UL; Mey­er, Bernd; Müller, Volker UL

in Proceedings of Crypto 2000 (2000)

In this paper we extend the ideas for differential fault attacks on the RSA cryptosystem to cryptosystems using elliptic curves. We present three different types of at­tacks that can be used to derive ... [more ▼]

In this paper we extend the ideas for differential fault attacks on the RSA cryptosystem to cryptosystems using elliptic curves. We present three different types of at­tacks that can be used to derive information about the secret key if bit errors can be inserted into the elliptic curve computations done in a tamper-proof device. The effec­tiveness of the attacks was proven in a software simula­tion of the described ideas. [less ▲]

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See detailDifferential Game with (A)symmetric Players and Heterogeneous Strategies
Zou, Benteng UL

E-print/Working paper (2013)

This paper presents one kind of heterogeneous strategies in some differential games where one player plays open-loop strategy and the other one plays Markovian strategy. On top of the stationary path ... [more ▼]

This paper presents one kind of heterogeneous strategies in some differential games where one player plays open-loop strategy and the other one plays Markovian strategy. On top of the stationary path, this kind of strategies enable the study of trajectory dynamics, even for asymmetric players’ with non-linear-quadratic games. [less ▲]

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See detailDifferential Games with (A) symmetric Players and Heterogeneous Strategies
Zou, Benteng UL

in Journal of Reviews on Global Economics (2016), 5

One family of heterogeneous strategies in differential games with (a)symmetric players is developed in which one player adopts an anticipating open-loop strategy and the other adopts a standard Markovian ... [more ▼]

One family of heterogeneous strategies in differential games with (a)symmetric players is developed in which one player adopts an anticipating open-loop strategy and the other adopts a standard Markovian strategy. Via conjecturing principle, the anticipating open-loop strategic player plans her strategy based on the possible updating the rival player may take. These asymmetric strategies should be appropriate choices in some modelling circumstances and they frame one of the infinitely many non-degenerate Markovian Nash Equilibrium. Except the stationary path, this kind of strategy makes the study of short-run trajectory possible, which usually are not subgame perfect. However, the short-run non-perfection may provide very important policy suggestions. [less ▲]

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See detailDifferential Games with (A)symmetric Players and Heterogeneous Strategies
Zou, Benteng UL

E-print/Working paper (2014)

One family of heterogeneous strategies in differential games with (a)symmetric players is developed in which one player adopts an anticipating open-loop strategy and the other adopts a standard Markovian ... [more ▼]

One family of heterogeneous strategies in differential games with (a)symmetric players is developed in which one player adopts an anticipating open-loop strategy and the other adopts a standard Markovian strategy. Via conjecturing principle, the anticipating open-loop strategic player plans his strategy based on the possible updating the rival player may take. These asymmetric strategies frame nondegenerate Markovian Nash Equilibrium, which can be subgame perfect. Except the stationary path, this kind of strategy makes the study of short-run trajectory possible, which usually are not subgame perfect. However, the short-run nonperfection provides very important policy suggestions. [less ▲]

Detailed reference viewed: 106 (8 UL)
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See detailDifferential Geometry
Poncin, Norbert UL

Learning material (2012)

Detailed reference viewed: 287 (40 UL)
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See detailDifferential graded Lie groups and their differential graded Lie algebras
Jubin, Benoît; Kotov, Alexei; Poncin, Norbert UL et al

in Transformation Groups (2022), 10.1007/s00031-021-09666-9

Detailed reference viewed: 111 (5 UL)
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See detailDifferential impairments across attentional networks in binge drinking.
Lannoy, Severine; Heeren, Alexandre; Moyaerts, Nathalie et al

in Psychopharmacology (2017), 234

RATIONALE: The cognitive deficits observed in young binge drinkers have been largely documented during the last decade. Yet, these earlier studies have mainly focused on high-level cognitive abilities ... [more ▼]

RATIONALE: The cognitive deficits observed in young binge drinkers have been largely documented during the last decade. Yet, these earlier studies have mainly focused on high-level cognitive abilities (particularly memory and executive functions), and uncertainty thus still abounds regarding the integrity of less complex cognitive processes in binge drinking. This is particularly true for attentional abilities, which play a crucial role in behavior regulation and are impaired in other alcohol-related disorders. OBJECTIVES AND METHODS: To specify the attentional deficits associated with binge drinking, two groups of university students (40 binge drinkers and 40 matched controls) performed the Attention Network Task, a theoretically grounded test assessing three independent attentional networks: alerting, orienting, and executive control. RESULTS: Binge drinkers displayed preserved orienting performance but impaired alerting and executive control. Binge drinking is thus not related to a general attentional impairment but rather to specific impairments of the alerting and executive control networks. CONCLUSIONS: These results underline that, beyond the already explored high-level deficits, binge drinking is also related to impairments for attentional abilities. In view of the role played by attentional impairments in alcohol dependence, the present data also suggest that rehabilitation programs should be developed to improve attentional abilities at the early stages of alcohol-related disorders. [less ▲]

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See detailDifferential inhibition of IL-6-type cytokine-induced STAT activation by PMA
Terstegen, L.; Maassen, B. G.; Radtke, S. et al

in FEBS Letters (2000), 478(1-2), 100-4

Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and ... [more ▼]

Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM). Since the LIF receptor also contains an SHP2 recruitment site whereas the OSM receptor lacks such a module, we propose that two SHP2 binding modules within a homo- or heterodimeric receptor are necessary to mediate the PMA inhibitory effect. [less ▲]

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See detailA differential network analysis approach for lineage specifier prediction in stem cell subpopulations
Okawa, Satoshi UL; Espinosa Angarica, Vladimir UL; Lemischka, Ihor et al

in Systems Biology and Applications (2015)

Detailed reference viewed: 293 (33 UL)