References of "Cell Host and Microbe"
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See detailSnapShot: The Expobiome Map
Aho, Velma UL; Ostaszewski, Marek UL; Martin-Gallausiaux, Camille et al

in Cell Host and Microbe (2022), 30(9), 1340

The human gut microbiome is intricately connected to health and disease. Microbiome-derived molecules are implicated in many chronic diseases involving inflammation. Herein, we summarize the diverse ... [more ▼]

The human gut microbiome is intricately connected to health and disease. Microbiome-derived molecules are implicated in many chronic diseases involving inflammation. Herein, we summarize the diverse complex of such immunogenic molecules, including nucleic acids, (poly)peptides, structural molecules, and metabolites. The interactions between this “expobiome” and human immune pathways are specifically illustrated in the context of chronic diseases. [less ▲]

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See detailThe gut microbiome molecular complex in human health and disease
Wilmes, Paul UL; Martin-Gallausiaux, Camille; Ostaszewski, Marek UL et al

in Cell Host and Microbe (2022), 30(9), 1201-1206

The human gut microbiome produces a functional complex of biomolecules, including nucleic acids, (poly) peptides, structural molecules, and metabolites. This impacts human physiology in multiple ways ... [more ▼]

The human gut microbiome produces a functional complex of biomolecules, including nucleic acids, (poly) peptides, structural molecules, and metabolites. This impacts human physiology in multiple ways, especially by triggering inflammatory pathways in disease. At present, much remains to be learned about the identity of key effectors and their causal roles. [less ▲]

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See detailHumanized mice for modeling human infectious disease: challenges, progress, and outlook.
Legrand, Nicolas; Ploss, Alexander; Balling, Rudi UL et al

in Cell Host and Microbe (2009), 6(1), 5-9

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and ... [more ▼]

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases. [less ▲]

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See detailMutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain.
Lee, Jong Seok; Krause, Roland UL; Schreiber, Jorg et al

in Cell Host and Microbe (2008), 3(2), 97-103

Attenuated strains of mycobacteria can be exploited to determine genes essential for their pathogenesis and persistence. To this goal, we sequenced the genome of H37Ra, an attenuated variant of ... [more ▼]

Attenuated strains of mycobacteria can be exploited to determine genes essential for their pathogenesis and persistence. To this goal, we sequenced the genome of H37Ra, an attenuated variant of Mycobacterium tuberculosis H37Rv strain. Comparison with H37Rv revealed three unique coding region polymorphisms. One polymorphism was located in the DNA-binding domain of the transcriptional regulator PhoP, causing the protein's diminished DNA-binding capacity. Temporal gene expression profiles showed that several genes with reduced expression in H37Ra were also repressed in an H37Rv phoP knockout strain. At later time points, genes of the dormancy regulon, typically expressed in a state of nonreplicating persistence, were upregulated in H37Ra. Complementation of H37Ra with H37Rv phoP partially restored its persistence in a murine macrophage infection model. Our approach demonstrates the feasibility of identifying minute but distinct differences between isogenic strains and illustrates the consequences of single point mutations on the survival stratagem of M. tuberculosis. [less ▲]

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