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See detailBrief hypnotherapeutic-behavioral intervention for functional abdominal pain and irritable bowel syndrome in childhood: A randomized controlled trial
Gulewitsch, Marco; Müller, Judith; Hautzinger, Martin et al

in European Journal of Pediatrics (2013)

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See detailDo male and female adolescents differ in the effect of individual and family characteristics on their use of psychotropic drugs?
Baumann, Michèle UL; Spitz, E.; Predine, R. et al

in European Journal of Pediatrics (2007), 166(1), 29-35

This study assesses the effects of individual and family characteristics on psychotropic drug use among male and female adolescents. The sample included 2,396 subjects attending two middle schools and two ... [more ▼]

This study assesses the effects of individual and family characteristics on psychotropic drug use among male and female adolescents. The sample included 2,396 subjects attending two middle schools and two high schools. Respondents completed self-administered questionnaires covering gender, age, body mass index, smoking, alcohol use, illicit drug use, tiredness during the daytime, selfreported personality traits, family conditions, and psychotropic drug use. The data were analyzed using logistic models. The prevalence of frequent psychotropic drug use (for headache, tiredness, nervousness, anxiety, insomnia) was 43.0% overall; twice as high among girls than boys. Among the girls, frequent psychotropic drug use was associated with frequent tiredness during the daytime (adjusted odds ratio OR 2.03, 95% CI 1.61–2.57), smoking(2.02, 1.50–2.71), alcohol use (1.34, 1.04–1.74), higher body mass index (>18 kg/m2, 1.54, 1.16–2.04), poor family atmosphere (1.33, 1.03–1.72), and being worried (1.93, 1.53–2.43) or easily becoming irritable (1.28, 1.01–1.62). In boys the factors with significant ORs were frequent tiredness during the daytime (2.21, 1.67–2.93), alcohol use (1.52, 1.15–2.01), and being worried (1.70, 1.28–2.26) or easily becoming irritable (1.42, 1.06–1.89); univariate analysis revealed a significant relationship with smoking and family atmosphere. An association was also observed for illicit drugs in both sexes and for age≥17 years in girls. Individual and family characteristics have marked influence on psychotropic drug use among both male and female adolescents. Preventive measures should be taken to make adolescents and their parents more aware of the risks and to improve their living conditions. [less ▲]

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See detailAcute pancreatitis after growth hormone treatment: disease or treatment linked?
De Beaufort, Carine UL; Beck, P.; Seligmann, R. et al

in European Journal of Pediatrics (2006), 12

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See detailOvernight metabolic profiles in very young insulin-dependent diabetic children
De Beaufort, Carine UL; Bruining, G. J.; Home, P. D. et al

in European Journal of Pediatrics (1986), 145(1-2), 73-76

The magnitude of the disturbance of metabolic control in diabetes mellitus in very young children has been recognised, but seldom studied. Limitations to studies are set by the difficulty of obtaining ... [more ▼]

The magnitude of the disturbance of metabolic control in diabetes mellitus in very young children has been recognised, but seldom studied. Limitations to studies are set by the difficulty of obtaining control data and until recently the lack of alternative therapies. Recently "mini" pumps for continuous subcutaneous insulin delivery have become available and may offer an alternative therapeutic possibility. The present investigation has been undertaken to collect overnight metabolic data of very young diabetic children (<6 years) controlled by standard injection therapy. During one admission to hospital frequent blood samples were collected for free insulin, glucose, alanine, lactate, glycerol and 3-hydroxybutyrate determinations. In all children (n=9) the profiles showed a steep rise in glucose from 04.30h (6.2±1.3 mmol/l) to 09.30h (17.8±2.4 mmol/l) (the so-called "dawn-phenomenon"). The nature of the changes in the intermediary metabolites suggested that rise in blood glucose was caused by insufficient insulin. We have attempted to explore the time relationship between the overnight drop in free insulin levels and the rises in blood glucose by a distribution-free statistical analysis, correlating successive changes in time between the two profiles. The analysis suggested a delay of 2-6 h between free insulin levels and their effects. In conclusion: a clear "dawn phenomenon" is seen in very young diabetic children, and contributes to their poor glycaemic control. More stable and higher insulin concentrations in the early morning, obtained perhaps by continuous subcutaneous insulin infusion, might ameliorate the overall glycaemic control in the very young diabetic child. © 1986 Springer-Verlag. [less ▲]

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