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ORBilu is a project developed by
  Teeth. Where and how to make them.; Balling, Rudi  in Trends in Genetics (1999), 15(2), 59-65 Organs have to develop at precisely determined sites to ensure functionality of the whole organism. Organogenesis is typically regulated by a series of interactions between morphologically distinct ... [more ▼] Organs have to develop at precisely determined sites to ensure functionality of the whole organism. Organogenesis is typically regulated by a series of interactions between morphologically distinct tissues. The developing tooth of the mouse is an excellent model to study these processes and we are beginning to understand the networks regulating reciprocal tissue interactions at the molecular level. Synergistic and antagonistic effects of signaling molecules including FGFs and BMPs are recursively used to induce localized responses in the adjacent tissue layer (mesenchyme or epithelium). However, at different phases of odontogenesis these secreted growth factors have distinct effects and at the same time they are regulated by different upstream factors. The mesenchymal transcription factors Msx1 and Pax9 are initially regulated by epithelial FGFs and BMPs, but subsequently they function upstream of these signaling molecules. This cascade provides a molecular model by which reciprocal tissue interactions are controlled. [less ▲] Detailed reference viewed: 195 (0 UL) Bioinformatics and the discovery of gene function; ; et al in Trends in Genetics (1996), 128(7), 244-245 Scientific history was made in completing the yeast genuine sequence, yet its 13 Mb are a mere starting point. Two challenges loom large: to decipher the function of all genes and to describe the workings ... [more ▼] Scientific history was made in completing the yeast genuine sequence, yet its 13 Mb are a mere starting point. Two challenges loom large: to decipher the function of all genes and to describe the workings of the eukaryotic cell in full molecular detail. A combination of experimental and theoretical approaches will be brought to bear on these challenges. What will be next in yeast genome analysis from the point of view of bioinformatics? [less ▲] Detailed reference viewed: 165 (0 UL)CRABP and the teratogenic effects of retinoidsBalling, Rudi in Trends in Genetics (1991), (7), 279-287 Detailed reference viewed: 109 (1 UL) |
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