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See detailSequence analysis of the Methanococcus jannaschii genome and the prediction of protein function
Andrade, M.; Casari, G.; deDaruvar, A. et al

in Computer Applications in the Biosciences [=CABIOS] (1997), 13(4), 481-483

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See detailPHD - AN AUTOMATIC MAIL SERVER FOR PROTEIN SECONDARY STRUCTURE PREDICTION
ROST, B.; SANDER, C.; Schneider, Reinhard UL

in Computer Applications in the Biosciences [=CABIOS] (1994), 10(1), 53-60

By the middle of 1993, > 30000 protein sequences had been listed. For 1000 of these, the three-dimensional (tertiary) structure has been experimentally solved. Another 7000 can be modelled by homology ... [more ▼]

By the middle of 1993, > 30000 protein sequences had been listed. For 1000 of these, the three-dimensional (tertiary) structure has been experimentally solved. Another 7000 can be modelled by homology. For the remaining 21000 sequences, secondary structure prediction provides a rough estimate of structural features. Predictions in three states range between 35% (random) and 88% (homology modelling) overall accuracy. Using information about evolutionary conservation as contained in multiple sequence alignments, the secondary structure of 4700 protein sequences was predicted by the automatic e-mail sewer PHD, For proteins with at least one known homologue, the method has an expected overall three-state accuracy of 71.4% for proteins with at least one known homologue (evaluated on 126 unique protein chains). [less ▲]

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