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See detailThe exposome and health: Where chemistry meets biology
Vermeulen, Roel; Schymanski, Emma UL; Barabási, Albert-László et al

in Science (2020), 367(6476), 392--396

Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To ... [more ▼]

Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The \textquotedblleftexposome\textquotedblright concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted. [less ▲]

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See detailTracking complex mixtures of chemicals in our changing environment
Escher, Beate I.; Stapleton, Heather M.; Schymanski, Emma UL

in Science (2020), 367(6476), 388--392

Chemicals have improved our quality of life, but the resulting environmental pollution has the potential to cause detrimental effects on humans and the environment. People and biota are chronically ... [more ▼]

Chemicals have improved our quality of life, but the resulting environmental pollution has the potential to cause detrimental effects on humans and the environment. People and biota are chronically exposed to thousands of chemicals from various environmental sources through multiple pathways. Environmental chemists and toxicologists have moved beyond detecting and quantifying single chemicals to characterizing complex mixtures of chemicals in indoor and outdoor environments and biological matrices. We highlight analytical and bioanalytical approaches to isolating, characterizing, and tracking groups of chemicals of concern in complex matrices. Techniques that combine chemical analysis and bioassays have the potential to facilitate the identification of mixtures of chemicals that pose a combined risk. [less ▲]

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See detailWavelike charge density fluctuations and van der Waals interactions at the nanoscale
Ambrosetti, Alberto; Ferri, Nicola; DiStasio Jr., Robert A. et al

in Science (2016), 351(6278), 1171-1176

Recent experiments on noncovalent interactions at the nanoscale have challenged the basic assumptions of commonly used particle- or fragment-based models for describing van der Waals (vdW) or dispersion ... [more ▼]

Recent experiments on noncovalent interactions at the nanoscale have challenged the basic assumptions of commonly used particle- or fragment-based models for describing van der Waals (vdW) or dispersion forces. We demonstrate that a qualitatively correct description of the vdW interactions between polarizable nanostructures over a wide range of finite distances can only be attained by accounting for the wavelike nature of charge density fluctuations. By considering a diverse set of materials and biological systems with markedly different dimensionalities, topologies, and polarizabilities, we find a visible enhancement in the nonlocality of the charge density response in the range of 10 to 20 nanometers. These collective wavelike fluctuations are responsible for the emergence of nontrivial modifications of the power laws that govern noncovalent interactions at the nanoscale. [less ▲]

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See detailReproducibility in density functional theory calculations of solids
Lejaeghere, K.; Bihlmayer, G.; Tkatchenko, Alexandre UL et al

in Science (2016), 351

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See detailIs low fertility really a problem? Population aging, dependency, and consumption
Lee, Ronald; Mason, Andrew; Olivera Angulo, Javier UL et al

in Science (2014), 346(6206), 229-234

Longer lives and fertility far below the replacement level of 2.1 births per woman are leading to rapid population aging in many countries. Many observers are concerned that aging will adversely affect ... [more ▼]

Longer lives and fertility far below the replacement level of 2.1 births per woman are leading to rapid population aging in many countries. Many observers are concerned that aging will adversely affect public finances and standards of living. Analysis of newly available National Transfer Accounts data for 40 countries shows that fertility well above replacement would typically be most beneficial for government budgets. However, fertility near replacement would be most beneficial for standards of living when the analysis includes the effects of age structure on families as well as governments. And fertility below replacement would maximize per capita consumption when the cost of providing capital for a growing labor force is taken into account. Although low fertility will indeed challenge government programs and very low fertility undermines living standards, we find that moderately low fertility and population decline favor the broader material standard of living. [less ▲]

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See detailImportance de la langue maternelle pour le development des enfants au Luxembourg
Aleksic, Gabrijela UL

Article for general public (2013)

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See detailThe Arabidopsis circadian clock incorporates a cADPR-based feedback loop
Dodd, A. N.; Gardner, M. J.; Hotta, C. T. et al

in SCIENCE (2007), 318(5857), 1789-1792

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine ... [more ▼]

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator’s transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock. [less ▲]

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See detailSequence interpretation. Functional annotation of mouse genome sequences.
Nadeau, J. H.; Balling, Rudi UL; Barsh, G. et al

in Science (2001), 291(5507), 1251-5

Detailed reference viewed: 103 (6 UL)